排序方式： 共有21条查询结果，搜索用时 15 毫秒
1.
Fernandez Frank Baker David P. Fu Yuan-Chih Muñoz Ismael G. Ford Karly Sarita 《Minerva》2021,59(1):79-98
Minerva - Over the course of the 20th century, unprecedented growth in scientific discovery was fueled by broad growth in the number of university-based scientists. During this period the American... 相似文献
2.
Yogesh M. Patel Sanidhya Jain Abhishek Kumar Singh Kedar Khare Sarita Ahlawat Supreet Singh Bahga 《Biomicrofluidics》2020,14(6)
We present design, characterization, and testing of an inexpensive, sheath-flow based microfluidic device for three-dimensional (3D) hydrodynamic focusing of cells in imaging flow cytometry. In contrast to other 3D sheathing devices, our device hydrodynamically focuses the cells in a single-file near the bottom wall of the microchannel that allows imaging cells with high magnification and low working distance objectives, without the need for small device dimensions. The relatively large dimensions of the microchannels enable easy fabrication using less-precise fabrication techniques, and the simplicity of the device design avoids the need for tedious alignment of various layers. We have characterized the performance of the device with 3D numerical simulations and validated these simulations with experiments of hydrodynamic focusing of a fluorescently dyed sample fluid. The simulations show that the width and the height of the 3D focused sample stream can be controlled independently by varying the heights of main and side channels of the device, and the flow rates of sample and sheath fluids. Based on simulations, we also provide useful guidelines for choosing the device dimensions and flow rates for focusing cells of a particular size. Thereafter, we demonstrate the applicability of our device for imaging a large number of RBCs using brightfield microscopy. We also discuss the choice of the region of interest and camera frame rate so as to image each cell individually in our device. The design of our microfluidic device makes it equally applicable for imaging cells of different sizes using various other imaging techniques such as phase-contrast and fluorescence microscopy. 相似文献
3.
Sonya M. Alemán Sarita Gaytán 《International journal of qualitative studies in education》2017,30(2):128-146
Scholars maintain that when race and racism are addressed as factors that continue to shape inequality in the classroom, white students often deny the validity of these claims, while Students of Color tend to feel empowered by them. However, drawing on open-ended interviews, focus group discussions, and survey data, we argue that some Students of Color resist critical race pedagogy and curriculum. Specifically, we identify and analyze how this push back is articulated through three triggers: (1) an entrenchment in majoritarian ideologies; (2) a disavowal of racialized oppression; and (3) a disinclination to scrutinize personal experiences marred by race. These dynamics illustrate what we call ‘resisting decolonization’ – a reluctance to grapple with pedagogies that destabilize dominant ideologies about race and racism in schools and disrupt mainstream ideas regarding ethnic or racial identity. We introduce this concept in an attempt to hone critical race pedagogy to better address the needs of Students of Color who sometimes unknowingly participate in the marginalization of Populations of Color through deficit thinking or through the denial of the continuing significance of race. 相似文献
4.
In this section of Resonance, we invite readers to pose questions likely to be raised in a classroom situation. We may suggest strategies for dealing with them, or invite responses, or both. “Classroom” is equally a forum for raising broader issues and sharing personal experiences and viewpoints on matters related to teaching and learning science. 相似文献
5.
Richard R. Rosenkranz Karly S. Geller Mitch J. Duncan Cristina M. Caperchione Corneel Vandelanotte Anthony J. Maeder 《Measurement in physical education and exercise science》2018,22(4):322-331
This cross-sectional study of 504 community-dwelling Australian adults (328 females, 176 males, mean age 50.8 ± 13.0 years) sought to examine the reliability and validity of measurement scales for physical activity (PA) self-efficacy and outcome expectations. Participants completed demographic and anthropometric measurements, and a 23-item psychosocial questionnaire pertinent to an intervention target of 10,000 steps per day. Exploratory (n = 252) and confirmatory (n = 252) factor analyses were conducted to determine psychometric properties of the measures. Based on theory and goodness-of-fit indices, six factors were extracted from the questionnaire: PA self-efficacy; PA barriers self-efficacy (including general, personal, and conflict); and physical and mental outcome expectations. From confirmatory factor analysis, the model demonstrated good data fit in four out of five indices: CFI = 0.99; TLI = 0.99; SRMR = 0.03; RMSEA = 0.03, 90%CI = 0.01–0.05, χ2 = 113.14 (88), p = 0.04; including good fit by sex, age, weight status, education, and birth country. PA interventions can employ our psychometrically sound social cognitive measures. 相似文献
6.
