首页 | 本学科首页   官方微博 | 高级检索  
相似文献
 共查询到20条相似文献，搜索用时 31 毫秒
1.
Metabolic disorders are classified clinically as a complex and varied group of diseases including metabolic syndrome, obesity, and diabetes mellitus. Fat toxicity, chronic inflammation, and oxidative stress, which may change cellular functions, are considered to play an essential role in the pathogenetic progress of metabolic disorders. Recent studies have found that cells secrete nanoscale vesicles containing proteins, lipids, nucleic acids, and membrane receptors, which mediate signal transduction and material transport to neighboring and distant cells. Exosomes, one type of such vesicles, are reported to participate in multiple pathological processes including tumor metastasis, atherosclerosis, chronic inflammation, and insulin resistance. Research on exosomes has focused mainly on the proteins they contain, but recently the function of exosome-associated microRNA has drawn a lot of attention. Exosomeassociated microRNAs regulate the physiological function and pathological processes of metabolic disorders. They may also be useful as novel diagnostics and therapeutics given their special features of non-immunogenicity and quick extraction. In this paper, we summarize the structure, content, and functions of exosomes and the potential diagnostic and therapeutic applications of exosome-associated microRNAs in the treatment of metabolic disorders.  相似文献   

2.
New technology devices such as iPads and iPods have become very popular and widely used in special education settings to teach students with disabilities. The 20 selected single-case design studies published by November 2015 were comprehensively reviewed to examine the effects of using iPads and iPods on academic performance and engagement of students with disabilities. This study also examined the approaches of using the devices during instruction. Results of the review indicated that using the devices was effective for enhancing both academic performance and engagement of students with disabilities. The results also indicated that the devices could be used for instruction in various ways, including use of a variety of types of applications and delivery of videos. Directions for future research and implications for practice are discussed.  相似文献   

3.
Objective: To develop a new bioinformatic tool based on a data-mining approach for extraction of the most infor-mative proteins that could be used to fred the potential biomarkers for the detection of cancer. Methods: Two independent datasets from serum samples of 253 ovarian cancer and 167 breast cancer patients were used. The samples were examined by surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF MS). The datasets were used to extract the informative proteins using a data-mining method in the discrete stationary wavelet transform domain. As a dimensionality re-duction procedure, the hard threshoiding method was applied to reduce the number of wavelet coefficients. Also, a distance measure was used to select the most discriminative coefficients. To find the potential biomarkers using the selected wavelet coefficients, we applied the inverse discrete stationary wavelet transform combined with a two-sided t-test. Results: From the ovarian cancer dataset, a set of five proteins were detected as potential biomarkers that could be used to identify the cancer patients from the healthy cases with accuracy, sensitivity, and specificity of 100%. Also, from the breast cancer dataset, a set of eight proteins were found as the potential biomarkers that could separate the healthy cases from the cancer patients with accuracy of 98.26%, sensitivity of 100%, and specificity of 95.6%. Conclusion: The results have shown that the new bioinformatic tool can be used in combination with the high-throughput proteomic data such as SELDI-TOF MS to find the potential biomarkers with high discriminative power.  相似文献   

4.
肿瘤相关巨噬细胞(TAM)是肿瘤微环境中比例最高的免疫细胞,对肿瘤的发生和发展起着重要的作用。在肿瘤的进展过程中,microRNA可以通过转录后调控的方式作用于多种靶点与信号通路来影响TAM的表型。本文主要讨论了microRNA对巨噬细胞分化、功能性极化和细胞间信息交流的调控作用。首先,microRNA参与了从髓样细胞向成熟巨噬细胞的分化过程,这一过程直接影响了肿瘤微环境中肿瘤细胞对巨噬细胞的招募。其次,microRNA参与了TAM的功能极化,使之表现为促癌或抑癌表型,影响了肿瘤的生长和转移。第三,肿瘤细胞与巨噬细胞间的相互作用对肿瘤微环境的形成和肿瘤的进展而言是必要的,microRNA可以通过胞外颗粒的形式作为交流的媒介。此外,本文还讨论了巨噬细胞相关microRNA作为肿瘤诊断和预后标志物的潜在价值,以及基于巨噬细胞相关microRNA的肿瘤治疗新策略的应用前景。  相似文献   

