Investigation of the association between all-trans-retinol dehydrogenase (RDH8) polymorphisms and high myopia in Chinese     

Yu YS  Wang LL  Shen Y  Yap MK  Yip SP  Han W 《Journal of Zhejiang University. Science. B》2010,11(11):836-841

Retinoic acid level in the retina/choroid is altered in induced myopia models. All-trans-retinol dehydrogenase (RDH8) is an important enzyme of retinoic acid metabolism. This study aimed to investigate the association of the RDH8 gene with high myopia. Three single nucleotide polymorphisms (SNPs) [RDH851 (rs2233789), RDH8E5a (rs1644731), and RDH855b (rs3760753)] were selected, based on the linkage disequilibrium pattern of RDH8 from a previous study, and genotyped for 160 Han Chinese nuclear families with highly myopic (−10 diopters or worse) offspring as well as in an independent group with 166 highly myopic cases (−10 diopters or worse) and 211 controls. Family-based association analysis was performed using the family-based association test (FBAT) package, and genotype relative risk (GRR) was calculated using the GenAssoc program. Population-based association analysis was performed using Chi-square test. These SNPs were in linkage equilibrium with each other. SNPs RDH851 (rs2233789) and RDH8E5a (rs1644731) both did not show association with high myopia. SNP RDH855b (rs3760753) demonstrated significant association (P=0.0269) with a GRR of 0.543 (95% confidence interval=0.304–0.968, P=0.038). The association became statistically insignificant, however, after multiple comparison correction. Haplotype analysis did not show a significant association either. Population-based association analysis also showed no significant association (P>0.05). Our family- and population-based data both suggest that the RDH8 gene is unlikely to be associated with high myopia in Chinese.  相似文献   

基于Web标准的CSS在Dreamweaver8中的使用   总被引：1，自引：0，他引：1  

毋玉芝  靳孝峰 《焦作大学学报》2010,24(2):99-100

首先通过分析Web标准的内涵,指出使用CSS样式表格式化网页的重要性。为满足不断增长的喜欢使用Dreamweaver8软件设计网页的设计人员的需求,文章介绍了在DW8中使用CSS格式化网页的方法。  相似文献   

中共"八大"前后的马克思主义中国化     

王先俊 《安徽师范大学学报(人文社会科学版)》2006,34(4):373-379

中共“八大”前后是马克思主义中国化的一个重要阶段。在这一阶段,党根据建设社会主义的新课题,提出了马克思主义中国化的新任务,并通过努力取得了丰富的成果,推进了马克思主义中国化的历史进程,丰富了中国化马克思主义的内容。  相似文献   

由"八大家"观"唐宋文"     

段军  杨泽林 《河北北方学院学报(社会科学版)》2006,22(2):7-10

“八大家”是“唐宋文”的杰出代表,也是“唐宋文”的缩影。通过对“八大家”的分析,以点带面,既可以看出“唐宋文”数量可观、风格多样、体式齐备、理论丰富扣骈散并进的整体风貌,又可以加深对“八大家”的了解,还可认识到唐文、宋文在数量、风格、体式、理论等方面的差异,可谓“一举三得”。  相似文献   

我国数字内容产业的商业模式研究     

刘健  杨海平 《图书情报工作》2010,54(23):11-88

数字内容产业急需解决的问题是缺乏商业模式的支持,文章在原磊提出的“3-4-8”商业模式体系的基础上增加参考文献,对数字内容产业的价值主张、价值网络、价值维护、价值实现四个构成单元进行分析,构建数字内容产业的商业模式。  相似文献   

我国8～9岁女子体操运动员力量素质指标筛选及评价     

郑湘平  吕万刚  高红梅  袁卫华  孙伟  姚吉庆 《武汉体育学院学报》2012,46(6):68-73

采用文献资料法、专家调查法和数理统计法,对我国25名8～9岁女子体操运动员力量素质进行研究,筛选出对8～9岁女子体操运动员专项成绩有显著影响的力量素质指标,运用灰色关联方法确定力量素质指标的权重系数,采用累进积分和百分位数法制定8～9岁女子体操运动员力量素质评分标准和等级标准。  相似文献   

