我国城市化道路研究述评     

冯睿  张沫 《金陵科技学院学报(社会科学版)》2011,25(1)

改革开放以后的30年来,城市化一直是我国经济社会发展的热点,城市化道路选择问题也成为学术界讨论的焦点。围绕城市化道路选择问题的激烈争论迄今没有停止,并演化出几种主流的观点。在分别对这几种主要观点进行简要述评的基础上,指出中等城市在城市化中的战略地位,积极合理地发展中等城市和城市带,将会迅速推进我国城市化进程。  相似文献   

如何正确理解马克思主义理论的革命性和建设性     

曹亚芳 《陕西理工学院学报(社会科学版)》2011,29(2):9-12

在当前中国社会中,马克思主义理论的革命性正在遭受蚕食消解。正确理解马克思主义理论革命性和建设性的辩证关系,进一步巩固马克思主义的指导思想地位,才能保证中国特色社会主义建设事业取得胜利。  相似文献   

基于多变量优化MGM(1,n)模型的郑州市用水量预测     

王国富  李艳军 《安阳工学院学报》2011,10(6):69-71

用水量是城市发展水平的重要评价指数。鉴于用水量系统复杂性和非线性的特征,结合郑州市居民用水量的历史数据,通过建立优化背景值的MGM(1,n)模型,实例预测郑州市2008至2015年用水量需求并指出城市居民用水量发展趋势。  相似文献   

海峡两岸现代竞技武术的比较研究   总被引：1，自引：0，他引：1  

刘成  高楚兰 《Journal of Zhangzhou Technical Institute》2011,13(1):61-67

采用文献资料法、专家访谈法、比较分析法、逻辑分析法等对海峡两岸竞技武术的发展史、管理机制与运行机制以及人才培养等方面进行比较研究,分析出两岸在上述方面的差异与共同之处,并客观的剖析出双方各自的优势与不足之处,去芜存菁,力求对海峡两岸的竞技武术交流成效的提升梳理出思路,也为竞技武术的国际性发展提供借鉴和参考。  相似文献   

Red pigment production by Penicillium purpurogenum GH2 is influenced by pH and temperature     

Méndez A  Pérez C  Montañéz JC  Martínez G  Aguilar CN 《Journal of Zhejiang University. Science. B》2011,12(12):961-968

The combined effects of pH and temperature on red pigment production and fungal morphology were evaluated in a submerged culture of Penicillium purpurogenum GH2, using Czapek-Dox media with d-xylose as a carbon source. An experimental design with a factorial fix was used: three pH values (5, 7, and 9) and two temperature levels (24 and 34 °C) were evaluated. The highest production of red pigment (2.46 g/L) was reached with a pH value of 5 and a temperature of 24 °C. Biomass and red pigment production were not directly associated. This study demonstrates that P. purpurogenum GH2 produces a pigment of potential interest to the food industry. It also shows the feasibility of producing and obtaining natural water-soluble pigments for potential use in food industries. A strong combined effect (p<0.05) of pH and temperature was associated with maximal red pigment production (2.46 g/L).  相似文献   

Ds-echinoside A, a new triterpene glycoside derived from sea cucumber, exhibits antimetastatic activity via the inhibition of NF-κB-dependent MMP-9 and VEGF expressions     

Zhao Q  Liu ZD  Xue Y  Wang JF  Li H  Tang QJ  Wang YM  Dong P  Xue CH 《Journal of Zhejiang University. Science. B》2011,12(7):534-544

