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1.
Supriya Simon A Dinesh Roy D Jayapal V Vijayakumar T 《Indian journal of clinical biochemistry : IJCB》2011,26(1):50-56
Cardiovascular autonomic neuropathy (CAN) is one of the most clinically significant complications of diabetes mellitus. Even
though many ethological factors have been attributed for the pathogenesis of this disease no attempts were made to correlate
DNA damage as a causative factor. Hence the present study was undertaken to asses the extent of somatic DNA damages by cytokinesis-block
micronuclei assay (CBMN). An attempt is also being made to correlate the habits and/or risk factors and socioeconomic status
with CAN. The CBMN frequency of 46 patients suffering from autonomic neuropathy was compared with that of 25 healthy age and
sex matched controls. All the subjects were suffering from type 2 diabetes for at least 8 years and have varying degrees of
coronary artery diseases. The mean CBMN frequency of the patients was statistically higher than that of the healthy control
subjects (P < 0.05). The CBMN frequency was found to be significantly altered in CAN patients who where physical inactivity and smoking.
A significant correlation could also be observed between CAN and smoking, diabetes mellitus, hypertension, dyslipidemia, abdominal
obesity, and physical activity. 相似文献
2.
K Sudha Ashalatha V Rao S. N. Rao Anjali Rao 《Indian journal of clinical biochemistry : IJCB》2002,17(1):34-41
Oxidative stress is implicated in the etiopathogenesis of a variety of human diseases. Therefore, in the present study, erythrocyte
lipid peroxidation, percentage hemolysis, antioxidant enzymes viz., glutathione reductase, glutathione peroxidase, superoxide
dismutase and plasma antioxidants viz., ceruloplasmin, vitamins A,E and C have been determined in 19 patients with tubercular
meningitis (TBM) and 50 normals. Six patients who were treated with antibiotics were considered for the follow up. The statistical
analysis was carried out by Mann Whitney U test and Wilcoxon rank sum test. Lipid peroxidation (P<0.02), percentage hemolysis
(P<0.001) and plasma ceruloplasmin (P<0.0001) of TBM patients were significantly higher, whereas erythrocyte glutathione reductase
(P<0.05) and plasma antioxidant vitamins A, E and C (P<0.01, P<0.05 respectively) were significantly lower than those of the
controls. In the follow up patients the glutathione reductase and catalase levels were significantly high (P<0.05) compared
to their pre-treated condition. Vitamin C and E levels have attained normal range. This study indicated that the blood antioxidant
status of TBM patients which was low compared to controls improved after treatment, suggesting the role of free radicals in
TBM. 相似文献
3.
Anurag Srivastava L. D. Joshi S. P. Singh 《Indian journal of clinical biochemistry : IJCB》1989,4(1):50-57
Normal and alloxan induced diabetic guinea pigs were kept on whole seed diet of green gram for 4 weeks. Serum total lipids
were found to be significantly decreased in both normal and diabetic guinea pigs (P <0.001)—Both free and esterified fractions
of cholesterol were found to be lowered significantly in diabetic animals (P<0.05; <0.01, respectively), whereas only esterified
fraction was reduced significantly in case of normals (P<0.05). Significant lowering of triglyceride levels (P<0.01) was also
noticed in both normal as well as diabetic guinea pigs while phospholipids remained almost unaffected. Green gram feeding
decreased the total cholesterol / phospholipid ratio from 0.630 to 0.625 in normal and from 1.039 to 0.850 in diabetic guinea
pigs indicating its antiatherogenic nature. 相似文献
4.
A. Madhusudhana Rao A. R. Bitla E. P. Reddy V. Sivakumar P. V. L. N. Srinivasa Rao 《Indian journal of clinical biochemistry : IJCB》2010,25(1):47-50
The present study was carried out to explore the altered lipid, lipoprotein and apoprotein abnormalities along with lipoprotein
(a) in chronic kidney disease patients with stage I to V which were further divided into group 1 (stage I and II), group 2
(stage III and IV) and group 3 (stage V). 50 chronic kidney disease patients with stage I to V and 20 healthy normal subjects
as controls were recruited for this study. Among the various parameters tested triglyceride levels were high in group 1 and
2, whereas VLDL cholesterol, Lp (a) and apo B levels were significantly high in all the groups when compared to controls (P<0.05).
