Genetic Polymorphism of Angiotensin II Type 1 Receptors and Their Effect on the Clinical Outcome of Captopril Treatment in Arab Iraqi Patients with Acute Coronary Syndrome (Mid Euphrates)     

Fadhaa A. Ghafil  Bassim I. Mohammad  Hussain S. Al-Janabi  Najah R. Hadi  Hayder A. Al-Aubaidy 《Indian journal of clinical biochemistry : IJCB》2021,36(1):81

Genetic variation in the angiotensin II type 1 receptor (AT1R) has an important effect on the outcome of acute coronary syndrome (ACS) initiated treatment with captopril. This study aims to investigate the impact of genetic polymorphism of AT1R (rs5186 and rs275651) on the ACS outcome in Iraqi patients treated with captopril. A total of 250 Iraqi individuals with ACS were included in this case—control study and they were divided into two study groups; Study group 1 included 125 participants who were prescribed captopril, 25 mg twice daily and study group 2 included 125 participants who received no captopril as part of their ACS treatment (control study). The AT1R gene (rs5186) CC genotype was found to be associated with ST-elevation myocardial infarction (STEMI) (Odd’s ratio (O.R) = 1.2, P = 0.7), while AC was associated with Non-ST-elevation myocardial infarction (NSTEMI) and unstable angina (UA) (O.R = 1.2, P = 0.8). AC genotype is more prone to have Percutaneous coronary intervention (PCI) after ACS attack (O.R = 1.2, P = 0.6). CC genotype had a risk to get less improvement (O.R = 1.6, P = 0.5), so might require higher doses of captopril during acute coronary insult. The AT1R gene (rs275651) AA genotype was associated with UA (O.R = 1.3, P = 0.9). AA and AT genotypes were more prone to have PCI after ACS attack (O.R = 3.9 P = 0.2, O.R = 3.5, P = 0.3 respectively) and thus requiring higher doses of captopril. We conclude that the AT1R rs5186, rs275651 genetic polymorphisms might partially affect the clinical outcome of ACS patients treated with captopril and might have captopril resistance which requires higher doses.  相似文献   

习惯行为、执行意向与青少年身体活动意向与行为:基于计划行为理论的扩展模型     

王丽娟  郑丹蘅 《上海体育学院学报》2020,(2):22-32

在计划行为理论(TPB)的基础上,引入身体活动习惯行为与执行意向,构建扩展TPB(METPB)模型,检验该模型对9~19岁青少年群体的中高强度身体活动(MVPA)的适用性,探讨该模型对小学、初中及高中阶段青少年MVPA影响的差异。结果显示:假设模型的拟合度可以接受,纳入习惯行为与执行意向后,METPB显著地提高了其对身体活动行为的解释力。态度和感知行为控制对MVPA行为意向有显著性影响,解释了31.4%的行为意向方差;行为意向和习惯行为对MVPA行为有显著性影响,解释了18.7%的行为方差;执行意向加强了行为意向朝实际行为的转换。METPB模型对于不同学习阶段青少年MVPA意向及行为的影响有显著性差异。其中:主观规范对小学生与初中生MVPA意向产生了显著性影响,而对高中生的MVPA意向并无显著性影响;感知行为控制对3个阶段学生的MVPA意向产生的影响随着学习阶段的上升不断增强。建议:在对于青少年身体活动的干预中,政府、家庭、学校应重视培养学生对于身体活动参与的正确态度,提高其参与身体活动的意愿,培养其参与身体活动的行为习惯,且在对青少年身体活动干预时考虑学习阶段的差异。  相似文献   

From the body to the city: participatory action research with social cartography for transformative education and global citizenship     

Monique Leivas 《Educational Action Research》2019,27(1):40-56

ABSTRACT

In times of globalization we are facing a crisis of care. The invisibility of relations of domination and oppression against nature, women and girls, as well as the elderly, generate inequalities and structural problems that increase the unsustainability of life on the planet. The uncertainty towards the future, generated by climate change, pollution and scarcity of water resources, is leading us towards war or revolution – a revolution that requires the involvement of the new generations to transform reality and confront contemporary problems. In this sense, it is necessary to educate, raise awareness and empower girls and boys in citizen participation, in overcoming gender inequalities and in the development of fairer and more sustainable practices and behaviours. The participatory action-research experience with social cartography ‘From the Body to the City’, promoted by the Institute of Innovation and Knowledge Management – INGENIO (CSIC-UPV) in collaboration with the primary school CEIP Vicente Gaos of Valencia (Spain), developed together with the students of 4th primary grade, intended to reflect and act collectively on our territories from the principles of transformative education and global citizenship.  相似文献   

