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大鼠佐剂关节炎血清细胞因子水平与炎症及病理变化的相关性研究 总被引：1，自引：0，他引：1
目的为进一步探讨细胞因子在类风湿关节炎中的作用．方法５０只ＳＤ大鼠以完全弗氏佐剂（ＦＣＡ）形成ＡＡ动物模型．随机分为Ⅰ组（２周）、Ⅱ组（３周）、Ⅲ组（４周）、Ⅳ组（８周）以及Ⅴ组（正常对照）．分别对各组大鼠血清前炎症细胞因子ＴＮＦ－α、ＩＬ－６以及抑制性细胞因子 ＩＬ－４、 ＩＬ－ １０水平进行测定（ＥＬＩＳＡ法）．同时检查炎症指标血沉（ＥＳＲ）、关节肿胀度、病理切片，所有结果进行对比并做动态分析．结果ＡＡ大鼠Ⅰ－Ⅲ组ＥＳＲ水平及关节肿胀度与对照组均有显著差异（Ｐ＜０．０１）；ＴＮＦ－α组水平各组均高于正常（Ｐ＜０．０５，Ｐ＜０．０１，Ｐ＜０．００１）；ＩＬ－６水平Ⅱ组（Ｐ＜０．０５）、Ⅲ组高于正常；ＩＬ－４水平Ⅰ组、Ⅱ组低于正常组，Ⅲ组、Ⅳ组高于正常组，但均无显著性意义；与正常组比较，ＩＬ－１０水平Ⅰ组（Ｐ＜０．００１）、Ⅱ组（Ｐ＜０．０５）、Ⅲ组均低于正常，Ⅳ组高于正常组并有非常显著性意义（Ｐ＜０．０１）；细胞因子动态观察结果，ＴＮＦ－α、ＩＬ－ ６水平随急性期（第２周）开始而升高，高峰水平随急性期过去（第８周）而下降．而调节性因子ＩＬ－４、ＩＬ－１０高峰时间滞后于炎症因子，并随慢性期延长而升高．结论ＡＡ大? 相似文献
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本文介绍了ＴＣ－１型小微波与ＷＳＦ８－０３型大微波在中频转接时所遇到的问题及其改造方法． 相似文献
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本文阐述了Ｅ－ＭＡＩＬ（电子邮件）的特点,着重讨论了Ｅ－ＭＡＩＬ在远距离教育中在传播教学内容及增强师生之间的双向交流和反馈的强大作用,并提出了一些具体实施的技巧。 相似文献
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以玉米Ｆ１减弱表达基因的ｃＤＮＡ片段为探针，从建立的玉米ｃＤＮＡ的文库中分离到相应的ｃＤＮＡ克隆．经测序和序列同源分析证明，该ｃＤＮＡ编码６－磷酸果糖－２－激酶／果糖－２，６－二磷酸酶，其氨基酸序列与人类、大鼠、牛和鸡等动物肝脏相同基因对应区段的相似性分为为６５．７％，６３．４％，６３．７％和６１．２％． 相似文献
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为了解我校学生的健康状况及乙肝疫苗对我校学生的预防效果，１９９６年５月中旬，采用酶标法治地９６届毕业的８３８人进行了乙型肝炎表面抗原和乙型肝炎表面抗体的测定，８３８人中，入校时ＨＢｓＡｇ阳性者８３人，占９．９％，至今ＨＢｓＡｇ仍阳性者５３人，占６．３％，原ＨＢｓＡｇ阳性，现转阴性３０人，占３．６％。７５５人ＨＢｓＡｇ阴性者，经接种乙肝疫苗后，现抗－ＨＢｓ阳性５００人，占接种人数６６．２２％，抗－Ｈ 相似文献
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杨树 《昆明师范高等专科学校学报》1999,21(4):29-30
提出了一个合成7－（4－磺苯基偶氮）－8－羟基喹啉的新方法,该方法对于8－羟基喹啉的偶氮化合物的合成及其它偶氮类化合物的合成均具有借鉴意义。 相似文献
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在二甲苯介质中用邻硝基苯甲酸和１，３－二氨基丙烷合成了Ｎ，Ｎ’－双（２－硝基苯甲酰基）－１．３－丙二胺，用元素分析、红外光谱等进行表征、确认。产率８３．８％．熔点１６２～１６３℃． 相似文献
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甘薯渣中β—胡萝卜素的提取工艺研究初报 总被引：4，自引：0，他引：4
赵永光 《河北职业技术师范学院学报》2000,14(2):48-50
探讨了从甘薯渣中提取β－胡萝卜素的最佳工艺。最佳的工艺流程为,薯渣挤压脱水,干燥并粉碎为精细的颗粒,利用热石油醚提取,过滤,提取液利用配有溶剂回收装置的密封容器蒸馏,β－胡萝卜素从粗制浓缩溶剂中结晶,产率可达９５．８％。 相似文献
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毛雯 《江西教育学院学报》2005,26(3):18-20
以鄱阳湖泥鳅头肾为材料，通过体内注射植物血凝素(PHA)经短期培养后，活体注射秋水仙素，空气干燥制片法制作染色体玻片标本，对泥鳅的染色体组型进行分析。结果表明：其二倍体染色体数目2n=50。核型公式有两种，分别是：8m 6sm 36t，NF=64；8m 6sm 2st 34t，NF=64。 相似文献
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Much has been made about the difficulties students have in transferring their learning from one context to another. We suggest that students learning from examples use imitation, a subtype of analogical problem solving (APS). Whereas APS involves manipulating a mental representation, imitation involves mapping the surface features of a source example to a target problem and no assumptions are made about what a student knows. Often imitating a close variant of a source problem is likely to be relatively successful; however, trying to solve a distant variant by imitating an example creates difficulties in mapping values and adapting the source example to the target. In this paper we argue that some students' inability to transfer their learning is very often due to the teaching material rather than any failure on the part of the student. To this end, we have developed an interpretation theory based on the proportional analogy framework (a:b::c:d) which can be applied to text analysis. The theory is demonstrated using examples taken mainly from computer programming textbooks. 相似文献
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Objective： To study the effect of levobupivacaine and bupivacaine on the contractility of isolated uterine muscle strips from pregnant and non-pregnant female rats. Methods： Full-thick myometrial strips were prepared from 18- to 2 l-day pregnant （n=8） and non-pregnant rats （n=7）. After contractions became regular, strips were exposed to cumulative concentrations of the two drugs from 10^-8 to 10^-4 mol/L, amplitude and frequency of the uterine contraction was recorded. Results： Two local anesthetics caused a concentration dependent inhibition on contractility of myometrial strips from pregnant and non-pregnant rats. In the myometrium from non-pregnant rats, -log/C50 of levobupivacaine and bupivacaine were 4.85 and 4.25 respectively. In the myometrium from pregnant rats, similar concentrations of levobupivacaine and bupivacaine were observed, -log/C50 were 2.7 and 2.9 respectively. Levobupivacaine produced an increase in amplitude of contractions, while bupivacaine showed an increased trend in frequency. Conclusion： These results demonstrate that levobupivacaine and bupivacaine may inhibit myometrium contractility. The inhibitory effect of levobupivacaine or bupivacaine is not enhanced by gestation in rat. Levobupivacaine may have more positive influence than bupivacaine in pregnant myometrium. 相似文献
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Effects of Early Intervention on Intellectual and Academic Achievement: A Follow-up Study of Children from Low-Income Families 总被引：8，自引：1，他引：8