However, LDL cholesterol level was significantly low in group 3 only as compared to control group (P<0.05). Apoprotein AI
values also showed significant decrease in all groups as compared to controls (P<0.05). Though total cholesterol levels in
group 1 and LDL levels in group 1 and 2 were higher than controls, but the values attained not statistically significant (P>0.05).
In conclusion high levels of VLDL cholesterol, Lp (a), apo B and low levels of apoprotein AI as reported in this study are
the major lipid disorders in the development of cardiovascular complications at all the stages in these patients. 相似文献
5.
A. Dasgupta J. K. Agarwal S. S. Dubey 《Indian journal of clinical biochemistry : IJCB》1992,7(1):33-36
The aim of the present study was to evaluate the serum levels of lecithin cholesterol acyl transferase and lipoprotein cholesterol in hyperthyroid patients. The serum levels of total cholesterol and triacylglycerols were also determined in order to assess the lipid status of these patients. It was observed that serum content of total cholesterol (TC), low density lipoprotein cholesterol (LDL-C) and high density liproprotein cholesterol (HDL-C) were significantly lower (P<0.001) in these patients whereas serum triacylglycerols (Tg.) and very low density lipoprotein cholesterol (VLDL-C) (P>0.05) did not show any significant change as compared to control values. However, the serum level of lecithin cholesterol acyl transferase (LCAT) was significantly higher (P<0.001) in these patients. It is concluded that an increased LCAT activity plays a significant role in regulating lipoprotein cholesterol levels in hyperthyroid patients. 相似文献
6.
D. Rajasekhar K. S. S. Saibaba P. V. L. N. Srinivasa Rao S. A. A. Latheef G. Subramanyam 《Indian journal of clinical biochemistry : IJCB》2004,19(2):53-59
In an attempt to search for risk factors which can explain the increasing prevalence of coronary heart disease (CHD) in Indian
population, we conducted a case-control study to assess the association of Lipoprotein (a)(Lp(a)) with CHD. One hundred and
fifty one consecutive patients with clinical and angiographic evidence of CHD and forty-nine healthy controls were drawn for
the study. Triglycerides, very low density cholesterol (VLDL-C), total cholesterol (total-C)/high density cholesterol (HDL-C)
ratio, low density cholesterol (LDL-C)/HDL cholesterol ratio and Lp(a) were found to be higher in patients than controls.
In female sex and in those with family history of CHD, higher total and LDL cholesterol levels were observed to be associated
with higher Lp(a) levels. Lp(a) levels were also found to be higher in triple vessel disease than other vessel disease patients.
Significant difference in Lp(a) levels were observed between normal coronaries vs. single and triple vessel disease(P<0.05)
and also between single vs. double and triple vessel disease (P<0.01).Lp(a) levels correlated positively with vessel severity(P<0.005).
Lp(a) levels >25 mg/dl were associated with coronary heart disease (Odds ratio 1.98 P<0.05 95% CI 0.007–1.18). Our findings
suggest a cut-off level of 25mg/dl for determination of risk of CHD. Studies from different areas involving larger sample
size are needed to confirm the findings of the present study. 相似文献
7.
Santoshi R. Ghodake A. N. Suryakar R. D. Ankush K. Shaikh A. V. Katta 《Indian journal of clinical biochemistry : IJCB》2010,25(1):82-85
Nephrotic syndrome is the common chronic disorder characterized by alteration of permeability of the glomerular capillary
wall, resulting in its inability to restrict the urinary loss of proteins. Nephrotic syndrome is characterized by heavy proteinuria,
hypoalbuminemia, hyperlipidemia associated with peripheral edema. The molecular basis of glomerular permselectivity remains
largely unknown. In recent years it has been proposed that Nephrotic syndrome is a consequence of an imbalance between oxidant
and antioxidant activity. The present study was aimed to test that the reactive oxygen species are the mediators of excessive
protein permeability and other complications of Nephrotic syndrome. For this 30 adults with Nephrotic syndrome were studied.
