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1.
有氧运动对非酒精性脂肪性肝病身体成分和肝脏声像图的影响 总被引：3，自引：0，他引：3
为探讨有氧运动对非酒精性脂肪性肝病患者身体成分、肝脏声像图的干预效果,本研究将研究对象随机分为运动组和对照组,运动组采用个体化的运动处方进行为期12周有计划、有规律的运动锻炼,对照组不参加特殊运动,观察时间同治疗组.在实验前后分别测试两组研究对象的身体成分和肝脏B超检查.研究结果表明:运动组通过12周健步走有氧运动后,其身体成分指标(体重、体脂肪、体脂百分数、腰臀比、体重指数BMI)较运动前有显著性的下降(P＜0.01);运动组肝脏B超检查结果显示总有效率明显高于对照组,两组相比在统计学上有显著性差异(P＜0.01).实验结论:科学、规律、个体化的健步走有氧运动的实施对非酒精性脂肪性肝病起着积极、有效、重要的防治作用,值得在社区、临床上大力推广应用. 相似文献
2.
摘要：目的：旨在研究有氧运动抑制高脂饮食导致的肝脂肪变性、炎症和纤维化的效果，探讨有氧运动促进肝细胞线粒体增殖和线粒体自噬、改善脂肪肝细胞线粒体质量控制、抑制氧化应激的可能机制。方法：雄性健康SD大鼠随机分为普通安静组（ND），高脂安静组（C），高脂长期运动组（RE），分别给予普通饲料或高脂饲料，高脂组前七周给予普通饲料，后16周给予高脂饲料。RE组大鼠进行跑台运动，25 m/min, 60 min/d, 5 d/周, 23 周。结果：C组大鼠发生脂肪性肝炎和肝纤维化，NAS评分、血脂、血ALT和肝MDA较ND组显著性升高，肝SOD活性较ND组显著性下降； RE组大鼠NAS评分、血脂、ALT水平和肝MDA含量较C组显著性下降，肝SOD活性显著性升高；肝细胞线粒体增殖和自噬调控相关的转录因子SIRT1、Parkin和LC3II的表达上，RE组较C组显著性升高；RE组肝细胞COX IV表达和线粒体膜电位较C组显著性增加。结论：有氧运动抑制NAFLD大鼠肝炎和肝纤维化的发生，其机制与促进SIRT1表达，改善线粒体自噬和增殖功能，减少ROS生成、抑制氧化应激有关。 相似文献
3.
目的：探讨 FATmax 强度运动对非酒精性脂肪肝患者（NAFLD）干预的效果,并建立运动干预方案。方法：46~59 岁 NAFLD 中度以上女性患者
40 名,随机平均分为干预组和对照组;经递增负荷试验确定 FATmax 强度研制处方,干预组进行 24 周运动干预,试验前后测量 BMI、 身体成分、 血脂、
瘦素（Leptin）、 乙酰辅酶 A 羧化酶（ACC）、 乙酰辅酶 A 脱氢酶（ACADS）、 脂蛋白脂肪酶（LPL）和 NAFLD 程度等进行对比。结果：中年女性 NAFLD 的
FATmax 强度对应心率为（115±6）次 /min,速度为（5.12±1.93）km/h;干预组干预后 BMI、 体脂百分比、 腹部脂肪、 腰臀比、 最大摄氧量及 Leptin、 TG 和
LDL 水平显著降低（ P＜0.05）;ACC、 ACADS、 LPL 显著升高（ P<0.01）;其中,4 人从中度脂肪肝改善为轻度脂肪肝,5 人从重度脂肪肝改善为中度脂肪
肝,对照组无明显变化。结论：持续 24 周规律的 FATmax 强度运动对于 NAFLD 有良好的改善作用。 相似文献
4.
摘要：目的：探讨运动对非酒精性脂肪肝（NAFLD）的预防作用及作用机理。方法： SD雄性大鼠随机分为对照组、模型组和运动组3 组。对照组给予普通饲料喂养,模型组予高脂饲料喂养,运动组在高脂饲料喂养的同时予运动干预,连续8周,直至实验结束。HE染色观察肝脏病理形态变化,TUNEL法测肝细胞凋亡,western blot检测CHOP、Caspase12和JNK蛋白表达,免疫组化检测CHOP、Caspase12和JNK蛋白阳性表达。结果：1）与对照组比较,模型组肝细胞脂肪性变明显,肝细胞凋亡指数升高,CHOP、Caspase12、JNK蛋白表达及阳性表达增加;2）与模型组比较,运动组肝细胞脂肪变性减轻,肝细胞凋亡指数减少,CHOP、Caspase12、JNK蛋白表达及阳性表达降低。结论：8周高脂饮食可成功复制NAFLD动物模型,内质网应激介导细胞凋亡参与NAFLD形成。运动对NAFLD形成具有较好的预防作用,其机制可能与运动可降低内质网应激介导细胞凋亡蛋白CHOP、JNK和Caspase12在肝细胞的表达,抑制肝细胞凋亡有关。 相似文献
5.
