焊接培训中疑点、难点解析     

李妙珍 《石家庄职业技术学院学报》2007,19(4):41-43

分析了在焊工培训中遇到的疑点、难点问题：如焊接中的横向变形、角变形，实践中的运条，并对其进行了理论分析，介绍了解决焊接中变形问题的具体措施及运条时应注意的事项．  相似文献   

Advances in nanomaterials for treatment of hypoxic tumor     

Mei-Zhen Zou  Wen-Long Liu  Han-Shi Chen  Xue-Feng Bai  Fan Gao  Jing-Jie Ye  Han Cheng  Xian-Zheng Zhang 《国家科学评论(英文版)》2021,8(2)

The hypoxic tumor microenvironment is characterized by disordered vasculature and rapid proliferation of tumors, resulting from tumor invasion, progression and metastasis. The hypoxic conditions restrict efficiency of tumor therapies, such as chemotherapy, radiotherapy, phototherapy and immunotherapy, leading to serious results of tumor recurrence and high mortality. Recently, research has concentrated on developing functional nanomaterials to treat hypoxic tumors. In this review, we categorize such nanomaterials into (i) nanomaterials that elevate oxygen levels in tumors for enhanced oxygen-dependent tumor therapy and (ii) nanomaterials with diminished oxygen dependence for hypoxic tumor therapy. To elevate oxygen levels in tumors, oxygen-carrying nanomaterials, oxygen-generating nanomaterials and oxygen-economizing nanomaterials can be used. To diminish oxygen dependence of nanomaterials for hypoxic tumor therapy, therapeutic gas-generating nanomaterials and radical-generating nanomaterials can be used. The biocompatibility and therapeutic efficacy of these nanomaterials are discussed.  相似文献   

Biodegradable magnesium alloy with eddy thermal effect for effective and accurate magnetic hyperthermia ablation of tumors     

Nailin Yang  Fei Gong  Liang Cheng  Huali Lei  Wei Li  Zongbin Sun  Caifang Ni  Zhanhui Wang  Zhuang Liu 《国家科学评论(英文版)》2021,8(1)

Magnetic hyperthermia therapy (MHT) is able to ablate tumors using an alternating magnetic field (AMF) to heat up magnetocaloric agents (e.g. magnetic nanoparticles) administered into the tumors. For clinical applications, there is still a demand to find new magnetocaloric agents with strong AMF-induced heating performance and excellent biocompatibility. As a kind of biocompatible and biodegradable material, magnesium (Mg) and its alloys have been extensively used in the clinic as an implant metal. Herein, we discovered that the eddy thermal effect of the magnesium alloy (MgA) could be employed for MHT to effectively ablate tumors. Under low-field-intensity AMFs, MgA rods could be rapidly heated, resulting in a temperature increase in nearby tissues. Such AMF-induced eddy thermal heating of MgA could not only be used to kill tumor cells in vitro, but also be employed for effective and accurate ablation of tumors in vivo. In addition to killing tumors in mice, we further demonstrated that VX₂ tumors of much larger sizes growing in rabbits after implantation of MgA rods could also be eliminated after exposure to an AMF, illustrating the ability of MgA-based MHT to kill large-sized tumors. Moreover, the implanted MgA rods showed excellent biocompatibility and ∼20% of their mass was degraded within three months. Our work thus discovered for the first time that non-magnetic biodegradable MgA, an extensively used implant metal in clinic, could be used for effective magnetic thermal ablation of tumors under a low-field-intensity AMF. Such a strategy could be readily translated into clinical use.  相似文献   

TRAIL与肿瘤治疗     

周银燕  郦萍  吴雪昌 《科技通报》2009,25(3)

TRAIL是肿瘤坏死因子(TNF)超家族的成员之一,通过与受体结合而诱导细胞程序性死亡.TRAIL能够选择性地诱导肿瘤细胞凋亡,而对正常组织细胞几乎没有毒性,因此目前受到人们广泛的关注.本文介绍了TRAIL及其受体的表达调控,TRAIL的凋亡途径,以及TRAIL在肿瘤治疗中的研究进展,以期为TRAIL应用于临床肿瘤治疗提供一定的参考.  相似文献   

