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1.
Matteo Vidali Vincenza Bianchi Marco Bagnati Nadia Atzeni Andrea Marco Bianchi Giorgio Bellomo 《Biochemia medica : ?asopis Hrvatskoga dru?tva medicinskih biokemi?ara / HDMB》2014,24(1):175-179
Introduction:
In this work we report on the possible effect of the medical therapy on CDT concentration in a chronic alcohol abuser, with known medical history (July 2007 – April 2012) and alcohol abuse confirmed by relatives.Case history:
At the end of 2007, patient displayed the following laboratory results: AST 137 U/L, ALT 120 U/L, GGT 434 U/L, MCV 101 fL and CDT 3.3%. On December 2007, after double coronary artery bypass surgery, he began a pharmacological treatment with amlodipine, perindopril, atorvastatin, isosorbide mononitrate, carvedilol, ticlopidine and pantoprazole. In the next months, until may 2011, the patient resumed alcohol abuse, as confirmed by relatives; however, CDT values were repeatedly found negative (0.8% and 1.1%) despite elevated transaminases and GGT, concurrent elevated ethyl glucuronide concentration (> 50 mg/L) and blood alcohol concentration (> 1 g/L). Alcohol consumption still continued despite increasing disulfiram doses ordered by an Alcohol Rehab Center. On May 2011, the patient was transferred to a private medical center where he currently lives.Conclusions:
This study suggests the possibility that a medical therapy including different drugs may hamper the identification of chronic alcohol abusers by CDT. 相似文献2.
Indian ethnicity by itself is a strong risk factor for development of CAD in Indian postmenopausal women due to lower HDL
levels as compared to Whites and women of oriental origin. We evaluated and compared the short-term effects of menopause,
estrogen replacement therapy and combined estrogen and progestin replacement therapy on various atherogenic indices. 40 postmenopausal
women, both surgical and natural (20 each) were selected. 10 surgical postmenopausal women were given 0.625 mg conjugated
estrogens daily for 6 months and 10 natural postmenopausal women were given 0.625 mg conjugated estrogen with 2.5 mg medroxyprogesterone
acetate daily. 20 women were included in the control group and given placebo. Fasting venous blood samples were analyzed for
extended lipid profile and calculated atherogenic indices before starting the therapy and after 1,3 and 6 months. LDL and
Apolipoprotein B increased (p<0.05) and those of Apolipoprotein A1 and HDL decreased in the control groups. In both the study
groups levels of serum cholesterol and LDL decreased (p<0.05) and those of HDL and Apolipoprotein A1 increased (p<0.01). LDL/HDL,
Apo B/ApoA1, Total Cholesterol/HDL decreased significantly (p<0.05) in both the study groups compared to the control groups.
The effect of estrogen alone was more significant as compared to combination therapy. Log Triglycerides (TG)/HDL ratio showed
a decrease in women on estrogen alone but the difference was not significant. Our study confirms that short term HRT has a
favorable effect on atherogenic indices in Indian postmenopausal women. 相似文献
3.
运动性贫血时大鼠红细胞锌卟啉、转铁蛋白受体及营养干预的影响 总被引：3，自引：2，他引：1
红细胞锌卟啉、红细胞膜转铁蛋白受体是反映铁贮备的指标,实验结果表明:运动训练导致运动性贫血大鼠红细胞锌原卟啉含量和红细胞膜转铁蛋白受体含量明显增加,且与血清铁呈高度相关,说明红细胞锌卟啉是反映缺铁性贫血的良好指标,而红细胞膜转铁蛋白受体含量能更为准确地反映红细胞内和机体铁代谢状况;抗贫血铁制剂复合营养补剂的干预显著降低了运动性贫血大鼠红细胞锌原卟啉和红细胞膜转铁蛋白受体含量,并通过对这些机体铁代谢状况指标的改善反映抗贫血铁制剂复合营养补剂对提高大鼠红细胞铁贮备和维持大鼠铁代谢稳定具有积极作用. 相似文献
4.
对肝肾疾病进行转铰蛋白(Transferren简称TF)和铜蓝蛋白(Ceruloplasmin简称CP)测定,结果表明:各组肝炎病人的TF均显著低于正常组,且谷丙转氨酶异常和HBsAg阳性者TF含量明显低于正常者,TF可作为判断肝病预后的一个指标。肾炎病人的TF也比正常人低,CP含量各组不一,肝癌患者的CP(52.44±8.73mg％)显著高于正常人(46.75±7.92mg％),乙型肝炎病人和正常组间未见差异.肝豆状核变性患者CP非常显著低于正常人,故检测CP有助于鉴别肝硬化和肝癌,同时对临床诊断肝豆状桉变性提供一项可靠的客观指标. 相似文献
5.
高住低练指在运动员居住在相对较高的海拔高度,接受低氧暴露,同时在平原训练的一种科学化训练方法。多年来,高住低练对人体机能和运动能力的影响一直是研究的热点。高住低练可以在一定程度上提高运动员回到平原后的运动能力,创造好成绩,也得到了广大教练员和运动员的认同,高原低氧暴露对人体器官系统机能的影响也得到了更为深入的研究。发表在《Eur J Appl Physiol》2006年第96卷第4期上Paul Robach等人的论文“高住低练对高水平游泳运动员红细胞生成和有氧运动的影响”探讨了优秀游泳运动员在高住低练期间血液红细胞系指标的变化规律,以及对运动员有氧运动能力的影响,为高水平游泳运动员进行高住低练提供了实验依据。 相似文献
6.
