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Age-related macular degeneration (AMD) is still an incurable blinding eye disease because of complex pathogenic mechanisms and unusual diseased regions.With the use of chemical biology tools,great progress has been achieved in improving the understanding of AMD pathogenesis.The severity of AMD is,at least in part,linked to the non-degradable lipofuscin bis-retinoids in retinal pigment epithelial (RPE).This material is thought to result from the lifelong accumulation of lysosomal residual bodies containing the end products derived from the daily phagocytosis of rod outer segments by RPE cells.Here,we present previously recognized bis-retinoids with focus on structures and biosynthetic pathways.In addition to a brief discussion on the mutual conversion relationships of bis-retinoids,future perspectives and the medical relevance of such studies on these lipofuscin constituents are also highlighted. 相似文献
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Wu Xiao-hong Fang Jing-wen Huang Yin-qiong Bai Xue-feng Zhuang Yong Chen Xiao-yu Lin Xia-hong 《Journal of Zhejiang University. Science. B》2020,21(11):911-920
Journal of Zhejiang University-SCIENCE B - To investigate the value of optic disc retinal nerve fiber layer (RNFL) thickness in the diagnosis of diabetic peripheral neuropathy (DPN). Ninety... 相似文献
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目的：探讨青光眼术后发生视网膜脱离进行激光治疗的临床疗效。方法：对8例青光眼术后发生上方裂孔的孔源性视网膜脱离的患者未采用手术治疗，而是先通过合适的体位及双眼包扎后，当视网膜下液全部或大部分吸收后采用了激光封闭视网膜裂孔的方法。结果：随访6月～1年，8例患者视网膜均复位,且未破坏青光眼手术的效果。结论：对于青光眼术后上方视网膜裂孔的孔源视网膜脱离，通过合适的体位及双眼包扎后，当视网膜下液全部或大部分吸收后可采用激光封闭视网膜裂孔，不用手术治疗，以避免因手术治疗而破坏抗青光眼手术的效果。 相似文献
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Qiu-xia Jin Xin-ran Dong Jing-meng Chen Ke Yao Ya-lin Wu 《Journal of Zhejiang University. Science. B》2014,15(7):661-669
Gene and drug therapies are being developed to alleviate vision loss in patients with Stargardt’s disease and age-related macular degeneration (AMD). To evaluate the therapeutic effects of these treatments, organic solvents are routinely used to extract and quantify bisretinoid lipofuscin constituents, such as N-retinylidene-N-retinyl-ethanolamine (A2E) and all-trans-retinal dimer (ATR-dimer). By high-performance liquid chromatography (HPLC), we found that A2E and ATR-dimer were both altered by tetrahydrofuran (THF) and chloroform, but were stable in dimethyl sulfoxide (DMSO) or methanol (MeOH). In addition, cyclohexane and ethanol (EtOH) did not alter ATR-dimer, whereas an alteration of A2E occurred in EtOH. On the basis of these findings, we designed processes II–IV, generated by modifications of process I, a routine method to measure bisretinoid compounds in vivo. Extra amounts of either ATR-dimer or A2E in mouse eyecups were released by processes II–IV versus process I. Efforts to clarify the effects of organic solvents on lipofuscin pigments are important because such studies can guide the handling of these fluorophores in related experiments. 相似文献
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Objectives
To present a detailed confession from a perpetrator of Shaken Baby syndrome.Methods
Case study.Results
We present a confession of Shaken Baby syndrome describing how the perpetrator severely injured a 3 year old with repeated bursts of acceleration-deceleration (shaking). The child sustained retinal and intracranial hemorrhage. Details of the confession and circumstances by which it was obtained lead us to believe its accuracy.Conclusions
Accurate perpetrator confessions offer useful windows into realities and pathophysiology of abusive head trauma. 相似文献
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