The control group comprised 30 healthy adults matched for age. Serum levels of lipid peroxides, nitric oxide (NO⊙), α- tocopherol,
ascorbic acid, erythrocyte superoxide dismutase activity, serum albumin, uric acid, cholesterol and plasma total antioxidant
capacity were measured. Student’s ‘t’ test was applied for statistical analysis. There was a significant increase in lipid
peroxide (1.58 ± 0.42 in controls, 3.64 ±1.3 in patients) (P<0.001) levels in study group as compared with controls. α-tocopherol
(12.95 ± 1.04 in controls, 9.93 ± 1.43 in patients) (P<0.001), erythrocyte SOD activity(1.88 ± 0.9 in controls 1.07 ± 0.5
in patients) (P=0.01), serum albumin(4.06 ± 0.50 in controls, 3.04 ± 0.11 in patients) (P<0.001), and plasma total antioxidant
capacity (847.33 ± 126.83 in controls, 684.00±102.94 in patients) (P<0.001) were significantly decreased. There was non-significant
increase in uric acid (P>0.05), a non-significant decrease in NO⊙ (38.48 ± 15.47 in controls 37.47 ± 14.27 in patients) (P>0.05)
and ascorbic acid levels ascorbic acid,( 0.95 ± 0.31in controls 0.79 ± 0.30 in patients) (P>0.05) in study group as compared
with controls. Imbalance between oxidants and antioxidants may contribute to pathogenesis of proteinuria and related complications
in nephrotic syndrome. 相似文献
8.
Rajesh Bhagwat S. P. Joshi Pradeep Salgia Achal Sepaha 《Indian journal of clinical biochemistry : IJCB》1997,12(1):81-85
Lipid abnormalities remain to be a major cause of early mortality in patients with chronic renal failure (CRF). In present
study, 114 (one hundred fourteen) CRF patients without any additional cause of dyslipidemia were divided into groups on the
basis of etiologies of CRF. Blood samples from each group were analyzed for total cholesterol, triglyceride and HDL cholesterol
along with blood urea nitrogen and serum creatinine. 25 healthy individuals without any obvious disease were taken as control.
Patients from all the groups showed a marked hypertriglyceridemia of 232 (SD±77) mg/dl (P<0.001) as compared to control. Levels
of HDL cholesterol were found to be significantly low 20 (±11) mg/dl (p<0.001) in all the groups. LDL cholesterol showed an
increase 104 (±30) mg/dl as compared to control group which is not statistically significant. Present study reveals that,
CRF patients show an uniform dyslipidemia irrespective of etiologies leading to CRF. This dyslipidemia is also independent
of serum creatinine levels. Although, these lipid abnormalities may not solely cause mortality in CRF patients, they may act
as modulators in accelerating atherogenesis which in turn cause early mortality in CRF patients. 相似文献
9.
K. K. Reddy T. Ramachandraiah K. Soorya Kumari P. Reddanna K. Thyagaraju 《Indian journal of clinical biochemistry : IJCB》1992,7(2):125-133
The association of serum antioxidatns and lipids was studied in 350 urban individuals with an age range of 40–76 years, in comparison with a control rural sample of equal size. Glutathione Peroxidase (GPx) activity was found to be significantly higher in urban population when compared to rural population. Urban population were characterised by elevated levels of serum cholesterol (SC), low density lipoprotein cholesterol (LDLC) and triglycerides (TG) in comparison with rural population. In urban females both tocopherol (T) and GPx were negatively related with age. The serum lipid levels were found to be increased with age in urban population when compared to rural population. Further the correlation coefficients revealed that LDLC positively (.285:P<.05), and TG inversely (?.512:P<.05) related to ascorbic acid (AA), and an inverse association of SC (?.625:P<.05), high density lipoprotein cholesterol (HDLC) (?.369:P<.05) and LDLC (?.532:P<.05) with T in urban population. In rural population GPx shown a good positive correlation with lipid levels. The results of this study revealed that accumulation of lipids with unaltered antioxidants may be the consequence of urbanization. 相似文献
10.
V. N. Thorat A. N. Suryakar A. S. Sardeshmukh S. S. Sarawade 《Indian journal of clinical biochemistry : IJCB》2004,19(2):32-35
In the present study, the role of serum lipid peroxide and serum nitric oxide as oxidants and erythrocytic superoxide dismutase
& serum vitamin E as antioxidants were determined in the 50 neonates with hypoxic ischaemic encephalopathy. (HIE) as against
25 healthy neonates as controls 50 patients of HIE were further divided into two groups i. e. mild and moderate HIE patients.
All subjects were in the age group of 37–41 weeks of gestation. The levels of serum lipid peroxide, serum nitric oxide and
erythrocytic superoxide dismutase were significantly elevated in both groups of neonates with HIE than those of controls (P<0.001),
whereas serum vitamin E levels were significantly decreased in both groups of HIE patients than those of controls (P<0.001).
A positive correlation was obtained between serum lipid peroxide and erythrocytic superoxide dismutase (r=+0.86). Alterations
in the status of oxidants and antioxidants indicate role of free radicals in the development of HIE. 相似文献
11.
