蛋白质loop区域闭合数值方法分析与比较     

孙路  吕强  徐维维  权丽君 《人天科学研究》2013,(8):29-33

针对蛋白质loop区域的闭合问题,比较分析了两种来源于机器人学的数值方法——循环坐标下降法（CCD）和雅可比矩阵方法,进行了实现并设计实验。在计算时间和闭合效率方面循环坐标下降法要明显优于雅可比矩阵方法,而雅可比矩阵方法则可以较平均地改变每一个二面角值。  相似文献   

微量蛋白质的光散射测定     

冯宁川  许红平  张国彬 《宁夏师范学院学报》2001,22(3):30-32

提出了测定微量蛋白质的新方法，蛋白质，包括牛血清白蛋白（BSA），人血清白蛋白（HSA），牛血红蛋白（HB）能在PH4．3的酸性介质中与桑色素结合，使桑色素的光散射信号提高，在最佳实验条件下，BSA浓度在0．5－0．8ug/ml范围内呈线性关系，将这一方面用于合成样品中微量蛋白质的测定，结果满意。  相似文献   

Dyslipidemia in pregnancy may contribute to increased risk of neural tube defects -a pilot study in north Indian population     

Supriya Gupta  Sarika Arora  S. S. Trivedi  Ritu Singh 《Indian journal of clinical biochemistry : IJCB》2009,24(2):150-154

Neural tube defects are congenital structural abnormalities of the brain and vertebral column resulting from improper or non-timely closure of the neural tube. Prevalence of neural tube defects is reported to be higher among women with diabetes mellitus and obesity. This study was designed to investigate the relation between the presence of dyslipidemia in antenatal patients and the risk of fetal neural tube defects. The present study was an observational, cross-sectional study involving 129 pregnant women in 16 to 18 weeks gestation period. Of these, 80 women had normal pregnancies and 49 were clinically high-risk cases for neural tube defects. Fasting blood samples were analyzed for blood sugar and lipid profile by enzymatic assay and alpha-fetoprotein levels using Enzyme Immunoassay. Alpha-fetoprotein (AFP) values were converted to Multiples of Median (MoM) appropriate for the gestational age. Based on AFP values, women were labeled as screen negative (AFP <2 MoM, n= 102) and screen positive (AFP > 2 MoM, n =27). Screen positive women were further evaluated by ultrasound and 21 women were found to carry a neural tube defects positive pregnancy. Statistical analysis was done on SPSS software. Body weight of the women showed a significant positive correlation with serum triglycerides, plasma sugar and AFP MoM values. A significant difference was observed in serum cholesterol levels (p= 0.038), triglycerides (p=0.001) and plasma sugar levels (p=0.002) between normal women and those with neural tube defects positive pregnancy. The Odds ratio for neural tube defects risk in dyslipidemic cases was 24.23 (CI 4.73 − 148.60) with a relative risk of 12.12. Dyslipidemia especially hypertriglyceridemia was found to be significantly associated with fetal neural tube defects.  相似文献   

生物信息学中的马尔可夫模型   总被引：1，自引：0，他引：1  

曹晓燕  徐安龙 《中山大学学报论丛》2000,20(1):1-9

随着人类基因组研究的不断发展,在世界各个（Genbank,SwissPort等）数据库中积累了大量蛋白质、核酸序列数据,如何分析和处理这些数据以获得更多的信息成为科学家们关心的核心问题,并由此产生了生物信息学。文章介绍了在生物信息学研究中常见的几种用于数据库搜索、序列比较、建立蛋白质模型、发现新基因等研究的马尔可夫模型。  相似文献   

男子短跑300m不同强度跑中血乳酸、血尿素、尿蛋白变化的实验研究   总被引：4，自引：1，他引：3  

龙斌  熊西北 《北京体育大学学报》2003,26(5):630-632,637

对男子400m短跑运动员采用300m不同负荷跑的血乳酸、血尿素、尿蛋白变化进行了实验研究,发现相同距离,不同的负荷量和强度对人的机体产生的影响不同,训练的效果、达到的训练目的也不相同。建议训练应根据需要有目的地选择负荷量和强度。  相似文献   

