Genetic Polymorphism of Angiotensin II Type 1 Receptors and Their Effect on the Clinical Outcome of Captopril Treatment in Arab Iraqi Patients with Acute Coronary Syndrome (Mid Euphrates)     

Fadhaa A. Ghafil  Bassim I. Mohammad  Hussain S. Al-Janabi  Najah R. Hadi  Hayder A. Al-Aubaidy 《Indian journal of clinical biochemistry : IJCB》2021,36(1):81

Genetic variation in the angiotensin II type 1 receptor (AT1R) has an important effect on the outcome of acute coronary syndrome (ACS) initiated treatment with captopril. This study aims to investigate the impact of genetic polymorphism of AT1R (rs5186 and rs275651) on the ACS outcome in Iraqi patients treated with captopril. A total of 250 Iraqi individuals with ACS were included in this case—control study and they were divided into two study groups; Study group 1 included 125 participants who were prescribed captopril, 25 mg twice daily and study group 2 included 125 participants who received no captopril as part of their ACS treatment (control study). The AT1R gene (rs5186) CC genotype was found to be associated with ST-elevation myocardial infarction (STEMI) (Odd’s ratio (O.R) = 1.2, P = 0.7), while AC was associated with Non-ST-elevation myocardial infarction (NSTEMI) and unstable angina (UA) (O.R = 1.2, P = 0.8). AC genotype is more prone to have Percutaneous coronary intervention (PCI) after ACS attack (O.R = 1.2, P = 0.6). CC genotype had a risk to get less improvement (O.R = 1.6, P = 0.5), so might require higher doses of captopril during acute coronary insult. The AT1R gene (rs275651) AA genotype was associated with UA (O.R = 1.3, P = 0.9). AA and AT genotypes were more prone to have PCI after ACS attack (O.R = 3.9 P = 0.2, O.R = 3.5, P = 0.3 respectively) and thus requiring higher doses of captopril. We conclude that the AT1R rs5186, rs275651 genetic polymorphisms might partially affect the clinical outcome of ACS patients treated with captopril and might have captopril resistance which requires higher doses.  相似文献   

运动与血睾酮   总被引：5，自引：0，他引：5  

黄何平  朱俊英 《四川体育科学》2004,(2):27-29

血睾酮作为雄性激素的代表，与机体的运动能力有密切的关系。本文综述了血睾酮的生理特点、作用、以及运动对血睾酮影响的研究进展，旨在促进国内体育科学工作者对血睾酮有更深的理解、研究和应用  相似文献   

音乐对有氧耐力素质影响的研究   总被引：1，自引：0，他引：1  

洪显君 《成都体育学院学报》2002,28(2):95-96

有氧耐力是指运动员在供氧充足的情况下克服疲劳的能力，其训练目的在于增强有机体氧气运输系统的机能。将音乐引入有氧耐力训练，用呼吸频率变化等生理指标，对实验组和对照组在其提高幅度上进行实验分析，证明音乐有助于有氧耐力的提高。  相似文献   

运动对呼吸链抗氧化能力的影响   总被引：1，自引：1，他引：0  

龚煦琳 《辽宁体育科技》2005,27(2):38-39

呼吸链是防御氧攻击的一道重要屏障，还原型CoQ10细胞色素c是呼吸链中抗氧化的重要物质；运动对呼吸链的抗氧化能力有重要影响。复合物Ⅰ活性与运动量、强度和时间密切相关；急性力竭运动可以使细胞色素c活性降低；辅酶Q的含量与自由基的产生呈线性相关。  相似文献   

Physical activity and nutrition guidelines to help with the fight against COVID-19     

Kayvan Khoramipour  Aref Basereh  Amirhoseein Ahmadi Hekmatikar  Lindy Castell  Ruheea Taskin Ruhee 《Journal of sports sciences》2021,39(1):101-107

ABSTRACT

As the world is witnessing the epidemic of coronavirus disease 2019, emerging genetics and clinical pieces of evidence suggest a similar immunopathology to those of severe acute respiratory syndrome and Middle East respiratory syndrome. Staying at home to prevent the spread of the virus and consequently being largely inactive is associated with unintended consequences. These can actually enhance the infection risk and exacerbate poor health conditions including impaired immune function. Physical activity is a feasible way of improving health, particularly physical and mental health in a time of social isolation. However, people with certain health conditions in these circumstances may need a special physical activity programme in addition to any exercise they may already be performing via online programmes. This review aims to provide practical guidelines during the COVID-19 quarantine period. We suggest performing aerobic, resistance training, respiratory muscle training and yoga in the healthy, and in those with upper respiratory tract illness, patients with lower respiratory tract illness should be restricted to respiratory muscle training and yoga. In addition, vitamins D and C, omega-3 fatty acids, and regular consumption of fruit and vegetables might be considered as nutritional aids to support the immune system in those affected by COVID-19.  相似文献   