血管紧张素转化酶基因I/D多态性与高血压脑梗塞发病的相关性 总被引:2,自引:0,他引:2
采用PCR方法分别检测82例高血压合并脑梗塞患者(BI)、67例单纯高血压患者(EH)和95例健康对照者(C)的血管紧张素转化酶(ACE)基因I/D多态性类型,并分析ACE基因I/D多态性分布与高血压合并脑梗塞发病的相关性.结果显示,BI组ACE基因的D/D基因型频率和D等位基因频率(分别为0.341和0.524)显著高于C组(分别为0.200和0.374,P<0.05)和EH组(分别为0.179和0.358,P<0.05),而EH组和C组ACE基因的D/D基因型频率和D等位基因频率无显著性差异.该研究结果表明,ACE基因的D/D基因型可能是高血压合并脑梗塞发病的独立危险因素. 相似文献
12.
Renu Garg Manju Verma S. P. Mathur P. S. Murthy 《Indian journal of clinical biochemistry : IJCB》1996,11(2):182-186
Lipid peroxidation products and antioxidants were estimated in either blood, serum or erythrocytes of 25 cases of early and 25 of advanced senile (50–60 years) cataract and 30 persons of age matched healthy controls. Serum lipid peroxidation products (as malondialdehyde) were significantly higher in patients with early senile (0.25±0.05 μm/dl, P<0.05) and advanced senile cataract (0.29±0.05 μm/dl, P<0.001) as compared to healthy controls (0.22±0.07 μm/dl). Erythrocyte superoxide dismutase levels were lower in patients with early senile (730±60.5 units/gm Hb) and significantly lower in advanced senile (712±50.2 units/gm Hb, P<0.05) cataract than those in healthy controls (767±59.5 units/gm Hb). Serum α-tocopherol was significantly lower (P<0.05) in only advanced senile cataract (0.69±0.08 mg/dl) but not in early senile cataract (0.75±0.08 mg/dl) when compared with healthy controls (0.75±0.09 mg/dl). There was no significant difference in the erythrocyte concentration of reduced glutathione and serum levels of total proteins, β-carotene, vitamin A, ascorbic acid, calcium, magnesium and zinc. 相似文献
13.
J. O. Adebayo A. O. Akinyinka G. A. Odewole J. I. Okwusidi 《Indian journal of clinical biochemistry : IJCB》2007,22(1):29-32
The effect of caffeine intake on the risk of coronary heart disease was studied. Twenty-one rats used were randomly divided
into three experimental groups, the first group served as the control while the second and third groups were administered
caffeine orally at doses of 10mg/kg body weight and 20mg/kg body weight respectively for fourteen days. Caffeine, at 10mg/kg
body weight, significantly increased (P<0.05) serum LDL- cholesterol concentration and coronary heart disease risk ratio while
it significantly reduced (P<0.05) serum triacylglycerol concentration when compared with controls. At 20mg/kg body weight,
caffeine significantly increased (P<0.05) coronary heart disease risk ratio while it significantly reduced (P<0.05) serum
HDL-cholesterol concentration and serum triacylgycerol concentration when compared with controls. No dose response effect
was observed possibly suggestive of a threshold effect. These results suggest that caffeine predisposes consumers of caffeine
containing beverages to coronary heart disease. 相似文献
14.
Joya Ghosh T. K. Mishra Y. N. Rao S. K. Aggarwal 《Indian journal of clinical biochemistry : IJCB》2006,21(1):181-184
Coronary artery disease is a major cause of morbidity and has various risk factors. Lipid profile i.e. low HDL-cholesterol,
high LDL cholesterol, high total cholesterol, high triglycerides playing important role in its causation. Recently interest
has been shown in the oxidized fraction of LDL as one of the risk factors. In the present study 60 age and sex matched normal
healthy individuals were taken as controls and 60 patients of CAD were taken. Cholesterol was measured by enzymatic method,
HDL cholesterol by phosphotungstate precipitation method. Serum levels of LDL fraction of cholesterol was measured by a new
and simpler method of precipitation. Result was expressed as mol/L of diene conjugates. It was observed that LDL cholesterol,
VLDL cholesterol, total cholesterol, total cholesterol: HDL cholesterol, LDL cholesterol: HDL cholesterol were significantly
raised and HDL cholesterol was significantly low in patients. (p<0.001). Though HDL cholesterol was significantly raised in
females as compared to males in both the groups (p<0.001). Serum level of total cholesterol, oxidized LDL:HDL cholesterol
were also raised significantly (p<0.05). The level of oxidized LDL showed an increasing trend in patients. 相似文献
15.
