共查询到18条相似文献，搜索用时 734 毫秒
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DOMS和EIMD的机制主要有机械损伤、代谢产物堆积、肌肉痉挛、急性炎症反应、自由基损伤等学说,目前常用的检测指标有Mb、MHC、CK、CK．MM及其亚型、sTnI、IL-6和骨骼肌骨架蛋白desmin等，CK-MM及其亚型、sTnI和IL-6可以作为运动性骨骼肌损伤检测的特异性敏感标志物：运动预处理、适宜的物理手段、抗氧化剂、药物以及传统医疗手段能减轻DOMS，对EIMD具有一定的保护作用。 相似文献
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篮球运动员大负荷运动训练后血清肌红蛋白与肌酸激酶及其同工酶的变化 总被引：6，自引：0，他引：6
为了探索运动员大负荷运动后血清肌红蛋白(Mb)与肌酸激酶(CK)及其同工酶的变化规律,本文研究了体育学院男子篮球运动员大负荷运动后血清Mb与CK水平的变化.结果发现,血清CK及其同工酶CK-MM在运动后24h出现显著性增加(P＜0.05);血清Mb和CK-MM3%在运动后即刻出现显著性增加(P＜0.05);血清心肌特异性肌钙蛋白(cTNI)在运动前后无显著变化.这些结果表明,运动后血清Mb与CK及其同工酶是来自骨骼肌;运动后血清Mb、CK-MM3%变化可能是比CK及其同工酶CK-MM更敏感的骨骼肌损伤诊断指标. 相似文献
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离心运动致大鼠骨骼肌微损伤形态学及血清CK活性变化的研究 总被引：1，自引：0，他引：1
以成年雄性SD大鼠为研究对象,从离心运动致大鼠骨骼肌微损伤形态学及血清CK活性变化的角度,探讨骨骼肌微损伤形态学与血清CK活性间的变化规律,为骨骼肌运动性损伤机制的探索及预防与康复等提供实验依据.动物模型采用一次持续性下坡跑运动训练.训练结束后,按不同时间点取血、取材.骨骼肌光镜切片(HE)制作与观察,血清肌酸激酶活性的测定采用南京建成生物工程研究所提供的肌酸激酶(CK)试剂盒和6010紫外-可见分光光度计,数据处理采用SPSS13.0软件.结果:大鼠离心运动后骨骼肌组织损伤形态学和CK活性均出现不用程度的变化,骨骼肌微损伤形态学改变在运动后24～48h最为明显,而血清CK活性的峰值出现于离心运动后即刻,表明血清CK活性与骨骼肌损伤的形态学改变并不一致,骨骼肌损伤的形态学变化呈时相性、延迟性的特征. 相似文献
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运动性骨骼肌微损伤机制的研究进展 总被引：7，自引：2，他引：5
综述运动性骨骼肌微损伤机制的研究进展,将其归纳为机械损伤学说、代谢学说(包括能量代谢紊乱学说、细胞内钙稳态失调学说和自由基学说等)、炎症反应学说等不同假说。认为:运动性骨骼肌微损伤的机制仍处于探索之中,应综合机械损伤和化学损伤等假说解释运动性骨骼肌微损伤。 相似文献
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实验旨在观察预热休克对一次性大负荷运动造成大鼠骨骼肌运动性损伤是否具有保护作用。实验采用大鼠热休克模型,用物理加热方法使大鼠体温升高到40.5℃~41.5℃,持续10~15min,在室温下恢复24h后进行一次性大负荷运动(速度为27m/min,坡度0°,时间为90min)。通过对比预热和室温组大鼠运动后即刻、24h、48h血清中的肌酸激酶(CK)、乳酸脱氢酶(LDH),来确定预热休克对大鼠运动所致骨骼肌损伤是否具有保护作用,以及是否能够加速骨骼肌运动性损伤的恢复。结果发现,预热组运动后即刻、24h,血清中激酶和乳酸脱氢酶活性均比室温组低(P<0.05);运动后48h,预热组较室温组血清中肌酸激酶和乳酸脱氢酶活性略低,没有显著性差异,两组肌酸激酶值比室温基础组略高,也没有显著性差异;预热运动后48h组乳酸脱氢酶与室温基础组相比略高,没有显著性差异;室温运动后48h组乳酸脱氢酶较室温基础组明显偏高,具有显著性差异(P<0.05)。提示,预热休克对于一次性大负荷运动所致的大鼠骨骼肌运动性损伤具有保护作用,并且能够促进骨骼肌运动性损伤的恢复。 相似文献
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运动性低血睾酮与肾阳虚大鼠能量代谢的比较研究 总被引：2，自引：0，他引：2
以大鼠为对象,用长期大强度、较长时问游泳造成运动性低血睾酮,以0．5％腺嘌呤喂饲造成肾阳虚．并就两种状态下大鼠体内糖储备及骨骼肌能量代谢进行了探讨。结果表明：运动性低血睾酮大鼠肝、肌糖原含量均增加,而且骨骼肌无氧供能的CK、PK活性没有改变,但MDH活性明显升高(P(O．05)。肾阳虚则造成体内肝、肌糖原的明显减少(P<0、05),骨骼肌中CK活性的显降低(P<0．05)．但对骨骼肌中PK及MDH的活性则没有影响。可以认为,肾阳虚及运动性低血睾酮在对大鼠能量代谢影响方面,是两种不同的状态。 相似文献
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目的:研究力竭运动对小鼠骨骼肌氧化应激和DNA损伤的影响,探讨骨骼肌细胞DNA损伤的氧化损伤机制,进一步揭示运动性疲劳的损伤机理;方法:采用单细胞凝胶电泳对力竭运动小鼠不同恢复期骨骼肌细胞的DNA损伤效应进行测定;结果:小鼠骨骼肌细胞在大强度力竭运动后即刻和24 h的DNA损伤显著高于对照组损伤水平(P＜0.05),其中即刻组的DNA损伤程度最为显著(P＜0.01),而运动后48 h彗星各项指标与对照组的差异无统计学意义(P＞0.05);结论:力竭运动所致的骨骼肌细胞DNA损伤与氧化应激水平有密切的关系,运动性氧应激参与介导了细胞DNA损伤,运动性氧应激是组织细胞DNA损伤的机制之一,适时有效的抗氧化剂补充将有利于防护组织细胞DNA损伤. 相似文献
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Stephan Sorichter Johannes Mair Arnold Koller Erich Muller Christian Kremser Werner Judmaier 《Journal of sports sciences》2013,31(9):687-691
The aim of this study was to examine the relationship between myosin heavy chain (MHC) release as a specific marker of slow-twitch muscle fibre breakdown and magnetic resonance imaging (MRI) of skeletal muscle injury after eccentric exercise. The effects of a single series of 70 high-intensity eccentric contractions of the quadriceps femoris muscle group (single leg) on plasma concentrations of creatine kinase and MHC fragments were assessed in 10 young male sport education trainees before and 1 and 4 days after exercise. To visualize muscle injury, MRI of the loaded thigh was performed before and 4 days after the eccentric exercise. All participants recorded an increase ( P ? 0.05) in creatine kinase after exercise. In five participants, T2 signal intensity was unchanged post-exercise compared with pre-exercise and MHC plasma concentration was normal; however, they showed an increase ( P ? 