Genetic Polymorphism of Angiotensin II Type 1 Receptors and Their Effect on the Clinical Outcome of Captopril Treatment in Arab Iraqi Patients with Acute Coronary Syndrome (Mid Euphrates)     

Fadhaa A. Ghafil  Bassim I. Mohammad  Hussain S. Al-Janabi  Najah R. Hadi  Hayder A. Al-Aubaidy 《Indian journal of clinical biochemistry : IJCB》2021,36(1):81

Genetic variation in the angiotensin II type 1 receptor (AT1R) has an important effect on the outcome of acute coronary syndrome (ACS) initiated treatment with captopril. This study aims to investigate the impact of genetic polymorphism of AT1R (rs5186 and rs275651) on the ACS outcome in Iraqi patients treated with captopril. A total of 250 Iraqi individuals with ACS were included in this case—control study and they were divided into two study groups; Study group 1 included 125 participants who were prescribed captopril, 25 mg twice daily and study group 2 included 125 participants who received no captopril as part of their ACS treatment (control study). The AT1R gene (rs5186) CC genotype was found to be associated with ST-elevation myocardial infarction (STEMI) (Odd’s ratio (O.R) = 1.2, P = 0.7), while AC was associated with Non-ST-elevation myocardial infarction (NSTEMI) and unstable angina (UA) (O.R = 1.2, P = 0.8). AC genotype is more prone to have Percutaneous coronary intervention (PCI) after ACS attack (O.R = 1.2, P = 0.6). CC genotype had a risk to get less improvement (O.R = 1.6, P = 0.5), so might require higher doses of captopril during acute coronary insult. The AT1R gene (rs275651) AA genotype was associated with UA (O.R = 1.3, P = 0.9). AA and AT genotypes were more prone to have PCI after ACS attack (O.R = 3.9 P = 0.2, O.R = 3.5, P = 0.3 respectively) and thus requiring higher doses of captopril. We conclude that the AT1R rs5186, rs275651 genetic polymorphisms might partially affect the clinical outcome of ACS patients treated with captopril and might have captopril resistance which requires higher doses.  相似文献   

学校武术教学内容建构的路径思考     

曹〓华  张〓峰 《广州体育学院学报》2019,(4):126-1900/5/7

运用问卷调查、访谈、现场实测、逻辑分析等研究方法,对我国校园迷你棒球课程人文优势和内容架构进行探讨。研究结果表明学生对我国校园棒球人文底蕴和内涵优势较认可；迷你棒球课程极易开展，娱乐性、趣味性和安全性高，锻炼价值和教育功能强，值得学校社会推广。新时期迷你棒球课程对促进学生德智体美全面发展和培养特长爱好、满足学生个体差异需求和促进一带一路沿线文化交流以及开拓师生国际视野、汲取世界优秀体育人文思想有较高社会价值和现实意义。  相似文献   

Paternal support for child sexual abuse victims: A qualitative study     

《Child abuse & neglect》2019

BackgroundThe current state of knowledge regarding the role of non-offending fathers in supporting their sexually abused children is very scarce.ObjectiveThe objective of this study is to further our understanding of fathers’ roles following disclosure of their children’s sexual abuse (SA) by evaluating fathers’ perceptions of the impact of disclosure on their involvement and support of their children.Participants and methodThis qualitative study relies on individual semi-structured interviews conducted with 17 fathers of allegedly abused children.ResultsInductive thematic analysis first highlighted that some reported a period of disengagement from the child during which they put into question their role and attitudes, followed by a period of re-involvement. This period of difficulties experienced by some fathers in regard to their involvement towards their children was due to either their own important psychological distress, their ambivalence towards their child or even because of feelings of uneasiness experienced during physical contact with them. Despite this, findings indicate the presence of thoughts and attitudes that suggest children are a source of concern for fathers. The four forms of abuse-specific support previously observed among mothers (believing the child, seeking out professional services, protecting him/her from the offender, supporting him/her emotionally) were also observed among fathers. In accordance with the activation theory, a form of support specific to fathers, namely, encouraging the child to open up to and explore the world outside the family, thereby, fostering the child’s self-esteem development, was observed and constitutes a relevant finding.ConclusionClinical and empirical implications are discussed.  相似文献   

用户动机视角下的Altmetrics指标研究     

刘晓娟  王晨琳 《图书情报知识》2020,(3):63-70,96

[目的/意义]从用户动机视角对Altmetrics指标的本质和价值进行分析,使Altmetrics的应用更为科学合理。[研究设计/方法]首先对相关文献中的动机进行组织提炼与规范化表述。在此基础上引入用户行为理论解释和分析用户动机体现的指标价值。再选取Twitter提及量指标,使用内容分析法进行案例研究。[结论/发现]提炼出19种用户动机,其中有6种动机会降低指标应用价值。[创新/价值]探索Altmetrics数据的产生机制,在一定程度上回答了Altmetrics指标可用性问题。  相似文献   

欧洲九国共产党情报局机关刊物《争取持久和平,争取人民民主!》与中国关系考述(1949-1956)     