In order to determine whether the screening of lipid profile is justified in patients with hypothyroidism we estimated serum
lipids in cases having different levels of serum TSH. 60 patients of hypothyroidism in the age group of 20 to 60 yrs were
studied for thyroid profile over a period of one year. On the basis of serum TSH level the cases were divided into three groups:
In the first group TSH concentration was 8.8±2.99 μlU/ml, 95% confidence interval (Cl) 8.8±1.07, whereas serum total cholesterol
and LDL-chol levels were 196±37.22 and 126±29.17 mg/dl respectively. The statistical analysis of these two groups showed a
significant correlation between raised TSH levels and serum total cholesterol and LDL-chol (P<0.05 & P<0.01) respectively.
We conclude that hypothyrodism is associated with changes in lipid profile. 相似文献
16.
Santosh C. Das Aminu Z. Mohammed Sani U. Al-Hassan Abraham A. Otokwula Uche P. Isichei 《Indian journal of clinical biochemistry : IJCB》2007,22(2):79-83
In order to see the pattern of changes in differential serum lipid and lipoprotein fractions as a risk marker of coronary
complication in paired ‘maternal—neonate’ blood samples in an iodine deficient zone, 26 pregnant women and their corresponding
new born infants at term delivery from the iodine deficient Bassa region of Plateau state, Nigeria were assessed and the results
were compared with those seen in a similar 44 group of women and their newborns assessed in non lodine deficient region of
Jos. The serum thyroid function and lipid and lipoprotein profiles were determined by ‘ELISA’ and ‘enzymatic’ methods respectively.
Urinary iodide excretion level was also measured in 14 pregnant women in Bassa, 23 pregnant women in Jos and 16 non pregnant
control from Jos. Results indicate that the pregnant women assessed in Bassa were iodine deficient (P<0.01) and their thyroid
status was strikingly reduced as reflected by a drop in serum level of T4/TBG ratio (P<0.01) and a rise in TSH (P<0.005) in
comparison to that seen in Jos. There was marked hypertriglyceridaemia and total hypercholesterolaemia (P<0.005), with differential
significant rise in LDL cholestotol fraction (P<0.005) in the women assessed in Bassa as compared to Jos. The HDL cholesterol
however dropped less significantly in the group (P<0.05) with a concurrent marked rise (P<0.001) in the serum ratio of LDL
cholesterol/HDL cholesterol, total cholesterol/HDL cholesterol and triglycerides/HDL cholesterol in the lodine deficient group.
A similar pattern of changes were seen in the corresponding neonates in the Bassa group as compared to Jos group. It is concluded
that the pregnant women and their newborn offsprings living in a longstanding environmental iodine deficiency run a higher
risk of developing coronary complications than those living in non endemic region. It is striking that such newborns surrounded
by a continued state of lodine deficient may at a later adult-period of life develop marked risk of coronary complication
and other features of hyperlipidaemias associated with varying thyroid insufficiency and accompanied iodine deficiency disorders.
Prophylaxis measures as intervention has been highlighted. 相似文献
17.
Anindya Dasgupta Aparna Khan Ushasi Banerjee Mrinalkanti Ghosh Mrinal Pal Kanika M. Chowdhury Sayantan Dasgupta 《Indian journal of clinical biochemistry : IJCB》2013,28(2):169-176
The purpose of this study was to assess the predictive values of central obesity and hyperandrogenemia in development of insulin resistance and dyslipidemia in the polycystic ovarian syndrome (PCOS) patients in our region. Differences of fasting blood glucose level, insulin resistance index HOMA-IR, lipid parameters, waist hip ratio (WHR), body mass index, LH/FSH ratio and testosterone levels between 45 PCOS cases and 35 age matched controls were obtained. Strength of association between different parameters in the case group was assayed by Pearson’s correlation analysis. Dependence of insulin resistance and WHR on different predictors was assessed by multiple linear regression assay. Total cholesterol, LDL cholesterol, LH, FSH, LH/FSH ratio, WHR and insulin resistance were significantly higher in the case group (p < 0.05). Serum testosterone showed strong correlation with insulin resistance and LH/FSH ratio (r = 0.432 and 0.747, p = 0.01 and 0.001 respectively) in the PCOS patients while WHR and serum testosterone level stood out to be most significant predictors for the insulin resistance (β = 0.361 and 0.498; p = 0.048 and 0.049 respectively). Hyperandrogenemia and central obesity were the major factors predicting development of insulin resistance and its related metabolic and cardiovascular complications in our PCOS patients. We suggest early monitoring for androgen level and WHR in these patients for predicting an ensuing insulin resistance and modulating the treatment procedure accordingly to minimise future cardiovascular risks. 相似文献
18.
