共查询到20条相似文献，搜索用时 46 毫秒
1.
V. L. C. Fernandes D. K. Bhasin S. V. Rana 《Indian journal of clinical biochemistry : IJCB》2006,21(1):169-172
The aim of this study was to measure the levels of lactase, sucrase, maltase, leucine amino peptidase and gamma-glutamyl transpeptidase
in duodenum of Indian patients with duodenal ulcer. The effect of duodenum inflammation on these brush border enzymes has
also been analysed in this study. Levels of lactase, sucrase, maltase, leucine amino peptidase and gamma-glutamyl transpeptidase
were assessed in duodenal biopsies of 20 patients of duodenal ulcer and 20 non-ulcer dyspepsia. The duodenal biopsy specimens
were also examined histopathologically for presence or absence of inflammation. There was no significant difference (p>0.05)
in the activity of above mentioned enzyme levels in both the groups. Only levels of gamma-glutamyl transpeptidase were significantly
decreased in patients of duodenal ulcer with duodenal inflammation. This study shows that only the levels of gamma-glutamyl
transpeptidase were significantly decreased in patients of duodenal ulcer with inflammation but no change in duodenal enzymes
due to duodenal ulcer as compared to non-ulcer dyspepsia. 相似文献
2.
Divya Mahajan Anju Jain Varsha Singh A. K. Jain G. R. K. Rao Gopal Nath 《Indian journal of clinical biochemistry : IJCB》2008,23(3):243-245
Helicobacter pylori remains a controversial organism with regards to humans, its epidemiology still unclear nearly two decades
after discovery. The present study was undertaken to estimate the prevalence of the organism in the gastrointestinal tract
in symptomatic and asymptomatic subjects to understand its precise natural history in India. A total of 154 specimens were
a part of the study. These included gastric biopsies from peptic ulcer disease and Non ulcer dyspepsia subjects, as visualized
on endoscopy, saliva and stool samples from apparently normal healthy adults. Nested polymerase chain reaction was performed
using the primers Hp1, Hp2, Hp3 targeting 16S rRNA gene. A prevalence of 65.1%, 100%, 66.7%, and 73.3% respectively was observed
by polymerase chain reaction. No association was observed between the H.pylori status and the disease condition of the patient. 相似文献
3.
Ragini Srivastava Antara Kashyap Mohan Kumar Gopal Nath Ashok Kumar Jain 《Indian journal of clinical biochemistry : IJCB》2013,28(1):19-23
Helicobacter pylori infection stimulates strong local inflammatory and specific IgA antibody production. The influence of antibodies on the bacterial colonization is not clear. Here, we have analysed the association between the mucosal IgA level and IL-1β in various manifestations of the infection seen endoscopically. Antral biopsies of 57 dyspeptic patients were taken for culture, histology and estimation of mucosal levels of anti-H. pylori IgA and IL-1β. Mean mucosal IgA level was higher in patients with normal mucosa compared to all other groups and lower IgA level was associated with higher bacterial density. IL-1β was higher in ulcer patients and suspicious malignancy group as compared to normal group and higher level of IL-1β was associated with higher grades of metaplasia. Present study indicates that local immunity seems to have a protective role against H. pylori infection and higher level of IL-1β induced by the pathogen may be associated with metaplasia and carcinogenesis. 相似文献
4.
对以上消化道症状而就诊的３２１例慢性胃炎患者行胃镜及幽门螺杆菌（ＨＰ）检测和胃粘膜病理学检查，结果显示慢性萎缩性胃炎的ＨＰ检出率为７６．１％，显著高于慢性浅表性胃炎的检出率５６．３％（Ｐ＜０．０１），ＨＰ感染患者胃粘膜萎缩和肠化生的发生率分别为２６．３％和２９．９％，显著高于无ＨＰ感染者胃粘膜萎缩和肠化生的发生率１２．６％及１９．７％（Ｐ＜０．０１和Ｐ＜０．０５）．且ＨＰ感染与胃粘膜萎缩程度有显著关系，而与肠化生程度和不典型增生无显著关系（Ｐ＞０．０５）．提示ＨＰ感染可以使胃粘膜萎缩和肠化生的发病率升高，并认为ＨＰ感染可能为胃癌发生的危险因素之一． 相似文献
5.
