Genetic Polymorphism of Angiotensin II Type 1 Receptors and Their Effect on the Clinical Outcome of Captopril Treatment in Arab Iraqi Patients with Acute Coronary Syndrome (Mid Euphrates)     

Fadhaa A. Ghafil  Bassim I. Mohammad  Hussain S. Al-Janabi  Najah R. Hadi  Hayder A. Al-Aubaidy 《Indian journal of clinical biochemistry : IJCB》2021,36(1):81

Genetic variation in the angiotensin II type 1 receptor (AT1R) has an important effect on the outcome of acute coronary syndrome (ACS) initiated treatment with captopril. This study aims to investigate the impact of genetic polymorphism of AT1R (rs5186 and rs275651) on the ACS outcome in Iraqi patients treated with captopril. A total of 250 Iraqi individuals with ACS were included in this case—control study and they were divided into two study groups; Study group 1 included 125 participants who were prescribed captopril, 25 mg twice daily and study group 2 included 125 participants who received no captopril as part of their ACS treatment (control study). The AT1R gene (rs5186) CC genotype was found to be associated with ST-elevation myocardial infarction (STEMI) (Odd’s ratio (O.R) = 1.2, P = 0.7), while AC was associated with Non-ST-elevation myocardial infarction (NSTEMI) and unstable angina (UA) (O.R = 1.2, P = 0.8). AC genotype is more prone to have Percutaneous coronary intervention (PCI) after ACS attack (O.R = 1.2, P = 0.6). CC genotype had a risk to get less improvement (O.R = 1.6, P = 0.5), so might require higher doses of captopril during acute coronary insult. The AT1R gene (rs275651) AA genotype was associated with UA (O.R = 1.3, P = 0.9). AA and AT genotypes were more prone to have PCI after ACS attack (O.R = 3.9 P = 0.2, O.R = 3.5, P = 0.3 respectively) and thus requiring higher doses of captopril. We conclude that the AT1R rs5186, rs275651 genetic polymorphisms might partially affect the clinical outcome of ACS patients treated with captopril and might have captopril resistance which requires higher doses.  相似文献   

高校体育教学中学生伤害事故责任划分探讨   总被引：2，自引：0，他引：2  

倪东业  王冕 《湖北体育科技》2003,22(4):557-558

高校体育教学中发生伤害事故的原因有多种。章提出学生伤害事故处理的主要原则，对学校和教师的责任承担作出具体分析，提出伤害事故预防的建议。  相似文献   

短跨技术中节奏问题的研究   总被引：2，自引：0，他引：2  

张勉 《安徽体育科技》2002,23(2):53-55

我国的短跨运动成绩在90年代以后,只有男子优秀跨栏运动员李彤曾以13.37的成绩进入世界先进水平行列.在此之后我国的短跨水平便一直处于停滞不前甚至下滑的局面,为此我国的体育工作者们在跨栏理论和实践过程中做了大量的研究工作.本文以世界优秀女子跨栏运动员Brigta Bukovec技术中的节奏特点与我国优秀女子跨栏运动员进行比较,希望能够找出一些问题所在.  相似文献   

Should Gender Differences be Considered When Assessing Student Satisfaction in the Online Learning Environment for Millennials?          下载免费PDF全文

Heather Lea Harvey  Sanjai Parahoo  Mohammad Santally 《Higher Education Quarterly》2017,71(2):141-158

The majority of today's students in online higher education are millennials and have grown up using technology. Therefore, there is a need to determine if their expectations from online learning are different from previous contextual studies and whether or not these vary across gender. This study used a mixed method approach, using focus groups, followed by online surveys of 834 undergraduate students from the University of Mauritius enrolled in an online course. Using factor analysis and structural equation modelling, the study found no significant differences based on gender for millennials, but identified three significant antecedents of student satisfaction for both males and females: university reputation; physical facilities; and instructor empathy.  相似文献   

上海市在职教师融合教育自我效能感的调查研究     

昝飞  刘春玲  王勉  Umesh Sharma 《中国特殊教育》2011,(5)

本研究采用Sharma等人编制的<教师融合教育自我效能感量表>以及<融合教育忧虑量表>对上海市110名特殊教育学校教师以及213名普通学校教师进行了调查,结果发现:两类教师对开展融合教育具有一定水平的自我效能感;特殊教育学校教师的自我效能感要高于普通学校教师;普通学校教师在开展融合教学以及与他人合作方面的自我效能感普遍低于特殊教育学校教师,但在行为管理方面,则与特殊教育学校教师没有差异;两类教师对开展融合教育抱有中等水平的忧虑,且融合教育自我效能感与其忧虑水平存在显著负相关,教师对开展残疾学生教学的自信心水平越高,则对融合教育的忧虑越少.教师融合教育忧虑程度对自我效能感的方差贡献率超过50%以上.  相似文献   

Reaching Out to Veteran Teachers     

Masami Matoba  Yoshiaki Shibata  Mohammad Reza Sarkar Arani 《TechTrends》2007,51(3):21-29

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广义模态逻辑研究中的若干问题   总被引：1，自引：0，他引：1  

冯棉 《华东师范大学学报(哲学社会科学版)》2001,33(5):141-146

模态理论不仅涉及逻辑的可能性，也涉及事实的可能性，两存在着重要的差异；在对“罗斯悖论”的剖析中引入可能算子，通过对道义悖论作时态的分析，以辨明义务的相对性，是消除道义悖论的一条可行的途径。  相似文献   

How online career counseling changes career development: A life design paradigm     

Nooshin Pordelan  Ahmad Sadeghi  Mohammad Reza Abedi  Marjan Kaedi 《Education and Information Technologies》2018,23(6):2655-2672

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多方位地提高大学英语写作能力     

王冕 《张家口职业技术学院学报》2006,19(4):45-46

文章主要探讨英语教学中，如何提高大学生英语写作水平，必须在平时加强词句训练，克服母语思维干扰，比较英汉思维方式的差异，增加阅读量，注重课堂有针对性的讲解，有目的地培养和提高学生的写作能力。  相似文献   

组织文化度量模型的构建与实证研究     

张勉  李海  闫举刚 《科学学与科学技术管理》2007,28(12):193-200

采用多维尺度分析法,通过考察26位专家对组织文化结构的空间认知模式,确定了一个五维度的组织文化度量模型,包括人际和谐、开放创新、短期结果、竞争效率和严格控制。我们还在6家组织中进行了问卷调查,获得607份有效问卷。通过对数据进行验证性因子分析,初步建立了相应的测量量表(DOCQ)。  相似文献