Impact of age on host responses to diet-induced obesity:Development of joint damage and metabolic set points     

Kelsey H.Collins  Graham Z.MacDonald  David A.Hart  Ruth A.Seerattan  Jaqueline L.Rios  Raylene A.Reimer  Walter Herzog 《运动与健康科学(英文)》2020,9(2):132-139,197

Background:Osteoarthritis is one of the leading causes of pain and disability worldwide,and a large percentage of patients with osteoarthritis are individuals who are also obese.In recent years,a series of animal models have demonstrated that obesity-inducing diets can result in synovial joint damage(both with and without the superimposition of trauma),which may be related to changes in percentage of body fat and a series of low-level systemic inflammatory mediators.Of note,there is a disparity between whether the dietary challenges commence at weaning,representing a weanling onset,or at skeletal maturity,representing an adult onset of obesity.We wished to evaluate the effect ofthe dietary exposure time and the age at which animals are exposed to a high-fat and high-sucrose(HFS) diet to determine whether these factors may result in disparate outcomes,as there is evidence suggesting that these factors result in differential metabolic disturbances.Based on dietary exposure time,we hypothesized that rats fed an HFS diet for 14 weeks from weaning(HFS Weanling) would demonstrate an increase in knee joint damage scores,whereas rats exposed to the HFS diet for 4 weeks,starting at 12 weeks of age(HFS Adult) and rats exposed to a standard chow diet(Chow)would not display an increase in knee joint damage scores.Methods:Male Sprague-Dawley rats were fed either an HFS diet for 14 weeks from weaning(HFS Weanling) or an HFS diet for 4 weeks,starting at 12 weeks of age(HFS Adult).At sacrifice,joints were scored using the modified Mankin Criteria,and serum was analyzed for a defined subset of inflammatory markers(Interleukin-6,leptin,monocyte chemoattractant protein-1,and tumor necrosis factorα).Results:When the HFS Weanling and HFS Adult groups were compared,both groups had a similar percent of body fat,although the HFS Weanling group had a significantly greater body mass than the HFS Adult group.The HFS Weanling and HFS Adult animals had a significant increase in body mass and percentage of body fat when compared to the Chow group.Although knee joint damage scores were low in all 3 groups,we found,contrary to our hypothesis,that the HFS Adult group had statistically significant greater knee joint damage scores than the Chow and HFS Weanling groups.Furthermore,we observed that the HFS Weanling group did not have significant differences in knee joint damage scores relative to the Chow group.Conclusion:These findings indicate that the HFS Weanling animals were better able to cope with the dietary challenge of an HFS diet than the HFS Adult group.Interestingly,when assessing various serum proinflammatory markers,no significant differences were detected between the HTS Adult and HFS Weanling groups.Although details regarding the mechanisms underlying an increase in knee joint damage scores in the HFS Adult group remain to be elucidated,these findings indicate that dietary exposure time maybe less important than the age at which an HFS diet is introduced.Moreover,increases in serum proinflammatory mediators do not appear to be directly linked to knee joint damage scores in the HFS Weanling group animals but may be partially responsible for the observed knee joint damage in the adults over the very short time of exposure to the HFS diet.  相似文献   

Adaptation and evaluation of a learning analytics dashboard to improve academic support at three Latin American universities     

Julio Guerra  Margarita Ortiz-Rojas  Miguel Angel Zúñiga-Prieto  Eliana Scheihing  Alberto Jiménez  Tom Broos  Tinne De Laet  Katrien Verbert 《British journal of educational technology : journal of the Council for Educational Technology》2020,51(4):973-1001

Despite the success of academic advising dashboards in several higher educational institutions (HEI), these dashboards are still under-explored in Latin American HEI's. To close this gap, three different Latin American universities adapted an existing advising dashboard, originally deployed at the KU Leuven to their own context. In all three cases, the context was the main ruling factor to these adaptations. In this paper, we describe these adaptions using a framework that focuses on four different elements of the context: Objectives, Stakeholders, Key moment and Interactions. Evaluation of the adapted dashboards in the three different Latin American universities is conducted through pilots. This evaluation shows the value of the dashboard approach in different contexts in terms of satisfaction, usefulness and impact in academic decision-making and advising tasks. The main contribution of this paper is the systematic reporting of the adaptations to an academic advising dashboard and showing the value of an academic advising dashboard on academic decision-making and advising tasks.  相似文献   

Cognitive-inspired domain adaptation of sentiment lexicons     

Frank Z. Xing  Filippo Pallucchini  Erik Cambria 《Information processing & management》2019,56(3):554-564

Sentiment lexicons are essential tools for polarity classification and opinion mining. In contrast to machine learning methods that only leverage text features or raw text for sentiment analysis, methods that use sentiment lexicons embrace higher interpretability. Although a number of domain-specific sentiment lexicons are made available, it is impractical to build an ex ante lexicon that fully reflects the characteristics of the language usage in endless domains. In this article, we propose a novel approach to simultaneously train a vanilla sentiment classifier and adapt word polarities to the target domain. Specifically, we sequentially track the wrongly predicted sentences and use them as the supervision instead of addressing the gold standard as a whole to emulate the life-long cognitive process of lexicon learning. An exploration-exploitation mechanism is designed to trade off between searching for new sentiment words and updating the polarity score of one word. Experimental results on several popular datasets show that our approach significantly improves the sentiment classification performance for a variety of domains by means of improving the quality of sentiment lexicons. Case-studies also illustrate how polarity scores of the same words are discovered for different domains.  相似文献   