Bibhas Roy Gautam Chattopadhyay Debasish Mishra Tamal Das Suman Chakraborty Tapas K. Maiti 《Biomicrofluidics》2014,8(3)
An on-chip lectin microarray based glycomic approach is employed to identify glyco markers for different gastritis and gastric cancer. Changes in protein glycosylation have impact on biological function and carcinogenesis. These altered glycosylation patterns in serum proteins and membrane proteins of tumor cells can be unique markers of cancer progression and hence have been exploited to diagnose various stages of cancer through lectin microarray technology. In the present work, we aimed to study the alteration of glycan structure itself in different stages of gastritis and gastric cancer thoroughly. In order to perform the study from both serum and tissue glycoproteins in an efficient and high-throughput manner, we indigenously developed and employed lectin microarray integrated on a microfluidic lab-on-a-chip platform. We analyzed serum and gastric biopsy samples from 8 normal, 15 chronic Type-B gastritis, 10 chronic Type-C gastritis, and 6 gastric adenocarcinoma patients and found that the glycoprofile obtained from tissue samples was more distinctive than that of the sera samples. We were able to establish signature glycoprofile for the three disease groups, that were absent in healthy normal individuals. In addition, our findings elucidated certain novel signature glycan expression in chronic gastritis and gastric cancer. In silico analysis showed that glycoprofile of chronic gastritis and gastric adenocarcinoma formed close clusters, confirming the previously hypothesized linkage between them. This signature can be explored further as gastric cancer marker to develop novel analytical tools and obtain in-depth understanding of the disease prognosis. 相似文献
6.
The antiulcerogenic effects of the methanolic extract ofSolanum nigrum berries (SBE) on aspirin induced ulceration in rats with respect to antioxidant status in the gastric mucosa have been investigated.
Oxygen free radicals are considered to be important factors in the pathogenesis of gastric ulcer. The level of lipid peroxides,
which were elevated highly in rats with acute gastric mucosal injury was taken as an index of oxidative stress. The activities
of antioxidant defense enzymes were also decreased considerably by oral gastric administration of aspirin. The decreased levels
of antioxidant enzymes and increased mucosal injury were altered to near normal status upon pretreatment with (SBE) when compared
to the ulcer induced rats. The results indicate that (SBE) may exert its gastroprotective effect by a free radical scavenging
action. Our observations suggest that (SBE) may have considerable therapeutic potential in the treatment of gastric diseases. 相似文献
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Moushumi Lodh Debkanta Pradhan Abhishek Mukherjee 《Indian journal of clinical biochemistry : IJCB》2011,26(4):423-425
We report an unusual presentation of primary biliary cirrhosis. We present the case of a 31-year-old Indian woman who presented
to the hospital with non specific complaints of gastritis, reduced appetite and marked weight loss and no complaints of pruritus.
Serum liver enzymes were elevated. Cytoplasmic pattern of antinuclear antibodies was found on immunofluorescence microscopy
accompanied by positive anti smooth muscle antibody. Endoscopy revealed esophageal varices. Following a liver biopsy, the
diagnosis of primary biliary cirrhosis was made. It is important to consider the diagnosis of hepatic cirrhosis when patient
presents with gastritis, reduced appetite and marked weight loss in both the presence and absence of ascites. 相似文献
9.
本实验研究治疣净对十二指肠、直肠、肛门及阴道粘膜的刺激作用、防护及组织学改变。实验结果表明，治疣净对粘膜刺激作用表现为上皮脱落、组织水肿、坏死、血管充血及炎性反应。凡士林、植物油、氯氟舒松软膏对治疣净的损伤均有防护作用，以凡士林最佳，植物油次之，氯氟舒松软膏最差。 相似文献
10.
