hs-CRP and oxidative stress in young CAD patients: A pilot study     

Suman B. Sharma  Seema Garg  Abhinav Veerwal  Sridhar Dwivedi 《Indian journal of clinical biochemistry : IJCB》2008,23(4):334-336

Premature coronary artery disease (CAD) is common in India. We, therefore, studied oxidative stress, dyslipidemia, and high sensitivity-C reactive protein (hs-CRP) levels in young CAD patients. Present study consisted of male CAD patients below 40 years and age and sex matched healthy controls (n=30 each). Fasting blood samples were analyzed for serum lipid profile, malondialdehyde, antioxidant enzymes and hs-CRP levels. Dyslipidemia was observed in 90% of the young CAD patients, of which 72.2% showed increased serum triglycerides and decreased HDL-cholesterol. LDL-cholesterol levels were high in 77.8%. Serum malondialdehyde and hs-CRP levels were increased significantly (p<0.0001) as compared to controls. hs-CRP levels were in high risk range in all the young patients. However, glutathione peroxidase activity was reduced significantly (p<0.05). Our data suggests that elevated hs-CRP levels along with dyslipidemia and oxidative stress adds to the predictive value of premature CAD in young Indians.  相似文献   

Research agenda for social and collaborative information seeking     

Chirag Shah  Rob Capra  Preben Hansen 《Library & information science research》2017,39(2):140-146

Scholars in diverse fields of inquiry have identified the need to expand individual-based information seeking and behavior models and systems to incorporate social as well as collaborative dimensions. However, the research areas of Social Information Seeking (SIS) and Collaborative Information Seeking (CIS) have been largely disconnected from one another despite a few notable attempts to study them under one umbrella. Researchers in these communities have recently realized the value of bringing SIS and CIS together for two main reasons: often it is impossible to separate social and collaborative dimensions in a project; and by considering these two aspects of information seeking, we may be able to support human information behavior in ways not previously possible. A brief synthesis of work in the domains of SIS and CIS is presented here. Then, an integrated view is presented to consider Social and Collaborative Information Seeking (SCIS) as an intersection and extension of SIS and CIS. Benefits of this approach are discussed and the integrated view is used as the basis to present a research agenda that outlines opportunities and challenges unique to SCIS.  相似文献   

The orchestration of a collaborative information seeking learning task     

Simon?KnightEmail authorView author&#;s OrcID profile  Bart?Rienties  Karen?Littleton  Dirk?Tempelaar  Matthew?Mitsui  Chirag?Shah 《Information Retrieval》2017,20(5):480-505

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Canada’s Implementation of the Right to Education for Students with Disabilities     

Seema Shah 《International Journal of Disability, Development & Education》2010,57(1):5-20

This article analyses the content and legal implementation of the right to education as a human right in Canada. It seeks to expose the extent to which Canadian legislative mechanisms have succeeded in protecting the right to education of students with disabilities by using students with epilepsy as a test case. To that end, the article examines the barriers faced by students with epilepsy in realising their right to education. It explores the content of the right to education in international law so as to provide an ideal against which the legal implementation of the right to education in Canada can be measured. In examining the degree to which legal implementation of the right to education for students with disabilities lives up to the ideals espoused in international law, the article analyses the effectiveness of the legal mechanisms that implement the right to education for students with epilepsy in addressing the three types of barriers faced by these students. The revelation of where students with epilepsy fall through the cracks serves as a reflection of the limits of current legal mechanisms in protecting the right to education for students with disabilities.  相似文献   

The Indian academic profession     

A. B. Shah 《Minerva》1973,11(1):137-139

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Hyperhomocysteinemia and cardiovascular disease: The nutritional perspectives     

Rajesh Pandey  Seema Gupta  Harbans Lal  H. C. Mehta  S. K. Aggarwal 《Indian journal of clinical biochemistry : IJCB》2000,15(1):20-30