5.
Hepatitis B virus (HBV)-induced liver failure is an emergent liver disease leading to high mortality. The severity of liver failure may be reflected by the profile of some metabolites. This study assessed the potential of using metabolites as biomarkers for liver failure by identifying metabolites with good discriminative performance for its phenotype. The serum samples from 24 HBV-induced liver failure patients and 23 healthy volunteers were collected and analyzed by gas chromatography-mass spectrometry (GC-MS) to generate metabolite profiles. The 24 patients were further grouped into two classes according to the severity of liver failure. Twenty-five commensal peaks in all metabolite profiles were extracted, and the relative area values of these peaks were used as features for each sample. Three algorithms, F-test, k-nearest neighbor (KNN) and fuzzy support vector machine (FSVM) combined with exhaustive search (ES), were employed to identify a subset of metabolites (biomarkers) that best predict liver failure. Based on the achieved experimental dataset, 93.62% predictive accuracy by 6 features was selected with FSVM-ES and three key metabolites, glyceric acid, cis-aconitic acid and citric acid, are identified as potential diagnostic biomarkers.  相似文献   

6.
自20世纪80年代中期开始,我国实行“对外开放”政策,允许在中国境内创办外国（海外）学校。不列颠哥伦比亚（BE）省是加拿大第一个允许在国外进行合作办学的省份,1995年创办第一所海外学校（在加拿大,所有和教育相关的事务都由各省负责）。这些在国外创办的学校和项目都是私立学校,要同时遵守中国和BC的法律,采用BE的课程、学习目标和教材,以及雇用在BC获得认证的教师和校长。这类学校经过BE教育部的认证,并定期接受检查。加拿大其他省份也纷纷效仿,2007年初加拿大在中国的合作办学机构大约有80所（此时中国约有800所中外合作办学机构）。虽然由于增长的需求,该类学校数量增长迅速,但它们仍处于中国学校体系的边缘。除了目前的经济衰退在短期内会对中外合作办学的需求产生负面影响外,还有一些关键问题,将会长期影响其生存能力。在此将简要讨论其中四个方面．  相似文献   

7.
This is the report of a five month study, undertaken by Sundridge Park Training Technologies in association with Guildford Educational Services to assess the potential of smart card technology to support learning and the management of learning. The study had two strands—the state of the art of the technology and its potential for supporting, delivering and managing learning. In addition to a study of the literature and extensive discussions with people using smart cards, potential users of smart card and visionaries, the project team developed two illustrative systems using cards to store personal data relating to education and training. The term ‘smart card’ is often used loosely to describe three different types of card, each of which is similar in general shape and size to a traditional credit card. These are: memory cards, laser cards—and true smart cards incorporating a processor and memory. This study has been concerned with memory cards and smart cards. The focus for smart card applications has been predominantly financial: there are relatively few applications in education or training. A notable exception is the large scale project at the University of Bologna which uses smart cards to manage the progress and achievements of a large number of students in the Department of Electronics. The two illustrative systems provided valuable experience of using memory cards and smart cards in quasi‐real education and training applications. They highlighted the problems of limited memory capacities and confirmed the high level of user acceptance reported by other trials. We can expect considerable advances in the technology of both memory cards and smart cards over the next months and years. The memory capacities of both types of cards will increase many‐fold and the unit costs will fall as large quantities of cards are produced for financial applications. Education and training applications will benefit from this expanding market. The major surprise from the study was the level of interest in the work and the enthusiasm expressed by almost all of those who came to hear of it. The general level of awareness of smart card technology was found to be low. However, the requirement for a system which will enable individuals to manage and own their learning on an extended timescale was generally recognised. Some of the possible applications for smart cards and memory cards in education and training had emerged before the official start of the study and it is clear that the technology is potentially pervasive. The project team and those consulted identified a wide range of possible applications both in education and in training. These focussed on assessment, personal course planning and management, identification of relevant learning opportunities, and the ownership of learning. It was felt that, over the next few years, smart cards are very likely to be in common use as credit cards for financial applications. Therefore, their use for education and training should be planned now. The recommendations from the study are that: More detailed studies are needed to find out how smart cards and memory cards could be used by different organisations in a fully operational system; Standards should be established for smart card applications in education and training, similar to those governing financial applications; Applications should be developed after the standards have been established. To be convincing, these should take a case study approach with small pilot studies in a variety of contexts and must follow real needs rather than attempt to drive them; The case studies would then form the basis for a campaign to increase awareness of smart cards and their potential for education and training, together with a programme for building an infrastructure to support the proposed systems. The public sector should fund the task of developing standards and providing interfaces with existing educational systems and projects to demonstrate the feasibility of various applications. Since educational standards have a European dimension, the European Community may be a source of support for work in the area of standards. At the same time, private sector funding should be sought for skill development and career development systems in industry and in education. The Training Agency itself should consider the application of smart card technology to the control and management of the Youth Training Scheme (YTS).  相似文献   