急性运动降低感染风险的免疫调节机制     

陈巍  侯莉娟 《中国体育科技》2020,(5):14-20

由于新型冠状病毒(2019-nCoV)感染的肺炎疫情暴发,人们将居家运动作为提高免疫力与保持健康的重要手段,运动与免疫的关系再度受到关注。一般认为,在充分恢复的前提下进行规律的中高强度运动可提高免疫功能,而急性运动(acute exercise)可能抑制免疫功能并增加感染风险。急性运动后外周血淋巴细胞计数及功能降低、免疫球蛋白A水平分泌减少被认为是运动抑制免疫的理论基础。但目前这种独立于非运动因素影响免疫功能增加感染风险的认识受到了现有研究的挑战。急性运动可通过应激反应将淋巴细胞亚群迅速动员至循环中,运动结束后,淋巴细胞亚群又会迅速迁移至外周组织。淋巴细胞的重新分布(lymphocyte redeployment)可能是一种进化保守的免疫机制,这一过程强化了外周组织的免疫监视与调节功能,有助于提升机体抵抗感染能力。因此,从这一视角就急性运动对机会性感染风险及免疫功能影响的现状进行综述。  相似文献   

外泌体来源的半乳糖凝集素-9预测肝移植术后排斥发生及预后（英文）     

Ai-bin ZHANG  Yi-fan PENG  Jun-jun JIA  Yu NIE  Shi-yu ZHANG  Hai-yang XIE  Lin ZHOU  Shu-sen ZHENG 《Journal of Zhejiang University. Science. B》2019,(7):605-612

目的:外泌体及其内容物是各种肝脏疾病的潜在生物标志物。本研究探索外泌体及其内容物在肝移植排斥反应及预后中的作用。创新点:本研究发现外泌体及内含物半乳糖凝集素-9(galectin-9)在肝移植术后排斥及预后预测中发挥重要作用。方法:分别从急性排斥和肝功能稳定患者提取外泌体,进行分离、鉴定并检测其内含蛋白。候选蛋白通过在73个急性排斥病人和63个肝功能稳定病人切除肝的组织芯片中进行验证。最后将蛋白表达量和临床参数纳入Kaplan-Meier生存率和Cox回归分析。结论:外泌体来源的galectin-9可作为预测肝移植术后排斥发生及预后的生物学指标。  相似文献   

Educational software for simulating risk of HIV infection     

Rothberg  Madeleine A.  Sandberg  Sonja  Awerbuch  Tamara E. 《Journal of Science Education and Technology》1994,3(1):65-70

  相似文献   

啤酒酵母阻断白色念珠菌感染的实验研究     

刘为国  刘超  李维佳  高爽  秦美霞  王爽 《大连大学学报》2006,27(2):84-87

目的:探讨啤酒酵母菌对白色念珠菌感染的影响作用及机制.方法:用啤酒酵母免疫家兔后,经家兔耳的皮下注射白色念珠菌,建立播散性念珠菌病动物感染模型,观察啤酒酵母菌免疫组和对照组家兔的感染状况;通过测定抗体效价和巨噬细胞吞噬功能,了解啤酒酵母的免疫效果.结果:观察显示:①免疫组兔耳皮下注射区红肿面积明显小于对照组;②肾脏充血及肿胀程度免疫组小于对照组,同时,对照组肾脏出现肉眼可见的脓肿灶;③病理诊断显示,免疫组炎性细胞浸润范围小;④免疫组抗体效价明显高于对照组,吞噬百分率与吞噬指数,免疫组与对照组有明显差异(P<0.01).结论:啤酒酵母能够提高机体免疫功能,减轻白色念珠菌的局部感染及全身感染.  相似文献   

猪瘟与蓝耳病混合感染的诊断与治疗方法     

陈桂香  银梅  范国英 《河南职业技术师范学院学报》2011,(2):57-60,65

通过流行病学调查、临床表现、病理剖检对新乡市长垣县赵堤镇某猪场发生的一起以体温升高、不食、腹泻、耳部发绀、鼻部、腹下、臀部、四肢末端发紫为特征的疾病,做出初步诊断为猪瘟与蓝耳病混合感染,然后采取10份病料经处理后用正向间接血凝试验检测CSF,酶联免疫吸附试验检测PRRS,结果表明CSF的阳性率为80%,PRRS的阳性率为60%,从而确诊该病为CSF与PRRS混合感染,通过采取自家苗、抗猪瘟血清、接种疫苗三种方法作比较,同时肌肉注射杂症一针,菌毒急救,拌料饲喂防蓝灵,金方案Ⅱ型,饮水中添加口服补液盐,电解多维等综合防治措施,结果显示自家苗治疗效果最好,病情得到控制,治愈率达70%,为目前规模化猪场混合感染的快速检测和治疗提供了可参考性的建议.  相似文献