0.05) in creatine kinase after exercise. For the remaining five participants, there was an increase in T2 signal intensity of the loaded vastus intermedius and vastus lateralis. These changes in MRI were accompanied by an increase in MHC plasma concentration ( P ? 0.01) as well as an increase in creatine kinase ( P ? 0.01). We suggest that changes in MRI T2 signal intensity after muscle damage induced by eccentric exercise are closely related to damage to structurally bound contractile filaments of some muscle fibres. Additionally, MHC plasma release indicates that this damage affects not only fast-twitch fibres but also some slow-twitch fibres. 相似文献
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本文观察了两种不同方式的力量练习对血清CK、Mb和尿3-MH水平及肌肉酸痛的影响。结果显示：第二次练习的负荷递增方式为“阶梯式”,其练习后血清CK、Mb水平和尿3－MH排泄量的升高幅度明显低于第一次“斜坡式”练习后,且恢复较快,肌肉酸痛程度也有所降低。提示：适宜的训练方式可能减轻由于高强度力量训练引起的骨骼肌纤维损伤。 相似文献
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Sorichter S Mair J Koller A Müller E Kremser C Judmaier W Haid C Calzolari C Puschendorf B 《Journal of sports sciences》2001,19(9):687-691
The aim of this study was to examine the relationship between myosin heavy chain (MHC) release as a specific marker of slow-twitch muscle fibre breakdown and magnetic resonance imaging (MRI) of skeletal muscle injury after eccentric exercise. The effects of a single series of 70 high-intensity eccentric contractions of the quadriceps femoris muscle group (single leg) on plasma concentrations of creatine kinase and MHC fragments were assessed in 10 young male sport education trainees before and 1 and 4 days after exercise. To visualize muscle injury, MRI of the loaded thigh was performed before and 4 days after the eccentric exercise. All participants recorded an increase (P < 0.05) in creatine kinase after exercise. In five participants, T2 signal intensity was unchanged post-exercise compared with pre-exercise and MHC plasma concentration was normal; however, they showed an increase (P < 0.05) in creatine kinase after exercise. For the remaining five participants, there was an increase in T2 signal intensity of the loaded vastus intermedius and vastus lateralis. These changes in MRI were accompanied by an increase in MHC plasma concentration (P< 0.01) as well as an increase in creatine kinase (P < 0.01). We suggest that changes in MRI T, signal intensity after muscle damage induced by eccentric exercise are closely related to damage to structurally bound contractile filaments of some muscle fibres. Additionally, MHC plasma release indicates that this damage affects not only fast-twitch fibres but also some slow-twitch fibres. 相似文献
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《European Journal of Sport Science》2013,13(3):249-254
Abstract The present study compared the changes in markers of muscle damage after bouts of resistance exercise employing the Multiple-sets (MS) and Half-pyramid (HP) training systems. Ten healthy men (26.1±6.3 years), who had been involved in regular resistance training, performed MS and HP bouts, 14 days apart, in a randomised, counter-balanced manner. For the MS bout, participants performed three sets of maximum repetitions at 75%-1RM (i.e. 75% of a One Repetition Maximum) for the three exercises, starting with the bench press, followed by pec deck and decline bench press. For the HP bout, the participants performed three sets of maximum repetitions with 67%-1RM, 74%-1RM and 80%-1RM for the first, second and third sets, respectively, for the same three exercise sequences