Genetic Polymorphism of Angiotensin II Type 1 Receptors and Their Effect on the Clinical Outcome of Captopril Treatment in Arab Iraqi Patients with Acute Coronary Syndrome (Mid Euphrates)     

Fadhaa A. Ghafil  Bassim I. Mohammad  Hussain S. Al-Janabi  Najah R. Hadi  Hayder A. Al-Aubaidy 《Indian journal of clinical biochemistry : IJCB》2021,36(1):81

Genetic variation in the angiotensin II type 1 receptor (AT1R) has an important effect on the outcome of acute coronary syndrome (ACS) initiated treatment with captopril. This study aims to investigate the impact of genetic polymorphism of AT1R (rs5186 and rs275651) on the ACS outcome in Iraqi patients treated with captopril. A total of 250 Iraqi individuals with ACS were included in this case—control study and they were divided into two study groups; Study group 1 included 125 participants who were prescribed captopril, 25 mg twice daily and study group 2 included 125 participants who received no captopril as part of their ACS treatment (control study). The AT1R gene (rs5186) CC genotype was found to be associated with ST-elevation myocardial infarction (STEMI) (Odd’s ratio (O.R) = 1.2, P = 0.7), while AC was associated with Non-ST-elevation myocardial infarction (NSTEMI) and unstable angina (UA) (O.R = 1.2, P = 0.8). AC genotype is more prone to have Percutaneous coronary intervention (PCI) after ACS attack (O.R = 1.2, P = 0.6). CC genotype had a risk to get less improvement (O.R = 1.6, P = 0.5), so might require higher doses of captopril during acute coronary insult. The AT1R gene (rs275651) AA genotype was associated with UA (O.R = 1.3, P = 0.9). AA and AT genotypes were more prone to have PCI after ACS attack (O.R = 3.9 P = 0.2, O.R = 3.5, P = 0.3 respectively) and thus requiring higher doses of captopril. We conclude that the AT1R rs5186, rs275651 genetic polymorphisms might partially affect the clinical outcome of ACS patients treated with captopril and might have captopril resistance which requires higher doses.  相似文献   

Validity and reliability of a linear positional transducer across commonly practised resistance training exercises     

Harry F. Dorrell  Joseph M. Moore  Mark F. Smith  Thomas I. Gee 《Journal of sports sciences》2019,37(1):67-73

This study investigated the validity and reliability of the GymAware PowerTool (GPT). Thirteen resistance trained participants completed three visits, consisting of three repetitions of free-weight back squat, bench press, deadlift (80% one repetition maximum), and countermovement jump. Bar displacement, peak and mean velocity, peak and mean force, and jump height were calculated using the GPT, a three-dimensional motion capture system (Motion Analysis Corporation; 150 Hz), and a force plate (Kistler; 1500 Hz). Least products regression were used to compare agreeability between devices. A within-trial one-way ANOVA, typical error (TE; %), and smallest worthwhile change (SWC) were used to assess reliability. Regression analysis resulted in R² values of >0.85 for all variables excluding deadlift mean velocity (R² = 0.54–0.69). Significant differences were observed between visits 3-2 for bench press bar displacement (0.395 ± 0.055 m; 0.383 ± 0.053 m), and deadlift bar displacement (0.557 ± 0.034 m; 0.568 ± 0.034 m). No other significant differences were found. Low to moderate TE (0.6–8.8%) were found for all variables, with SWC ranging 1.7–7.4%. The data provides evidence that the GPT can be used to measure kinetic and kinematic outputs, however, care should be taken when monitoring deadlift performance.  相似文献   

城市居民休闲化趋势与大众体育的开发和指导   总被引：17，自引：1，他引：16  

陈颖川  吉建秋  刘建军 《中国体育科技》2003,39(1):32-34

从 3个层面分析了开发体育的休闲功能与开发休闲培训对休闲文化产生的意义 ,休闲服务将从标准化和集中化转向个性化服务发展 ,发展、健全健身娱乐市场 ,能进一步满足人们日趋多元化、高质量的休闲生活的需要。  相似文献   