Paternal support for child sexual abuse victims: A qualitative study     

《Child abuse & neglect》2019

BackgroundThe current state of knowledge regarding the role of non-offending fathers in supporting their sexually abused children is very scarce.ObjectiveThe objective of this study is to further our understanding of fathers’ roles following disclosure of their children’s sexual abuse (SA) by evaluating fathers’ perceptions of the impact of disclosure on their involvement and support of their children.Participants and methodThis qualitative study relies on individual semi-structured interviews conducted with 17 fathers of allegedly abused children.ResultsInductive thematic analysis first highlighted that some reported a period of disengagement from the child during which they put into question their role and attitudes, followed by a period of re-involvement. This period of difficulties experienced by some fathers in regard to their involvement towards their children was due to either their own important psychological distress, their ambivalence towards their child or even because of feelings of uneasiness experienced during physical contact with them. Despite this, findings indicate the presence of thoughts and attitudes that suggest children are a source of concern for fathers. The four forms of abuse-specific support previously observed among mothers (believing the child, seeking out professional services, protecting him/her from the offender, supporting him/her emotionally) were also observed among fathers. In accordance with the activation theory, a form of support specific to fathers, namely, encouraging the child to open up to and explore the world outside the family, thereby, fostering the child’s self-esteem development, was observed and constitutes a relevant finding.ConclusionClinical and empirical implications are discussed.  相似文献   

欧洲九国共产党情报局机关刊物《争取持久和平,争取人民民主!》与中国关系考述(1949-1956)     

哈战荣 《图书馆杂志》2020,(4):21-26

《争取持久和平,争取人民民主!》是20世纪40年代中后期,欧洲九个社会主义国家的共产党和工人党为了一致行动而建立的情报局机关刊物。该刊物对新中国初期我国经济社会建设及成就进行了大量宣传与报道,对加强我国与世界其他爱好和平、渴求民主的各国人民加强互信、长存友谊贡献很大,也对当前学者研究新中国初期我国经济社会发展的过程、成就和经验等提供了原始史料,学术研究意义也很重大。但是,目前对这份刊物及其发挥过的重大作用了解的人少之又少,时值中国共产党成立100周年之际,对其创刊与发行的历史过程进行回顾、宣传中国社会经济发展的全貌进行展示、推动世界社会主义运动的作用进行肯定,意义都很重大。  相似文献   

Porto street stage at Rally Portugal: the determinants of the length of stay     

Ana Pinto Borges  Elvira Vieira 《Journal of Sport Tourism》2020,24(1):1-17

ABSTRACT

We present the determinants of the length of stay (LOS) of Porto Street Stage that integrated the program of the 52nd edition of Rally de Portugal. Sport events assume an important role in the marketing of tourism destinations. However, when we compare them with other segments in tourism, it still remains underexplored. This study represents an opportunity to contribute to the literature, and it could become a significant toll for the organizers, public entities and other stakeholders. We contemplate a set of information and data that may improve the management of the future editions in a more rigorous and effective way. As we are dealing with an international event, it is an occasion to enlist tourists and promote the tourist destination. We applied a quantitative analysis and considered the sociodemographic characteristics of the spectators, factors that influenced the trip, expenses per day in the city, level of satisfaction with the event, and the intention to return. An OLS regression model, a Weibull survival model and a zero-truncated negative binomial regression model were estimated, and the results were compared. On the LOS determinants it is not common to consider the influence of each item of expenditure during the stay and the satisfaction levels with the event and different effects were observed. The travel and accommodation expenditures present a negative effect on the LOS. In the opposite side the satisfaction level and intention to return, both present a positive effect on the LOS. The sociodemographic characteristics have diverse impacts on the LOS.  相似文献   

Responses to oral glucose challenge differ by physical activity volume and intensity: A pilot study     