8.
INTRODUCTION Ovarian cancer is the most lethal gynecologicmalignancy. Poor survival rates are mainly attribut-able to late diagnosis. Most patients at diagnosis haveadvanced stage disease. The 5-year survival rate forlate clinical stage ovarian cancer is only 25%, but forearly stage disease, the survival rate can be as high as90%. CA125, the most widely used biomarker forovarian cancer, does not have a satisfying positivepredictive value. In early stage ovarian cancer,40%–50% pati…  相似文献   

9.
情绪调节的神经科学研究表明,情绪与认知之间的相互作用是适应性情绪调节能力发展的基础。儿童情绪调节发展的两个重要的候选神经标识器类型,分别标识了情绪需求条件下的注意控制和消极情绪的注意加工。现有事件相关电位研究表明,N2、Nc、误差相关负波、晚正电位这些反映情绪、认知整合的ERPs成分可作为儿童和成人情绪调节的临床指标,并且有可能起到情绪调节神经标识器和预测特定情感障碍风险的作用。在探究情绪调节和情感心理病理学神经标识器的未来研究中,应充分重视情绪对认知的作用,改善研究方法并关注个体差异。  相似文献   

10.
The identification and use of molecular biomarkers have greatly improved the diagnosis and treatment of malignant tumors. However, a much deeper understanding of oncogenic proteins is needed for the benefit to cancer patients. The lipid raft marker proteins, flotillin-1 and flotillin-2, were first found in goldfish retinal ganglion cells during axon regeneration. They have since been found in a variety of cells, mainly on the inner surface of cell membranes, and not only act as a skeleton to provide a platform for protein–protein interactions, but also are involved in signal transduction, nerve regeneration, endocytosis, and lymphocyte activation. Previous studies have shown that flotillins are closely associated with tumor development, invasion, and metastasis. In this article, we review the functions of flotillins in relevant cell processes, their underlying mechanisms of action in a variety of tumors, and their potential applications to tumor molecular diagnosis and targeted therapy.  相似文献   

11.
The purpose of this review is to learn from rigorous evaluations of alternative technology applications how features of using technology programs and characteristics of their evaluations affect reading outcomes for students in grades K-12. The review applies consistent inclusion standards to focus on studies that met high methodological standards. A total of 84 qualifying studies based on over 60,000 K-12 participants were included in the final analysis. Consistent with previous reviews of similar focus, the findings suggest that educational technology applications generally produced a positive, though small, effect (ES = +0.16) in comparison to traditional methods. There were differential impacts of various types of educational technology applications. In particular, the types of supplementary computer-assisted instruction programs that have dominated the classroom use of educational technology in the past few decades were not found to produce educationally meaningful effects in reading for K-12 students (ES = +0.11), and the higher the methodological quality of the studies, the lower the effect size. In contrast, innovative technology applications and integrated literacy interventions with the support of extensive professional development showed more promising evidence. Although many more rigorous, especially randomized, studies of newer applications are needed, what unifies the methods found in this review to have great promise is the use of technologies in close connection with teachers’ efforts.  相似文献   

12.
Prostate cancer (PCa) is the second most common male cancer worldwide and the fifth leading cause of death from cancer in men. Early detection and risk stratification is the most effective way to improve the survival of PCa patients. Current PCa biomarkers lack sufficient sensitivity and specificity to cancer. Metabolite biomarkers are evolving as a new diagnostic tool. This review is aimed to evaluate the potential of metabolite biomarkers for early detection, risk assessment, and monitoring of PCa. Of the 154 identified publications, 27 and 38 were original papers on urine and serum metabolomics, respectively. Nuclear magnetic resonance (NMR) is a promising method for measuring concentrations of metabolites in complex samples with good reproducibility, high sensitivity, and simple sample processing. Especially urine-based NMR metabolomics has the potential to be a cost-efficient method for the early detection of PCa, risk stratification, and monitoring treatment efficacy.  相似文献   

13.
纳米二氧化钛已是防晒霜、化妆品和光催化剂等的常用成分。纳米二氧化钛的大量应用,已被证明具有潜在的环境负面影响与人体健康风险。如何分析环境中工程纳米二氧化钛的理化性质无疑是认识其潜在风险的关键课题。 研究方法：从工程纳米颗粒可用的表征与测定方法（如电镜显微方法、色谱与质谱技术等）的优缺点出发,结合稳定同位素与稀有元素示踪技术来探讨环境中工程纳米二氧化钛颗粒的分析方法。 重要结论：环境中工程纳米二氧化钛的表征与测定方法仍需深入的研究,其可靠性需要现有各种分析技术的相互验证、良好的样品预处理技术和参考物质、以及稳定同位素与稀有元素技术示踪的配合。  相似文献   