Sandhya Mishra Dharamveer Yadav Monika Gupta Hemant Mishra Praveen Sharma 《Indian journal of clinical biochemistry : IJCB》2013,28(1):79-83
Non-alcoholic fatty liver disease shares many features of metabolic syndrome and its presence could signify a substantial cardiovascular risk above and beyond that conferred by individual risk factors. This study is an attempt to investigate the association of non-alcoholic fatty liver disease with carotid intima-media thickness and plaque as surrogate measures of increased cardiovascular risk. The study was conducted on 645 non diabetic, non alcoholic subjects in the age range of 20–60 years. Metabolic syndrome was assessed by using ATP III and ADA (2005) criteria. Anthropometric factors—waist circumference and blood pressure were measured. Fasting serum samples were analyzed for glucose, triglyceride, cholesterol and its fractions, insulin, alanine and aspartate transaminases, gamma glutamyl transferase and free fatty acids. Insulin resistance and secretion were calculated by homeostasis model and insulin sensitivity by QUICKI index. Liver ultrasonographic scanning was used for assessing fatty liver. Carotid atherosclerosis was assessed by B-mode ultrasonography of common carotid artery and internal carotid artery. The prevalence of non-alcoholic fatty liver disease was 15.6 % in non alcoholic population and 68.5 % of non-alcoholic fatty liver disease had metabolic syndrome, which was associated with hyperinsulinemia, insulin resistance, insulin insensitivity along with elevated levels of waist circumference, blood pressure, triglyceride, FFA and decreased HDL cholesterol. NAFLD patients had markedly greater carotid intima media thickness than non NAFLD subjects with MCIMT of 591.6 ± 108 and 489.5 ± 132.4 μm (P < 0.001) and plaque prevalence of 19.2 and 2.2 %, respectively, thus the carotid intima media thickness is associated with NAFLD. 相似文献
6.
《European Journal of Sport Science》2013,13(7):994-1003
AbstractNon-alcoholic fatty liver disease (NAFLD) is a common chronic liver disorder which is associated with accumulation of fats in the liver. It causes a wide variety of pathological effects such as non-alcoholic steatohepatitis (NASH) and cirrhosis, insulin resistance, obesity, hypertension, dyslipidaemia, diabetes and cardiovascular disease. The molecular mechanisms that cause the initiation and progression of NAFLD are not fully understood. Oxidative stress (OS) induced by reactive oxygen species (ROS) and inflammation are likely a significant mechanism which can lead to hepatic cell death and tissue injury. Mitochondrial abnormalities, down-regulation of several antioxidant enzymes, glutathione (GSH) depletion and decreased activity of GSH-dependent antioxidants, accumulation of leukocytes and hepatic inflammation are the major sources of ROS overproduction in NAFLD. Excessive production of ROS suppresses the capacity of other antioxidant defence systems in NAFLD and causes further oxidative damage. Regular exercise can be considered as an effective strategy for treatment of NAFLD. It improves NAFLD by reducing intrahepatic fat content, increasing β-oxidation of fatty acids, inducing hepato-protective autophagy, overexpressing peroxisome proliferator-activated receptor- γ (PPAR-γ), as well as attenuating hepatocyte apoptosis and increasing insulin sensitivity. Exercise training also suppresses ROS overproduction and OS in NAFLD via up-regulation of several antioxidant enzymes and anti-inflammatory mediators. Therefore, an understanding of these molecules and signalling pathways gives us valuable information about NAFLD progression and a method for developing a suitable clinical treatment. This review aimed to evaluate sources of ROS and OS in NAFLD and the molecular mechanisms involved in the beneficial effects of exercises on NAFLD. 相似文献
7.
