Immersion experiences and behavioural patterns in game-based learning     

Mei-En Hsu  Meng-Tzu Cheng 《British journal of educational technology : journal of the Council for Educational Technology》2021,52(5):1981-1999

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Promoting children's inquiry performances in alternate reality games: A mobile concept mapping-based questioning approach     

Hsin-Yi Liang  Tien-Yu Hsu  Gwo-Jen Hwang 《British journal of educational technology : journal of the Council for Educational Technology》2021,52(5):2000-2019

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Tracking control of nonlinear automobile idle-speed time-delay system via differential geometry approach     

Ting-Li Chien  Ching-Yu Hsu 《Journal of The Franklin Institute》2005,342(7):760-775

This paper is concerned with the problem of global asymptotical tracking of single-input single-output (SISO) nonlinear time-delay control systems. Based on the input-output feedback linearization technique and Lyapunov method for nonlinear state feedback synthesis, a robust globally asymptotical output tracking controller design methodology for a broad class of nonlinear time-delay control systems is developed. The underlying theoretical approaches are the differential geometry approach and the composite Lyapunov approach. One utilizes the parameterized co-ordinate transformation to transform the original nonlinear system into singularly perturbed model and the composite Lyapunov approach is then applied for output tracking. For the view of practical application, the proposed control methodology has been successfully applied to the famous nonlinear automobile idle-speed control system.  相似文献   

A uniformly loaded infinite-length thin plate bent to a cylindrical surface in the presence of couple-stresses     

Y.C. Hsu 《Journal of The Franklin Institute》1971

Exact solutions, based on couple-stresses plane strain theory of elasticity, are presented for the normal, shear and couple-stresses, displacements and rotations of an infinite-length (in z-axis) rectangular thin plate simply supported at two opposite edges (i.e.x=±L) and bent by a uniform load. Exact solutions reduce to classical values as l→0. Here l is defined as the new elastic material constant taking account of couple stresses.  相似文献   

Exploring the educative power of an experienced mathematics teacher educator-researcher     

Kai-Lin Yang  Hui-Yu Hsu  Fou-Lai Lin  Jian-Cheng Chen  Ying-Hao Cheng 《Educational Studies in Mathematics》2015,89(1):19-39

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Technologies and Reformed-Based Science Instruction: The Examination of a Professional Development Model Focused on Supporting Science Teaching and Learning with Technologies     

Campbell  Todd  Longhurst  Max L.  Wang  Shiang-Kwei  Hsu  Hui-Yin  Coster  Dan C. 《Journal of Science Education and Technology》2015,24(5):562-579

Journal of Science Education and Technology - While access to computers, other technologies, and cyber-enabled resources that could be leveraged for enhancing student learning in science is...  相似文献   

Sustained release of hydrophobic drugs by the microfluidic assembly of multistage microgel/poly (lactic-co-glycolic acid) nanoparticle composites     

Myat Noe Hsu  Rongcong Luo  Kerwin Zeming Kwek  Yong Chen Por  Yong Zhang  Chia-Hung Chen 《Biomicrofluidics》2015,9(5)

The poor solubility of many newly discovered drugs has resulted in numerous challenges for the time-controlled release of therapeutics. In this study, an advanced drug delivery platform to encapsulate and deliver hydrophobic drugs, consisting of poly (lactic-co-glycolic acid) (PLGA) nanoparticles incorporated within poly (ethylene glycol) (PEG) microgels, was developed. PLGA nanoparticles were used as the hydrophobic drug carrier, while the PEG matrix functioned to slow down the drug release. Encapsulation of the hydrophobic agents was characterized by fluorescence detection of the hydrophobic dye Nile Red within the microgels. In addition, the microcomposites prepared via the droplet-based microfluidic technology showed size tunability and a monodisperse size distribution, along with improved release kinetics of the loaded cargo compared with bare PLGA nanoparticles. This composite system has potential as a universal delivery platform for a variety of hydrophobic molecules.  相似文献   