Follow-up data, obtained 4–7 years after intervention ended, are presented for the Carolina Abecedarian Project, an experimental study of early childhood educational intervention for children from poverty families. Subjects were randomly assigned to 1 of 4 intervention conditions: educational treatment from infancy through 3 years in public school (up to age 8); preschool treatment only (infancy to age 5); primary school treatment only (age 5–8 years), or an untreated control group. Positive effects of preschool treatment on intellectual development and academic achievement were maintained through age 12. School-age treatment alone was less effective. Results generally supported an intensity hypothesis in that scores on cognitive and academic achievement measures increased as duration of treatment increased. 相似文献
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OBJECTIVE: The goals of this research are to develop and test a prospective model of attention problems in sexually abused children that includes fixed variables (e.g., gender), trauma, and disclosure-related pathways. METHODS: At Time 1, fixed variables, trauma variables, and stress reactions upon disclosure were assessed in 156 children aged 8-13 years. At the Time 2 follow-up (8-36 months following the initial interview), 56 of the children were assessed for attention problems. RESULTS: A path analysis involving a series of hierarchically nested, ordinary least squares multiple regression analyses indicated two direct paths to attention problems including the child's relationship to the perpetrator (beta=.23) and dissociation measured immediately after disclosure (beta=.53), while controlling for concurrent externalizing behavior (beta=.43). Post-traumatic stress symptoms were only indirectly associated with attention problems via dissociation. Taken together, these pathways accounted for approximately 52% of the variance in attention problems and provided an excellent fit to the data. CONCLUSIONS: Children who report dissociative symptoms upon disclosure of CSA and/or were sexually abused by someone within their family are at an increased risk of developing attention problems. PRACTICE IMPLICATIONS: Findings from this study indicate that children who experienced sexual abuse at an earlier age, by someone within their family, and/or report symptoms of dissociation during disclosure are especially likely to benefit from intervention. Effective interventions should involve (1) providing emotion regulation and coping skills; and (2) helping children to process traumatic aspects of the abuse to reduce the cyclic nature of traumatic reminders leading to unmanageable stress and dissociation. 相似文献
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Chen XC Weng J Chen XQ Du JZ Zhu MP Pan YQ Liu M 《Journal of Zhejiang University. Science. B》2008,9(9):739-746
Objective: To study the relationships among magnetic resonance imaging (MRI), histological findings, and insulin-like growth factor-I (IGF-I) in steroid-induced osteonecrosis of the femoral head in rabbits. Methods: Thirty rabbits were randomly divided into experimental Group A (n=15) and control Group B (n=15). The 7.5 mg/kg (2 ml) ofdexamethasone (DEX)and physiological saline (2 ml) were injected into the fight gluteus medius muscle twice at one-week intervals in animals of Groups A and B, respectively. At 4, 8 and 16 weeks after obtaining an MRI, the rabbits were sacrificed and the femoral head from one side was removed for histological study of lacunae empty of osteocytes, subchondral vessels, and size of fat cells under microscopy, and the femoral head from the other side was removed for enzyme-linked immunoadsorbent assay (ELISA) for IGF-I.Results: At 4, 8 and 16 weeks after treatment, no necrotic lesions were detected in Group B, while they were detected in Group A.Light microscopy revealed that the fat cells of the marrow cavity were enlarged, subchondral vessels were evidently decreased,and empty bone lacunae were clearly increased. The IGF-I levels in Group A were significantly higher than those in Group B. At 8 weeks after the DEX injection, the MRI of all 20 femora showed an inhomogeneous, low signal intensity area in the femoral head,and at 16 weeks, the findings of all 10 femora showed a specific "line-like sign". The MRI findings of all femora in Group B were normal. Conclusion: MRI is a highly sensitive means of diagnosing early experimental osteonecrosis of the femoral head. However, the abnormal marrow tissues appeared later than 4 weeks when the expression of IGF-I increased. This reparative factor has an early and important role in response to steroid-induced osteonecrosis of the femoral head, and provides a theoretical foundation for understanding the pathology and designing new therapies. 相似文献
