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研究表明,高血压与痰瘀关系十分密切,而随着生活水平改变,痰瘀互结已成为高血压病的主要常见中医证型,文章就近十年来痰瘀互结型高血压病因病机、相关客观指标、中医药治疗进展作一综述。 相似文献
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目的:研究非特异性腰痛患者的中医证型的分布特点及用药规律。方法:通过住院电子系统收集2011年5月到2017年2月到广西中医药大学附属瑞康医院住院治疗的符合诊断标准的患者作为研究对象,了解其中医的辨证分型,分析其分布特点,并对治疗上所涉及的中药汤剂及院内中药制剂进行研究,分析其用药规律。结果:共有275例患者符合纳入标准,证型分布主要以血瘀气滞型为主,占45.8%,与其他证型相比差异有统计学意义(P0.05);该病多发于40~54岁这个年龄段,占118例,与其他年龄段相比差异有统计学意义(P0.05);比较不同年龄段与该病中医证型分布,差异无统计学意义(P0.05),但不同的年龄段其中医证型分布仍有一定倾向性;针对该病的中药用药情况,主要以补益药、理气药、活血化瘀药及化痰祛湿为主。结论:本病多发于40~54岁的中年人群,以血瘀气滞型多见,其证型的分布与年龄存在一定的相关性,针对该病的治疗主要以补益为主,兼顾活血、理气及化痰祛湿等。 相似文献
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目的:检测肾组织中磷脂酶A2受体(M-type phospholipase A2 receptor,PLA2R)的表达,探究肾组织中PLA2R与特发性膜性肾病及中医证型的联系。方法:回顾性分析2016年4月至2019年6月广西中医药大学附属瑞康医院经肾活检证实的70例肾病综合征(nephrotic syndrome,NS)患者作为研究对象,其中包括30例特发性膜性肾病、1例乙型肝炎病毒相关性膜性肾病、2例V型狼疮肾炎、6例Ig A肾病、6例微小病变性肾病、4例系膜增生性肾小球肾炎和1例局灶节段性肾小球硬化及20例非膜性肾小球疾病。结果:(1)IMN组、SMN组、对照组PLA2R在肾脏组织表达的阳性率分别为22/30(73.33%)、6/20(30%)、3/20(15%),三组间肾组织PLA2R的表达有显著统计学差异(P0.05);(2)三组患者实验室指标相比较,血肌酐、血清白蛋白、尿β2微球蛋白、24 h尿蛋白定量、总胆固醇均无统计学差异(P0.05);(3)中医证型与肾组织PLA2R的表达之间差异无统计学意义(P0.05)。结论:(1)肾组织PLA2R的表达可用于MN,可用于IMN和SMN的鉴别诊断;(2)中医证型与相关指标有一定的相关性,与肾组织PLA2R的表达不存在相关性。 相似文献
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目的:观察脑梗死恢复期中医证型分布特点,并探讨其与血脂、CRP的关系。方法:将90例入组的脑梗死恢复期患者,按照中医症候分型标准分为3组(气虚血瘀证、痰瘀阻络证、阴虚风动证),同时选取30例健康体检人群作为对照组。各组于入组后24小时内进行血脂及CRP检测。结果:90例脑梗死恢复期患者气虚血瘀证患者43例,占47.8%,明显高于痰瘀阻络证、阴虚风动证组。与对照组比较,各证型中TG、TC、LDL-c水平均明显升高,其中以痰瘀阻络型明显高于其他证型。结论:脑梗死恢复期患者中医证候分型以气虚血瘀证型为主,痰瘀阻络证患者的TG、TC、LDL-c、CRP水平较高(P0.05),中医的痰瘀可能与血脂、CRP存在着一定的关系。 相似文献
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目的:分析桥本氏甲状腺炎合并甲状腺乳头癌中医证型与超声特征,通过中医证型联合超声特征实现桥本氏甲状腺炎合并甲状腺乳头癌中医预防和治疗。方法:回顾性分析2013年1月～2019年2月在广西中医药大学第一附属医院进行甲状腺结节手术427例,经手术病理确诊为桥本氏甲状腺炎合并甲状腺乳头癌患者40例作为研究组,同时选取46例经过病理确诊桥本氏甲状腺炎结节型患者作为对照组。比较两组资料中医证型与超声特征。结果:①两组资料中医分型存在差异性,研究组以痰凝血瘀互结型为主,对照组以脾肾阳虚型为主,两组资料中医分型差异具有统计学意义(P0.05)。②两组资料超声特征在粗钙化、内部血流、颈部淋巴结肿大方面差异有统计学意义(P0.05)。结论:通过中医辨证分型结合超声特征实现桥本氏甲状腺炎合并甲状腺乳头癌中医预防与治疗。 相似文献
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企业信用能力表征量双重相关性实证研究 总被引：2，自引：0，他引：2
摘要：通观国内当前实务操作和理论研究中企业信用评价指标体系之间的差异、矛盾不难发现,指标及其权重的设置不仅普遍缺乏可靠的依据而且具有明显的随意性,从而不仅让人对企业信用评价之客观性、科学性产生质疑,而且提示企业信用评价指标体系相关性理论--评价指标与企业信用的相关性和评价指标之间相关性研究的缺失。鉴此,本文遵循理论分析和实证研究相结合的原则,探讨了企业信用能力评价指标的上述双重相关性问题,得出目前企业信用评价模型或指标体系中信用能力评价常用指标中有一半基于指标间的高度相关性而完全可相互替代,仅有不足一半的指标与企业信用存在显著相关性的结论;并基于信用能力评价指标与企业信用的相关性初步得出各指标的评价权重。 相似文献
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高血压病是全身系统性疾病,其主要危害是血管病变所引起的并发症。目前对高血压血管病变的研究很多,但早些时候人们往往更注重研究高血压和血管的一些形态学指标的相关性,如颈动脉斑块、内-中膜厚度(IMT)等,但临床实际工作中发现,单纯从颈动脉结构变化来评价高血压病有其局限性,近年对血管功能方面的研究逐渐受到人们的重视。本文通过汇总并整理国内外对高血压病和颈动脉内膜功能相关性的研究文献,以利于其他学者研究参考。 相似文献
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目的:观察中药益气活血、化痰通络法治疗椎-基底动脉供血不足(VBI)性眩晕的临床疗效,从血液流变学、头颅多普勒超声的相关指标改变,进一步研究其作用机理。方法:将符合纳入标准的100例患者随机分为两组。治疗组50例,口服益气活血、化痰通络中药;对照组50例,口服西药:甲磺酸倍他司汀片12mg,一天3次。两周为一疗程。分别比较两组治疗前后临床疗效、中医症候,并检测血液流变学指标及头颅多普勒超声的变化。结果:(1)临床疗效:治疗组总有效率为90.00%,明显优于对照组的76.00%(P0.05)。(2)中医症候:治疗组总有效率94%,对照组总有效率80%,治疗组对中医证候的改善明显优于对照组。(3)血液流变学:对血液流变学各指标的降低治疗组明显优于对照组(P0.05)。(4)经颅多普勒超声:治疗组对平均血流速度的提高明显优于对照组(P0.05)。结论:益气活血、化痰通络方药治疗VBI性眩晕,服用方便、安全,疗效确切,值得临床推广。 相似文献
