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Proteins and glutathione (GSH) levels were estimated in the experimental groups. Levels of both proteins and glutathione in
the control and the treated groups were found to be significantly decreased compared to the normal group. The results show
that supplementation of riboflavin has beneficial effect by alleviating the oxidant injuries to GSH and proteins, which are
involved in the maintenance of transparency and protection of thiol groups of the lens. Thus, riboflavin has an active role
in the lens metabolism and has a potential to improve the metabolic activity of the cataractous lenses. 相似文献
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Putative Role of Cardio Metabolic Risk Among Poorly Controlled Asthmatics in South Indian Population
Murugaiyan Sathish Babu K. P. Sreesoorya Surendra K. Menon Subiman Saha A. R. Srinivasan S. Arul Vijaya Vani R. Reeta V. Kuzhandai Velu 《Indian journal of clinical biochemistry : IJCB》2017,32(2):225-229
Mortality and morbidity attributed to asthma remains to be the biggest nightmare worldwide. Hence, the study was aimed to compare the cardio metabolic risk factors as assessed by Body mass index (BMI), waist hip ratio (WHR), serum triacylglycerol and uric acid in well controlled and poorly controlled asthmatics and to correlate these parameters with the severity of asthma. A case control study was conducted on 90 subjects who were segregated into well controlled asthmatics (n = 30) and poorly controlled asthmatics (n = 30) who were diagnosed based on Global initiative for Asthma management guidelines and healthy volunteers (n = 30). Centrifuged fasting venous blood samples were used for biochemical analysis, pulmonary function test, BMI, and waist hip ratio (WHR) were measured. The statistical analysis was done using SPSS version 17. There was a significant increase in BMI, WHR, lipid profile, serum uric acid and decrease in forced expiratory volume (FEV1), forced vital capacity (FVC), and FEV1/FVC in poorly controlled asthmatics. There was a significant association between FEV1 and serum uric acid, BMI and Triacylgycerol in poorly controlled asthmatics. Poorly controlled asthmatics have greater risk of developing cardiometabolic problems. Serum uric acid can be used as one of the severity markers in asthma to assess cardio metabolic risk. 相似文献
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The proposed work aims to explore and compare the potency of syntactic-semantic based linguistic structures in plagiarism detection using natural language processing techniques. The current work explores linguistic features, viz., part of speech tags, chunks and semantic roles in detecting plagiarized fragments and utilizes a combined syntactic-semantic similarity metric, which extracts the semantic concepts from WordNet lexical database. The linguistic information is utilized for effective pre-processing and for availing semantically relevant comparisons. Another major contribution is the analysis of the proposed approach on plagiarism cases of various complexity levels. The impact of plagiarism types and complexity levels, upon the features extracted is analyzed and discussed. Further, unlike the existing systems, which were evaluated on some limited data sets, the proposed approach is evaluated on a larger scale using the plagiarism corpus provided by PAN1 competition from 2009 to 2014. The approach presented considerable improvement in comparison with the top-ranked systems of the respective years. The evaluation and analysis with various cases of plagiarism also reflected the supremacy of deeper linguistic features for identifying manually plagiarized data. 相似文献
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C. V. Divyambika S. Sathasivasubramanian G. Vani A. J. Vanishree N. Malathi 《Indian journal of clinical biochemistry : IJCB》2018,33(3):348-355
This study aimed to correlate the oxidative stress marker levels in saliva with the clinical stage based on mouth opening, fibrotic bands and histopathological grades of oral submucous fibrosis (OSF) patients. The study included patients clinically diagnosed with OSF (n = 63) and equal number of age and gender matched controls. Patients with OSF were defined by mouth opening stage, fibrotic bands and histopathological grades. Unstimulated saliva from both control and OSF patients were analysed for oxidative markers like lipid peroxides (LPO), non-enzymic antioxidants [reduced glutathione (GSH), vitamin A, vitamin E, vitamin C] and enzymatic antioxidants [glutathione peroxidase (GPx), superoxide dismutase (SOD)] and correlated with different stages and grades. Total salivary protein and LPO were significantly increased in OSF group with no significant change in the levels of GSH compared to controls. In OSF patients, a significant decrease in the levels of vitamins A, C and E was observed. The activities of salivary SOD and GPx were significantly decreased in OSF patients compared to controls. These changes significantly correlated with the increasing and differing grades of OSF that reflects increased oxidative stress with the progress of OSF. 相似文献
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Sujatha Baskaran Vani Brahmachari 《Indian journal of clinical biochemistry : IJCB》2000,15(1):145-157
The first report of X-linked mental retardation correlated with the presence of marker chromosome came in 1940. It was in 1990 that the molecular basis of fragile X syndrome was deciphered. This elucidation marked the discovery of a novel process of mutation designated as dynamic mutations, resulting in the expansion of a triplet repeat sequence within the human genome. Subsequently several human genetic disorders involving triplet repeat expansion have been discovered. Almost all the disorders are known to affect the nervous system and/or the brain. This review presents an overview of fragile sites in the genome and the molecular genetics of fragile X syndrome. 相似文献
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Vani Brahmachari 《Resonance》1996,1(10):14-25
Mutations are vital in deciphering the regulated expression of genes in all organisms. In humans, study of mutant traits has helped in the management of genetic disorders. This article focuses on the nature of mutations that are encountered in general and the possible ways in which these mutations are produced. 相似文献
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Renuka Raju Sujai Suneetha Karuna Sagili Vani C Meher V Saraswathi A V V Satyanarayana Lavanya M Suneetha 《Indian journal of clinical biochemistry : IJCB》2005,20(1):123-128
The antibody response to the 38kDa, 16kDa and Lipoarabinomannan (LAM) antigens ofMycobacterium tuberculosis was evaluated using three different ELISAs based on these antigens. The study group included tuberculosis patients (n=52),
patients with HIV and TB co-infection (n=10), other chest symptomatics (n=5), HIV infected individuals (n=10), leprosy cases
(n=7) and healthy controls (n=75). The results indicate that the 38kDa and LAM based ELISA for IgM/IgG has a low specificity
(ranging from 69–85%) and sensitivity (ranging from 55–78%). When three ELISAs are carried out on a single patient the probability
of detection of tuberculosis was significantly increased to 95.2% indicating that a single ELISA test is of low sensitivity
and that a combination of ELISA’s may be needed to be of any value as a diagnostic test for tuberculosis. Additionally, a
western blot assay of the serum antibody response to protein fraction ofM. tuberculosis was analysed in 15 tuberculosis patients and five healthy controls. A multiple antibody response to various M.tuberculosis proteins was observed which varied from patient to patient as compared to controls who showed a single 38–39 kDa protein
band positivity. These finding suggest that a western blot assay which determines the antibody response to a set of antigenic
components ofM. tuberculosis could be a better serological test for the diagnosis of tuberculosis in our population. 相似文献
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Vani Brahmachari 《Resonance》1996,1(6):41-49
The selective elimination of human chromosomes in mousehuman hybrid cells generates a unique system for cytogenetic analysis. The use of such somatic cell hybrids in chromosome mapping is discussed in this part of the series. 相似文献
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