Trevor N. Simper  Cecile Morris  Anthony Lynn  Ciara O'Hagan  Karen Kilner 《运动与健康科学(英文)》2020,9(6):645-650

BackgroundOne-hour postprandial hyperglycemia is associated with increased risk of type 2 diabetes and cardiovascular disease. Physical activity (PA) has short-term beneficial effects on post-meal glucose response. This study compared the oral glucose tolerance test results of 3 groups of people with habitually different levels of PA.MethodsThirty-one adults without diabetes (age 25.9 ± 6.6 years; body mass index 23.8 ± 3.8 kg/m²; mean ± SD) were recruited and divided into 3 groups based on self-reported PA volume and intensity: low activity < 30 min/day of moderate-intensity activity (n = 11), moderately active ≥ 30 min/day of moderate-intensity PA (n = 10), and very active ≥ 60 min/day of PA at high intensity (n = 10). Participants completed an oral glucose tolerance test (50 g glucose) with capillary blood samples obtained at baseline, 15 min, 30 min, 45 min, 60 min, 90 min, and 120 min post-ingestion.ResultsThere were no significant differences between groups for age or body fat percentage or glycated hemoglobin (p > 0.05). The groups were significantly different in terms of baseline glucose level (p = 0.003) and, marginally, for gender (p = 0.053) and BMI (p = 0.050). There was a statistically significant effect of PA on the 1-h postprandial glucose results (p = 0.029), with differences between very active and low activity groups (p = 0.008) but not between the moderately active and low activity groups (p = 0.360), even when baseline glucose level and gender differences were accounted for. For incremental area under the curve there was no significant effect of activity group once gender and body fat percentage had been accounted for (p = 0.401). Those in the low activity group took 15 min longer to reach peak glucose level than those in the very active group (p = 0.012).ConclusionThe results suggest that high levels of PA have a beneficial effect on postprandial blood glucose profiles when compared to low and moderate levels of activity.  相似文献   

已婚妇女就业意愿对其育后就业决策的影响     

郭舒婧 《保定学院学报》2020,(1):22-28

“全面二孩”政策的实施对大多数女性的生活和生育产生了很大的影响。大多数生育后的女性要面临的一个重要选择就是出去就业还是在家带孩子?运用社会性别理论提出假设:大多数妇女育后选择是否就业主要取决于丈夫的家庭利益,而不是其个人的就业意愿;城镇已婚育龄妇女就业意愿对其育后就业决策更有积极影响;教育程度高的已婚育龄妇女就业意愿对其育后就业决策更有积极影响。通过实证研究和二元logistic回归模型分析,结果显示,三个假设都得到了部分验证。  相似文献   

试论《明人十二像册》高度写真风格的中国渊源     

黄乐乐 《美育学刊》2020,11(2):116-120

现藏于南京博物院的一批无款写真头像《明人十二像册》,是中国写实画的一座高峰。对于这个像册的绘画风格,现当代学者多半都偏向认为是受到西方绘画的影响。但经与西方圣像画比较研究,像册仍属于中国本土的绘画传统,受到了宋代山水画和花鸟画高度写真精神的影响。  相似文献   

坦桑尼亚县域与城乡交通通达水平空间格局特征     

张家旗  陈爽  高群  ISMAEL A. Kimirei 《中国科学院大学学报》2019,36(6):766-773

坦桑尼亚是"一带一路"倡议通向非洲、辐射非洲内陆的重要门户，它在快速城市化过程中面临交通基础设施严重短缺问题。基于坦桑尼亚公路、铁路、机场、港口、人口和城市分布数据，运用GIS空间分析技术，结合交通通达指数模型，从县域与城乡两个层面对坦桑尼亚交通通达水平的空间格局特征进行定量分析。研究发现：1）坦桑尼亚县域交通通达水平空间分布极不均衡，高值连片区主要位于东北沿海和维多利亚湖沿岸，低值连片区主要位于中央铁路线中段以北、中央铁路线南部的广大地区；2）受地理区位、资源禀赋、殖民历史、政府政策等影响，城市与乡村地区之间的交通通达水平差异十分显著。研究结果有助于坦桑尼亚制定区域交通发展政策和优化资源配置，同时对中-坦产业精准对接和产能转移具有一定的促进意义。  相似文献