人体运动能力与蛋白质需要量浅析     

陈日红 《湖南城市学院学报》2002,19(3):93-95

对蛋白质的若干生理作用、蛋白质在机体内的有关代谢及与体育运动的关系进行了分析  相似文献   

不同蛋白质水平的日粮对实验大鼠生长发育、繁殖性能的影响     

孙全文  杜建华  常宝 《河北北方学院学报(医学版)》2003,20(5):14-16

目的 :了解不同水平的蛋白质日粮对实验大鼠生长发育、繁殖性能的影响。方法 :用三种不同蛋白质水平的日粮饲喂实验大鼠 ,观察其生长发育、繁殖性能并测量相关数据。结果 :饲喂高蛋白配方大鼠其体重、平均日增重及料重比等指标极显著 (P <0 .0 1 )或显著 (P <0 .0 5)高于低蛋白配方组和中等水平蛋白配方组。结论 :实验大鼠在生长发育高峰期可喂以高蛋白日粮 ,之后喂以中等水平蛋白质日粮 ,既可保证动物质量 ,亦可获得较好的经济效益  相似文献   

热休克蛋白(HSP70、HSP27)在食管癌组织中表达的意义     

张世棋  马春梅  蒋丽娜  薄爱华  张晓丽  邢立强 《河北北方学院学报(医学版)》2002,19(2):56-57

目的 :探讨HSP70和HSP2 7在食管癌组织中的表达情况。方法 :采用SP免疫组织化学染色检测 5 9例食管癌组织中HSP70和HSP2 7。结果 :HSP70和HSP2 7的总阳性率分别为 6 4.4 1% (38/5 9)和 5 8.6 2 % (34/5 8) ,HSP70和HSP2 7的共同阳性率为 30 .0 0 % (9/30 )。结论 :在食管癌中HSP70和HSP2 7普遍表达。  相似文献   

Bread wheat varieties as influenced by different nitrogen levels   总被引：4，自引：2，他引：2  

Hussain I  Khan MA  Khan EA 《Journal of Zhejiang University. Science. B》2006,7(1):70-78

INTRODUCTION Dera Ismail Khan lies in Pakistan’s arid zone (71.07° longitude, 31.57° latitude and 500 m above sea level). This zone is in the extreme south of (NWFP) Pakistan at the bank of the River Indus. Dera Ismail Khan is bounded by Sulaiman Range to the West, the Indus River on the East, Marwat and Bhit- tani Ranges on the North and Vehowa Nala (Punjab) on the South. Besides certain local variability the area is comprised of four basic divisions viz mountains, a series …  相似文献   

The binding media of the polychromy of Qin Shihuang's Terracotta Army   总被引：2，自引：0，他引：2  

Ilaria Bonaduce  Catharina Blaensdorf  Patrick Dietemann  Maria Perla Colombini   《Journal of Cultural Heritage》2008,9(1):103-108

The “Terracotta Army” is a worldwide known archaeological finding in China. It is a part of the burial complex of the emperor Qin Shihuangdi (259–210 BC), which is still under excavation and study. The fact that the sculptures, chariots and weapons of the First Chinese Emperor's Terracotta Army were originally all painted in bright colours is still not widely known. The chemical characterisation of the paint medium was performed through an analytical procedure based on GC-MS. The proteinaceous binder was identified for the first time through a desalting procedure used in proteomics. The identification of egg as a paint binder is extremely interesting in terms of the historical significance of the work of art itself and important in terms of the method of conservation. Moreover it represents one of the first steps towards an understanding of the painting technique used on ancient sculptures in China, of which – despite their fame – nothing is yet known.  相似文献