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<正>病证结合血瘀证诊断及疗效评价标准的缺失是当前中医药行业的瓶颈问题,严重限制了以血瘀证这一临床最常见证候为主要证型的心脑血管疾病中医诊断及疗效评价的标准化和客观化。来自中国中医科学院西苑医院的主任医师付长庚,是我国首批中医传承博士后,“国家万人计划”青年拔尖人才,第五批全国中医临床优秀人才,全国中医药创新骨干人才,中国青年科技奖获得者,中华中医药学会科学技术奖-中青年创新人才奖获得者。十余年来,他埋首浩瀚古今文献、坚守临床一线,将传统中医与现代技术理念相结合,开展中西医结合防治心血管疾病的临床和基础研究,包括中医证候标准化研究,建立了可用于量化诊断和证候疗效评价的冠心病血瘀证诊断标准,突破瓶颈,推动了行业发展,为发扬中医药文化贡献了创新力量。 相似文献
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实验诊断是现代医学不可缺少的一个重要组成部分，是由血液学、生物化学、人体寄生学、微生物学、免疫学等多摹础学科所组成。随着现代医学的进步和人们对疾病的不断认识，对疾病的诊断和治疗越来越依赖实验室的检验结果，多数诊疗的决定是根据实验检验结果作出的。因此，实验室检验结果的准确可靠性在今天的医疗实践中起着举足轻重的作用，无论是临床诊断和治疗、临床研究或基础理论研究及卫生防疫、祖国医学等研究工作都离不开实验诊断。 相似文献
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Blood analysis plays a major role in medical and science applications and white blood cells (WBCs) are an important target of analysis. We proposed an integrated microfluidic chip for direct and rapid trapping WBCs from whole blood. The microfluidic chip consists of two basic functional units: a winding channel to mix and arrays of two-layer trapping structures to trap WBCs. Red blood cells (RBCs) were eliminated through moving the winding channel and then WBCs were trapped by the arrays of trapping structures. We fabricated the PDMS (polydimethylsiloxane) chip using soft lithography and determined the critical flow velocities of tartrazine and brilliant blue water mixing and whole blood and red blood cell lysis buffer mixing in the winding channel. They are 0.25 μl/min and 0.05 μl/min, respectively. The critical flow velocity of the whole blood and red blood cell lysis buffer is lower due to larger volume of the RBCs and higher kinematic viscosity of the whole blood. The time taken for complete lysis of whole blood was about 85 s under the flow velocity 0.05 μl/min. The RBCs were lysed completely by mixing and the WBCs were trapped by the trapping structures. The chip trapped about 2.0 × 103 from 3.3 × 103 WBCs. 相似文献
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This study proposes a capillary dielectrophoretic chip to separate blood cells from a drop of whole blood (approximately 1 μl) sample using negative dielectrophoretic force. The separating efficiency was evaluated by analyzing the image before and after dielectrophoretic force manipulation. Blood samples with various hematocrits (10%–60%) were tested with varied separating voltages and chip designs. In this study, a chip with 50 μm gap design achieved a separation efficiency of approximately 90% within 30 s when the hematocrit was in the range of 10%–50%. Furthermore, glucose concentration was electrochemically measured by separating electrodes following manipulation. The current response increased significantly (8.8-fold) after blood cell separation, which was attributed not only to the blood cell separation but also to sample disturbance by the dielectrophoretic force. 相似文献
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Geoffrey Baird 《Biochemia medica : ?asopis Hrvatskoga dru?tva medicinskih biokemi?ara / HDMB》2013,23(1):19-27