文化意识与外语教学     

王春娣  纪雪梅 《内蒙古师范大学学报(教育科学版)》2001,14(6):91-93

语言交际成功的一半是在于文化意识和语言习得。学习外语的人到了一定程度普遍都有一种感受 :掌握一门外语 ,学好一门外语与对该语言文化的认识了解有很大的关系。尤其与外国人交流时 ,除了语言方面存在的障碍以外 ,不同文化意识是交际中的又一障碍。笔者认为 :不仅外语教师要注重加强文化意识 ,而且还把这种文化意识观浸注到教学之中  相似文献   

The Clarke County (Alabama) War Memorial: Kairos and Chronos United in the Sacred Commemoration and Contemplation of Five Wars     

Alison I. English 《Journal of American culture (Malden, Mass. : 2003)》2004,27(4):384-405

  相似文献   

从比较的角度看中、美两国职业篮球市场的主题和差异   总被引：2，自引：0，他引：2  

陈颖川  吉建秋  史江杰 《北京体育大学学报》2004,27(11):1566-1568

我国职业篮球联赛正在形成和发展之中,通过研究美国职业篮球(NBA)市场的发展轨迹,从6个方面分析了它的特征与运作过程:以俱乐部为骨架的职业联盟;以市场为导向的职业市场;以严密的法律和游戏规则为指针;以超前的经营理念为发展方向;以明星效应与各种媒体的精心组合为焦点;以转会市场及选秀制度规范了竞争的公平性.经过对比分析,提出了我国职业篮球市场在变迁过程中存在的差异及由此产生的发展对策.  相似文献   

体育舞蹈在高校素质教育中的作用     

季晓静  聂军 《湖北体育科技》2004,23(1):129-131

21世纪是高科技飞跃发展的知识经济社会，人才的竞争日趋激烈。因此推行素质教育是高等学校面向21世纪的重要任务。体育舞蹈是融体育、音乐、舞蹈为一体的新型体育课程，对全面培养大学生综合素质、增强大学生生理、心理健康、发展个性、审美能力的提高具有重要作用。  相似文献   

《尧典》与“诗言志”的关系：从一个侧面探索上古辨伪的新思路     

纪准 《山西大学师范学院学报》2006,5(5):79-85

“诗言志”是中国诗学的第一个理论命题，对它的研究绕不开它与《尧典》的关系。一般说来，任何历史事件在进入史册以前，都存在一个口耳相传的阶段，我们应该把事实和书写区别开。具体到史前史，我们尤其不能带着文明的偏见，歪曲文字成熟以前的种种人文现象。从地下考古的成绩来看，《尧典》所载尧舜禹的时代是基本可信的；其文明程度也并非我们想象的那么低下。反映诗歌舞合一的“诗言志”由一个熟练掌握这种高度文明的史前历史人物说出来，完全是可能的。  相似文献   

体操跳马踺子类动作研究     

纪仲秋  姜桂萍 《天津体育学院学报》2004,19(4):32-33

运用运动生物力学的三维DLT研究方法对踺子类李小鹏跳和女子经常采用的尤尔钦科动作进行了解分析,得知,李小鹏动作命名的踺子上板转体180°前手翻转体900°动作,李起跳的水平速度达到5.48m/s,尤尔钦科动作为5.02m/s。李的起跳时间用了0.14s,尤尔钦科动作用了0.12s。因为有转体的原因,踏板李小鹏跳的左肩角度达到157°,而不转体的尤尔钦科动作为106°。离板瞬间重心点和起跳点连线和水平面的角度尤尔钦科动作为86°,李的角度为89°,这样力能更好地向上传递。重心最高点尤尔钦科动作为2.50m,李小鹏跳重心最高点2.91m,在这样的高度内完成了空中旋的动作。  相似文献   

对部分研究生跟骨骨强度状况的初步调查     

季钢 《首都体育学院学报》2004,16(1):113-114

本实验采用定量超声技术对首都体育学院男、女共77名研究生的跟骨骨强度进行了测定。结果表明:我院研究生骨强度男性高于女性,而与日本同性别、同龄青年相比无统计差异。  相似文献