恶性肿瘤患者心理特点及护理     

张金华 《淮南职业技术学院学报》2009,9(2):122-124

在各种疾病中,很少有如恶性肿瘤那样给人以巨大的精神压力,恶性肿瘤不仅影响一个人的正常生活,也危害其家庭,不仅破坏机体的正常功能,也可造成身体形象的改变,更加重了患者的恐惧、疑虑、忧郁、绝望等情绪反应,如果肿瘤患者能乐观地对待生活,保持良好的心理状态,改正不良的生活习惯和行为,积极地配合治疗,往往会取得良好的效果,提高生存质量,促进病情好转,对肿瘤患者的康复具有重要意义。  相似文献   

端粒与端粒酶--人类攻克癌症的新契机     

庄景凡 《岳阳职业技术学院学报》2006,21(2):51-53

端粒,是染色体末端所特有的结构,其长度与细胞的复制及衰老有关;端粒酶,是一种催化延长端粒末端的反向转录酶。近年来的研究显示,绝大部分恶性肿瘤具有端粒酶活性表达,该酶在肿瘤的治疗和发展中起着重要作用。因此,有效地控制端粒酶活性,有可能为人类攻克癌症提供一个新的契机。  相似文献   

新型抗凋亡基因Survivin与肿瘤的研究进展   总被引：2，自引：0，他引：2  

唐忠辉 《莆田学院学报》2003,10(3):19-22

综述Survivin是一种新型凋亡抑制因子,主要通过抑制Caspase-3和Caspase-7的活性而阻断细胞凋亡过程。指出Survivin选择性地表达于胚胎发育组织和大多数肿瘤组织,而正常成人分化组织中不表达。认为Survivin参与了细胞周期调控,与肿瘤的发展和血管形成有关,可作为肿瘤治疗的新靶点。  相似文献   

氟伐他汀对不稳定型心绞痛患者血清白介素-18和肿瘤坏死因子α干预的研究     

詹文娴  杨波  刘文卫  刘永胜 《襄樊职业技术学院学报》2008,7(3):22-24

目的研究氟伐他汀对不稳定型心绞痛患者血清白介素-18（IL-18）和肿瘤坏死因子α（TNFα）的影响。方法选择2006年9月至2007年7月79例不稳定型心绞痛患者,入院后随机分为2组：氟伐他汀干预组42例：常规药物治疗基础上加用氟伐他汀40mg／d;对照组37例：常规药物治疗。分别于药物治疗前、药物治疗后2周采集静脉血,测定血清IL-18和TNFα的浓度。结果药物治疗后,对照组（P〈0．05）及氟伐他汀干预组（P〈0．01）血清IL-18和TNF＆浓度均明显降低;氟伐他汀干预组血清IL-18（P〈0．01）和TNFα（P〈0．01）浓度明显低于同期对照组。结论氟伐他汀可明显降低不稳定型心绞痛患者血清IL-18和TNFα浓度。  相似文献   

陈延昌治疗恶性肿瘤学术经验     

李和平 《孝感职业技术学院学报》2005,8(3):85-87

恶性肿瘤的治疗发展到今天，越来越趋向于在整体观念基础上进行合理、有计划、多学科参与的综合治疗。湖北省肿瘤医院陈延昌主任医师临证凡四十年，在这方面积累了丰富经验。概括起来即：同中求异，诊断注重辨病与辨证相结合；虚实夹杂，治疗不舍扶正与祛邪相结合；点面一体，用药讲究一般与特殊相结合；善守贵变，疗程坚持长期与临时应变相结合。以上四个结合，对于指导恶性肿瘤的临床具有实用价值。  相似文献   

腹膜及腹膜后间质瘤11例临床病理分析     

孙静阳  任欣  于晶功  许朝军  胡波 《大连大学学报》2005,26(2):78-80,84

[目的]探讨腹膜、腹膜后间质瘤的临床病理特点.[方法]对大连大学附属医院近3a收治11例腹膜、腹膜后间质瘤患者的临床病理特点及用免疫组织化学方法检测CD117、CD34、SMA、S100蛋白表达的情况进行回顾性分析.[结果]11例患者中发生于结肠(横结肠)上区3例,结肠(横结肠)下区8例.肿瘤未能完整切除者4例.肿瘤大小≤2cm者2例,>2～5cm者1例,>5～10cm者3例,>10cm者5例.细胞形态以梭形细胞为主9例,以上皮样细胞为主2例.11例患者CD117全部阳性,CD34阳性7例,SMA阳性5例,S100全阴性.[结论]结果提示腹膜、腹膜后间质瘤作为GIST的一种特殊类型,有着其自身的临床病理特点.  相似文献