Burri E Beglinger C 《Biochemia medica : ?asopis Hrvatskoga dru?tva medicinskih biokemi?ara / HDMB》2011,21(3):245-253
Suspicion of inflammatory bowel disease should be raised in any patient with chronic or recurrent abdominal pain and diarrhoea. However, symptoms of inflammatory bowel disease (IBD) overlap with functional gastrointestinal disorders and those patients may not need endoscopy. Currently, colonoscopy with multiple biopsies is considered the gold standard to establish the diagnosis of IBD. Unfortunately, patient selection for endoscopy based on symptoms is not reliable. The use of guidelines of appropriateness for endoscopy yields significantly more significant findings but the selection criteria suffer from low specificity. Calprotectin is a calcium binding protein of neutrophil granulocytes that correlates well with neutrophil infiltration of the intestinal mucosa when measured in faeces. In the last decade, a large body of evidence on the diagnostic value of faecal calprotectin has accumulated and measurement of calprotectin in faeces has been suggested as a surrogate marker of intestinal inflammation. Testing of faecal calprotectin has been highly useful to distinguish organic from functional intestinal disorders in patients with abdominal complaints. Additionally, faecal calprotectin has reliably identified colonic inflammation in patients with suspected IBD. The use of this inexpensive and widely available test in the evaluation and risk stratification in patients with abdominal complaints is likely to increase in the future. 相似文献
11.
本文详细报道了滇蜀豹子花的核型，发现居群中存在两种细胞型，即A型和B型。A型参考核型为2n = 24＝2m(2SAT)+2sm+8st(4SAT)+12t(2SAT)，其第3号两条同源染色体长臂均无居间随体：B型参考核型为2n=24＝2m(2SAT)+2sm+8st(2SAT)+12t(3SAT)+0—1b，其第3号一条同源染色体长臂紧靠着丝点处有一大而明显的居间随体，而另一条同源染色体则无，构成明显的3号染色体的结构杂合性。统计表明，居群中二者的比例近似为1A；2B。研究还发现了大量的体细胞染色体结构变异核型，表明滇蜀豹子花核型尚未趋于稳定，还处于强烈分化之中，高频率的体细胞染色体结构变异是其种内分化不可忽视的一种进化要素。 相似文献
12.
对４６例幽门螺杆菌相关性十二指肠溃疡给予羟氨苄青霉素、灵滴灵、痢特灵以及雷尼替丁联合治疗，观察６个月，溃疡愈合率达８４．７％，幽门螺杆菌根除率７３．９％，幽门螺杆菌根除组溃疡愈合率９４．１％，明显视于未消除组。 相似文献
13.
土地利用变化与优化配置的综合研究是土地科学和可持续发展的重要议题,我国滨海盐碱地是重要的后备土地资源,研究其利用变化与优化对于缓解人地矛盾,改善生态环境和促进可持续发展具有战略意义。本文制定了滨海盐碱地盐化程度分级分类标准,提出了依据区域盐碱程度和耕层土壤全盐含量进行土地利用优化的对策和"台田-浅池"优化利用模式。黄骅1986年-2006年间土地利用变化剧烈,耕地增加14.31%,建设用地增长93.95﹪,未利用地减少23.07%。2006年,黄骅非盐碱耕地、轻度、中度、重度以上盐碱耕地分别占耕地面积的54.67%、27.01%、12.55%和5.77%。盐碱地开垦是黄骅耕地增长的主要方式。黄骅实施"台田-浅池"模式后,耕地面积降为28.7%,沼泽湿地和盐碱草地增加,可收到生态安全与生产高效的效果。研究成果可为滨海盐碱地资源的持续利用管理提供科学依据。 相似文献
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15.
Yousef Rezaei Chianeh Rashmi Manjunath Krishnananda Prabhu Donald Fernandes M. Vidyasagar Asha Kamath 《Indian journal of clinical biochemistry : IJCB》2014,29(2):238-241
Oral squamous cell carcinoma is one of the most common malignancies recognized. Biomarkers which can predict presence of cancer and its progression can help in better management of these disorders. Over production of lipid peroxidation byproducts and disturbances in antioxidant defense system have been implicated in the pathogenesis of several diseases including oral cancer. Studies have shown a correlation of butyrylcholinesterase (BChE), with tumourigenesis, cell proliferation and cell differentiation. Earlier we have observed a significant elevation in plasma BChE and protein thiols in oral cancer patients which correlated well with stages of cancer. As it was not clear whether the above markers will be altered in saliva of oral cancer patients this study was undertaken. Institutional Ethics Committee gave permission to carry out this study. Total of 55 subjects comprising healthy controls (n = 30) and biopsy proven oral cancer patients (n = 25) consented to participate in this study. Salivary samples from cases were taken before any definitive treatment. Protein thiols and BChE were estimated in salivary samples using validated assay methods. Oral cancer patients had a significant increase in pre-treatment salivary BChE levels (p ≤ 0.001) and a significant decrease (p ≤ 0.001) in salivary thiols as compared to respective values in controls. Salivary protein thiols and BChE may have a role in pathophysiology of oral cancer. Saliva can be used as a potential non-invasive screening tool in oral cancer patients. 相似文献
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Rukmini M. S. Benedicta D'Souza Vivian D'Souza 《Indian journal of clinical biochemistry : IJCB》2004,19(2):114-118
Free radical mediated pathological processes may have a role in schizophrenia. Free radicals (oxy radicals, such as superoxide,
hydroxyl ions and nitric oxide) cause cell injury, when they are generated in excess or when the antioxidant defense is impaired.
