糖尿病大鼠主动脉结缔组织生长因子表达情况及氨基胍对其表达影响     

顾秀峰  刘乃丰  刘勇 《河北北方学院学报(医学版)》2004,21(2):21-23

目的:为探讨糖尿病患者易患动脉粥样硬化是否与结缔组织生长因子有关以及可能的干预药物.方法:建立大鼠糖尿病模型,随机分为正常对照组、糖尿病组、糖尿病盐酸氨基胍治疗组和糖尿病葛根素治疗组.应用逆转录聚合酶链式反应检测各组大鼠主动脉结缔组织生长因子mRNA表达水平.结果发现,糖尿病组大鼠主动脉结缔组织生长因子mRNA明显高于对照组(P＜0.01),葛根素治疗组和氨基胍治疗组结缔组织生长因子mRNA明显低于糖尿病组(P＜0.01),氨基胍治疗组、葛根素治疗组与对照组比较有显著差异(P＜0.05).结果:结缔组织生长因子过多表达与糖尿病患者易患动脉粥样硬化有关.结论:氨基胍、葛根素可降低糖尿病大鼠主动脉结缔组织生长因子mRNA过多表达.  相似文献   

高校教师糖尿病患病风险及相关危险因素的研究     

张严  ;鲍捷  ;马胜  ;周青  ;王杰龙 《体育科技》2014,(2):82-84

对高校教师糖尿病患病风险进行测试,并对危险因素进行分析,为糖尿病的早发现及早预防提供科学的依据。方法：采用eZscan-糖尿病早期检测系统测量960名高校教师的糖尿病患病风险;常规测量法测量腰围和臀围,并算出腰臀比;最后结合问卷调查法,获得基本资料。结果：年龄、高血压史、腰臀比、周锻炼次数与高校教师糖尿病发病风险显著性相关,且存在性别差异。结论：（1）年龄与糖尿病患病风险高度相关,教师年龄越大,患糖尿病风险越高。（2）糖尿病风险与高血压史有相关性,有高血压史的教师糖尿病患病风险增高,且男性高于女性。（3）糖尿病风险与腰臀比高度相关。教师中腰臀比超标者发生糖尿病风险高,且男性尤其明显,腰臀比正常者发生糖尿病风险低,且女性尤其明显。（4）教师周锻炼次数与糖尿病患病风险呈显著性负相关,体育锻炼是糖尿病预防及控制有效方法。  相似文献   

系统性健康教育对糖尿病患者疾病不确定感的影响     

刘鸿丽 《德州学院学报》2013,(6):54-56,72

探讨系统性健康教育模式对糖尿病患者疾病不确定感的影响.方法 将2010年6月一2011年6月在我院内分泌科住院的132例糖尿病患者,采用Mishel疾病不确定感量表,按入院先后顺序分为观察组和对照组,每组各66例,观察组采用“面对面”的系统性健康教育方法,对照组只接受传统的健康教育方法.两组患者均在住院当天和出院前1天采用疾病不确定感量表测评.结果观察组出院前1天与入院当天比较P＜0.01,前后有统计学差异,说明经过系统化健康教育对观察组患者的疾病不确定感的得分有显著的影响;出院前1天,观察组与对照组比较P＜0.01,组间差异有统计学意义,说明经过系统化健康教育对观察组患者的疾病不确定感的得分的影响更显著.结论 对糖尿病患者提供系统性健康教育,能显著降低其疾病不确定感.  相似文献   

MTHFR (Ala 222 Val) polymorphism and AMI in patients with type II diabetes mellitus     

T. Angeline  G. Thiruvarutselvi  W. Isabel  Rita Mary Aruna  Rama Devi  Nirmala Jeyaraj 《Indian journal of clinical biochemistry : IJCB》2009,24(2):137-141