Blood gas testing is a commonly ordered test in hospital settings, where the results almost always have the potential to dictate an immediate or urgent response. The preanalytical steps in testing, from choosing the correct tests to ensuring the specimen is introduced into the instrument correctly, must be perfectly coordinated to ensure that the patient receives appropriate and timely therapy in response to the analytical results. While many of the preanalytical steps in blood gas testing are common to all laboratory tests, such as accurate specimen labeling, some are unique to this testing because of the physicochemical properties of the analytes being measured. The common sources of preanalytical variation in blood gas testing are reviewed here. 相似文献
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This research presents a multiple enzyme-doped thread-based microfluidic system for blood urea nitrogen (BUN) and glucose detection in human whole blood. A novel enzyme-doped thread coated with a thin polyvinylchloride (PVC) membrane is produced for on-site electrochemical detection of urea and glucose in whole blood. Multiple enzymes can be directly applied to the thread without delicate pretreatment or a surface modification process prior to sealing the thread with PVC membrane. Results indicate that the developed device exhibits a good linear dynamic range for detecting urea and glucose in concentrations from 0.1 mM–10.0 mM (R2 = 0.9850) and 0.1 mM–13.0 mM (R2 = 0.9668), which is suitable for adoption in detecting the concentrations of blood urea nitrogen (BUN, 1.78–7.12 mM) and glucose (3.89–6.11 mM) in serum. The detection result also shows that the developed thread-based microfluidic system can successfully separate and detect the ions, BUN, and glucose in blood. The calculated concentrations of BUN and glucose ante cibum (glucose before meal) in the whole blood sample are 3.98 mM and 4.94 mM, respectively. The developed thread-based microfluidic system provides a simple yet high performance for clinical diagnostics. 相似文献
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Homsy A van der Wal PD Doll W Schaller R Korsatko S Ratzer M Ellmerer M Pieber TR Nicol A de Rooij NF 《Biomicrofluidics》2012,6(1):12804-128049
Clinical point of care testing often needs plasma instead of whole blood. As centrifugation is labor intensive and not always accessible, filtration is a more appropriate separation technique. The complexity of whole blood is such that there is still no commercially available filtration system capable of separating small sample volumes (10-100 μl) at the point of care. The microfluidics research in blood filtration is very active but to date nobody has validated a low cost device that simultaneously filtrates small samples of whole blood and reproducibly recovers clinically relevant biomarkers, and all this in a limited amount of time with undiluted raw samples. In this paper, we show first that plasma filtration from undiluted whole blood is feasible and reproducible in a low-cost microfluidic device. This novel microfluidic blood filtration element (BFE) extracts 12 μl of plasma from 100 μl of whole blood in less than 10 min. Then, we demonstrate that our device is valid for clinical studies by measuring the adsorption of interleukins through our system. This adsorption is reproducible for interleukins IL6, IL8, and IL10 but not for TNFα. Hence, our BFE is valid for clinical diagnostics with simple calibration prior to performing any measurement. 相似文献