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为探讨癌胚抗原(CEA)和核仁组成区蛋白(AgNOR)在胃粘膜活检中对良、恶性病变的诊断意义,我们取105例标本进行观察。结果表明:CEA和AgNOR计数在单纯性胃炎、肠上皮化生、异型增生和胃癌中表达有关系,其阳性率和计数依次增高。CEA、AgNOR表达有显著性差异。因此,CEA、AgNOR对癌和癌前病变的诊断和治疗具有一定参考意义。 相似文献
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We describe a case of poorly differentiated adenocarcinoma of stomach, which did not present typical symptoms of gastrointestinal
malignancy on first visit. The patient, a 62 year old smoker presented with shortness of breathe and pain in right lumbar
region with no history of fever. Bone scans revealed multiple hot spots in skull, sternum, lumbar vertebrae and both iliac
crests. A series of tumor markers were ordered which include PSA, CEA, CA19.9, CA 72.4 and AFP. Serum PSA and AFP concentrations
were within normal range. Serum CEA and CA 72.4 were raised significantly. Markedly elevated levels of serum CA19.9 were found
(>45000 U/ml) in this patient. CT chest and bronchoscopic examination ruled out the possibility of cancer lung. Upper GI tract
endoscopy was done to find out lesion in GI tract. An ulcerative lesion was found in lesser curvature of stomach. Histopathological
examination of endoscopic biopsy revealed a poorly differentiated adenocarcinoma of stomach. An unusually high serum CA19.9
(>45000U/ml) in case of gastric carcinoma has not been reported earlier. 相似文献
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目的:通过回顾性研究,知道我省不同级别医院对泌尿系统常见疾病治疗费用形成状况和存在问题,探讨其成因和健康消费的科学对策。方法:随机确立不同地区、不同级别医院各一个,对这些医院2001年1月1日至12月31日住院病人泌尿系统常见病的肾结石、膀胱炎、急性肾炎、慢性肾炎、泌尿道感染作回顾性调查研究,应用CEA对费用进行计算,并对产生原因作初步的探讨。结果与结论:三甲医院的总费用明显高于二甲(乙)医院的费用(p<0.01)。不同疾病、不同医院的费用构成比不同。 相似文献
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以鲁米诺还原纳米银作为信号分子标记癌胚抗原（CEA）,结合具有良好生物相容性的纳米金,固定癌胚抗原抗体于金电极上,成功建立了用于检测人血清中CEA含量的电化学发光（ECL）免疫分析方法.利用该方法可在浓度为0.1-50ng· mL-1的线性范围内稳定监测人血清中CEA的含量,检测限为0.05ng·mL-1.将该电化学发光传感器应用于健康志愿者的血清中进行CEA的检测,结果令人满意.相对标准偏差小于7.2％,平均回收率为97.2-102.9％,具有良好的稳定性和重现性. 相似文献
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Sharmila Upadhya Subramanya Upadhya D. M. Vasudevan 《Indian journal of clinical biochemistry : IJCB》2003,18(1):46-51
The study was designed to evaluate the significance of tissue polypeptide specific antigen (TPS) in patients with histologically
proven ovarian and colorectal cancer following treatment along with CA125 (in ovarian cancer) and CEA (in colorectal cancer).
Patients were grouped as follows:
In patients with ovarian and colorectal cancer, the mean TPS levels were significantly higher in patients of group II compared
to group I. The percentage of patients above cut-off levels for TPS were 17.4% in group I and 95.5% in group II. Similar results
were observed with the mean levels of CA125. In colorectal cancer patients, the percentage of patients above cut-off levels
for CEA and TPS were 70% and 30% in group I and 100% in group II for both the markers. Our observations indicate that TPS
may be used as a common marker to indicate metastases in patients with ovarian and colorectal cancer. 相似文献
| Group I | : Patients with stable disease |
| Group II | : Patients with metastasis and relapse |
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利用酶联素和组化法和ABC免疫组化法进行88例消化道恶性肿瘤的雌激素受体(ER)、孕激素受体(PR)和癌胚抗原(CEA)的相关性研究。结果表明:(1)ER、PR水平与组织学分级呈负相关性。(2)低分化腺癌CEA阳性率最高,且淋巴结转移者CEA均为阳性,提示CEA与肿瘤的恶性度呈正相关。因此性激素受体和CEA提供了肿瘤组织不同的生物学信息,同时检测ER、PR及CEA水平对分泌治疗,手术范围及判断预后更有价值。 相似文献
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目的:探讨血清糖类抗原CA199糖类抗原CA724癌胚抗原CEA在结直肠癌的TNM分期中的临床应用价值。方法:观察组结直肠癌患者100例与对照组同期非消化道肿瘤的住院病人100例,空腹抽取静脉血,采用罗氏公司E601电化学发光全自动免疫分析仪和罗氏原装试剂盒检测血清中CEA、CA199、CA724值。应用SPSS 17.0软件进行统计学处理,计量资料以均数±标准差f±s)表示,采用单因素方差分析进行统计,计数资料采用X-2检验,P0.05为差异有统计学意义。结果:在单项检测中,CEA的敏感率最高,达37%,且CEACA199CA724.在两项联合检测中CA199+CEA的敏感度最高达53%,三项联合检测敏感度达64%,在各种联合检测中最高。三项肿瘤标志物的阳性率和升高水平随肿瘤的TNM分期的增加而递增。结论:三项肿瘤标志物的单一检测敏感度较低,肿瘤标志的联合检测结直肠癌可以提高敏感性,以CEA+CA199+CA724的效果最好,CA199+CEA次之。CA199、CA724、CEA三项肿瘤标志物的阳性率及升高水平依肿瘤的TNM分期的增加呈递增趋势。 相似文献
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目的对56例进展期胃癌患者进行4种血清肿瘤标记物联合检测评价,探索优选检测项目,提高诊断的灵敏度、准确性.方法应用酶免双抗夹心法测定SIMA和应用放射免疫方法测定CEA、CA50、CA19-9,共测定正常对照组33例健康成人和进展期胃癌56例.结果胃癌组4种血清肿瘤标记物均与正常对照组差异有显著性意义(p＜0.05),其中正常对照组SIMA为(8.09±1.94)×103u/L,胃癌组SIMA为(90.47±28.51)×103u/L.SIMA的灵敏度和准确性高于其它3种,与CEA灵敏度相比,差异无显著意义(p＞0.05),SIMA与CEA组合灵敏度升高至81.76%,高于单项灵敏度,高于其它组合灵敏度,差异有显著意义(p＜0.05).结论SIMA是一种敏感的新型血清肿瘤标记物,SIMA和CEA可以作为联合检测胃癌的首选标志. 相似文献
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