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Chandrawati Kumari Bijo Varughese Siddarth Ramji Seema Kapoor 《Indian journal of clinical biochemistry : IJCB》2016,31(4):414-422
Pre analytical process of extraction for accurate detection of organic acids is a crucial step in diagnosis of organic acidemias by GCMS analysis. This process is accomplished either by solid phase extraction (SPE) or by liquid–liquid extraction (LLE). Both extraction procedures are used in different metabolic laboratories all over the world. In this study we compared these two extraction procedures in respect of precision, accuracy, percent recovery of metabolites, number of metabolites isolated, time and cost in a resource constraint setup. We observed that the mean recovery from SPE was 84.1 % and by LLE it was 77.4 % (p value <0.05). Moreover, the average number of metabolites isolated by SPE and LLE was 161.8 ± 18.6 and 140.1 ± 20.4 respectively. The processing cost of LLE was economical. In a cost constraint setting using LLE may be the practical option if used for organic acid analysis. 相似文献
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Ramzi El-Haddadeh Vishanth Weerakkody Mohamad Osmani Dhaval Thakker Kawaljeet Kaur Kapoor 《Government Information Quarterly》2019,36(2):310-320
With the advancement of disruptive new technologies, there has been a considerable focus on personalisation as an important component in nurturing users' engagement. In the context of smart cities, Internet of Things (IoT) offer a unique opportunity to help empower citizens and improve societies' engagement with their governments at both micro and macro levels. This study aims to examine the role of perceived value of IoT in improving citizens' engagement with public services. A survey of 313 citizens in the UK, engaging in various public services, enabled through IoT, found that the perceived value of IoT is strongly influenced by empowerment, perceived usefulness and privacy related issues resulting in significantly affecting their continuous use intentions. The study offers valuable insights into the importance of perceived value of IoT-enabled services, while at the same time, providing an intersectional perspective of UK citizens towards the use of disruptive new technologies in the public sector. 相似文献
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R. Kumar R. Kapoor B. Mittal A. Kumar R. D. Mittal 《Indian journal of clinical biochemistry : IJCB》2003,18(2):209-215
Metabolic abnormalities were investigated in 44 stone patients with first time (group 1) and 56 with 2 times stone formation
(group 2), and in 25 normal individuals. 24hr urine was analysed spectrophotometrically for oxalate, calcium, magnesium, citrate,
uric acid, phosphate and creatinine. Hypocitraturia and hyperoxaluria were the common abnormalities in the stone formers.
Stone patients had significantly higher urinary oxalate, calcium and uric acid and lower phosphate than normal individuals.
Citrate/calcium and magnesium/calcium ratio were significantly high in normal individuals than stone formers. Patients in
group 2 excreted significantly higher urinary calcium and lower citrate that patients in group 1. Citrate/calcium ratio was
higher in group 1 than group 2. Hypocitraturia, hyperoxaluria, hypercalciuria and increased citrate/calcium and magnesium/calcium
ratio seem to be an essential risk factor for stone formation. Patients with recurrent stone formation could be distinguished
from patients with first time stone formation on the basis of urinary calcium and citrate. 相似文献
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This paper proposes a new scheme for ensuring data consistency in unstructured p2p networks where peers can subscribe to multiple content types (identified by labels) and are rapidly informed of content updates. The idea is based on using a static tree structure, the Cluster-K+ tree, that maintains most of the structural information about peers and labels. A label denotes a set of replicated or co-related data in the network. The Cluster-K+ tree provides efficient retrieval, addition, deletion and consistent updates of labels. Our proposed structure guarantees a short response search time of O(H + K), where H denotes the height of the tree and K the degree of an internal tree node. We present theoretical analytic bounds for the worst-case performance. To verify the bounds, we also present experimental results obtained from a network simulation. The results demonstrate that the actual performance of our system is significantly better than the theoretical bounds. 相似文献
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Shailendra KAPOOR 《Journal of Zhejiang University. Science. B》2013,14(1):85-86
I read with great interest the recent article "Curcumin inhibits proliferation of human lens epithelialcells: a proteomic analysis"by Hu et al. (2012), pub-lished in Journal of Zhejiang University-SCIENCE B(Biomedicine & Biotechnology). Curcumin may be ofsignificant benefit in other optic disorders 相似文献
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This study attempts to describe some possible elaborations of the cultivation hypothesis and present relevant evidence from a Korean student sample. Using the postulates and methodology of the cultivation analysis approach to mass communication, this investigation employs a two‐pronged research strategy: message system analysis and cultivation analysis. Message system analysis consisted of one‐week sample of Korean television programs from the three television networks in June 1991. For cultivation analysis, a questionnaire was administered to 1,200 Korean students attending eight junior and senior high schools from five different states in July, 1991. Within the clear limitations of measures, the results suggested that viewers differentially perceive the social reality of different content types. The findings seem to indicate that the degree of cultivation effects is not uniform across different kinds of television programming. 相似文献
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R. Kapoor D. B. Gundpatil B. L. Somani T. K. Saha S. Bandyopadhyay P. Misra 《Indian journal of clinical biochemistry : IJCB》2014,29(2):213-220
Cancer cells generally exhibit increased glycolysis for ATP generation (the Warburg effect). Compounds that inhibit glycolysis have potential applications in cancer treatment. dl-glyceraldehyde (DLG) and 2-Deoxyglucose (2-DG) have been proven effective in the inhibition of glucose metabolism. Ehrlich ascites carcinoma (EAC) cells were injected intraperitoneally (i.p) in 10–12 weeks old Swiss albino mice, weighing between 20 and 30 g. The anticancer activity of DLG and 2-DG were determined by tumor volume, tumor weight, viable and nonviable tumor cell count, average survival time, percentage increase in life span and tumor inhibition ratio. The blood samples were obtained for biochemical analysis after 9 days of treatment to study the effect on liver, kidney and haematological parameters. Histopathological examination of liver and kidney was also performed. One-way ANOVA test and Dunnett’s test were used for comparisons of parameters in study groups. Both DLG and 2-DG individually decreased the tumor weight, tumor volume, viable tumor cell count and significantly increased the life span of treated mice, however the combination was found to be better. The biochemical parameters of liver and kidney functions and haematological parameters were restored close to control group as compared with the EAC bearing mice. Histopathological examination of liver and kidney in EAC control group showed large areas of necrosis, congestion and mononuclear cell infiltration but such changes were not observed in liver and kidney sections observed after i.p injection of DLG and 2-DG for 9 days. Improvement was much better in the group where combination of these two drugs were used. 相似文献
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