Genetic Polymorphism of Angiotensin II Type 1 Receptors and Their Effect on the Clinical Outcome of Captopril Treatment in Arab Iraqi Patients with Acute Coronary Syndrome (Mid Euphrates)     

Fadhaa A. Ghafil  Bassim I. Mohammad  Hussain S. Al-Janabi  Najah R. Hadi  Hayder A. Al-Aubaidy 《Indian journal of clinical biochemistry : IJCB》2021,36(1):81

Genetic variation in the angiotensin II type 1 receptor (AT1R) has an important effect on the outcome of acute coronary syndrome (ACS) initiated treatment with captopril. This study aims to investigate the impact of genetic polymorphism of AT1R (rs5186 and rs275651) on the ACS outcome in Iraqi patients treated with captopril. A total of 250 Iraqi individuals with ACS were included in this case—control study and they were divided into two study groups; Study group 1 included 125 participants who were prescribed captopril, 25 mg twice daily and study group 2 included 125 participants who received no captopril as part of their ACS treatment (control study). The AT1R gene (rs5186) CC genotype was found to be associated with ST-elevation myocardial infarction (STEMI) (Odd’s ratio (O.R) = 1.2, P = 0.7), while AC was associated with Non-ST-elevation myocardial infarction (NSTEMI) and unstable angina (UA) (O.R = 1.2, P = 0.8). AC genotype is more prone to have Percutaneous coronary intervention (PCI) after ACS attack (O.R = 1.2, P = 0.6). CC genotype had a risk to get less improvement (O.R = 1.6, P = 0.5), so might require higher doses of captopril during acute coronary insult. The AT1R gene (rs275651) AA genotype was associated with UA (O.R = 1.3, P = 0.9). AA and AT genotypes were more prone to have PCI after ACS attack (O.R = 3.9 P = 0.2, O.R = 3.5, P = 0.3 respectively) and thus requiring higher doses of captopril. We conclude that the AT1R rs5186, rs275651 genetic polymorphisms might partially affect the clinical outcome of ACS patients treated with captopril and might have captopril resistance which requires higher doses.  相似文献   

Validity and reliability of a linear positional transducer across commonly practised resistance training exercises     

Harry F. Dorrell  Joseph M. Moore  Mark F. Smith  Thomas I. Gee 《Journal of sports sciences》2019,37(1):67-73

This study investigated the validity and reliability of the GymAware PowerTool (GPT). Thirteen resistance trained participants completed three visits, consisting of three repetitions of free-weight back squat, bench press, deadlift (80% one repetition maximum), and countermovement jump. Bar displacement, peak and mean velocity, peak and mean force, and jump height were calculated using the GPT, a three-dimensional motion capture system (Motion Analysis Corporation; 150 Hz), and a force plate (Kistler; 1500 Hz). Least products regression were used to compare agreeability between devices. A within-trial one-way ANOVA, typical error (TE; %), and smallest worthwhile change (SWC) were used to assess reliability. Regression analysis resulted in R² values of >0.85 for all variables excluding deadlift mean velocity (R² = 0.54–0.69). Significant differences were observed between visits 3-2 for bench press bar displacement (0.395 ± 0.055 m; 0.383 ± 0.053 m), and deadlift bar displacement (0.557 ± 0.034 m; 0.568 ± 0.034 m). No other significant differences were found. Low to moderate TE (0.6–8.8%) were found for all variables, with SWC ranging 1.7–7.4%. The data provides evidence that the GPT can be used to measure kinetic and kinematic outputs, however, care should be taken when monitoring deadlift performance.  相似文献   

中国竞技体育人力资源相关问题探讨   总被引：5，自引：0，他引：5  

肖林鹏  赵云宏  张兆青  骆意 《广州体育学院学报》2003,23(6):8-9

对竞技体育人力资源的概念、特点等问题进行了探讨：研究表明，竞技体育人力资源是指竞技体育发展所需人员的现实及潜在禀赋的总和。处于不同层次、不同领域的众多人员组成了竞技体育人力资源系统：竞技人力资源具有稀缺性、目标性、整体性及调控性等特点.  相似文献   

基于因果分析的AHP方法在运动员选材中的应用研究   总被引：6，自引：0，他引：6  

邵桂华  孙庆祝 《中国体育科技》2003,39(4):15-16

分析了AHP方法的特点 ,提出了可以克服其缺陷的基于因果分析的修正AHP方法 ,并将其运用于篮球运动员选材指标体系的确定和评估之中。  相似文献   

甘肃省大学生心理健康状况调查   总被引：4，自引：0，他引：4  

孟峰年 《中国体育科技》2003,39(3):38-39

运用问卷调查、文献资料调研和数理统计等方法 ,对甘肃省 9所高校的 94 3名男、女大学生进行了心理健康状况的调研分析 ,据此提出了若干建议。  相似文献   

我国职业篮球俱乐部运行管理中的法律问题研究   总被引：6，自引：0，他引：6  

于振峰  李晨峰  王传友  谢恩杰 《中国体育科技》2003,39(7):4-5

从职业篮球俱乐部的成立、我国职业篮球俱乐部的外部关系、与运动员有关的法律问题、与我国职业篮球俱乐部经营开发有关的法律法规以及关于体育纠纷的问题五个方面进行论述 ,寻求适合我国职业篮球俱乐部的发展道路  相似文献   

美国竞技体育"霸主"地位之透析   总被引：8，自引：0，他引：8  

赵云宏  张秀华 《中国体育科技》2003,39(10):60-62

通过查阅文献资料、访问调查、数理统计等方法 ,分析了美国参加奥运会以来的实力表现 ,在此基础上 ,对导致美国竞技体育霸主地位的因素——世界政治格局变化、西方文化精神、美国的社会分层结构、黑人的先天优势、高校竞技体育、发达的职业体育、科学化训练等进行了全面的论述 ,以为我国的竞技体育决策部门提供参考。  相似文献   

论高校体育教学改革中的若干问题   总被引：30，自引：0，他引：30  

苏训诚 《中国体育科技》2003,39(3):8-9

以我国高校大范围的样本调查入手 ,从多方位、多角度论证我国高校体育教学模式改革的有关问题。  相似文献   

中华人民共和国第10届冬季运动会冰壶比赛调研报告   总被引：8，自引：1，他引：7  

刘春华 《中国体育科技》2003,39(10):21-22

采用文献资料调研、数理统计、调查等方法 ,对参加第 10届冬运会各参赛队情况进行调研分析 ,根据我国冰壶运动的现状及发展趋势进行研究 ,找出目前存在的问题 ,并提出相关建议。  相似文献   

体育技术课教学中的测量与评价     

王亚斌 《体育科学研究》2001,5(3):50-52

体育技术的教学,是以身体素质为基础,运动能力和大脑思维为主导的复杂过程.应该遵循人体生长发育的规律,采取因势利导的原则,运用体育测量的科学性和体育评价的方法指导体育技术的教学.  相似文献