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Nakano T Itoyama T Yoshida K Sawada Y Ikeda S Fukuda T Matsuda T Negoro M Arai F 《Biomicrofluidics》2010,4(4):46505
We proposed and fabricated multiscale transparent arteriole and capillary vessel models with circular cross sections of 10-500 μm using photolithography. The circularities of the fabricated 10, 50, and 500 μm diameter microchannels were 84.0%, 61.5%, and 82.3%, respectively. Next, we connected these different models to realize a circulation type blood vessel model simulating arteriole networks. We proposed a novel connection method using an intermediate connector made of wax, which we used to connect these models to make a circulation model. In flow experiments, the fabricated models showed no leakage and circulation models with seamless connections were achieved. 相似文献
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Toshiaki Miyamoto Saya Hashimoto Hideya Yanamoto Mai Ikawa Yoshiki Nakano Takashi Sekiyama 《European Journal of Sport Science》2018,18(8):1119-1127
Purpose: Brain-derived neurotrophic factor (BDNF) is well known for its potential to promote brain plasticity. It has been proposed that combining cognitive and physical exercise (CCPE) may have the potential to generate more synergistic benefits in cognitive function than either cognitive exercise (CE) or physical exercise (PE) alone. The purpose of this study was to examine acute responses of peripheral BDNF levels and cognitive performance to CE, PE, and CCPE.Methods: Thirteen healthy adult men participated in four experimental sessions; a 30-min CE, a 30-min cycling PE at an intensity of 60% peak oxygen uptake, a 30-min CCPE at the same intensity as PE, and a 30-min session of complete rest. Plasma BDNF levels and cognitive performance were measured before and after each session.Results: Both PE and CCPE significantly increased plasma BDNF levels (p?p?≥?.05), and there was no significant difference in peripheral BDNF levels between PE and CCPE (p?≥?.05). No session induced a significant change in cognitive performance (p?≥?.05).Conclusions: Our study suggests that CE and PE have different responses of peripheral BDNF levels and that CCPE had no additional or synergistic effect on peripheral BDNF levels compared with PE alone. This study offers further insights into the potential mechanisms underlying the respective roles of CE, PE, and CCPE for peripheral BDNF levels and cognitive performance. 相似文献
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The Native American population is severely underrepresented in empirical test validity research despite being overrepresented in special education programs and at increased risk for psychoeducational evaluation. The structural validity of the Wechsler Intelligence Scale for Children – Fourth Edition (WISC‐IV) was investigated with a sample of 176, six‐to‐sixteen‐year‐old Native American children referred for a psychoeducational evaluation. Confirmatory factor analysis procedures replicated the normative first‐order factor structure and a higher‐order general ability factor that accounted for the greatest amount of common (69%) and total (33%) variance. These results support the structural validity of the WISC‐IV with a referred Native American sample and suggest that interpretation of the WISC‐IV scores should not neglect the strong general ability factor. 相似文献
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David Van Kleeck Gerald Langford Jimmie Lundgren Hikaru Nakano Allison Jai O'Dell Trey Shelton 《Cataloging & classification quarterly》2016,54(7):452-467
This article presents a case study of quality management for print and electronic resource metadata, summarizing problems and solutions encountered by the Cataloging and Discovery Services Department in the George A. Smathers Libraries at the University of Florida. The authors discuss national, state, and local standards for cataloging, automated and manual record enhancements for data, user feedback, and statewide consortial factors. Findings show that adherence to standards, proactive cleanup of data via manual processes and automated tools, collaboration with vendors and stakeholders, and continual assessment of workflows are key to the management of biblio-graphic data quality in consortial academic libraries. 相似文献
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Tomiko Yakura Naoyuki Hatayama Chikako Kawahara Yusuke Ohmichi Mika Ohmichi Nobutaro Ban Shuichi Hirai Takashi Nakano Munekazu Naito 《Anatomical sciences education》2022,15(2):392-402
Although the methods for medical education continue to evolve due to the development of medicines, the cadaver dissection course still plays a fundamental role. The cadaver dissection course allows students to learn to handle instruments correctly while actively exploring three-dimensional anatomy. However, dissection comes with the risk of accidental injury. In recent years, the number of classes offered for the cadaver dissection course has decreased while the amount of knowledge required in clinical medicine has increased. Simulation-based education (SBE) has been proven to be an effective educational method that enhances the development of practical skills by integrating learners' knowledge and skills. This study aimed to investigate the effect of SBE as a preparatory education course when taken prior to a medical student's enrollment in the cadaver dissection course. In the present study, an SBE assuming practical cadaver dissection course was performed in the Clinical Simulation Center. The frequency of injury rates per 1000 h of cadaver dissection course was significantly less in 2017 and 2018 compared to that in 2016. Two years after the implementation of the SBE, average student self-efficacy scores and written examination scores significantly increased, whereas self-contentment scores were relatively unchanged. The results showed that the implementation of SBE decreased the incidence of injuries and improved students' overall self-efficacy scores and increased acquisition of knowledge evident on written examination score. Therefore, SBE as a preparatory education course may effectively promote the combined development of dissection skills and anatomical knowledge in the subsequent fundamental cadaver dissection course. 相似文献
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Dielectrophoresis (DEP) of biomolecules has large potential to serve as a novel selectivity parameter for bioanalytical methods such as (pre)concentration, fractionation, and separation. However, in contrast to well-characterized biological cells and (nano)particles, the mechanism of protein DEP is poorly understood, limiting bioanalytical applications for proteins. Here, we demonstrate a detailed investigation of factors influencing DEP of diagnostically relevant immunoglobulin G (IgG) molecules using insulator-based DEP (iDEP) under DC conditions. We found that the pH range in which concentration of IgG due to streaming iDEP occurs without aggregate formation matches the pH range suitable for immunoreactions. Numerical simulations of the electrokinetic factors pertaining to DEP streaming in this range further suggested that the protein charge and electroosmotic flow significantly influence iDEP streaming. These predictions are in accordance with the experimentally observed pH-dependent iDEP streaming profiles as well as the determined IgG molecular properties. Moreover, we observed a transition in the streaming behavior caused by a change from positive to negative DEP induced through micelle formation for the first time experimentally, which is in excellent qualitative agreement with numerical simulations. Our study thus relates molecular immunoglobulin properties to observed iDEP, which will be useful for the future development of protein (pre)concentration or separation methods based on DEP. 相似文献
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David Van Kleeck Hikaru Nakano Gerald Langford Trey Shelton Jimmie Lundgren Allison Jai O'Dell 《Cataloging & classification quarterly》2017,55(7-8):560-577
This article presents a case study of quality management issues for electronic resource metadata to assess the support of user tasks (find, select, and obtain library resources) and potential for increased efficiencies in acquisitions and cataloging workflows. The authors evaluated the quality of existing bibliographic records (mostly vendor supplied) for e-resource collections as compared with records for the same collections in OCLC's WorldShare Collection Manager (WCM). Findings are that WCM records better support user tasks by containing more summaries and tables of contents; other checkpoints are largely comparable between the two source record groups. The transition to WCM records is discussed. 相似文献