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丝裂素活化蛋白激酶家族是多条信号转导途径中的关键物质。为进一步促进运动员心脏形成机理的研究,加深在细胞和分子生物学水平对运动性心肌肥大的认识,通过文献检索方法,综述丝裂素活化蛋白激酶在运动性心肌肥大信号转导中所起的作用。研究显示:运动性心肌肥大是运动特殊环境刺激下,心脏发生的生理性反应;由刺激到心脏表型的变化,依赖于一系列复杂的细胞内信号转导过程;丝裂素活化蛋白激酶是许多信号通路的汇聚点,其在运动性心肌肥大中也起了重要的信号介导作用。 相似文献
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心肌营养素-1(CT-1)是新近发现的促心肌肥大因子,除了有利于心脏发育并对心脏起一定的保护作用外,最主要的功能是通过作用于心肌细胞及促成纤维细胞生长和胶原合成来参与和调节心肌肥大。本文从其结构功能及引起心肌肥大的信号转导等方面对其导致的心肌肥大的生物学机制作以综述。 相似文献
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不同训练方式对大鼠心脏肥大的作用差异 总被引：1，自引：0，他引：1
采用大鼠强制游泳的方法，研究了高强度间歇训练与耐力性持续训练对心脏重量及心重／体重比率的影响。６周训练后发现高强度间歇训练对心脏重量影响较小；耐力性训练致心脏绝对质量明显增加，其增大程度对运动持续时间有较大的依赖性。实验结果还显示，两训练组雌鼠的心重／体重比率均高于同组雄鼠。 相似文献
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Matthew J. Barnes Jeremy Fraser Karl Coley Blake G. Perry 《Research quarterly for exercise and sport》2013,84(4):504-510
ABSTRACTPurpose: The purpose of this study was to identify whether post-resistance exercise (REx) blood flow restriction (BFR) can elicit a similar acute training stimulus to that offered by either heavy REx or traditional low-load BFR REx. Method: Ten men completed trials with 30% one-repetition maximum (1RM) for 5 sets of 15 repetitions without BFR (30%), with BFR during exercise (30% RD), and with postexercise BFR (30% RP) and at 75% 1RM for 3 sets of 10 repetitions. Lactate and cortisol were measured before and up to 60 min after exercise. Thigh circumference, ratings of perceived exertion (RPE), and pain were measured before and after exercise. Surface electromyography was measured during exercise. Results: All conditions had a large effect (effect size [ES] > 0.8) on lactate, with the largest effects observed with the 75% condition; no differences were observed between the 30% conditions. All conditions had a moderate effect (ES > 0.25 ≤ 0.4) on increasing thigh circumference. This effect was maintained (ES = 0.35) with the application of BFR after REx (30% RP). Change in RPE, from the first to last set, was significantly greater with 30% RD compared with other conditions (all p < .05). Electromyography amplitude was higher and percentage change was greater for the 75% condition compared with the other conditions (both p < .05). Conclusions: The application of BFR immediately post-REx altered several of the responses associated with REx that is aimed at inducing muscular hypertrophy. Additionally, these changes occurred with less pain and perceived exertion suggesting that this form of REx may offer an alternative, tolerable method of REx. 相似文献
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目的：探讨持续不卧床腹膜透析（CAPD）患者不同腹膜转运功能下微炎症的发生情况、心脏结构、营养状况及存活率情况。方法：腹膜透析患者腹膜透析治疗3个月～1年并除外炎症、肿瘤、急性冠脉综合症等伴随疾病的患者人选本研究,通过腹膜平衡试验（PET）判断腹膜通透性,根据试验结果将患者分为2组：高转运、高平均转运的患者为高通透性组（H／A;D／Pcreat≥0．65,D为透析液肌酐浓度,P为血浆肌酐浓度）;低转运和低平均转运患者为低通透性组（L／A;D／P〈0．65）。对入选患者随访26个月或腹膜治疗终点（死亡或转为血液透析或行肾移植）,观察结束检测患者血CRP,了解患者微炎症的发生情况。同时检测患者的血白蛋白、血红蛋白、主观综合营养评估（SGA）、KT／Vurea,心脏B超检查记录各心腔的大小,计算左心室心肌重量指数,并对两组间生存率分析。结果：高通透性组CRP升高（CRP〉5mg／L）的比例大于低通透组（P〈0．05）;营养状况较低通透组差并普遍存在左心室肥大（P〈0．05）,但小分子清除率方面差异无统计学意义（P〉0．05）;高通透组2年生存率79．24％,低通透性组两年生存率89．39％。结论：腹膜高通透性患者微炎症的发生率高于低通透性患者,且营养情况差,左心室肥大发生增加,存活率降低,提示我们对腹膜高通透性患者应早期给予干预措施以提高患者存活率、改善预后。 相似文献
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Effect of matrine and carvedilol on collagen and MMPs activity of hypertrophy myocardium induced by pressure overload 总被引：3，自引：0，他引：3
Zhang YJ Xiang MX San J Cheng G Wang SS 《Journal of Zhejiang University. Science. B》2006,7(3):245-250
INTRODUCTION Matrine, a monomer of traditional Chinese medi-cine, comes from leguminosae plants such as Kusheng, is quinoilizidine with four-loop and molecular formula of C15H24N20. Matrine has been proved to have anti-arrhythmia (Xu et al., 2004), anti-hypoxia and decreasing heart rate effects (Zhang et al., 1990a; 1990b) in many animal experiments, and has the role of inducing calmness (Luo et al., 2001) and lowering body temperature (Tao and Wan, 1992). Traditional Chinese medicin… 相似文献
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