Genetic Polymorphism of Angiotensin II Type 1 Receptors and Their Effect on the Clinical Outcome of Captopril Treatment in Arab Iraqi Patients with Acute Coronary Syndrome (Mid Euphrates)     

Fadhaa A. Ghafil  Bassim I. Mohammad  Hussain S. Al-Janabi  Najah R. Hadi  Hayder A. Al-Aubaidy 《Indian journal of clinical biochemistry : IJCB》2021,36(1):81

Genetic variation in the angiotensin II type 1 receptor (AT1R) has an important effect on the outcome of acute coronary syndrome (ACS) initiated treatment with captopril. This study aims to investigate the impact of genetic polymorphism of AT1R (rs5186 and rs275651) on the ACS outcome in Iraqi patients treated with captopril. A total of 250 Iraqi individuals with ACS were included in this case—control study and they were divided into two study groups; Study group 1 included 125 participants who were prescribed captopril, 25 mg twice daily and study group 2 included 125 participants who received no captopril as part of their ACS treatment (control study). The AT1R gene (rs5186) CC genotype was found to be associated with ST-elevation myocardial infarction (STEMI) (Odd’s ratio (O.R) = 1.2, P = 0.7), while AC was associated with Non-ST-elevation myocardial infarction (NSTEMI) and unstable angina (UA) (O.R = 1.2, P = 0.8). AC genotype is more prone to have Percutaneous coronary intervention (PCI) after ACS attack (O.R = 1.2, P = 0.6). CC genotype had a risk to get less improvement (O.R = 1.6, P = 0.5), so might require higher doses of captopril during acute coronary insult. The AT1R gene (rs275651) AA genotype was associated with UA (O.R = 1.3, P = 0.9). AA and AT genotypes were more prone to have PCI after ACS attack (O.R = 3.9 P = 0.2, O.R = 3.5, P = 0.3 respectively) and thus requiring higher doses of captopril. We conclude that the AT1R rs5186, rs275651 genetic polymorphisms might partially affect the clinical outcome of ACS patients treated with captopril and might have captopril resistance which requires higher doses.  相似文献   

Discrete Choice Modeling in Education: An Innovative Method to Assess Teaching Practices     

Vasilis Grammatikopoulos  Athanasios Gregoriadis  Michalis Linardakis 《Educational Measurement》2019,38(3):46-54

Self‐reported measures are an easy, time‐efficient, and low‐cost way to collect research data compared to other assessment methods. They are, however, characterized by several limitations regarding the quality and the clarity of the data they produce, especially when they are implemented in education. The main purpose of the current study was to use a method called discrete choice modeling (DCM) in education, in order to develop a self‐reported instrument that will reduce the bias for socially desirable responses and to assess teachers’ practices in physical activity. DCM method has the ability to overcome the respondents’ tendency to answer in a socially desirable way. A nationally representative sample of 531 Greek early educators participated in this study and were administered a self‐assessment questionnaire based on DCM. Results showed that the DCM based newly developed instrument manages to assess effectively educators’ practices and provided evidence of the applicability of the method in education. Further implications and future recommendations regarding the effective application of DCM in education are discussed.  相似文献   

学习团队协作信息搜索的共享心智模型研究   总被引：1，自引：0，他引：1  

颜端武  张馨月  汤佳丽  苏琼 《图书情报工作》2020,64(8):3-12

[目的/意义] 对协作信息搜索进行深入研究，为专业化协作信息搜索系统平台建设优化等提供启发和借鉴。[方法/过程] 聚焦于学习团队的信息搜索行为，以高校学生为研究样本，以共享心智模型为切入点，采用扎根理论研究方法，探讨协作信息搜索中团队共享心智模型建构过程。[结果/结论] 识别出四大核心环节——个体感知与探索、团队任务解析、团队信息收集和团队信息整合，并理清各环节的认知活动与共享心智模型内容要素。  相似文献   

一次性塑料快餐盒盖成型工艺分析及逆向设计     

吕淑艳 《包头职业技术学院学报》2020,(1):1-2,15

采用逆向思维方法,详细分析了一次性快餐盒盖的成型工艺,并对其结构进行改进设计。为那些以实物为制造基础的产品的设计提供了借鉴,在缩短产品开发周期,提高经济效益方面,起着重要作用。  相似文献   

基于ICWGT和灰色关联分析法的起重机安全评价     

肖汉斌  熊楚宸  祝锋  刘敏 《上海海事大学学报》2020,41(2):117-122

针对目前起重机安全评价过于依赖主观权重且忽视起重机安全状态变化趋势的问题，建立基于改进博弈论组合赋权法（improved combination weighting method of game theory，ICWGT）和灰色关联分析法的起重机安全评价体系。在该评价体系中，收集样本数据以确定评价值，构建评价等级空间来计算起重机行为特征序列与标准行为特征序列的关联系数。运用ICWGT在层次分析法和信息熵 未确知测度理论确定的主、客观权重中寻找平衡。充分考虑专家经验和样本数据，确定优化权重以改善关联系数的分配问题，从而获取起重机灰色关联度评价值和安全等级，旨在对起重机安全状态变化趋势进行更加准确的定量描述和定性分析。实例分析验证了该评价体系的有效性。  相似文献   

电视新闻策划的实践思考     

夏冰 《浙江传媒学院学报》2003,10(3):18-20

新闻策划是对新闻报道活动的策划,电视新闻策划是现代社会受众和电视自身发展的需要。电视新闻的策划重在发挥电 视传播的优势,强调整体的协作。  相似文献   

中国传统文化与学校体育可持续发展   总被引：2，自引：0，他引：2  

吴刚 《湖北体育科技》2003,22(2):156-157,160

中国传统文化是学校体育可持续发展的外环境因素，它主要由儒家、道家和禅宗文化构成，具有中庸和平、泛道德性、人文精神、非独立性、静止停滞、乡土情结等特质，通过研究它的理性因素对学校体育可持续发展的正面影响和非理性因素带来的负面影响，来探讨在学校体育思想、内容和方法上应采取的发展对策。  相似文献   

GM(1,h)系统状态模型在田径训练中的应用   总被引：4，自引：0，他引：4  

刘嘉津  孙桂云 《上海体育学院学报》2003,27(1):78-81,F003

将多因素整体状态GM（1，h)模型及其特列GM（1，1）模型结合起来，用于高水平田径训练的建模问题研究，使建立的系统模型既能反映系统内部多因素的整体关系，又能满足超前预测和规划的需要，旨为田径训练提供了一种有效的科学方法。  相似文献   

开展数学建模教学促进基础教育改革     

潘胜洪 《扬州教育学院学报》2003,21(3):78-80

随着基础教育课程改革的深入,在中小学开展数学建模教学已经成为一项重要内容。本文试图从数学建模教学的意义、教学环节等几方面揭示数学建模教学对于基础教育改革的重要性。  相似文献   

我国文献计量学论文的主题分布研究   总被引：1，自引：0，他引：1  

熊滨 《江西图书馆学刊》2003,33(4):64-66

从主题分析和关键词分析的角度对我国献计量学论的主题内容进行了归纳和分类，以期深入认识该领域献的现状及其发展水平，明确该学科今后的发展重点和方向。  相似文献