Several members of the vitamin B-complex family are known to participate in the normal metabolism of homocysteine (Hcy). Leaving aside the genetic determinants of hyperhomocysteinemia (HHC), the deficiencies of these vitamins can also result in HHC. The situation of sustained and long standing HHC is likely to be prevalent in population groups with low/average socio-economic status, geriatric population and alcohol abusers. If not corrected by supplementation, these population groups certainly are more vulnerable to develop atherosclerosis (AS) and subsequently, cardiovascular disease (CVD). Hyperhomocysteinemia per se and/or HHC-induced oxidative stress result(s) in chronic chemical endothelial injury/dysfunction, smooth muscle proliferation, prothrombotic state and oxidation of low density lipoproteins (LDL) leading to diverse cardiovascular complications. In the first decade of the new millennium, major research efforts would be directed towards understanding the basic mechanism of HHC-induced oxidative stress and the pathophysiology of HHC-induced CVD, culminating in the evolution of hitherto unknown therapeutic strategies such as nutriceuticals and oxidant-antidotes.  相似文献   

翻转课堂联合WebQuest在信息素养教学中的应用     

吴瑨  高山  隆茜 《数字图书馆论坛》2014,(11):63-66

翻转课堂侧重在课外完成知识的学习,在课堂中完成知识的内化。但翻转课堂仅是一种教学组织方式,需配合具体的教学方法才能让翻转课堂“活”起来。WebQuest是一种在网络环境下任务驱动式的探究性学习方式,教师创建学习情境,引导学生利用网络资源以任务驱动进行自主探究活动,并以小组形式展开讨论与思考。将WebQuest与翻转课堂联合应用于信息素养教育,有助于活跃学生思维。  相似文献   

水产类创新创业教育基地建设新模式探究     

何珊  曹海鹏  谭洪新 《中国科教创新导刊》2014,(4):16-17

本文分析了国内高校创新创业教育基地在机构设立、制度保障、校企合作方面的建设情况,提出了高校与地方水产行政管理部门共建水产类创新创业教育基地在学生个人发展、创新与创业项目转化、资源利用率提升三方面的优势,并进一步指出了与地方水产行政管理部门共建水产类创新创业教育基地的实施路径,以期建设一种特色的水产类创新创业教育基地的创新模式.  相似文献   

Disconnecting to Connect: Developing Postconnectivist Tactics for Mobile and Networked Technical Communication     

Gustav Verhulsdonck  James Melton  Vishal Shah 《Technical Communication Quarterly》2019,28(2):152-164

ABSTRACT

In a networked society, humans are connected through mobile devices to always-on networks, and these technologies merge with us in new ways. In this environment, studying human-networked interactions involves an expanded type of usability. In this article, we argue that a key component of usability is how humans connect and disconnect from these networks. For this reason, the authors advocate studying how users connect and disconnect between online and offline contexts in their everyday life. Such an effort involves questioning our assumptions about the role of connection in usability and introduces methodological issues in studying these processes. These shifts require our research to be more multidisciplinary and more methodologically demanding, with major implications for the portability and durability of technical communication research.  相似文献   

Attitudes of academic staff towards their own work and towards external evaluation,from the perspective of self-determination theory: Estonian case     

Riin Seema  Maiki Udam  Heli Mattisen 《Quality in Higher Education》2016,22(2):117-126

The purpose of this study was to ascertain the attitudes of academic staff towards their own work as well as towards external evaluations. The study was based on (1) an analysis of assessment reports of institutional accreditations conducted by the Estonian Quality Agency for Higher and Vocational Education and (2) self-determination theory on intrinsic and extrinsic motivation. The satisfaction of academic staff with their own teaching and research competencies was measured and links among the following attitudes were analysed: sense of competence, intrinsic motivation for research, attitudes towards assessment of students and towards external evaluations. The results indicate that a correlation between attitudes towards work and towards external evaluation exists and that the attitudes of academic staff at universities and professional higher education institutions differ. The study involved 252 academic staff members and showed that competent and intrinsically motivated people perceive external evaluation more positively, thus supporting self-determination theory.  相似文献