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1.
Salmanzadeh A Kittur H Sano MB C Roberts P Schmelz EM Davalos RV 《Biomicrofluidics》2012,6(2):24104-2410413
Ovarian cancer is the leading cause of death from gynecological malignancies in women. The primary challenge is the detection of the cancer at an early stage, since this drastically increases the survival rate. In this study we investigated the dielectrophoretic responses of progressive stages of mouse ovarian surface epithelial (MOSE) cells, as well as mouse fibroblast and macrophage cell lines, utilizing contactless dielectrophoresis (cDEP). cDEP is a relatively new cell manipulation technique that has addressed some of the challenges of conventional dielectrophoretic methods. To evaluate our microfluidic device performance, we computationally studied the effects of altering various geometrical parameters, such as the size and arrangement of insulating structures, on dielectrophoretic and drag forces. We found that the trapping voltage of MOSE cells increases as the cells progress from a non-tumorigenic, benign cell to a tumorigenic, malignant phenotype. Additionally, all MOSE cells display unique behavior compared to fibroblasts and macrophages, representing normal and inflammatory cells found in the peritoneal fluid. Based on these findings, we predict that cDEP can be utilized for isolation of ovarian cancer cells from peritoneal fluid as an early cancer detection tool. 相似文献
2.
Two experiments investigated the effect of kanji morphemic homophony on lexical decision and naming. Effects were examined from both the left-hand and right-hand positions of Japanese two-kanji compound words. The number of homophones affected the processing of compound words in the same way for both tasks. For left-hand kanji, fewer morphemic homophones led to faster lexical decision and whole-word naming. For right-hand kanji, the number of morphemic homophones did not affect either lexical decision or naming. This effect of homophonic density suggested that, when a kanji-compound word is to be processed, phonological information of its kanji constituents is automatically activated and reverberates back to generate a series of orthographic representations of kanji morphemic homophones, but not in a completely parallel fashion. 相似文献
3.
Takahito Iga Hiroyuki Nunome Shinya Sano Nahoko Sato Yasuo Ikegami 《Sports biomechanics / International Society of Biomechanics in Sports》2018,17(4):477-493
To assess ball impact force during soccer kicking is important to quantify from both performance and chronic injury prevention perspectives. We aimed to verify the appropriateness of previous models used to estimate ball impact force and to propose an improved model to better capture the time history of ball impact force. A soccer ball was fired directly onto a force platform (10 kHz) at five realistic kicking ball velocities and ball behaviour was captured by a high-speed camera (5,000 Hz). The time history of ball impact force was estimated using three existing models and two new models. A new mathematical model that took into account a rapid change in ball surface area and heterogeneous ball deformation showed a distinctive advantage to estimate the peak forces and its occurrence times and to reproduce time history of ball impact forces more precisely, thereby reinforcing the possible mechanics of ‘footballer’s ankle’. Ball impact time was also systematically shortened when ball velocity increases in contrast to practical understanding for producing faster ball velocity, however, the aspect of ball contact time must be considered carefully from practical point of view. 相似文献
4.
Hiroyuki Nunome Yasuo IkegamI Rumi Kozakai Tommy Apriantono Shinya Sano 《Journal of sports sciences》2013,31(5):529-541
Abstract Detailed time-series of the resultant joint moments and segmental interactions during soccer instep kicking were compared between the preferred and non-preferred kicking leg. The kicking motions of both legs were captured for five highly skilled players using a three-dimensional cinematographic technique at 200 Hz. The resultant joint moment (muscle moment) and moment due to segmental interactions (interaction moment) were computed using a two-link kinetic chain model composed of the thigh and lower leg (including shank and foot). The mechanical functioning of the muscle and interaction moments during kicking were clearly illustrated. Significantly greater ball velocity (32.1 vs. 27.1 m · s?1), shank angular velocity (39.4 vs. 31.8 rad · s?1) and final foot velocity (22.7 vs. 19.6 m · s?1) were observed for the preferred leg. The preferred leg showed a significantly greater knee muscle moment (129.9 N · m) than the non-preferred leg (93.5 N · m), while no substantial differences were found for the interaction moment between the two legs (79.3 vs. 55.7 N · m). These results indicate that the highly skilled soccer players achieved a well-coordinated inter-segmental motion for both the preferred and non-preferred leg. The faster leg swing observed for the preferred leg was most likely the result of the larger muscle moment. 相似文献
5.
In 1972 a longitudinal study was launched in one of the largest department store chains in Japan. The purpose of this study was to investigate the managerial career development of the newly hired college graduates. The research design required repeated monitoring of a newcomer's progress within the organization at seven different points in time over a three-year period. The study investigated basic questions concerning the process of managerial career development: (1) Why do some people achieve a higher level of management progress during the early period of their organizational career, while others do not? (2) What are the important indicators of management development during the formative years in business? (3) How accurately can development in management be predicted? (4) What are the organizational and personal consequences of managerial development? Over the three-year period of this study data were collected on 80 newly hired college graduates. Two models that have been used to understand the process of early management development in the United States were tested. Results were compatible with these models. Performance at the end of three years was found to be significantly related to both initially assessed potential (assessment model) and developed working relationships (vertical exchange model). Other professional and organizational outcomes were significantly related to developed working relationships. The implications of this cultural generality are discussed. 相似文献
6.