长期运动训练对青年男性淋巴细胞凋亡及线粒体DNA修复酶的影响     

代志军  朱荣 《西安体育学院学报》2012,29(3):350-354

目的探究长期运动训练对青年男性淋巴细胞凋亡及线粒体DNA(mtDNA)修复酶(8-氧鸟嘌呤DNA糖基化酶,OGG1)的影响及可能机制。方法训练组为20名男子足球专业运动员,对照组为20名男子大学生。2组均在功率自行车上完成递增负荷力竭运动。运动前和运动后即刻采集静脉血。流式细胞法检测淋巴细胞凋亡率,比色法检测超氧阴离子和羟自由基含量和Caspase-3,Caspase-9活性,高效液相色谱法检测mtDNA中8-氧鸟嘌呤(8-oxodG)含量,Western-blotting法检测线粒体OGG1蛋白(mtOGG1)表达水平。结果运动前和运动后,训练组与对照组比较,超氧阴离子、羟自由基、Caspase-3,Caspase-9活性、8-oxodG降低,OGG1升高;运动后,训练组与对照组比较,淋巴细胞凋亡率降低。对照组和训练组在运动后与运动前比较,淋巴细胞凋亡率、超氧阴离子、羟自由基、Caspase-3,Caspase-9活性和8-oxodG均升高,但训练组升高幅度低于对照组;运动后对照组OGG1降低,而训练组OGG1升高。结论一次性力竭运动诱导产生高水平ROS,并抑制mtOGG1表达,使mtDNA氧化损伤,促进淋巴细胞凋亡;长期耐力训练可通过抑制ROS生成,并提高mtOGG1表达,抑制运动性淋巴细胞凋亡。  相似文献   

Polymorphisms within the COL5A1 gene and regulators of the extracellular matrix modify the risk of Achilles tendon pathology in a British case-control study     

Karryn L. Brown  Kirsten B. Seale  Louis Y. El Khoury  Michael Posthumus  William J. Ribbans  Stuart M. Raleigh 《Journal of sports sciences》2017,35(15):1475-1483

Several genetic loci have been associated with risk of Achilles tendon pathology (ATP) within South African and Australian populations. The aim of this study was, therefore, to evaluate eight previously implicated genetic variants in an independent British population. A total of 130 asymptomatic controls (CON) and 112 participants clinically diagnosed with ATP comprising 87 individuals with chronic Achilles tendinopathy (TEN) and 25 with Achilles tendon ruptures (RUP) were included. All participants were genotyped for variants within the COL5A1, MIR608, IL-1β, IL-6 and CASP8 genes. Primary findings implicated COL5A1 and CASP8. Three inferred allele combinations constructed from COL5A1 rs12722, rs3196378 and rs71746744 were identified as risk modifiers. The T–C–D combination was associated with increased risk of ATP (P = 0.023) and RUP (P < 0.001), the C–A–I combination was associated with increased risk of ATP (P = 0.011), TEN (P = 0.011) and RUP (P = 0.011) and the C–C–D combination was associated with decreased risk of ATP (P = 0.011) and RUP (P = 0.004). The CASP8 rs3834129 DD genotype was associated with decreased risk of TEN (P = 0.020, odds ratio: 0.45, 95% confidence interval: 0.22–0.90) and the CASP8 I–G (rs3834129–rs1045485) inferred allele combination was associated with increased risk of TEN (P = 0.031). This study further highlights the importance of polymorphisms within COL5A1 and CASP8 in the aetiology of ATP.  相似文献   

对八运会女子跳马赛后的思考   总被引：4，自引：0，他引：4  

裴德华  王淑英  于涛 《中国体育科技》1998,(5)

本文通过对八运会体操比赛的调研,认为跳马仍是中国女子体操的弱项,并据此提出了相应的对策建议。  相似文献   

上海竞技体育实力的新变化及备战九运会的对策   总被引：3，自引：1，他引：2  

凌翔  王平  姜传银 《上海体育学院学报》1998,(3)

采用数理统计与对比分析的方法,探讨了上海代表团在第八届全运会上取得金牌与总分“双第一”的原因,即上海竞技体育实力的诸多新变化;同时,就上海代表团备战九运会所面临的机遇与挑战,提出了若干对策。  相似文献