Chen ZW Chen LY Dai HL Chen JH Fang LZ 《Journal of Zhejiang University. Science. B》2008,9(8):616-622
Objective:To investigate the relationship between alanine aminotransferase (ALT)levels and metabolic syndrome (MS)in nonalcoholic fatty liver disease(NAFLD).Methods:A total of 26527 subjects who received medical health checkup in our hospital from January 2005 to July 2007 were enrolled in the study.The diagnosis of fatty liver was based on ultrasound imaging.MS Was defined according to the criteria of the Adult Treatment Panel Ⅲ.ALT,triglyceride(TG),high density lipoprotein cholesterol(HDL-c),fasting plasma glucose(FPG),height,weight,waist circumference(WC),systolic blood pressure (SBP)and diastolic blood pressure(DBP)were measured in each subject to analyze the relationship between MS and ALT activity.Results:(1)The prevalence of NAFLD in men(30.94%)was significantly higher than that in women(15.65%);(2)The incidence of MS in NAFLD(33.83%)was significantly greater than that in non-NAFLD(10.62%);(3)Of the 6470 subjects with NAFLD,in the age-adjusted partial correlation analysis,there were statistically significant correlations between the ALT levels and most metabolic risk factors in each sex(P＜0.01),except that ALT levels had no correlation with HDL-c in women.Moreover,in the multiple stepwise regression analysis,SBP lost its significance,and WC,body mass index(BMI),age,DBP,TG and FPG were independently associated with ALT levels in both sexes (P＜0.05).HDL-c remained significant and was independently related to ALT leveis in men;(4)ALT levels were significantly higher in subjects with MS compared to those without MS(P＜0.001).Mean ALT levels increased with the number of MS cornponents in each sex (P.＜0.05 for trend).Conelusion:We found a strong relationship between ALT leveIs and MS in NAFLD and revealed that the cluster of MS components might be the predictor for ALT elevations. 相似文献
8.
Sandhya Mishra Dharamveer Yadav Monika Gupta Hemant Mishra Praveen Sharma 《Indian journal of clinical biochemistry : IJCB》2008,23(2):130-135
Metabolic syndrome contributes to pathogenesis of Type-2 diabetes and CAD. Insulin Resistance is the key factor of metabolic
syndrome implicated in development of Non Alcoholic Fatty Liver Disease (NAFLD). In present study we have investigated the
prevalence of NAFLD in metabolic syndrome and contribution of metabolic risk factors in causation of NAFLD in non-diabetic
North Indian male population. The study was conducted on 495 non-diabetic, nonalcoholic subjects (age 30–65 years). Metabolic
Syndrome was assessed by using ATP III and ADA (2005) criteria. Anthropometric factors-Waist circumference and blood pressure
were measured. Fasting serum samples were analyzed for Glucose, Triglycerides, Cholesterol and its fractions, Insulin, Alanine
transaminase, Aspartate transaminase, Gamma glutamyl transferase and free fatty acids. Insulin resistance was estimated by
Homeostasis Model and Insulin sensitivity by QUICKI Index. Liver ultrasonographic scanning was used for assessing fatty liver.
The prevalence of metabolic syndrome and NAFLD was 24% and 14.8% respectively in non-alcoholic population and 27% of metabolic
syndrome had NAFLD which was associated with hyperinsulinemia, insulin resistance, insulin insensitivity along with elevated
levels of waist circumference, blood pressure, triglyceride, FFA and decreased HDL-Cholesterol. The prevalence of NAFLD increased
with insulin resistance and clustering of metabolic risk factors. 相似文献
9.
健步走对非酒精性脂肪性肝病患者血液生化指标的影响 总被引：1，自引：0，他引：1
许寿生 《西安体育学院学报》2006,23(5):79-81,101
目的探讨健步走运动对非酒精性脂肪性肝病(NAFLD)患者血液生化指标的改善效果。方法选取NAFLD患者71人,随机分为运动组和对照组,运动组进行12 w个体化的健步走运动,而对照组不进行特殊运动;对比被试运动前后空腹血糖、血脂、血清游离脂肪酸水平变化。结果实验后运动组的空腹血糖、血脂、血清游离脂肪酸水平均明显低于实验前(P<0.05)。结论科学、规律、个体化的健步走可明显改善NAFLD患者的糖、脂质代谢紊乱,有显著的防治作用。 相似文献
10.
Li G Shi W Hug H Chen Y Liu L Yin D 《Biochemia medica : ?asopis Hrvatskoga dru?tva medicinskih biokemi?ara / HDMB》2012,22(1):92-99