14.
This paper reviews the research on the disruptive and transformative potential of newly-emerging cloud-based pedagogies. It takes into consideration the extent to which Cloud Computing can be leveraged to disseminate and scale web-based applications within and across learning contexts. It examines ideas from current literature in Web 2.0- and cloud-based education that might serve as useful when deploying cloud-based services and infrastructure. The paper draws on several key ideas to clarify how cloud- and Web 2.0-based pedagogies are informed by the shifting knowledge landscape, including a review of the concepts of disruptive pedagogies and transformative technologies. With recourse to emerging research on participatory cultures, the importance of coming to terms with newly emerging literacies, modalities, types of citizenship and ways of interacting and collaborating is addressed. Referring to notions of dialogic literacy, constructionist and co-constructivist learning, as well as possible models for online collaborative writing, the paper reviews current research on the capacity of web-based applications in enabling transformed learning and explores how this might enable broader, web-enabled participatory cultures within and beyond the institution, in light of the economies of scale made possible by cloud-based infrastructure.  相似文献   

15.
The technique of non-stationary oll film force database for hydrodynamic bearing is introduced and its potential applications in nonlinear rotor-dynamics are demonstrated.Through simulations of the locus of the shaft center aided by the database technique,nonlinear stability analysis can be performed and the natural frequency can be obtained as well.The easiness of “assembling” the individual bush forces from the database to form the bearing force.makes it very convenient to evaluate the stability of various types of journal bearings,Examples are demonstrated to show how the database technique makes it possible to get technically abundant simulation results at the expense of very short calculation time.  相似文献   

16.
高温质子导体在气体传感器,燃料电池,氢泵等方面有着十分广阔的应用前景,因此,作为一类新型材料,日益引起世界各国科学家的浓厚兴趣。介绍了高温质子导体的研究现状、应用前景,组成结构、传导机制、存在的问题及发展方向。  相似文献   

17.
Micro-pin-fin cooler mounted on the power chip enables the heat removal to meet modern microsystem requirement. Carbon nanotubes (CNTs) have been proven as a potential material for micro-coolers due to the superior thermal conductivity, good mechanical property and so forth, and there appear various applications of CNTs in the micro-cooler technology. In the present paper, an analysis of the thermal and hydraulic characteristics of the micro-pin-fin heat sink was conducted, where air was used as the cooling medium and an impinging jet was introduced to enhance the heat transfer. Three-dimension computational fluid dynamics (CFD) simulations were carried out for micro-pin-fin coolers with various parameters, including the pin-fin size and pattern as well as the jet velocity and nozzle diameter. The flow field and thermal properties of the micro-pin-fin heat sink were obtained, and the heat removal efficiency was evaluated.  相似文献   

18.
The solution of a slope stability problem can be approached by its least upper-bound and maximum lower-bound with high accuracy. The limit equilibrium methods that employ vertical slices imply a lower bound of the factor of safety. It has been successfully extended to the area of active earth pressure analysis that accounts for different input of locations of earth pressure applications. Those methods that employ slices with inclined interfaces give an upper-bound approach to the stability analysis. It enjoys a sound mechanical background and is able to provide accurate solutions of soil plasticity. It has been successfully extended to the area of bearing capacity analysis in which various empirical coefficients are no longer necessary. The 3D upper- and lower-bound methods under this framework have been made possible and show great potential for solving various engineering problems.  相似文献   

19.
美国中小学数学课程计划充分体现多样化、自主化的特色,尤其是高中会提供丰富的课程计划供不同学生选择.高中数学必修课程一般至少修3个学分的数学,包括代数1、几何、代数2等内容.美国高中数学选修课程很多.美国中小学数学教材呈现教材多样、目标明确、利于教学、资源丰富等特色.美国学校课堂教学重视多种学习方式、重视基础知识与基本技能教学、重视基本方法教学、重视问题解决教学、注重分层教育.。  相似文献   

20.
以环保型水性聚氨酯(WPU)作成膜物,把环保、高附加值及功能化作为涂膜设计理念,以低成本竹炭(BC)作功能助剂,旨在合成宜居多功能涂膜,通过BC改性及优化配方制备了BC/WPU功能涂膜。研究了BC改性剂种类、用量和添加量、粒度及分散时间等因素对功能涂膜性能的影响。结果表明:γ-胺丙基三乙氧基硅烷(γ-APTES)改性BC/WPU功能涂膜具有优异的导电、力学性能;在γ-APTES为BC质量的2%、BC用量为20%、BC粒度为500目、分散40 min条件下,制备的涂膜体积电阻率为1.7×104Ω.cm,铅笔硬度为4H,冲击强度≥70kg.cm,耐洗刷性能≥11350次。  相似文献   

设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号