Relation of uric acid levels to aortic root dilatation in hypertensive patients with and without metabolic syndrome     

Li-jiang Tang  Jian-jun Jiang  Xiao-feng Chen  Jian-an Wang  Xian-fang Lin  Yu-xi Du  Cong-feng Fang  Zhao-xia Pu 《Journal of Zhejiang University. Science. B》2010,11(8):592-598

Objective:Uric acid(UA) is considered to be a powerful predictor of cardiovascular risk and hyperuricemia might be involved in the metabolic syndrome(MS).This study aims to investigate the relation between UA levels and aortic root dilatation.Methods:A total of 348 hypertensive patients [age(67.5±9.8) years] with or without MS were included in the study.The aortic root diameters at the aortic annulus,the sinuses of Valsalva,the sinotubular junction,and the proximal part of the ascending aorta were measured using a two-dimensional(2D) echocardiography.Serum UA levels were also measured for all patients.Results:A high UA level is independently associated with aortic root diameters at the sinuses of Valsalva(P=0.001) and the proximal ascending aorta(P0.0001) in the hypertensive patients without MS.In contrast,aortic root diameters were not significantly related to UA levels in the hypertensive patients with MS.Furthermore,increased UA levels were associated with an increased risk for aortic root dilatation in the patients without MS(sex-adjusted hazard ratio 1.75,95% confidence intervals(CI) 1.27-2.41),but not in those with MS.Conclusions:This study demonstrated an independent relationship between the aortic root dimensions and increased levels of serum UA in the hypertensive patients without MS.Further understanding of the mechanisms underlying these associations may allow a clearer interpretation of the potential value of specific urate-lowering treatment on cardiovascular disease.  相似文献   

Pancreatic somatostatinoma with obscure inhibitory syndrome and mixed pathological pattern     

Bo Zhang  Qiu-ping Xie  Shun-liang Gao  Yan-biao Fu  Yu-lian Wu 《Journal of Zhejiang University. Science. B》2010,11(1):22-26

Somatostatinoma is a very rare neuroendocrine tumor that originates from D cells and accounts for less than 1% of all gastrointestinal endocrine tumors. The duodenum is the most frequent site for this tumor, followed by the pancreas. We here describe a 46-year-old Chinese woman who developed pancreatic somatostatinoma presenting with the characteristic “inhibitory” syndrome, but the symptoms were obscure and seemingly uncorrelated. This case is also unique for its large tumor size and mixed pathological pattern. Distal pancreatectomy was performed, and the patient has remained well since operation. As the syndromes of somatostatinoma may be obscure and atypical, clinicians should review all clinical findings to obtain an accurate diagnosis. Aggressive surgery is preferred to improve the survival.  相似文献   

A case of overlapping Bickerstaff＇s brainstem encephalitis and Guillain-Barre syndrome     

王德玍  汤颖  王晔 《Journal of Zhejiang University. Science. B》2006,7(2):138-141

Objective： There is no report on Bickerstaff s brainstem encephalitis （BBE） patients in China. We here report the first case of BBE in China. Methods： Clinical features, results of electromyography, eleetroencephalography （EEG）, magnetic resonance imaging （MRI） and cerebrospinal fluid （CSF） examination were studied to clarify the characteristics of this syndrome. Results： A 44-year-old man presented himself at our inpatient department with somnolence and dizziness as his initial symptoms. He developed multiple cranial nerves paralysis especially internal and external ophthalmoplegia, ataxia and tetraparesis within 1 week. His condition rapidly deteriorated, and he experienced coma. Electromyography showed indications of peripheral nerve dysfunction, electroencephalography revealed loss of basic rhythm, MR1 demonstrated high-intensity abnormalities on T2-weighted images of medulla oblongata, and CSF albuminocytological dissociation was defined abnormally as high protein. Ten months later, he almost completely recovered. Conclusion： BBE, fisher syndrome （FS） and Guillain-Barre syndrome （GBS） are similar clinically; BBE and FS were proposed to be the variant of GBS.  相似文献   

A probiotic treatment containing Lactobacillus, Bifidobacterium and Enterococcus improves IBS symptoms in an open label trial   总被引：7，自引：0，他引：7  

Fan YJ  Chen SJ  Yu YC  Si JM  Liu B 《Journal of Zhejiang University. Science. B》2006,7(12):987-991

INTRODUCTION Irritable bowel syndrome (IBS) is the most common functional gastrointestinal disorder. The typical symptoms are abdominal pain, flatulence, and irregular bowel movement. Prevalence rates are re- ported to be as high as 30% in the general population (Drossman et al., 1982), corresponding to about 25%~50% of all patients who need gastroenterolo- gist’s help (Everhart and Renault, 1991). Despite this high prevalence, the cause of IBS is unknown. Many factors are likely to …  相似文献   

