Genetic Polymorphism of Angiotensin II Type 1 Receptors and Their Effect on the Clinical Outcome of Captopril Treatment in Arab Iraqi Patients with Acute Coronary Syndrome (Mid Euphrates)     

Fadhaa A. Ghafil  Bassim I. Mohammad  Hussain S. Al-Janabi  Najah R. Hadi  Hayder A. Al-Aubaidy 《Indian journal of clinical biochemistry : IJCB》2021,36(1):81

Genetic variation in the angiotensin II type 1 receptor (AT1R) has an important effect on the outcome of acute coronary syndrome (ACS) initiated treatment with captopril. This study aims to investigate the impact of genetic polymorphism of AT1R (rs5186 and rs275651) on the ACS outcome in Iraqi patients treated with captopril. A total of 250 Iraqi individuals with ACS were included in this case—control study and they were divided into two study groups; Study group 1 included 125 participants who were prescribed captopril, 25 mg twice daily and study group 2 included 125 participants who received no captopril as part of their ACS treatment (control study). The AT1R gene (rs5186) CC genotype was found to be associated with ST-elevation myocardial infarction (STEMI) (Odd’s ratio (O.R) = 1.2, P = 0.7), while AC was associated with Non-ST-elevation myocardial infarction (NSTEMI) and unstable angina (UA) (O.R = 1.2, P = 0.8). AC genotype is more prone to have Percutaneous coronary intervention (PCI) after ACS attack (O.R = 1.2, P = 0.6). CC genotype had a risk to get less improvement (O.R = 1.6, P = 0.5), so might require higher doses of captopril during acute coronary insult. The AT1R gene (rs275651) AA genotype was associated with UA (O.R = 1.3, P = 0.9). AA and AT genotypes were more prone to have PCI after ACS attack (O.R = 3.9 P = 0.2, O.R = 3.5, P = 0.3 respectively) and thus requiring higher doses of captopril. We conclude that the AT1R rs5186, rs275651 genetic polymorphisms might partially affect the clinical outcome of ACS patients treated with captopril and might have captopril resistance which requires higher doses.  相似文献   

图书情报学领域学科交叉及其国家差异的动态分析     

王思茗  滕广青 《图书情报知识》2020,(3):109-118,F0003

[目的/意义]领域知识的跨学科交叉研究能够打破学科间的壁垒,有助于发现重大科学问题的解决方案。[研究设计/方法]基于图书情报学领域文献题录信息构建轻量级领域知识图谱,从中提取学科信息、国家信息、时间信息及其关联,采用时间与空间相结合的多维度分析方法,对学科交叉的演化进程以及国家差异进行跟踪与分析。[结论/发现]图书情报学领域内学科交叉现象日渐显著,各国家的学科交叉程度与倾向存在差异,一些目前尚不突出的交叉学科方向值得关注。[创新/价值]采用多维度视角分析学科交叉现象,相关结论可以为国家科技战略制定及学科发展规划提供有益参考。  相似文献   

Data Visualization as Participatory Research: A Model for Digital Collections to Inspire User-Driven Research     

A. Miller 《Journal of Web Librarianship》2019,13(2):127-155

The emerging creative practices of digital collections are increasing in prominence thanks to the access to, and appeal of, data visualizations. Interactive data visualizations, such as a map, timeline, chart, graph, or artist’s rendering of data, enable users to pursue their own research interests within a collection and participate in new areas of research. Use of these data visualizations enhances the scope of the collection and enables a modern and diverse thematic collection to emerge. This article considers the question: Does the addition of data visualizations affect how users participate with a research collection? Impacts on collection development, application of user-centered design, and analysis of users’ exploratory strategies are discussed. Examples of data visualizations used in digital humanities projects and digital collections are presented as case studies.  相似文献   

浅谈武术套路训练对青少年身心发展的影响     

庄竣博 《当代体育科技》2020,(11):55-55,57

本文采用文献综述法和逻辑分析方法,通过对武术神、意、气与动作内外相结合,使身心达到愉悦、全面的发展。武术训练对人的力量、灵敏、柔韧等身体素质的发展都有良好影响,强健体魄,缓解压力,保持一个舒畅愉快的心情。武术套路的训练不仅能塑造强健的身体,而且也承载着道德文化修养和精神传承的历史重任,经过研究和调查,很多青少年通过武术套路训练,提高了其自身的身体素质和顽强不屈的精神品格。  相似文献   

Diversity Literary Awards: A Tool for Assessing an Academic Library’s Collection     

Laurel Kristick 《资料收集管理》2020,45(2):151-161

Abstract

Diversity literary awards and other sources were used to create a list of high-quality titles written by and about underrepresented groups. This list was used to assess the diversity and inclusiveness of the library collections of a land-grant university in the Pacific Northwest and compare it to peer institutions. Gaps in the collection and acquisition processes were identified and will be used to improve the processes to increase the number of diverse titles added to the library’s collections.  相似文献   

The effect of number of siblings and birth order on educational attainment: Empirical Evidence from Chinese General Social Survey     

《International Journal of Educational Development》2020

Data from China demonstrate that the effect of the number of siblings on education is restricted by many factors, such as children’s gender, urban or rural household registration, whether there is only one child, the birth order of children within the family, and parents’ status. Chinese families have significant preferences for the eldest son and the youngest son. Moreover, research based on the natural experiment and instrumental variable approach suggests that market-oriented reform of education has increased the cost of family education expenditures since China’s reform and opening up, which further aggravates the negative impact on education of having many siblings in an urban setting.  相似文献   

我国开展女子十项全能运动的必要性及实施策略   总被引：3，自引：0，他引：3  

赵鲁南 《山东体育学院学报》2003,19(2):54-57

运用献资料、逻辑归纳、对比分析、专家访谈等方法，分析奥运会田径项目发展趋势，指出男女田径项目设置将最终走向数量、形式上完全融合，提出我国提前开展女子十项全能运动的原因、意义及实施措施，旨在为我国田径运动更好地开展及竞技运动水平的快速提高提供参考依据。  相似文献   

学校体育对中小学生心理健康教育影响作用探讨   总被引：30，自引：0，他引：30  

兰自力  骆映 《体育与科学》2003,24(1):72-74

通过文献资料研究、社会调查、专家访谈和比较分析等研究方法，对我国部分地区中小学生心理健康状况进行了调查分析，并运用体育学、保健学、教育学和心理学等学科理论知识与研究成果，探讨了学校体育对中小学生心理健康教育影响的积极效应与促进作用。  相似文献   

体育与(健康)课程中的心理健康教育     

王霞 《福建体育科技》2003,22(2):62-64

本文阐述了体育 (与健康 )课程中实施心理健康教育的意义及该课程对心理健康的影响 ,并对体育 (与健康 )课程中实施心理健康教育的途径进行了探讨 ,为全面推进素质教育 ,提高学生心理健康水平提供参考。  相似文献   

女排运动员的身心特征及训练要求     

刘惠莲 《军事体育进修学院学报》2003,22(1):53-55

从女排队员人体解剖、生理机能、心理状态、技战术特点及发展趋势等方面阐述女排队员的特征及训练原则，为女排运动训练及比赛提供一定的理论依据。  相似文献