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超速驱动对大鼠离体心脏影响的研究 总被引：3，自引：0，他引：3
为进一步研究疲劳状态下心脏的功能变化,以大鼠离体心脏为研究对象,采用Langendorff灌流装置,对离体心脏施加一定频率和强度的电驱动.研究表明,一定时间的超速驱动后,离体心脏出现明显缺血症状,心肌乳酸脱氢酶漏出增多,谷胱甘肽过氧化物酶活性降低,丙二醛含量增多,心肌组织和线粒体发生钙超载. 相似文献
2.
阮鸣 《南京晓庄学院学报》2006,22(4):115-117
目的:观察心安灵对冠脉结扎麻醉犬的保护作用.方法:麻醉犬冠脉结扎复制心肌缺血模型.观察给药后ST段偏移总和(Σ-ST)、ST段抬高≥2mv的个数(N-ST)、LDH、CK释放的变化.结果:心安灵可显著减少冠脉结扎所致的Σ-ST抬高和N-ST增加,同时减少血清中LDH和CK的释放.结论:心安灵对麻醉犬冠状动脉结扎所致的心肌缺血具有明显改善作用. 相似文献
3.
目的:临床试验表明,Ⅰ类抗心律失常药物虽能抑制心肌梗塞病人的室性心律失常,但增加死亡率,而胺碘酮(Ⅲ类药物)可提高心肌缺血患者的生存率.心室中层肌细胞(M细胞)有其独特的电生理特性并在心律失常发生中起重要作用.方法:采用细胞内玻璃微电极技术,用含胺碘硐或心律平的模拟缺血液灌流M细胞,了解在缺血情况下,两种药物分别对M细胞电生理有何影响.结果:(1)犬左心室M细胞的动作电位呈现出与心外膜层肌细胞相似的峰-谷-穹窿(spike and dome)形态;动作电位时程(APD)随基础起搏周长(BCL)延长而明显延长,即频率依赖性.(2)模拟缺血使M细胞的静息电位(RP)除极、动作电位幅值(APA)和Vmax减小、APD缩短,其APD的频率依赖性减弱或消失.(3)胺碘硐可延缓或减轻缺血引起的电生理变化.(4)心律平明显抑制M细胞的Vmax、APA,并随频率加快而作用增强.进一步加重了缺血引起的动作电位参数的改变,并可造成传导延缓或阻滞.结论:胺碘酮可减轻而心律平则加重缺血引起的M细胞的电生理改变.部分地解释了上述临床试验的结果. 相似文献
4.
对由于缺氧缺血及恢复期血液再灌注时引起心肌损害的可能机制分析、论证，认为缺氧缺血引起H^ ／Na^ 交换、H^ ／Ca^2 交换和Na^ ／Ca^2 交换活跃，以及自由基对生物膜的攻击作用导致细胞内Ca^2 代谢异常是心肌损害的主要原因。通过补充抗氧化剂、锌、镁等物质可有效地防止和减弱对心肌的伤害作用。 相似文献
5.
硫化氢（hydrogen sulfide,H2S）是继一氧化氮（nitric oxide,NO）和一氧化碳（carbon monoxide,CO）之后的第三种气体信号分子,其在体内由特殊的酶倦化产生,有其特殊的代谢过程.其在中枢神经系统中发挥着重要的作用,在生理状态下参与海马长时程增强、神经胶质细胞作用的发挥,通过影响下丘脑-垂体-肾上腺轴而影响神经内分泌过程,参与神经元氧化应激反应和脑血管功能的调节;H2S还参与多种中枢神经系统疾病如阿尔茨海默病、热性惊厥、唐氏综合症、脑缺血、脑缺血再灌注等的病理生理过程.该文就H2S在中枢神经系统的研究概况做了综述. 相似文献
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Woo Taek Kim Sung Gyun Ahn Jun-Won Lee Joong Kyung Sung Seung Hwan Lee Junghan Yoon 《Journal of Zhejiang University. Science. B》2010,11(8):627-630
It is a challenge to confirm chronic mesenteric ischemia (CMI) as a cause of gastrointestinal (Gl) symptoms such as postprandial epigastric bloating,anorexia,and debilitating weight loss.Endovascular intervention for CMI has been gaining popularity because of the high morbidity associated with surgical revascularization.However,in EVI for superior mesenteric artery (SMA) occlusion,the transfemoral approach is limited by difficulty in coaxial alignment of the guiding catheter,which leads to insufficient back-up support.Herein,we report on a 58-year-old male patient with chronic total occlusion of the SMA,which was successfully revascularized by endovascular intervention via the left radial artery.Transradial endovascutar therapy may be another treatment option for the treatment of CMI. 相似文献
8.