The prevalent Ala222Val single nucleotide polymorphism of the MTHFR gene has been shown to be associated with type II diabetes. The objective of the present study was to find out whether there is genetic predisposition for development of acute myocardial infarction in type II diabetes mellitus among South Indian Tamil population. PCR-based restriction enzyme analysis was performed in DNA isolated from 120 acute myocardial infarction patients with diabetes mellitus and 100 non diabetic healthy individuals with no documented cardiovascular diseases. The results indicate that the MTHFR 677TT genotype is absent in both case and controls. The MTHFR 677CT genotype was observed among 32 (26.7 %) cases and 20 (20%) controls and the MTHFR 677CC genotype among 88 (73.3%) cases and 80 (80%) controls. The allelic frequencies were in accordance to Hardy Weinberg equilibrium. There was no statistical difference in genotype distribution between cases and controls. In conclusion, we suggest that the analysis of MTHFR genotyping for C677T polymorphism alone need not be considered to find out whether there is genetic predisposition for development of acute myocardial infarction in type II diabetes mellitus among South Indian Tamil population.  相似文献   

糖尿病性脑卒中患者早期按摩配合运动疗法疗效分析   总被引：2，自引：0，他引：2  

李荣源  王安利 《北京体育大学学报》2009,32(1)

目的:研究糖尿病性脑血管病患者的康复问题,探讨采用以神经发育疗法和运动再学习技术为主的运动疗法,同时结合早期手法按摩在不同类型糖尿病性脑血管病患者康复治疗中的作用,为糖尿病性脑血管病患者的康复提供临床依据.方法:将80例38～73岁确诊为糖尿病性脑血管病的患者随机分为三组进行研究.结果:一个月的观察期后,各组患者的运动功能、日常生活活动能力均有改善,但综合康复组患者的疗效优于按摩组和对照组(P<0.05).接受相同方法治疗(综合康复或按摩)后的不同类型(缺血性或失血性)脑卒中相互比较,MBI与FMA评分增加幅度虽有不同,但差异不显著(P>0.05).结论:早期手法按摩治疗可以显著改善不同类型糖尿病性脑卒中患者的运动功能和日常生活活动能力,但手法按摩配合运动疗法的综合康复效果要明显好于单纯的手法按摩,相同治疗对不同类型糖尿病性脑卒中疗效是一致的.  相似文献   

Relationship of “weekend warrior” and regular physical activity patterns with metabolic syndrome and its associated diseases among Chinese rural adults     

Jing Xiao  Minjie Chu  Huan Shen  Wenlong Ren  Zhou Li  Tianqi Hua 《Journal of sports sciences》2018,36(17):1963-1971

Little is known about the “weekend warrior” pattern of physical activity (PA) where people perform all their PA in 1 or 2 sessions per week. We investigated the relationship of weekend warrior and other PA patterns with metabolic syndrome (MS) and its associated diseases. Data on sociodemographic and lifestyle characteristics were collected from the Nantong Metabolic Syndrome Study that included 13,505 women and 6,997 men between 2007 and 2008. Compared with inactive participants, weekend warriors were at lower risk of MS, diabetes, and hypertension; respective odds ratios (95% confidence intervals) for men and women were 0.58 (0.43–0.79) and 0.67 (0.52–0.86), 0.52 (0.34–0.79) and 0.52 (0.33–0.83), and 0.79 (0.63–0.99) and 0.71 (0.57–0.89). Similar results were observed with regular activity, at a frequency of >3 sessions per week. Both weekend warrior and regular PA patterns showed a 10–60% decrease in abnormal triglycerides, glucose, and blood pressure in both sexes; abnormal waist circumference in men only; and abnormal high-density lipoprotein in women only. Our observed cross-sectional relationships reflect that >150 min/week of moderate PA or 75 min/week vigorous-intensity PA is needed to prevent MS and its component diseases, even if in a short-bout, intermittent PA pattern.

