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Menon BR Rathi MA Thirumoorthi L Gopalakrishnan VK 《Indian journal of clinical biochemistry : IJCB》2010,25(4):401-404
The study was designed to evaluate the hepatoprotective activity of ethanolic extract of Bacopa monnieri in acute experimental liver injury induced by Nitrobenzene in rats. The extract at the dose of 200 mg/kg body weight was
administered orally once every day for 10 days. The increased serum marker enzymes, Aspartate transaminase, Alanine transaminase
and alkaline phosphatase were restored towards normalization significantly by the extract. Significant increase in SOD, CAT
and GPx was observed in extract treated liver injured experimental rats. Histopathological examination of the liver tissues
supported the hepatoprotection. It is concluded that the ethanolic extract of Bacopa monieri plant possess good hepatoprotective activity. 相似文献
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A. Supriya Simon D. Dinesh Roy V. Jayapal T. Vijayakumar 《Indian journal of clinical biochemistry : IJCB》2010,25(2):164-168
Cardiometabolic syndrome is one of the major public health issues of this century which describes a cluster of clinical characteristics.
Seventy two patients with coronary artery disease (CAD) and cardiometabolic syndrome and forty healthy age and sex matched
normal controls were selected for this study. Detailed clinical epidemiological and anthropometric characteristics were noted.
Lipid profile and Cytokinesis-block micronuclei (CBMN) assay using cytochalasin B were carried out in all the subjects. Serum
total cholesterol, triglyceride and LDL-cholesterol was significantly higher and HDL cholesterol was significantly lower in
patients compared to their normal counter-parts (P<0.05). CBMN frequency of the patients was significantly higher at all ages
compared to their normal counter parts (P<0.05). Various risk factors like diabetes, hypertension, dyslipidemia, abdominal
obesity, smoking and alcoholism were found influenced the CBMN frequency; but the changes were not significant. From this
study it can be concluded that DNA damage was found to be higher in patients with cardiometabolic syndrome which may be attributed
to the generation of free radicals associated with alcohol consumption, tobacco use, dyslipidemia and glucose intolerance
and the accumulation of free radicals with increase in age. 相似文献
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Studies on serum arginase have shown that it is having the least unexplained variation and its activity is closely related with the severity of jaundice. Arginase is thus stable, consistent, efficient, specific and sensitive to changes. It is a better indicator of hepatocellular damage. 相似文献
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Souvik Ghosh H.N. Verma Dinesh Chandra P. Nanda 《The Journal of Agricultural Education and Extension》2013,19(1-4):17-26
The key to agricultural development in the eastern region of India, where problems of excess water and water scarcity coexist, is the scientific management of water resources with the adoption of recommended water-management technologies. A vast networking of infrastructure for the development and dissemination of water- management technologies have been designed since the very inception of planned economic change. Despite these concerted efforts, a large number of recommended technologies are either being adopted in piece-meal or not at all. The research and extension systems have been generating and disseminating technologies, therefore, it was felt worthwhile to assess the feasibility and appropriateness of recommended tecnologies as perceived in the first instance by the personnel of the research system and followed by the extension personnel. These steps were felt to be a precursor to screen the recommended technologies for their dissemination and evaluation in different farming systems. The assessment of recommended water-management technologies was performed after their documentation from different organisations working in the field of water management in two eastern India states viz. Orissa and West Bengal. The perception of 30 personnel members of the research system regarding the feasibility of these technologies elucidated that out of 86 documented recommended water-management technologies, 40 were having feasibility scores of ≥ 4.0; 8 technologies with score £ 3.0 and the rest of the 38 technologies with a score between 3.0 and 4.0 on a feasibility continuum range from 1.0 (not feasible) to 5.0 (highly feasible). Out of 40 recommended technologies (already assessed as highly feasible by the research personnel), extension personnel have perceived 16 and 10 technologies as highly appropriate and feasible, respectively. While six and four technologies were found to be less appropriate and feasible, respectively. Correlation of all nine indicators of appropriateness with feasibility of technologies was significant. Five indicators of appropriateness viz. simplicity, physical compatibility, production sustainability, cultural compatibility and cost together constituted 36.8 per cent of the total variation in feasibility with the ‘t’ values and ‘F’ values being significant. It indicates that not appropriateness of technologies alone but other factors influence the feasibility of technologies. 相似文献
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The high mobility group (HMG) proteins I and Y are well characterised non-histone chromosomal proteins which bind to A-T rich
regions of DNA and regulate gene expression and/or DNA replication. A correlation has been demonstrated between the increased
expression of HMG-Y proteins and malignancy. However, it is not known whether the expression of HMGs particularly, the Y group,
is a function of proliferation rate. In the present study, we have used normal tissues of calf testes, thymus and liver. The
results show distinctly high expression of HMG-Y proteins in testes than in thymus and the expression was practically undetectable
in liver. The results suggest that even in normal tissues there is a direct correlation between the proliferation rate and
the expression of the HMG-Y proteins, which can partly explain its increased expression in cancer. 相似文献
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Chandrika D. Nayak Vaibhav Agarwal Dinesh M. Nayak 《Indian journal of clinical biochemistry : IJCB》2013,28(2):152-157
Objective: Fetus with intrauterine stress may exhibit programmed changes that can alter its metabolism and bear severe risk for diseases in adult life. The current study was designed to assess the correlation between cord blood lipid profile with the anthropometric data in neonates. Materials and methods: 146 newborn babies born at Dr. T M A Pai Hospital, Udupi were screened and their birth weight, length, head circumference and abdominal circumference were noted at birth. Umbilical cord blood samples were analyzed for total cholesterol, triglycerides (TG), high density lipoprotein (HDL) and low density lipoprotein (LDL). Infants were also grouped further based on gestational age (GA) and sex-adjusted birth weight percentiles into three groups i.e. Small for gestational age (SGA), Appropriate for gestational age (AGA) and Large for gestational age (LGA) for comparison of their lipid profiles. Inclusion criteria were normal fetal heart rate at birth and an APGAR score >7. Statistical significance of relation between lipid profile and anthropometry was done using ANOVA and Pearson correlation coefficient. Results: Triglycerides were significantly higher in babies with higher ponderal index (PI) than those with lower PI (P = 0.011). The TG level of SGA babies were significantly higher as compared to AGA group (P = 0.001). The LDL levels in neonates with higher abdominal circumference were significantly lower than those with lower AC (P = 0.019). Mean HDL levels were higher in neonates with larger AC, but not statistically significant. Maternal BMI had no influence on neonates’ lipid profile. Conclusion: Abnormal intrauterine milieu created by maternal changes during gestation may bear a profound impact on lipid metabolism in neonates, which may account for their differences in lipid profile and anthropometry at birth. 相似文献
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Sharon Farnel Ali Shiri Sandra Campbell Cathy Cockney Dinesh Rathi Robyn Stobbs 《Cataloging & classification quarterly》2017,55(5):289-306
This article describes the Digital Library North (DLN) project, a collaboration among researchers at the University of Alberta, staff at the Inuvialuit Cultural Resource Centre, and communities within the Inuvialuit Settlement Region (ISR) to develop a culturally appropriate metadata framework for a digital library of cultural resources. It will discuss gathering of data to inform the first iteration of the metadata framework and digital library prototype, as well as revisions made to both the framework and the digital library based on feedback obtained through community interaction with the prototype. 相似文献
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