沉痛的逍遥:论庄子的精神世界     

李进 《商丘师范学院学报》2013,(8):15-18

庄子学术本以讲明"无为"的政治理想为主旨,但残酷的政治现实促成其重心偏移至个人的安心立命之道,追求个体的精神自由,以获得自我超越与解脱。当知识分子的良知与道义感驱使庄子重新试图以自己的政治理想去干预现实政治时,现实却再次幻灭了他心中的理想。于是,庄子重又别无选择地逃返内心深处,作无奈而沉痛的逍遥游。庄子的一生是在理想与现实、入世与出世的矛盾与冲突中反复挣扎、徘徊、犹豫乃至于迷惑不已、痛苦不堪的一生。  相似文献   

肌筋膜疼痛综合征诱因及外治手段研究进展     

林键杰  张翔 《体育科技文献通报》2020,(4):28-31

不良生活习惯和伤后康复不佳导致的肌筋膜疼痛综合征已经成为当前影响人们生活质量的因素之一。本文运用文献资料法,梳理肌筋膜疼痛综合征的诱因及外治(非内服药物治疗)手段,探究其干预手段的疗效,由病因入手,研究最佳干预方法。综合研究表明:(1)肌筋膜疼痛综合征病因包括:骨骼肌及筋膜外伤、风寒入侵机体、慢性劳损、局部肌筋膜慢性炎症损伤等;(2)目前对肌筋膜疼痛综合征康复的方法主要以针刺和温和灸为主,本文纳入针刺治疗和温和灸治疗有效率高达89.5%和100%;(3)其发病的常见部位为腰背部及肩颈部,不同部位、不同病因的肌筋膜疼痛综合征应采取不同的治疗方式,复合治疗方法比单一手段干预效果更佳。  相似文献   

Young people with high‐functioning autism and Asperger's syndrome planning for and anticipating the move to college: what supports a positive transition?     

Wendy Mitchell  Bryony Beresford 《British Journal of Special Education》2014,41(2):151-171

For many young people in England, the move into continuing education involves a transfer from the school where they were educated to a further education college. For those with high‐functioning autism or Asperger's syndrome, this can be a challenging process. Past research has demonstrated some of the problems that these young people can encounter. This article by Wendy Mitchell and Bryony Beresford, both based in the Social Policy Research Unit at the University of York, adds to the evidence base by describing how best to support these young people, focusing specifically on ‘young person endorsed’ practice. Data are gleaned from qualitative interviews with 18 young people with high‐functioning autism/Asperger's syndrome. Findings reveal that young people welcomed the involvement of practitioners; however, specific forms of help and knowledge were particularly valued. In addition, it was parents, as opposed to professionals, who typically emerged as the most significant and valued source of support. Implications for practice are discussed, including the support needs of parents.  相似文献   

What does ‘inclusion’ mean for pupils on the autistic spectrum in mainstream secondary schools?     

Neil Humphrey  Sarah Lewis 《Journal of Research in Special Educational Needs》2008,8(3):132-140

The last decade has seen a groundswell of developments in educational policy in the UK relating to inclusive education for students with special educational needs (SEN). However, whether government policy has been fully implemented in schools remains a concern. The experience of students with autistic spectrum disorders (ASDs) provides an excellent case in point. An increasing number of such students are now educated in mainstream schools, but the limited research in this area has indicated that their experience of school is often marked by bullying, social isolation and anxiety. In light of this, the aim of the current study was to examine the extent to which inclusive educational policy was actually reflected in the practices of four mainstream secondary schools. An exploratory case study approach was adopted, utilising interviews with pupils, teachers, other school staff (e.g., senior managers, learning support assistants) and parents, observations of lessons and other contexts (e.g., lunch time), and document analysis. Our findings highlighted a number of school practices which acted as facilitators or barriers to students’ learning and participation, some of which were generic to SEN provision, and some of which appeared to be specific to those on the autistic spectrum. A discussion of these is presented to enable further understanding of, and inform practice relating to, the inclusion process for students with ASDs.  相似文献   

浅析下腰痛与坐姿关系     

陶萍 《金华职业技术学院学报》2008,8(4):37-38

下腰痛是临床常见病,其病因复杂,诊治困难,病理机制不清,但生物力学的改变始终是一重要原因。大量的研究资料表明,下腰痛与坐位姿势之间存在着一定的相关性。本文旨在总结不恰当的坐位姿势,探讨比较合适的坐位姿势。  相似文献   

肉鸡猝死的病因分析与防制措施     

张代涛 《襄樊职业技术学院学报》2003,2(4):12-12

1肉鸡猝死综合症的临床诊断1.1临床症状本病多发生于3—5周龄的雏鸡。患病鸡突然发病,平衡失调,两翅猛烈扑打,肌肉强痉挛,尖叫翻滚,呈仰卧姿势,头颈扭曲而亡。从发病到死亡经过不足一分钟。多发于生长快、外表健康、体状良好的鸡只。1.2病理变化对患病死亡后的鸡只剖检,发现冠髯和泄殖粘膜及脾脏充血,全身肌肉苍白,消化道内充满食物,肝脏肿大、质地易碎;肺肿大,弥漫淤血水肿,呈暗红色,气管内有泡沫状渗出物;心脏明显增大2—4倍,心肌松软,心包渗出液增多,静脉怒张。采集病料进行微生物培养阴性。1.3鉴别诊断本病与澳大利亚报道的肉鸡峰型死亡…  相似文献