Abbreviations: MS: Metabolic syndrome; WC: Waist circumference; TG: Triglycerides; HDL-c: High-density lipoprotein cholesterol; BP: Blood pressure; SBP: Systolic blood pressure, DBP: Diastolic blood pressure; PA: Physical activity; JIS: Joint Interim Statement; CVD: Cardiovascular disease; ATP III: US Third Report of the National Cholesterol Education Program, the Adult Treatment Panel; IDF: International Diabetes Federation; IPAQ: International Physical Activity Questionnaire; BMI: Body mass index; CDC: the Nantong Centers for Disease Control; OR: Odds ratio; CI: Confidence interval; SD: Standard deviation; IQR: Interquartile range.  相似文献   

RBC membrane composition in insulin dependent diabetes mellitus in context of oxidative stress     

Gauri S. Vahalkar  Vijaya A. Haldankar 《Indian journal of clinical biochemistry : IJCB》2008,23(3):223-226

Glyco-oxidation is considered as a source of permanent, cumulative, oxidative damage to long lived proteins in ageing and in diabetes. Although RBC depends solely on glucose for energy purpose, hyperglycemic state glycosylates hemoglobin, creates oxidative stress and puts the cellular components at risk. In view of this, RBC membrane composition was analyzed in diabetic patients. The results were compared with healthy age and sex matched control groups. When RBC membrane components such as protein, sialic acid, phospholipids and cholesterol were determined in insulin dependent diabetes mellitus, a significant rise in phospholipids and cholesterol and significant fall in sialic acid and protein content was noted. RBC membrane composition showed pronounced alterations in insulin dependent diabetes mellitus. These changes were accompanied by higher levels of lipid peroxidation products like Malondialdehyde.  相似文献   

运动是良医应用实例：美国糖尿病预防项目及其应用     

罗曦娟  张献博  徐峻华 《北京体育大学学报》2016,39(8):59-65+73

摘要：介绍第63届美国运动医学年会第7届运动是良医世界大会上有关美国糖尿病预防项目（DPP）最新推广应用的情况并追溯DPP的诞生和发展，目的在于为国内体医融合的研究及其科研成果的转化应用提供理论和实践参考。采用文献综述法对近20年来DPP相关论文资料进行综述，并结合第7届运动是良医世界大会上与DPP相关的最新报告内容，完整阐述DPP的诞生、发展和最新的推广应用情况，结合我国糖尿病预防的研究、实践和应用现状，提出在国内实施大范围糖尿病预防项目，特别是以运动为主的生活方式干预项目的必要性、可行性和注意事项，形成我国自己的应用模式并扩展到其他慢性疾病预防领域。  相似文献   

NIDDM合并肺部感染患者的免疫功能变化研究     

张丹  宫晓红  韩美君  赵彩红 《大连大学学报》2003,24(6):86-88

[目的]通过对免疫球蛋白(IgA、IgG、IgM),补体(C3、C4),T淋巴细胞亚群(CD3、CD4、CD8),可溶性白细胞介素2受体(SIL-2R)的检测,研究这些免疫指标与NIDDM(非胰岛素依赖性糖尿病)合并肺部感染患者的关系.[方法]采用双抗夹心法测SIL-2R,速率散射比浊法测免疫球蛋白和补体,单克隆法测淋巴细胞亚群等免疫指标.[结果]①糖尿病及其合并感染组SIL-2R显著高于正常对照组(P<0.01).CD4/CD8显著低于正常对照组(P<0.05);②合并感染组较正常对照组IgG、IgA、C3、C4显著升高(P<0.05、P<0.01、P<0.05、P<0.05),IgM无显著变化(P<0.05).[结论]NIDDM合并肺部感染可加重糖尿病及机体免疫功能低下,NIDDM合并肺部感染T淋巴细胞亚群(CD3、CD4、CD8),补体(C3、C4)免疫球蛋白(IgA、IgG)可溶性白细胞介素2受体(SIL-2R)的检测,可作为糖尿病及其合并感染者的病情变化的客观指标.  相似文献   

银杏叶提取物对糖尿病的药效学研究   总被引：2，自引：0，他引：2  

李旭升  王岚  陈国荣 《金华职业技术学院学报》2004,4(1):24-26

研究表明银杏叶提取物有广泛的药理作用及，临床应用价值，其化学成分种类较多。目前，临床上应用银杏叶提取物治疗糖尿病及其并发症已取得良好效果。  相似文献