| 运动对血小板内NO影响的研究进展 |
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| 引用本文： | 窦丽,张钧.运动对血小板内NO影响的研究进展[J].山西师大体育学院学报,2011,26(6):111-114. |
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| 作者姓名： | 窦丽 张钧 |
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| 作者单位： | 1. 南京林业大学体育部,江苏南京,210037
2. 扬州大学运动人体科学研究所,江苏扬州,225002 |
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| 摘 要： | 运动锻炼对高血压的发生、发展有良好的防治作用,其作用机制是多途径的。血小板内存在L-精氨酸/一氧化氮系统,自身能合成一氧化氮。血小板源一氧化氮,在调节血小板的粘附、聚集、血小板再摹集功能中起重要作用,并能延缓动脉血栓的形成。高血压时血小板内L-精氨酸/一氧化氮系统的功能下降,运动锻炼可改善血小板L-精氨酸/一氧化氮系统的功能,促进血小板L-精氨酸跨膜转运,提高血小板一氧化氮合酶的活性和血小板源一氧化氮活性。运动锻炼对血小板L-精氨酸/一氧化氮系统的调节作用可能是运动防治高血压血栓性并发症的一个新机制。
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| 关 键 词： | 血小板源NO 运动 高血压 L-精氨酸转运 一氧化氮合酶 |
Advances in Piatelet-derived Nitric Oxide and Exercise |
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| DOU Li,ZHANG Jun.Advances in Piatelet-derived Nitric Oxide and Exercise[J].Journal of Physical Education Institute of Shanxi Teachers University,2011,26(6):111-114. |
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| Authors: | DOU Li ZHANG Jun |
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| Institution: | 1. Department of PE Nanjing Forestry University, Nanjing, Jiangsu 210037, China; 2. Institute of Human Kinesiology, Yangzhou University, Yangzhou, Jiangsu 225002, China) |
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| Abstract: | There are many mechanisms involved in positive effect of exercise on Hypertension. Platelets possess the L-arginine-nitric oxide pathway, and platelet-derived nitric oxide acts a negative feedback mechanism to inhibit platelet adhesive, aggregation as well as platelet recruitment, and it may limit progression of intra-arterial thrombosis. Considerable evidence suggeste that platelet L-arginine-nitric oxide pathway is impaired in essential hypertension. Exercise training activates the L-arginine-nitric oxide pathway in platelet by improving activity of nitric oxide synthase and nitric oxide and increasing rates of L-arginine transport. Upregulation of platelet L-argi- nine-nitric oxide pathway after exercise, which may be a new mechanism for controlling the thrombotic complica- tions associated with hypertension. |
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| Keywords: | platelet-derived NO exercise hypertension L-arginine transport NO synthase |
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