Ds-echinoside A (DSEA), a non-sulfated triterpene glycoside, was isolated from the sea cucumber Pearsonothuria graeffei. In vitro and in vivo investigations were conducted on the effects of DSEA on tumor cell adhesion, migration, invasion, and angiogenesis. In this study, we found that DSEA inhibited the proliferation of human hepatocellular liver carcinoma cells Hep G2, with a half-maximal inhibitory concentration (IC₅₀) of 2.65 μmol/L, and suppressed Hep G2 cell adhesion, migration, and invasion in a dose-dependent manner. DSEA also reduced tube formation of human endothelial cells ECV-304 on matrigel in vitro and attenuated neovascularization in the chick embryo chorioallantoic membrane (CAM) assay in vivo. Immunocytochemical analysis revealed that DSEA significantly decreased the expression of matrix metalloproteinase-9 (MMP-9), which plays an important role in the degradation of basement membrane in tumor metastasis and angiogenesis. DSEA also increased the protein expression level of tissue inhibitor of metalloproteinase-1 (TIMP-1), an important regulator of MMP-9 activation. From the results of Western blotting, the expressions of nuclear factor-kappa B (NF-κB) and vascular endothelial growth factor (VEGF) were found to be remarkably reduced by DSEA. These findings suggest that DSEA exhibits a significant antimetastatic activity through the specific inhibition of NF-κB-dependent MMP-9 and VEGF expressions.  相似文献   

Effect of microcystin-LR on protein phosphatase 2A and its function in human amniotic epithelial cells     

Liang J  Li T  Zhang YL  Guo ZL  Xu LH 《Journal of Zhejiang University. Science. B》2011,12(12):951-960

Due to their toxicity, the increased distribution of microcystins (MCs) has become an important worldwide problem. MCs have been recognized as inhibitors of protein phosphatase 2A (PP2A) through their binding to the PP2A catalytic subunit. However, the exact mechanism of MC toxicity has not been elucidated, especially concerning the cellular response and its autoregulation. To further dissect the role of PP2A in MC-induced toxicity, the present study was undertaken to determine the response of PP2A in human amniotic epithelial (FL) cells treated with microcystin-LR (MCLR), one of the MC congeners. The results show that a low-dose treatment of MCLR in FL cells for 6 h induced an increase in PP2A activity, and a high-dose treatment of MCLR for 24 h decreased the activity of PP2A, as expected. The increased mRNA and protein levels of the PP2A C subunit may explain the increased activity of PP2A. Furthermore, MCLR altered microtubule post-translational modifications through PP2A. These results further clarify the underlying mechanism how MCLR affects PP2A and may be helpful for elucidating the complex toxicity of MCLR.  相似文献   

Polyethylenimine-cyclodextrin-tegafur conjugate shows anti-cancer activity and a potential for gene delivery     

Hu QD  Fan H  Lou WJ  Wang QQ  Tang GP 《Journal of Zhejiang University. Science. B》2011,12(9):720-729

Polyethylenimine-cyclodextrin-tegafur (PEI-CyD-tegafur) conjugate was synthesized as a novel multifunctional prodrug of tegafur for co-delivery of chemotherapeutic agent tegafur and enhanced green fluorescent protein (EGFP) reporter plasmid DNA. Conjugation of tegafur to PEI-CyD via chemical linkage was characterized by ¹H NMR spectrometry and ultraviolet (UV) spectrometry. PEI-CyD-tegafur was able to condense plasmid DNA into complexes of around 150 nm with positive charge at the N/P ratio of 25, in accordance with electron microscopy observation of compact and monodisperse nanoparticles. The results of in vitro experiments showed enhanced cytotoxicity and considerable transfection efficiency in B16F10 cell line. Therefore, PEI-CyD-tegafur may have great potential as a co-delivery system with anti-cancer activity and potential for gene delivery.  相似文献   

RRM1 gene expression in peripheral blood is predictive of shorter survival in Chinese patients with advanced non-small-cell lung cancer treated by gemcitabine and platinum     

Wang LR  Zhang GB  Chen J  Li J  Li MW  Xu N  Wang Y  Shen Tu JZ 《Journal of Zhejiang University. Science. B》2011,12(3):174-179

Objective  

To evaluate the predictive values of gene expressions of ribonucleotide reductase M1 (RRM1) and breast cancer susceptibility gene 1 (BRCA1) in peripheral blood from Chinese patients with non-small-cell lung cancer (NSCLC) treated with gemcitabine plus platinum.  相似文献   

Preparation of glucosamine by hydrolysis of chitosan with commercial α-amylase and glucoamylase     

Pan SK  Wu SJ  Kim JM 《Journal of Zhejiang University. Science. B》2011,12(11):931-934

Objective  

In order to overcome the defects of chemical hydrolysis approach to prepare glucosamine, an enzymatic hydrolysis method was developed.  相似文献