Rebeca V. R. Viana Vera L. Scatena Mayra T. Eichemberg Paulo T. Sano 《Cultural Studies of Science Education》2018,13(1):253-265
Considering that both Western Science and Local Knowledge Systems share a common ground—observations of the natural world—the dialogue between them should not only be possible, but fruitful. Local communities whose livelihoods depend on traditional uses of the local biodiversity not only develop knowledge about nature, making several uses of such knowledge, but, with that process, several inquiries about nature can be raised. Here we present our experience with the engagement of Western Science with golden grass artisan’s knowledge about the buriti palm (M. flexuosa). We applied 25 semi-directive interviews, combined with field diary and participative observation, in two quilombola communities from Jalapão region (Central-Brazil). One of the inquiries that emerged from the artisan’s perspectives was about the differences between male and female buriti palms’ fiber. We then engaged both local and scientific perspectives regarding this issue using plant anatomy as a dialogue instrument. Here we describe this experience and resort to Paulo Freire’s ideas on dialogue to argue that, to integrate Western Science and Local Knowledge Systems in a collaborative and contextualized perspective, the research should be faced as a mutual learning practice. 相似文献
7.
Katsuo Tamaoka 《Reading and writing》2007,20(5):413-439
The present study investigated the effects of lexical homophony on the processing of Japanese two-kanji compound words. Experiment
1 showed that participants took longer to perform lexical decisions for words with a high degree of lexical homophony than
those with no homophony. Interestingly, the same inhibitory trend was found in the naming task of Experiment 2. Participants
took longer to name words with a high degree of lexical homophony than those with no homophony. The consistency of an inhibitory
effect through the two experiments suggests that during naming and lexical decisions for Japanese two-kanji compound words,
an orthographic representation activates the phonological representation, which then leads to a rebounding activation of orthographic representations of homophonic forms. 相似文献
8.
The present study investigated the way in which the activation of semantic representations at the morpheme level affects the processing of two-kanji (morpheme) compound words. Three types of Japanese two-kanji compound words were used as stimulus items: (1) words consisting of two kanji representing opposite concepts (e.g., long + short = length), (2) words consisting of two kanji representing similar concepts (e.g., soft + flexible = pliable), and (3) control words consisting of two closely bound kanji (e.g., wild + field = wilderness). Words consisting of kanji of opposite concepts (M = 768 ms for LD and M = 645 ms for naming) were processed more slowly for lexical decision, but not for naming, than words with kanji of similar concepts (M = 743 ms for LD and M = 636 ms for naming), both of which were, furthermore, processed more slowly for lexical decision and naming than the control compound words (M = 716 ms for LD and M = 590 ms for naming). These results were explained in the framework of the multiple-level interactive-activation model as follows. Because kanji morphemes of opposite and similar concepts are semantically activated both as morpheme units and compound word units, semantic representations of the two morphemes and the compound word which they create compete with each other at the concept level, which slows down lexical decision and naming of the compound word. 相似文献
9.
Detailed time-series of the resultant joint moments and segmental interactions during soccer instep kicking were compared between the preferred and non-preferred kicking leg. The kicking motions of both legs were captured for five highly skilled players using a three-dimensional cinematographic technique at 200 Hz. The resultant joint moment (muscle moment) and moment due to segmental interactions (interaction moment) were computed using a two-link kinetic chain model composed of the thigh and lower leg (including shank and foot). The mechanical functioning of the muscle and interaction moments during kicking were clearly illustrated. Significantly greater ball velocity (32.1 vs. 27.1 m . s(-1)), shank angular velocity (39.4 vs. 31.8 rad . s(-1)) and final foot velocity (22.7 vs. 19.6 m . s(-1)) were observed for the preferred leg. The preferred leg showed a significantly greater knee muscle moment (129.9 N . m) than the non-preferred leg (93.5 N . m), while no substantial differences were found for the interaction moment between the two legs (79.3 vs. 55.7 N . m). These results indicate that the highly skilled soccer players achieved a well-coordinated inter-segmental motion for both the preferred and non-preferred leg. The faster leg swing observed for the preferred leg was most likely the result of the larger muscle moment. 相似文献
10.
Shinya Sano Yasuo Ikegami Hiroyuki Nunome Tommy Apriantono Shinji Sakurai 《Journal of sports sciences》2013,31(4):381-391
Abstract A new method was established for the continuous measurement of force applied from a springboard to a gymnast in vaulting (board reaction force). Male gymnasts performed a handspring vault using a springboard mounted on force platforms. A high-speed video camera sampled the springboard motion at 500 Hz. The springboard was initially partitioned into 29 segments. The force due to the accelerative motion of the springboard was determined by summing the forces of the individual segments. The board reaction force acting on the gymnast was calculated by subtracting the force due to the accelerative motion of the springboard and weight from the force recorded by the force platform. The new method succeeded in illustrating transient changes of the board reaction force. The horizontal and vertical components of the peak values of the board reaction force were three and two times greater respectively than the average values. A series of tests was conducted to determine whether the number of segments of the springboard model could be reduced without affecting accuracy. A model consisting of only four segments produced almost the same accuracy as the 29-segment model. The simplified model is recommended as a more efficient method to measure board reaction force. 相似文献