Biomarkers of inflammation and cardiac remodeling: the quest of relevant companions for the risk stratification of heart failure patients is still ongoing     

Gruson D  Ahn SA  Rousseau MF 《Biochemia medica : ?asopis Hrvatskoga dru?tva medicinskih biokemi?ara / HDMB》2011,21(3):254-263

Heart failure (HF) is a frequent chronic disease in elderly people and represents a major health and economic burden. The accurate diagnosis of HF and the identification of high risk patients is mandatory to select the appropriate therapy and care. HF is associated to cardiac remodeling and inflammation and to the release of neurohormones. If natriuretic peptides remain the biomarkers of choice for the diagnosis and the prognosis of HF, several biomarkers related to cardiac remodeling and inflammation are available for testing and may add valuable information for the risk estimation of HF patients and for the selection of the most appropriated therapy. Furthermore, the quest for new efficient biomarkers of cardiac remodeling and inflammation is still ongoing and new candidates have been identified for a potential use in daily clinical practices. However, before their potential translation to routine parameters several challenges ranging form the analytical validation to the cost-effectiveness estimation should be considered.  相似文献   

Archaeology in the Capital of Molecular Biology     

Morange  Michel 《Metascience》2003,12(2):195-197

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Guest editors’ preface     

Angelo Campodonico  Michel Croce  Maria Silvia Vaccarezza 《Journal of moral education》2019,48(3):275-279

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A Grounded Theory of Counselor Educators' Academic Leadership Development     

Danica G. Hays  Stephanie A. Crockett  Rebecca Michel 《Counselor Education & Supervision》2021,60(1):51-72

Counselor educators are well‐equipped to serve as academic leaders, yet little is known about what factors influence their engagement experiences. This grounded theory provides a theoretical model of academic leadership engagement based on interviews with 20 counselor educators with academic leadership experience. Implications for facilitating academic leadership engagement are provided.  相似文献   

Visible speech: The diverse oneness of writing systems     

Michel Paradis 《Reading and writing》1990,2(2):189-193

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SITUATIONS D'INITIATION AU RAISONNEMENT DÉDUCTIF     

Gilbert Arsac  Michel Mante 《Educational Studies in Mathematics》1997,33(1):21-43

We examine classroom situations which allow the learning of rules of mathematical reasoning. Drawing on an epistemological analysis and G. Brousseau's theory of situations, we define a priori theoretical characteristics which such situations must possess. We then use this analysis, and hypotheses about the cognitive functioning of pupils of this age, to establish learning situations for the rule of the excluded middle, and for the use of the figure in geometry. We report the results of experimentation with two of thses situations and show that, through the study of a mathematical problem, debate about these rules can be generated amongst students aged twelve to thirteen. We explain why, in our opinion, for epistemological reasons linked to the two particular rules concerned, it is necessary for the teacher to conclude the debate, and we examine our cognitive hypotheses against the actual results of experimentation.  相似文献   

A longitudinal confirmatory factor analysis of indirect and physical aggression: evidence of two factors over time?     

Vaillancourt T  Brendgen M  Boivin M  Tremblay RE 《Child development》2003,74(6):1628-1638

The purpose of the present study was to examine whether indirect aggression was distinct from physical aggression across developmental periods. Participants were 3,089 Canadian children aged 4 to 7 years (Time 1), 6 to 9 years (Time 2), and 8 to 11 years (Time 3). Confirmatory factor analysis using an accelerated longitudinal design confirmed a 2-factor model that was stable across cohorts, time, and sex. The longitudinal predictive links between indirect and physical aggression were also examined in a path analysis. Findings did not support the notion that maturation is associated with changes in the ways children aggress but rather suggest that children are consistent in the type of aggression they use over time, whether it be indirect or physical.  相似文献   

Pheromone synthesis in a biomicroreactor coated with anti-adsorption polyelectrolyte multilayer     

Dimov N  Muñoz L  Carot-Sans G  Verhoeven ML  Bula WP  Kocer G  Guerrero A  Gardeniers HJ 《Biomicrofluidics》2011,5(3):34102-3410212

To prepare a biosynthetic module in an infochemical communication project, we designed a silicon/glass microreactor with anti-adsorption polyelectrolyte multilayer coating and immobilized alcohol acetyl transferase (atf), one of the key biosynthetic enzymes of the pheromone of Spodoptera littoralis, on agarose beads inside. The system reproduces the last step of the biosynthesis in which the precursor diene alcohol (Z,E)-9,11-tetradecadienol is transformed into the major component (Z,E)-9,11-tetradecadienyl acetate. The scope of this study was to analyze and implement a multilayer, anti-adsorption coating based on layer-by-layer deposition of polyethylenimine/dextransulfate sodium salt (PEI/DSS). The multilayers were composed of two PEI with molecular weights 750 and 1.2 kDa at pH 9.2 or 6.0. Growth, morphology, and stability of the layers were analyzed by ellipsometry and atomic force microscopy (AFM). The anti-adsorption functionality of the multilayer inside the microreactor was validated. The activity of His(6)-(atf) was measured by gas chromatography coupled to mass spectrometer (GC-MS).  相似文献   

Profiles of educators     

Michel Soëtard 《Prospects》1991,21(1):125-135

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Learning for an Active Citizenship and Working Life: Main Challenges and Ongoing Innovations     

Alain Michel 《European Journal of Education》2015,50(4):379-382

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