Microscale flow propulsion through bioinspired and magnetically actuated artificial cilia     

Chia-Yuan Chen  Ling-Ying Cheng  Chun-Chieh Hsu  Karthick Mani 《Biomicrofluidics》2015,9(3)

Recent advances in microscale flow propulsion through bioinspired artificial cilia provide a promising alternative for lab-on-a-chip applications. However, the ability of actuating artificial cilia to achieve a time-dependent local flow control with high accuracy together with the elegance of full integration into the biocompatible microfluidic platforms remains remote. Driven by this motive, the current work has constructed a series of artificial cilia inside a microchannel to facilitate the time-dependent flow propulsion through artificial cilia actuation with high-speed (>40 Hz) circular beating behavior. The generated flow was quantified using micro-particle image velocimetry and particle tracking with instantaneous net flow velocity of up to 10¹μm/s. Induced flow patterns caused by the tilted conical motion of artificial cilia constitutes efficient fluid propulsion at microscale. This flow phenomenon was further measured and illustrated by examining the induced flow behavior across the depth of the microchannel to provide a global view of the underlying flow propulsion mechanism. The presented analytic paradigms and substantial flow evidence present novel insights into the area of flow manipulation at microscale.  相似文献   

Microwells support high-resolution time-lapse imaging and development of preimplanted mouse embryos     

Yu-Hsiang Chung  Yi-Hsing Hsiao  Wei-Lun Kao  Chia-Hsien Hsu  Da-Jeng Yao  Chihchen Chen 《Biomicrofluidics》2015,9(2)

A vital aspect affecting the success rate of in vitro fertilization is the culture environment of the embryo. However, what is not yet comprehensively understood is the affect the biochemical, physical, and genetic requirements have over the dynamic development of human or mouse preimplantation embryos. The conventional microdrop technique often cultures embryos in groups, which limits the investigation of the microenvironment of embryos. We report an open microwell platform, which enables micropipette manipulation and culture of embryos in defined sub-microliter volumes without valves. The fluidic environment of each microwell is secluded from others by layering oil on top, allowing for non-invasive, high-resolution time-lapse microscopy, and data collection from each individual embryo without confounding factors. We have successfully cultured mouse embryos from the two-cell stage to completely hatched blastocysts inside microwells with an 89% success rate (n = 64), which is comparable to the success rate of the contemporary practice. Development timings of mouse embryos that developed into blastocysts are statistically different to those of embryos that failed to form blastocysts (p–value < 10⁻¹⁰, two-tailed Student''s t-test) and are robust indicators of the competence of the embryo to form a blastocyst in vitro with 94% sensitivity and 100% specificity. Embryos at the cleavage- or blastocyst-stage following the normal development timings were selected and transferred to the uteri of surrogate female mice. Fifteen of twenty-two (68%) blastocysts and four of ten (40%) embryos successfully developed into normal baby mice following embryo transfer. This microwell platform, which supports the development of preimplanted embryos and is low-cost, easy to fabricate and operate, we believe, opens opportunities for a wide range of applications in reproductive medicine and cell biology.  相似文献   

Strategic fit among knowledge attributes,knowledge management systems,and service positioning     

Che-Hung?Lin  Fu-Sheng?TsaiEmail author  David D C?Tarn  Shu-Chuan?Hsu 《知识管理研究与实践》2015,13(3):272-280

Knowledge management systems (KMSs) support high-quality services while shaping and improving positioning of services. Given such strategic importance of KMS, this study explores the effects of different types of KMS, which respond to the attributes (i.e., diversity and tacitness) of collective knowledge, on service (re-)positioning. Through a case study of a financial consulting company at the core of KMSs, combinations of the two knowledge attributes are used to determine which type of KMS (i.e., information library, deepened stock, thought islands, and shared brain) offers the greatest efficiency and effectiveness in service (re-)positioning. The joint concerns of service innovation scope and specificity are also considered. Finally, the study discusses the theoretical and practical implications on KMS design and functionality in the new business age of service innovation.  相似文献