耐力运动对血色素及铁代谢状况的影响 总被引：1，自引：0，他引：1
本实验选取参加全国大学生运动会赛前集训的长跑运动员１０名（男、女各５名）,于集训初期进行了３０００米成绩测试,经过２个月课余训练,进行了第二次５０００米测试,于长跑测试前后分别采取血样进行有关指标测定。结果显示,两次耐力运动后红细胞数量（ＲＢＣ）和血红蛋白（Ｈｂ）含量均比运动前明显下降（Ｐ＜０．０１）。为探讨其下降机制,同步检测了血清铁蛋白（ＳＦ）和转铁蛋白（ＴＦ）。结果在两次不同距离练习后变化不相一致。第一次３０００米跑后,表现为ＳＦ和ＴＦ的下降（Ｐ＜０．０５）,揭示此种情况下的ＲＢＣ和Ｈｂ下降可能由于低铁及ＳＦ、ＴＦ的低水平,使Ｈｂ、ＲＢＣ生成减少所引起;第二次５０００米跑后,表现为ＳＦ和ＴＦ的上升（Ｐ＜０．０５）,提示此时的ＲＢＣ、Ｈｂ的降低可能由于长时间运动导致红细胞和Ｈｂ的破坏所引起,因为血清铁蛋白及转铁蛋白大多是由受损红细胞或死亡红细胞释放至血清的。另外,阶段性训练（２个月）前后对比可见,安静时ＳＦ在训练后期明显降低,提示长期大运动量耐力训练可能导致潜在的或早期缺铁症状。而训练后期的ＴＦ则有所上升,提示适应性铁转运加强。这就为运动性贫血及其机制的探讨提供了重要依据。 相似文献
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8.
冯瑞 《北京体育大学学报》2005,28(10):1367-1369
观察了运动性低铁状态大鼠骨髓细胞转铁蛋白(Tf)结合铁和非Tf结合铁摄入的变化.大鼠随机分为6个月的运动组(EG)和对照组(SG).SG平均每个幼红细胞Tf受体数为890 150±164 849个,而在EG为2 175 360±462 737个(P＜0.05),但受体的解离常数不受运动影响.EG中Tf的内吞平台和胞内铁聚积速度显著高于SG,胞浆和胞内膜成分中Tf结合铁和Fe(Ⅱ)摄入增加.EG的胞浆内Fe(Ⅱ)摄入的米氏常数值降低;细胞膜成分中Fe(Ⅱ)摄入的最大速度增加.上述结果表明:运动不仅通过增加Tf受体的表达促进Tf结合铁的内吞,而且增强非Tf结合铁的内吞途径.尽管这些变化的机制尚不清楚,但它们有利于运动时血红素的合成. 相似文献
9.
Subir Kumar Das Prasunpriya Nayak D. M. Vasudevan 《Indian journal of clinical biochemistry : IJCB》2003,18(2):111-118
A variety of laboratory tests are available to assist in the diagnosis of alcohol consumption and related disorders. The levels
of intake at which laboratory results become abnormal vary from person to person. Laboratory tests are particularly useful
in settings where cooperativeness is suspected or when a history is not available. Several biochemical and hematological tests,
such as γ-glutamyltransferase (GGT) activity, aspartate aminotransferase (AST) activity, high-density lipoprotein cholesterol
(HDL-C) content of serum, and erythrocyte mean corpuscular volume (MCV) are established markers of alcohol intake. Their validity
as markers is based largely on correlations with recent intake at a single time point and on decreases in elevated values
when heavy drinkers abstain from alcohol. These readily available laboratory tests provide important prognostic information
and should be integral part of the assessment of persons with hazardous alcohol consumption. There are several other markers
with considerable potential for more accurate reflection of recent alcohol intake. These include carbohydrate deficient transferrin,
β-hexosaminidase, acetaldehyde adducts and the urinary ratio of serotonin metabolites, 5-hydroxytryptophol and 5-hydroxyindoleacetic
acid. These markers provide hope for more sensitive and specific aids to diagnosis and improved monitoring for intake. 相似文献
10.
Carbohydrate deficient transferrin (CDT) is one of the conventional markers for chronic alcohol consumption, is used by researchers
and clinicians. A number of enzymes are affected by ethanol intake. The induction or inhibition of sialyl transferase and
plasma sialidase may be involved in the CDT level elevation. An alteration of protein transport during post-translational
modification could be a primary mechanism in the impairment of protein metabolism associated with chronic alcohol abuse. Transferrin
being a steroid responsive protein, sex-based hormonal variations might contribute to the lower sensitivity of CDT. Varying
hormonal statuses such as pregnancy, use of contraceptives, menopause/ menstrual cycle can alter iron homeostasis in women.
CDT levels are markedly affected by iron homeostasis. Several CDT assay methods appeared promising, but it is not readily
apparent which technique is the most accurate. Moreover, false-positive results of CDT have been reported in non-alcohol related
hepatic failure and in rare conditions. Therefore clinical interpretation of CDT needs careful assessment in patients with
alcohol-related or non-alcohol-related health disorders. 相似文献