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Objective To investigate the relationship between serum resistin level and acute coronary syndrome (ACS) or stable angina pectoris (SAP). Methods Sixty-five patients, with coronary artery disease, were enrolled and divided into three subgroupsacute myocardial infarction (AMI), unstable angina pectoris (UAP) and SAP, and 26 healthy people were recruited as controls in the cross-sectional study. Serum resistin levels were determined by ELISA (enzyme-linked immunosorbent assay), and WBC (white blood cell count), hsCRP (high sensitive C-reaction protein), CKmax (maximum ofcreatinkinase), CK-MBmax (maximum of isozyme of creatinkinase) and cTnImax (maximum oftroponin) were measured by standard laboratory methods. Results The serum resistin levels were 4 folds higher in AMI patients, 2.43 folds in UAP patients and 1.12 folds in SAP patients than in the healthy controls (P＜0.05). The resistin levels were also significantly different between AMI [(8.16±0.79) ng/ml], UAP [(5.59±0.75) ng/ml]and SAP [(3.45±0.56) ng/ml] groups (P＜0.01); WBC, hsCRP, CKmax, CK-MBmax and cTnImax were significantly increased in AMI patients over UAP and SAP patients. Spearman analysis showed that serum resistin levels were positively correlated with WBC (r=0.412, P=0.046), hsCRP (r=0.427, P=0.037), CKmax, CK-MBmax and cTnImax (r=0.731, 0.678, 0.656; P＜0.01). ConclusionSerum resistin levels increased with inflammatory factors and myocardial impairment. The results suggest that human resistin might play an important role in the pathogenesis of atherosclerosis and AMI as an inflammatory factor. 相似文献
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脂肪细胞因子对机体能量代谢及脂肪积累的调节 总被引：1，自引：0，他引：1
脂肪细胞因子是当今国际医学界的研究热点.现已发现人类脂肪细胞分泌几十种脂肪细胞因子(a出pocytokines),它们在体内发挥着脂肪体积传感器的作用,同时通过影响机体的能量代谢调节机体的脂肪积累.这里重点介绍那些在机体能量代谢平衡调控中起主要作用的脂肪细胞因子,如瘦素(Leptin)、肿瘤坏死因子(TNF)α、抵抗素(resistin)、脂联素(adiponectm)、白介素(IL)6等等.脂肪细胞因子调节机体能量代谢及脂肪积累的生理作用已日渐引起运动医学界的重视,它们可能成为运动减肥和糖尿病的运动治疗的新的研究领域. 相似文献
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Liu Y Wang Q Pan YB Gao ZJ Liu YF Chen SH 《Journal of Zhejiang University. Science. B》2008,9(1):44-50
Resistin, a newly discovered peptide hormone mainly secreted by adipose tissues, is present at high levels in serum of obese mice and may be a potential link between obesity and insulin resistance in rodents. However, some studies of rat and mouse models have associated insulin resistance and obesity with decreased resistin expression. In humans, no relationship between resistin level and insulin resistance or adiposity was observed. This suggests that additional studies are necessary to determine the specific role of resistin in the regulation of energy metabolism and adipogenesis. In the present study, we investigated the effect of resistin in vivo on glucose and lipid metabolism by over-expressing resistin in mice by intramuscular injection of a recombinant eukaryotic expression vector pcDNA3.1-Retn encoding porcine resistin gene. After injection, serum resistin and serum glucose (GLU) levels were significantly increased in the pcDNA3.1-Retn-treated mice; there was an obvious difference in total cholesterol (TC) level between the experiment and the control groups on Day 30. In pcDNA3.1-Retn-treated mice, both free fatty acid (FFA) and high density lipoprotein (HDL) cholesterol levels were markedly lower than those of control, whereas HDL cholesterol and triglyceride (TG) levels did not differ between the two groups. Furthermore, lipase activity was expressly lower on Day 20. Our data suggest that resistin over-expressed in mice might be responsible for insulin resistance and parameters related to glucose and lipid metabolism were changed accordingly. 相似文献
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Resistin levels of serum and follicular fluid in non-obese patients with polycystic ovary syndrome during IVF cycles 总被引：1，自引：0，他引：1
Lu XE Huang HF Li MG Zhu YM Qiang YL Dong MY 《Journal of Zhejiang University. Science. B》2005,6(9):897-902
INTRODUCTION Polycystic ovary syndrome (PCOS) is a leading cause of anovulatory infertility and affects 5%~10% of reproductive age women (Dunaif, 1997). It is characterized by hyperandrogenemia and chronic anovulation and is associated with insulin resistance, obesity and increased risk for type 2 diabetes (Kno- chenhauer et al., 1998). Insulin resistance is thought to play an important role in aetiology of PCOS (Chang et al., 1983; Shoupe et al., 1983). In vitro and in vivo studies … 相似文献
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脂肪组织不仅是储存脂肪的场所,还是一个功能活跃的内分泌器官,能分泌多种生物活性物质,这些物质统称为脂肪因子.其中有的是近几年发现的,有的则是早已发现但在最近几年才发现其在糖尿病中的作用.本文侧重对将其中的脂联素、内脏脂肪素、瘦素、肿瘤坏死因子α、抵抗素在2型糖尿病的病理生理过程中的一些作用及其机制进行探讨. 相似文献
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肥胖已成为社会公共健康问题．随着细胞与分子生物学技术的发展和应用，c出基因、瘦素、瘦素受体及瘦素作用机制，解耦联蛋白分子及其解耦联作用机理，抵抗素基因、抵抗素分子及抵抗素的生物学效应等方面取得了重要进展，为运动减肥提供了新的科学理论依据． 相似文献
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运动、脂肪细胞和胰岛素抵抗 总被引：4，自引：0，他引：4
脂肪细胞 (fattycells)不只是一个储存脂肪的场所 ,它在体内还扮演了一个十分活跃的角色。由脂肪细胞分泌的多种物质如瘦素 (leptin)、脂肪酸 (fattyacids)、抵抗素 (resistin)和脂联素 (adiponectin)、肿瘤坏死因子α(TNF α)、过氧化物酶体增殖物激活受体γ(PPARγ)等与胰岛素抵抗和耐糖性之间有紧密的关系。运动对脂类代谢和胰岛素受体(insulinreceptor,IR)以及相关信号转导蛋白均有影响 ,所以运动可以在预防、治疗 2型糖尿病中起到重要的作用。 相似文献
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刘一平 《河北体育学院学报》2007,21(4):4-8
抵抗素是脂肪细胞分泌的一种激素，具有抵抗胰岛素的作用，在联系肥胖与胰岛素抵抗等方面起着重要作用，是国内外研究的热点。而糖耐量减低（IGT）是糖尿病的前期表现，常与高胰岛素血症、肥胖及胰岛素抵抗（IR）等代谢综合征并存。国内外对IGT患者进行生活方式干预的试验说明运动可降低IGT向2型糖尿病的转化机率，但运动对抵抗素的影响存在不同的实验结果。研究动态表明，探讨糖耐量减低、抵抗素与运动的关系，揭示运动引起糖耐量减低患者抵抗素水平变化的机制具有广阔前景和重要意义。 相似文献
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肥胖已成为社会公共健康问题.随着细胞与分子生物学技术的发展和应用,ob基因、瘦素、瘦素受体及瘦素作用机制,解耦联蛋白分子及其解耦联作用机理,抵抗素基因、抵抗素分子及抵抗素的生物学效应等方面取得了重要进展,为运动减肥提供了新的科学理论依据. 相似文献