Basic fibroblast growth factor alleviates brain injury following global ischemia reperfusion in rabbits 总被引：9，自引：0，他引：9
Zhang M Ma YF Gan JX Jiang GY Xu SX Tao XL Hong A Li JK 《Journal of Zhejiang University. Science. B》2005,6(7):637-643
The aim of this study was to explore the protective effect of basic fibroblast growth factor (bFGF) on brain injury following global ischemia reperfusion and its mechanisms. Brain injury following global ischemia was induced by four vessels occlusion and systemic hypotension. Twenty-four rabbits were randomized into three groups: group A, only dissection of vessels; group B, intravenous infusion of normal saline after reperfusion for 6 h; group C, 30 μg/kg bFGF injected intravenously at the onset of reperfusion, then infused with 10 μg/(kg·h) for 6 h. Serum neuron specific enolase (NSE), S-100B, tumor necrosis factor-α(TNF-α), interleukin-1 (IL-1), interleukin-8 (IL-8) were measured before ischemia, 30 min after ischemia, 0.5, 1, 3, 6 h after reperfusion. Brain water content was determined and cerebral histopathological damages were compared. NSE and S-100B were increased 1 h after reperfusion and reached their peaks 6 h after reperfusion, but were much higher in group B than those in group C 3, 6 h after reperfusion. In groups B and C, TNF-a was increased after ischemia and IL-1 and IL-8 were increased significantly 0.5 h after reperfusion, then reached their peaks 6 h, 3 h, 6 h after reperfusion respectively. TNF-a and IL-8 at the time points of 1 h and 3 h and IL-1 at 3 h and 6 h in group C were correspondingly lower than those in group B. These indices in group A were nearly unchanged. There were less severe cerebral histopathological damages in group C compared with group B, but no difference in brain water content. It could be concluded that bFGF alleviates brain injury following global ischemia and reperfusion by down-regulating expression of inflammatory factors and inhibiting their activities. 相似文献
9.
Tester F. Ashavaid Ph.D. FACB Neena S. Kumbhat 《Indian journal of clinical biochemistry : IJCB》2005,20(1):72-79
Cardiac mitochondria provide energy for the contraction/relaxation cycle. The aim of our study was to isolate and characterize
mitochondria from Caprine hearts under control and in-vitro induced ischemia. A decrease in activities of all the enzymes
was observed in the ischemic models. Further characterization of proteins was done by SDS-PAGE and BN-PAGE. Lipids have been
characterized by analyzing the phospholipids by HPTLC and fatty acids by GLC in both groups. Our results indicated that injury
occurs early in the course of ischemia and progresses during ischemia. TBARS and carbonyl content have also been measured.
The in-vitro effects of fatty acids have been studied on the enzymes and complexes of mitochondria. 相似文献
10.
目的 :研究穴位埋线对无症状心肌缺血动态心电图的影响。方法 :以随机对照方法 ,观察治疗组 (穴位埋线 )和对照组 (普奈洛尔组 )对无症状心肌缺血的影响。结果 :两组治疗前后 ,在心肌缺血次数 ,心肌缺血持续时间 ,以及缺血总负荷方面有明显差异 ,P <0 .0 1,与对照组治疗后相比 ,无明显差异 ,P >0 .0 5。结论 :穴位埋线在改善无症状心肌缺血方面具肯定疗效。 相似文献