S. Mohanty P. K. Sahu M. K. Mandal P. C. Mohapatra A. Panda 《Indian journal of clinical biochemistry : IJCB》2006,21(1):101-105
This work was undertaken to investigate correlation between oxidative stress and initiation of pathogenesis of pregnancy induced
hypertension (PIH). Fifty primigravidae in age group of 20–35 years and gestational age 28–42 weeks with PIH were taken as
cases. Twenty healthy primigravidae with no medical and surgical complications of pregnancy and with blood pressure ≤140/90
mm Hg served as controls. The cases were again subgrouped as severe preeclampsia (12 in number) and mild pre-eclampsia (38
in number). All of them were evaluated for serum malondialdehyde (MDA), Serum vitamin E and plasma vitamin C levels. The serum
MDA levels were raised significantly in women with mild preeclampsia (P<0.01) and in women with severe preeclampsia (P<0.01)
in comparison to normal primi gravida. The serum vitamin E levels were decreased in primi gravida with mild preeclampsia (p<0.1)
and in primi with severe pre eclampsia (P<0.1) in comparison to normal primi gravida but the fall was not statistically significant.
There was a significant fall (P<0.05) in the vitamin C levels in primi with mild preeclampsia than in the normal primi. The
vitamin C levels in severe preeclamptic patients were lower than the normal primi but the fall was not statistically significant
(P=0.10). The serum MDA and vitamin E showed a negative correlation in all the cases. The serum MDA and plasma vitamin C also
showed a negative correlation in the control and study group. This observation suggests that in hypertensive disorders of
pregnancy there is an imbalance between lipid peroxidation and antioxidant vitamin status because of oxidative stress. The
decreased serum concentrations of the antioxidant vitamins supports the hypothesis that lipid peroxidation is an important
causative factor in the pathogenesis of preeclampsia. The rise in antioxidants is probably to compensate the increased peroxide
load in severe preeclampsia. 相似文献
19.
Suman B. Sharma Seema Garg Abhinav Veerwal Sridhar Dwivedi 《Indian journal of clinical biochemistry : IJCB》2008,23(4):334-336
Premature coronary artery disease (CAD) is common in India. We, therefore, studied oxidative stress, dyslipidemia, and high
sensitivity-C reactive protein (hs-CRP) levels in young CAD patients. Present study consisted of male CAD patients below 40
years and age and sex matched healthy controls (n=30 each). Fasting blood samples were analyzed for serum lipid profile, malondialdehyde,
antioxidant enzymes and hs-CRP levels. Dyslipidemia was observed in 90% of the young CAD patients, of which 72.2% showed increased
serum triglycerides and decreased HDL-cholesterol. LDL-cholesterol levels were high in 77.8%. Serum malondialdehyde and hs-CRP
levels were increased significantly (p<0.0001) as compared to controls. hs-CRP levels were in high risk range in all the young
patients. However, glutathione peroxidase activity was reduced significantly (p<0.05). Our data suggests that elevated hs-CRP
levels along with dyslipidemia and oxidative stress adds to the predictive value of premature CAD in young Indians. 相似文献
20.
Asaolu Modupe Fisayo 《Indian journal of clinical biochemistry : IJCB》2007,22(2):93-95
The plasma concentrations of total protein, albumin, immunoglobulins IgG, IgA and IgM and urinary protein were assayed in
250 pregnant Nigerian women with malaria and compared with 250 healthy pregnant women which served as controls. The mean values
of plasma total proteins, albumin, IgG and IgA were significantly lowered (P<0.05) while a slight increase in IgM was observed
in the malaria patients. Urinary proteins value of 23.10±0.50 mg/dl was obtained for the pregnant women with malaria, this
was significantly higher (P<0.05) than that of the controls with the corresponding value of 15.32±0.09 mg/dl. This study has
therefore demonstrated elevations of the urinary and decrease in plasma proteins in gestational malaria. These findings suggest
that the protein profile should be considered in the diagnosis and treatment of malaria. 相似文献