as the MS bout. The total volume of load lifted was equated between both bouts. Muscle soreness, plasma creatine kinase (CK) activity, myoglobin (Mb) and C-reactive protein (CRP) concentrations were assessed before and for three days after each exercise bout, and the changes over time were compared between MS and HP using two-way repeated measures ANOVA. Muscle soreness developed significantly (P<0.01) after both bouts, but no significant difference was observed between MS and HP. Plasma CK activity and Mb concentration increased significantly (P<0.01) without significant differences between bouts, and CRP concentration did not change significantly after either bout. These results suggest that the muscle damage profile is similar for MS and HP, probably due to the similar total volume of load lifted. 相似文献
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血清肌酸激酶与骨骼肌损伤关系的探讨 总被引：17，自引：0，他引：17
研究目的在于对血清肌酸激酶与骨骼肌损伤之间的关系进行探讨。采用跑台一次性离心运动至力竭的动物模型,48只7周龄雌性大鼠随机分为安静对照组和运动后即刻、1、2、4和7天组,测定血清肌酸激酶活性,同时通过HE染色分析骨骼肌形态学损伤变化。结果显示血清肌酸激酶活性峰值出现在运动后即刻,运动后1天迅速下降。HE染色结果则表明离心运动后骨骼肌损伤呈现延迟性时相特点,在运动后第2天骨骼肌损伤范围达到最大。本实验表明血清肌酸激酶与骨骼肌损伤的变化趋势并不一致,血清肌酸激酶水平不能反映骨骼肌损伤。 相似文献
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Kamandulis S Skurvydas A Snieckus A Masiulis N Aagaard P Dargeviciute G Brazaitis M 《Journal of sports sciences》2011,29(4):345-353
The aim of this study was to examine changes in indirect markers of muscle damage during 3 weeks of stretch-shortening exercise with a progressively increasing load and continued modulation of various key training variables. Eight healthy untrained men performed a drop-jump programme involving a progressive increase in load impact with respect to the number of jumps performed, drop (platform) height, squat depth amplitude, and addition of weights. Maximal concentric and isometric knee extensor strength were assessed immediately before and 10?min after each training session. Voluntary and 100 Hz-stimulation-evoked torque decreased acutely after each training session relative to pre-exercise values (P?相似文献
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Henry Brown Brian Dawson Martyn J. Binnie Hugh Pinnington Marc Sim Tristan D. Clemons 《European Journal of Sport Science》2017,17(6):741-747
This study compared markers of muscle damage and inflammation elevated by a matched-intensity interval running session on soft sand and grass surfaces. In a counterbalanced, repeated-measures and crossover design, 10 well-trained female athletes completed 2 interval-based running sessions 1 week apart on either a grass or a sand surface. Exercise heart rate (HR) was fixed at 83–88% of HR maximum. Venous blood samples were collected pre-, post- and 24?h post-exercise, and analysed for myoglobin (Mb) and C-reactive protein (CRP). Perceptual ratings of exertion (RPE) and muscle soreness (DOMS) were recorded immediately post- and 24?h post-exercise. A significant time effect showed that Mb increased from pre- to post-exercise on grass (p?=?.008) but not on sand (p?=?.611). Furthermore, there was a greater relative increase in Mb on grass compared with that on sand (p?=?.026). No differences in CRP were reported between surfaces (p?>?.05). The HR, RPE and DOMS scores were not significantly different between conditions (p > .05). These results suggest that in response to a matched-intensity exercise bout, markers of post-exercise muscle damage may be reduced by running on softer ground surfaces. Such training strategy may be used to minimize musculoskeletal strain while still incurring an equivalent cardiovascular training stimulus. 相似文献