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Persistence of bullying from childhood to adolescence--a longitudinal 8-year follow-up study 总被引：3，自引：0，他引：3
OBJECTIVE: To examine factors associated with bullying and victimization from age 8 to 16. METHOD: An 8-year longitudinal study included questions about bullying and victimization at age 8 and 16. Children were evaluated with Rutter scales by parents and teachers and with the Child Depression Inventory filled in by the children at age 8. When the children were at the age of 16 parents filled in the CBCL and adolescents the YSR. RESULTS: About 15% of boys and 7% of girls were bullied and 12% of girls and 13% of boys were victimized at age 16. Both bullying and victimization at age 16 were associated with a wide range of psychological problems at age 8 and 16, and with referral to child mental health services. Bullying at age 8 was associated with bullying at age 16, while victimization at age 8 was associated with victimization 8 years later. CONCLUSIONS: Bullying and victimization are often persistent and associated with severe emotional and behavior problems. Preventive efforts should be focused, and targeted at those children who are characterized by both psychological disturbance and bullying. 相似文献
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OBJECTIVE: Because little is known about the role of family problem-solving processes in the development of mothers' competencies in feeding a very low birth-weight (VLBW) infant, we explored the contribution made by the competence in negotiating displayed by a mother and family member as they jointly problem solve infant-care issues. The infant's neonatal biomedical condition, maternal depressive symptoms, and family poverty status may also contribute to feeding competencies. DESIGN: A sample of 41 mothers of VLBW infants from 2 longitudinal studies who were observed during feeding at 1 and 8 months infant postterm age, with a family member of their choosing, participated in a dyadic problem-solving exercise. We assessed maternal feeding competencies with the Parent-Child Early Relational Assessment (Clark, 1997) and dyadic negotiating competence using an observational scale from the Iowa Family Interaction Rating Scales (Melby & Conger, 2001). We classified infant condition through medical record audit. Maternal depressive symptoms were assessed with the Center for Epidemiologic Studies-Depression (CES-D) Scale (L. S. Radloff, 1977), and family poverty status was determined through the mother's report of family income. RESULTS: Mothers' feeding competencies, structured into 2 factors, Parental Positive Affective Involvement, Sensitivity, and Responsiveness (PPAISR) and Parental Negative Affect and Behavior (PNAB, scored in the direction of low negativity) were stable from 1 to 8 months, accounting for the entire set of predictor variables. Neonatal biomedical condition had no effect on either PPAISR or PNAB; depressive symptoms were negatively associated with PNAB at 8 months; poverty status negatively predicted both PPAISR and PNAB at 1 and 8 months; and negotiating competence of the mother-family member dyad was positively associated with PNAB at 1 month. CONCLUSIONS: Evidence that family poverty status and dyadic negotiating competence were both associated with maternal feeding competencies supports inclusion of these family-level variables in a model of feeding competencies. A mother's negotiating competence with another family member who takes a responsible role in infant care may support maternal feeding competencies during a VLBW infant's early weeks when parenting patterns are forming. 相似文献
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《Cultura y Educación》2013,25(4):509-521
AbstractThe purpose of this study was to examine the effects of three instructional approaches in secondary education students' physical self-concept after the implementation of an ultimate learning unit. A total of 274 (males: 151, females: 133) students (12 to 17 years of age) from an urban, coeducational high school (grades 8th to 12th) agreed to participate. They were distributed into three study groups in each grade: one group was taught using a Traditional approach (TRAD), another group was taught using the Sport Education model (SEM), and a third group was also taught using the Sport Education model and self-made materials (SEM-SM). The AF5-Self-Concept Questionnaire was administered to assess physical self-concept. The results showed that only the students in the SEM-SM group significantly increased their physical self-concept from initial to final tests. Self-made materials seem to have a significant positive effect, possibly due to their constructivist basis. 相似文献