哈战荣 《图书馆杂志》2020,(4):21-26

《争取持久和平,争取人民民主!》是20世纪40年代中后期,欧洲九个社会主义国家的共产党和工人党为了一致行动而建立的情报局机关刊物。该刊物对新中国初期我国经济社会建设及成就进行了大量宣传与报道,对加强我国与世界其他爱好和平、渴求民主的各国人民加强互信、长存友谊贡献很大,也对当前学者研究新中国初期我国经济社会发展的过程、成就和经验等提供了原始史料,学术研究意义也很重大。但是,目前对这份刊物及其发挥过的重大作用了解的人少之又少,时值中国共产党成立100周年之际,对其创刊与发行的历史过程进行回顾、宣传中国社会经济发展的全貌进行展示、推动世界社会主义运动的作用进行肯定,意义都很重大。  相似文献   

观念与实践:高等师范院校美术教师教育课程类型组织探索     

李静 《美育学刊》2020,(2):8-13

随着我国教育改革不断推进,基础教育美术课程改革也进入深水区,美术教育发展面临许多新问题、新情况和新挑战,其中,要求美术教师专业化成为许多矛盾汇聚的焦点。在职美术教师的发展起点在于职前培养,而培养职前美术教师的关键之一是相关课程的设置与实施过程。故从我国学校美术课程观历史发展脉络出发,倡导建立美术课程内容与教育哲学观念、理解与实践之间紧密联系的观点,基于“实践智慧”,提出组织具有批判性质、经验性质和体验性质三种特点的高等师范学院美术教师教育课程模式设置与实施思路。  相似文献   

试论《明人十二像册》高度写真风格的中国渊源     

黄乐乐 《美育学刊》2020,11(2):116-120

现藏于南京博物院的一批无款写真头像《明人十二像册》,是中国写实画的一座高峰。对于这个像册的绘画风格,现当代学者多半都偏向认为是受到西方绘画的影响。但经与西方圣像画比较研究,像册仍属于中国本土的绘画传统,受到了宋代山水画和花鸟画高度写真精神的影响。  相似文献   

坦桑尼亚县域与城乡交通通达水平空间格局特征     

张家旗  陈爽  高群  ISMAEL A. Kimirei 《中国科学院大学学报》2019,36(6):766-773

坦桑尼亚是"一带一路"倡议通向非洲、辐射非洲内陆的重要门户，它在快速城市化过程中面临交通基础设施严重短缺问题。基于坦桑尼亚公路、铁路、机场、港口、人口和城市分布数据，运用GIS空间分析技术，结合交通通达指数模型，从县域与城乡两个层面对坦桑尼亚交通通达水平的空间格局特征进行定量分析。研究发现：1）坦桑尼亚县域交通通达水平空间分布极不均衡，高值连片区主要位于东北沿海和维多利亚湖沿岸，低值连片区主要位于中央铁路线中段以北、中央铁路线南部的广大地区；2）受地理区位、资源禀赋、殖民历史、政府政策等影响，城市与乡村地区之间的交通通达水平差异十分显著。研究结果有助于坦桑尼亚制定区域交通发展政策和优化资源配置，同时对中-坦产业精准对接和产能转移具有一定的促进意义。  相似文献   

College students’ perceptions of television portrayals of Hispanics     

Narissra M. Punyanunt-Carter  Marilda J. Oviedo  Samer Melhem 《Qualitative Research Reports in Communication》2019,20(1):67-74

Based on questionnaire responses from 381 undergraduate students, this study sought to examine perceptions of Hispanics on television. Results revealed that college students perceive Hispanics portrayals on television are mainly stereotypical and often highlight negative perceptions (e.g., lazy and ill-tempered). Students regarded Hispanics to be hardworking and to prioritize culture. Perceptions of Hispanic men were mainly controlling figures and Hispanic women were mostly caretaking characters. These findings suggest that television can affect the way college students view and possibly communicate with Hispanics.  相似文献   

Triggering effects of mobile video marketing in nature tourism: Media richness perspective     

Ari Alamäki  Juho Pesonen  Amir Dirin 《Information processing & management》2019,56(3):756-770

The aim of this study was to investigate videos as potential triggers of behavior. Therefore, we applied the theories of triggers and media richness to learn about the triggering efficiency of mobile marketing videos on participants’ behavioral intentions. The experiment involved three distinct test groups, each comprising 41 student participants. From the perspective of media richness theory, we observed that the different kinds of videos had quite similar effects in terms of triggering behavioral changes. However, the mechanisms explaining why triggers were present differed for each video. Further, the results reveal that the consumer's position in the information search process was the most significant reason for the triggering of any kind of effect. In addition, the instructionally designed videos were able to exert an affective triggering effect: the more participants liked the video, the more it affected their participation intention and recall scores. This study extends the media richness research by demonstrating that the effects of media richness can vary within technically similar videos, as they form different logical connections among non-verbal visual cues related to a video's storyline.  相似文献