Both these processes seem to be affected in schizophrenia. In this study we investigated erythrocyte superoxide dismutase
(SOD) and catalase (CAT) activities as antioxidant enzymes, malondialdehyde (MDA) as a sign of lipid peroxidation in schizophrenic
patients. Activities of superoxide dismutase, catalase and malondialdehyde were greater in patients compared with the control
group which may reflect increased oxidative stress in the brain tissue of schizophrenics. In the patient group erythrocyte
SOD and CAT activities were weakly negative correlated with MDA concentration. These data reveal that antioxidant defense
mechanisms might be impaired in schizophrenic patients. These findings also provide a theoretical basis for the development
of novel therapeutic strategies, such as antioxidant supplementation. 相似文献
18.
对５６例消化性溃疡患者，平分两组分别用奥美拉唑及进口洛赛克治疗４周。结果：奥美后唑总有效率９６％，洛赛克１００％，两者差异无显著性；两组治疗前后快速尿素酶试验阳性率相比差异无显著性；治疗前与治疗后胃液ｐＨ值相比两组差异均有高度显著性。奥美拉唑费用低，有推广价值。 相似文献
19.
基于决策树方法的干旱区盐渍地信息提取——以渭干河-库车河三角洲绿洲为例 总被引：6，自引：0，他引：6
以渭干河-库车河三角洲绿洲为例，探讨了干旱区盐生植被红柳覆盖的盐渍地信息的提取方法。利用TM卫星图像数据，分析了研究区主要地物的光谱特征及其波段间的相互运算，从而分析不同地物之间的可分性。研究表明：K-L-3（第三主成分）是提取重度盐渍地信息的最佳波段，TM1是区分红柳覆盖区（轻、中度）盐渍地信息的最佳波段，提取盐渍地信息时混分的水体信息可以通过MNDWI（改进归一化差异水体指数）设定一定的阈值予以剔除，混分的植被信息可以通过NDVI设定一定的阈值予以剔除。根据以上分析，建立决策树模型，在各节点设计不同的分类器，最后得到盐渍地信息的提取结果。然后进行精度评价，结果表明，该方法的总体提取效果较好，是干旱区监测盐渍地变化的有效手段。 相似文献
20.
渤海滨海重黏性盐渍土淋溶过程中的盐碱变化 总被引：2，自引：0，他引：2
本文对渤海西岸重黏质盐渍土进行土柱淋溶脱盐过程的研究,结果表明:在淋溶过程中,随着土壤含盐量的下降,在整个过程中,Na+、Cl-随土壤含盐量的下降而下降;由于土壤盐离子的初始含量和迁移能力的不同,K+、Ca2+、Mg2+、SO42-的含量随淋溶水增加而减小,在淋溶水接近土壤质量后含量稳定;而HCO3-与其它离子不同,出现随淋溶液增加而缓慢增加的趋势。随着土壤盐离子的迁移,土壤的pH值随土壤含盐量的的减小而呈现增大的趋势,从原土的8.50增加到土壤含盐量为1.6g/kg时的9.86,并在土壤含盐量小于1g/kg后又略有下降,但仍保持在一个较高的水平上。淋溶实验表明,在滨海重黏性盐渍土的淋溶改良过程中,需要注意因脱盐而造成的土壤碱性增加的现象,控制淋溶水的数量和采取其他相应的降碱措施。 相似文献