Biomarkers of inflammation and cardiac remodeling: the quest of relevant companions for the risk stratification of heart failure patients is still ongoing     

Gruson D  Ahn SA  Rousseau MF 《Biochemia medica : ?asopis Hrvatskoga dru?tva medicinskih biokemi?ara / HDMB》2011,21(3):254-263

Heart failure (HF) is a frequent chronic disease in elderly people and represents a major health and economic burden. The accurate diagnosis of HF and the identification of high risk patients is mandatory to select the appropriate therapy and care. HF is associated to cardiac remodeling and inflammation and to the release of neurohormones. If natriuretic peptides remain the biomarkers of choice for the diagnosis and the prognosis of HF, several biomarkers related to cardiac remodeling and inflammation are available for testing and may add valuable information for the risk estimation of HF patients and for the selection of the most appropriated therapy. Furthermore, the quest for new efficient biomarkers of cardiac remodeling and inflammation is still ongoing and new candidates have been identified for a potential use in daily clinical practices. However, before their potential translation to routine parameters several challenges ranging form the analytical validation to the cost-effectiveness estimation should be considered.  相似文献   

Archaeology in the Capital of Molecular Biology     

Morange  Michel 《Metascience》2003,12(2):195-197

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History of childhood abuse in Portuguese parents     

Figueiredo B  Bifulco A  Paiva C  Maia A  Fernandes E  Matos R 《Child abuse & neglect》2004,28(6):669-682

OBJECTIVE: The study examines the self-reported prevalence of childhood physical and sexual abuse in a large sample of Portuguese parents. METHOD: Nearly 1,000 parents (506 mothers and 426 fathers) were selected through public primary schools from the Northern area of Portugal. All completed the Portuguese version of the Childhood History Questionnaire (CHQ) [Journal of Family Violence 5 (1990) 15]. RESULTS: Results show that the prevalence of abuse was 73%, but more severe physical abuse involving sequelae/injury was reported by 9.5%. Most physical abuses began prior to age 13, with half continuing after age 13. No gender differences were found for rates of physical abuse. However, among the milder physical abuse without sequelae/injury, those women who experienced "whipping" or "slapping/kicking" were more likely to do so from their mothers than fathers. Among men who were "slapped/kicked" this was more likely to be from their fathers. Low rates of sexual abuse were found at 2.6% with no gender or age differences. Lack of a supportive adult in childhood related to the more severe abuses, but only in adolescence. Portuguese rates of abuse were consistently lower than those reported in USA and Spanish studies using the CHQ. CONCLUSIONS: This is the first retrospective, self-report study of childhood abuse in a large sample of Portuguese parents and, even with a participation rate of 69%, shows lower rates than in US and Spanish samples.  相似文献   

Guest editors’ preface     

Angelo Campodonico  Michel Croce  Maria Silvia Vaccarezza 《Journal of moral education》2019,48(3):275-279

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A Grounded Theory of Counselor Educators' Academic Leadership Development     

Danica G. Hays  Stephanie A. Crockett  Rebecca Michel 《Counselor Education & Supervision》2021,60(1):51-72

Counselor educators are well‐equipped to serve as academic leaders, yet little is known about what factors influence their engagement experiences. This grounded theory provides a theoretical model of academic leadership engagement based on interviews with 20 counselor educators with academic leadership experience. Implications for facilitating academic leadership engagement are provided.  相似文献   

Evaluating effects of different forms of revision instruction in upper-primary students     

López  Paula  Torrance  Mark  Rijlaarsdam  Gert  Fidalgo  Raquel 《Reading and writing》2021,34(7):1741-1767

Reading and Writing - This study aimed to establish (a) whether teaching students revision skills provides benefit over and above teaching strategies for setting explicit goals for the...  相似文献   

Visible speech: The diverse oneness of writing systems     

Michel Paradis 《Reading and writing》1990,2(2):189-193

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SITUATIONS D'INITIATION AU RAISONNEMENT DÉDUCTIF     

Gilbert Arsac  Michel Mante 《Educational Studies in Mathematics》1997,33(1):21-43

We examine classroom situations which allow the learning of rules of mathematical reasoning. Drawing on an epistemological analysis and G. Brousseau's theory of situations, we define a priori theoretical characteristics which such situations must possess. We then use this analysis, and hypotheses about the cognitive functioning of pupils of this age, to establish learning situations for the rule of the excluded middle, and for the use of the figure in geometry. We report the results of experimentation with two of thses situations and show that, through the study of a mathematical problem, debate about these rules can be generated amongst students aged twelve to thirteen. We explain why, in our opinion, for epistemological reasons linked to the two particular rules concerned, it is necessary for the teacher to conclude the debate, and we examine our cognitive hypotheses against the actual results of experimentation.  相似文献   

A longitudinal confirmatory factor analysis of indirect and physical aggression: evidence of two factors over time?     

Vaillancourt T  Brendgen M  Boivin M  Tremblay RE 《Child development》2003,74(6):1628-1638

The purpose of the present study was to examine whether indirect aggression was distinct from physical aggression across developmental periods. Participants were 3,089 Canadian children aged 4 to 7 years (Time 1), 6 to 9 years (Time 2), and 8 to 11 years (Time 3). Confirmatory factor analysis using an accelerated longitudinal design confirmed a 2-factor model that was stable across cohorts, time, and sex. The longitudinal predictive links between indirect and physical aggression were also examined in a path analysis. Findings did not support the notion that maturation is associated with changes in the ways children aggress but rather suggest that children are consistent in the type of aggression they use over time, whether it be indirect or physical.  相似文献   

Warm elaborated feedback. Exploring its benefits on post-feedback behaviour     

Raquel De Sixte  Amelia Mañá  Vicenta Ávila  Emilio Sánchez 《教育心理学》2020,40(9):1094-1112

Abstract

This study provides evidence on the impact of including warm messages in elaborated feedback. These messages are aimed at the motivational process that can be mobilised by feedback and that which can condition its reception and the way students face the task (post-feedback behaviour). In a task where secondary school students had to learn a new strategy for improving their reading skills in a computer-based environment, we compared the use of elaborated feedback with the use of elaborated feedback enhanced with motivational messages (warm elaborated feedback) and a control condition (without feedback). The results showed that students receiving warm elaborated feedback revisited the text more often than those receiving only the elaborated feedback, and that both groups revisited the text more than the control group. This finding suggests that controlling the motivational aspects in feedback messages may increase the effectiveness of elaborated feedback.  相似文献