Analytical attractions and the techno-continuum: Conceptualising data obsessions and consequences in elite sport     

Geoffery Z. Kohe  Laura G. Purdy 《Sport, Education and Society》2019,24(7):742-755

The proliferation of sports science and technological innovation within performance settings has precipitated the generation of increasing volumes of data to aid athletes. Copious data production has also perpetuated the privileging of scientific information, and a ‘thirst’ for ‘more data’ as an unproblematic ‘truth’. Of significance is not merely the use of technology for the production of data-for-data's sake, or the utility of data for a greater cause (e.g. the good of the team), but the quest for personalised data for individual athletes to be analysed, and reflected upon ad nauseam. Furthering scholarship on disciplining bodies, we argue that increased technological consumption, and the related excessive quantification of athletes’ bodies via data production, adds further insecurity into performance sports work. Finally, attention is given to the cultural step-change new techno-dispositions may now present.  相似文献   

论教学活动中教师心理状态的自我调节特点     

杨玉红  З.Б.玛达丽耶娃 《兰州教育学院学报》2007,(3):59-61

本文探讨的是高情绪化和低情绪化教师心理自我调节的特点问题.通过抽样调查和分析获得了具有不同程度情绪化的教师心理自我调节风格特征的准确差异.  相似文献   

On the Complexity of the Reduction of Multidimensional Data Models     

A. A. Akhrem  V. Z. Rakhmankulov  K. V. Yuzhanin 《Scientific and Technical Information Processing》2017,44(6):406-411

In this paper, decomposition methods for multidimensional data hypercubes of OLAP systems are investigated. Criteria for reducing the computational complexity of the decomposition methods are presented and comparisons are made with the traditional solutions of multidimensional data analysis problems. Examples illustrating the application of these criteria to investigating the dynamics of computational complexity changes for specific types of reduction problems are considered.  相似文献   

Prospective Elementary Mathematics Specialists’ developing instructional practices: support and mentorship during an authentic residency     

Myers  Kayla D.  Auslander  Susan Swars  Smith  Stephanie Z.  Smith  Marvin E. 《Journal of Mathematics Teacher Education》2021,24(3):309-330

Journal of Mathematics Teacher Education - This case study explored Prospective Elementary Mathematics Specialists’ (PEMSs) pedagogical practices during a K-5 Mathematics Endorsement (K-5 ME)...  相似文献   

Effects of exposure to an aggressive model and "frustration" on children's aggressive behavior     

D Z Kuhn  C H Madsen  W C Becker 《Child development》1967,38(3):739-745

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The videoconferencing learning environment: Technology, interaction and learning intersect     

K. G. Saw  Omar Majid  N. Abdul Ghani  H. Atan  R. M. Idrus  Z. A. Rahman  K. E. Tan 《British journal of educational technology : journal of the Council for Educational Technology》2008,39(3):475-485

This paper is a study on the interaction patterns of distance learners enrolled in the Mathematics and Physics programmes of Universiti Sains Malaysia in the videoconferencing learning environment (VCLE). Interaction patterns are analysed in six randomly chosen videoconferencing sessions within one academic year. The findings show there are more interactions in the graphics display mode than the video display mode. The graphics display mode, which involves the simultaneous interaction of the teacher, students and course materials, shows greater student engagement in the VCLE. The focus on a three-component interaction in distance learning differs from previous studies which looked at distinct types of two-component interactions. The types of communicative interaction, in particular the explanatory and cognitive types which are dominant in the graphics display mode, are discussed within the construct of learning. The higher number of teacher-initiated interactions may also imply that the teacher plays a crucial role in creating and maintaining a community of inquiry focused on exploring and developing content as well as giving feedback on concepts, ideas or solutions.  相似文献   

Modelling impact of dredging and dumping in ebb-flood channel systems     

A. Hibma  Z. B. Wang  M. J. F. Stive  H. J. de Vriend 《天津大学学报(英文版)》2008,14(4):271-281

For a channel-shoal system in a funnel-shaped basin the impact of dredging and dumping is investigated using a complex process-based model. First, the residual flow and sediment transport circulations are analysed for the channel-shoal pattern, which has emerged after a long-term model simulation. Results are compared to the Western Scheldt estuary, which forms the inspiration for this study. Subsequently, different dredge and dump scenarios are modelled, according to a conceptual model, in which ebb-and flood-channels and enclosed shoals form morphodynamic units (cells) with their own sediment circulation. Model results show that dumping sediment in a channel further reduces the channel depth and induces erosion in the opposite channel, which enhances tilting of the cross-section of the cell and eventually can lead to the degeneration of a multiple channel system into a single channel. The impact of different dredging and dumping cases agrees with results from a stability analysis. This means that this type of model applied to a realistic geometry can potentially be used for better prediction of the impact of human interventions.  相似文献