Pratibha Dixit Shally Awasthi Nutan Maurya Sarita Agarwal M. Srinivasan 《Indian journal of clinical biochemistry : IJCB》2015,30(1):35-42
Cystic Fibrosis Trans membrane conductance regulator (CFTR) gene is an asthma susceptibility gene. In the present study we investigated the possible association of CFTR gene mutations in Indian asthmatic children as compared to controls. The study included 250 asthmatics and 250 age and sex matched controls. Case to control ratio for sample size was 1:1. Genotyping was performed for 24 CFTR gene mutations by ARMS-PCR and PCR–RFLP method. Among 24 CFTR gene mutations, heterozygous allele of R553X mutation was found in 4 (1.6 %) asthmatic cases and 2 (0.8 %) controls. Value of FVC and FEV1/FVC ratio were significantly lower in heterozygous individuals (p value <0.05). No significant difference was observed in the genotype and allele frequency of R553X mutation (OR = 1.339, 95 % CI = 0.755–2.374, p value = 0.685). Furthermore, all wild type homozygous alleles were observed in remaining 23 CFTR gene mutations. Our data concludes that R553X mutation was not significantly associated in Indian asthmatic children. 相似文献
7.
Lee Irene Grover Shuchi Martin Fred Pillai Sarita Malyn-Smith Joyce 《Journal of Science Education and Technology》2020,29(1):1-8
This article provides an introduction for the special issue of the Journal of Science Education and Technology focused on computational thinking (CT) from a disciplinary perspective. The special issue connects earlier research on what K-12 students can learn and be able to do using CT with the CT skills and habits of mind needed to productively participate in professional CT-integrated STEM fields. In this context, the phrase “disciplinary perspective” simultaneously holds two meanings: it refers to and aims to make connections between established K-12 STEM subject areas (science, technology, engineering, and mathematics) and newer CT-integrated disciplines such as computational sciences. The special issue presents a framework for CT integration and includes articles that illuminate what CT looks like from a disciplinary perspective, the challenges inherent in integrating CT into K-12 STEM education, and new ways of measuring CT aligned more closely with disciplinary practices. The aim of this special issue is to offer research-based and practitioner-grounded insights into recent work in CT integration and provoke new ways of thinking about CT integration from researchers, practitioners, and research-practitioner partnerships.
相似文献8.
Sarita N. Chavan Umesh More Shruti Mulgund Vishal Saxena Alka N. Sontakke 《Indian journal of clinical biochemistry : IJCB》2007,22(2):101-105
Osteoporosis encompasses a wide spectrum of conditions associated with imbalance of osteoclastic and osteoblastic activities.
The increased activity of osteoclasts leads to increased free radical formation and hence lipid peroxidation. Present study
probes into the role of antioxidants as a palliative treatment for osteoporosis. It involved 50 healthy controls and 75 clinically
diagnosed osteoporosis patients. Both the groups underwent baseline assessment of biochemical markers viz. osteoblastic markers:
serum Alkaline phosphatase. Free or ionic calcium and Inorganic phosphorus, osteoclastic markers: serum Tartarate resistant
acid phosphatase and Malondialdehyde and the antioxidant status: serum Superoxide dismutase and Erythrocyte reduced glutathione.
The osteoporotic group was then divided into groups A (Vitamin E-Evinal 400 mg), B (Vitamin C-Celin 500 mg), C (Vitamin E+C-Evinal+Celin)
for antioxidant supplementation for a period of 90 days. The results reveal that there is significant fall in concentration
of serum MDA (p<0.001), TrACP (p<0.01). Improvement in antioxidant status is reflected by significant rise in concentration
of serum SOD (p<0.001) and erythrocyte GSH (p<0.001) after 90 days of antioxidant supplementation in osteoporosis. The findings
indicate that on the whole bone status improved with prolonged antioxidant vitamin supplementation, which can be used as a
palliative treatment for osteoporosis. The efficacy is not affected whether the vitamins are administered singly or conjointly. 相似文献
9.
The direct, retention, and transfer effects of repeated word and pseudoword reading were studied in a pretest, training, posttest, retention design. First graders (48 good readers, 47 poor readers) read 25 CVC words and 25 CVC pseudowords in ten repeated word reading sessions, preceded and followed by a transfer task with a different set of items. Two weeks after training, trained items were assessed again in a retention test. Participants either received phonics feedback, in which each word was spelled out and repeated; word feedback, in which each word was repeated; or no feedback. During the training, both good and poor readers improved in accuracy and speed. The increase in speed was stronger for poor readers than for good readers. The good readers demonstrated a stronger increase for pseudowords than for words. This increase in speed was most prominent in the first four sessions. Two weeks after training, the levels of accuracy and speed were retained. Furthermore, transfer effects on speed were found for pseudowords in both groups of readers. Good readers performed most accurately during the training when they received no feedback while poor readers performed most accurately during the training with the help of phonics feedback. However, feedback did not differentiate for reading speed or for effects after the training. The effects of repeated word reading were found to be stronger for poor readers than for good readers. Moreover, these effects were found to be stronger for pseudowords than for words. This indicates that repeated word reading can be seen as an important trigger for the improvement of decoding skills. 相似文献
10.
Innovative Higher Education - The tenure evaluation process is characterized by a lack of clarity and governed by unspoken rules. At the same time, while institutions have increased the presence of... 相似文献