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The pathophysiology of irritable bowel syndrome (IBS) is complex and not fully understood, so the aim of this study was to evaluate whether visceral and somatic hypersensitivity, autonomic cardiovascular dysfunction, and low-grade inflammation of the gut wall are associated with diarrhea-predominant IBS (D-IBS). Sixty-two patients with D-IBS and 20 control subjects participated in the study. Using the ascending method of limits (AML) protocol, we demonstrated that D-IBS patients had significantly lower sensory thresholds compared with healthy controls (P<0.001). Using diverse methods, especially the ischemic sensitivity test, for the first time in China, we confirmed that D-IBS patients have somatic hypersensitivity. They had a significantly higher systolic blood pressure and heart rate after a cold stimulus, indicative of autonomic cardiovascular dysfunction. Compared with the control group, D-IBS patients had a significantly higher level of calprotectin (P<0.001). We also found significant correlations between visceral and somatic hypersensitivity, visceral hypersensitivity and autonomic cardiovascular dysfunction, and somatic hypersensitivity and autonomic cardiovascular dysfunction. Our findings may provide valuable suggestions for the treatment of D-IBS.  相似文献   
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A glutathione redox cycle is a major antioxidant defense system for the detoxification of reactive oxygen species within erythrocytes. Reactive oxygen species such as superoxide anions, hydrogen peroxide and hydroxyl radicals are generated as a host defense mechanism for killing of engulfed Leishmania donovani, a causative agent of visceral leishmaniasis, are capable of damaging lipids and other biomolecules when produced in excess. Erythrocytes are most vulnerable to Reactive oxygen species. In present study we aimed to evaluate erythrocyte reduced glutathione (GSH) levels as an antioxidant and erythrocyte malondialdehyde (MDA) as a marker of lipid peroxidation. The study included twenty-five Visceral leishmaniasis patients and they were followed up after their complete chemotherapy with antileishmanial drugs (sodium stibogluconate) for 30 days. Forty six age and sex matched healthy individuals were taken as controls. GSH levels in erythrocytes of visceral leishmaniasis patients were increased in spite of significant increased erythrocyte MDA as compared to controls. Whereas erythrocyte GSH and MDA levels of follow up patients were decreased as compared to patients before treatment groups. We concluded that visceral leishmaniasis patients are in oxidative stress which most likely induces the endogenous antioxidant such as GSH or its poor utilization by cells.  相似文献   
3.
女性和男性的疼痛感受不同,疼痛的患病率和严重程度也存在性别差异,这在临床研究和动物实验中均得到证实.性激素参与疼痛传播并调节内脏疼痛敏感性.有研究发现血清雌激素水平与内脏疼痛敏感性密切相关.本综述旨在总结雌激素在调节内脏痛中的作用及其相关的中枢和外周机制.  相似文献   
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目的:探讨运动与CLA对青春期肥胖大鼠内脏脂肪及肝肾功能的影响。方法:高脂饲养大鼠建模7周后,取24只肥胖大鼠随机分成4组,每组6只,分别为对照组、CLA组、运动组、运动+CLA组。运动方案为跑台坡度0°,速度为21-25 m/min,总运动时间60min/天,5次/周,给药方案为运动后即刻灌喂1.6g/kg剂量的CLA,共持续干预8周。干预结束后麻醉大鼠采集血液及组织,测肝肾功能和内脏脂肪重量。结果:8周干预后,运动组、运动+CLA组的体重、内脏脂肪重量及体脂率均明显低于对照组、CLA 组(P<0.01,P<0.05),对照组和CLA组无明显差异(P〉0.05);对照组、运动组、运动+CLA组谷草转氨酶和谷草丙比数值明显高于CLA组(P<0.01),其他组别之间无明显差异(P>0.05);运动组、运动+CLA组血尿素氮和肌酐较对照组、CLA 组有变化,但无明显差异(P>0.05)。结论:8周运动与 CLA干预可有效降低青春期肥胖大鼠体重、内脏脂肪重量、体脂率,运动结合CLA能显著减少内脏脂肪含量,增加瘦体重,降低体脂率,具有明显的减肥效果。运动和CLA干预有一定的保肝作用,对肾脏功能无明显影响。  相似文献   
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