排序方式: 共有27条查询结果,搜索用时 20 毫秒
1.
M. Maneesh Sanjiba Dutta Amit Chakrabarti D M Vasudevan 《Indian journal of clinical biochemistry : IJCB》2007,22(1):138-142
Infertility is well-established harmful effect in chronic alcoholism and so far, there is no effective treatment for this
condition. The study was conducted to determine the effects of alpha tocopherol on ethanol induced testicular injuries in
male albino rats of Wistar strain. Five groups (n=6) of animals were used. Group I served as control. Group II received daily
1.6g ethanol/kg body weight/day for 4 weeks orally. Group III received 1.6g ethanol+80mg alpha tocopherol/kg body weight/day
for four weeks orally. Group IV received 1.6g ethanol/kg body weight for/day 4 weeks and followed by 80mg alpha tocopherol/kg
body weight/day for four weeks orally. Group V received 1.6g ethanol/kg body weight/day orally for 4 weeks, followed by 4
weeks abstinence. Twently-four hours after the last treatment the rats were sacrificed using anesthetic ether. Testes were
removed and used for the estimation of extent of lipid peroxidation and tissue levels of antioxidants and steroidogenic enzymes.
Alpha tocopherol treatment increased the activities of testicularΔ
5, 3β-HSD. Moreover, the treatment was also associated with significant decrease in testicular oxidative stress. Ethanol-induced
oxidative stress and decreased steroidogenesis can be reversed by treatment with alpha tocopherol. 相似文献
2.
In paper conservation ethanol is used as an antifungal agent. However, information on the antifungal efficacy of this alcohol is scarce and often inconsistent. In this study, we clarify if ethanol is effective and safe to use in paper conservation in the short as well as in the long term. None of the tested ethanol concentrations (5–100%) promoted conidia germination, but rather delayed or entirely inhibited it, depending on alcohol concentration and contact time. In a simulation of an interventive treatment of samples colonized by fungi, all the tested ethanolic solutions (30, 70, and 100%) revealed antifungal activity. The best results were obtained with 70% ethanol, showing fungicidal properties on four of the five-tested fungal species (Aspergillus niger, Cladosporium cladosporioides, Penicillium chrysogenum, and Penicillium corylophilum). No deleterious effects of 70% ethanol on the tested paper were observed either in the short or in the long term. 相似文献
3.
Chen Y Si JM Liu WL Cai JT Du Q Wang LJ Gao M 《Journal of Zhejiang University. Science. B》2007,8(9):632-637
Several models of experimental ulcerative colitis have been reported previously. However, none of these models showed the optimum characteristics. Although dextran sulfate sodium-induced colitis results in inflammation resembling ulcera-tive colitis, an obvious obstacle is that dextran sulfate sodium is very expensive. The aim of this study was to develop an inex-pensive model of colitis in rats. Sprague-Dawley rats were treated with 2% dextran sulfate sodium in drinking water for 3 d fol-lowed by an intracolonic administration of 30% ethanol. The administration of 2% dextran sulfate sodium followed by 30% ethanol induced significant weight loss, diarrhea and hematochezia in rats. Severe ulceration and inflammation of the distal part of rat colon were developed rapidly. Histological examination showed increased infiltration of polymorphonuclear leukocytes, lymphocytes and existence of cryptic abscesses and dysplasia. The model induced by dextran sulfate sodium at lower concentra-tion followed by 30% ethanol is characterized by a clinical course, localization of the lesions and histopathological features similar to human ulcerative colitis and fulfills the criteria set out at the beginning of this study. 相似文献
4.
Ramesh Chandra Ritu Aneja Charu Rewal Swati Bhowmik Sujata K. Dass Ritu Jain 《Indian journal of clinical biochemistry : IJCB》2000,15(2):141-147
In the current study, we report perturbations in hepatic, renal and splenic heme synthesis at the level of the rate limiting
enzyme, δ-amino levulinic acid synthase (ALA-S) on ethanol administration independently and in conjunction with iron-protoporphyrin
(FePP) in male Wistar rats. Excessive ethanol administration (5 ml/kg bw) resulted in a significant induction of hepatic,
splenic and renal ALA-S activity. Simultaneous administration of FePP (50 μmol/kg bw) reverted the observed induction response
to a sharp decline. The features of the action of ethanol and FePP togetherin vivo, i.e. a substantial inhibition of ALA-S is suggestive of the beneficial effects of this formulation in acute attacks of porphyria. 相似文献
5.
Parsunpriya Nayak Subir Kumar Das D. M. Vasudevan 《Indian journal of clinical biochemistry : IJCB》2006,21(2):53-57
Aluminum and alcohol, both are well-accepted neurotoxin. The plausible mechanisms for their neurotoxicity are also common.
Therefore, the effect of ethanol on aluminum induced biochemical changes in rat brain is being studied. In the present study,
ethanol exposure significantly affected the aluminum and protein content of brain. The activities of acid phosphatase and
alkaline phosphatase were also changed. Aluminum exposure, on the other hand, contributed significantly in the alterations
of aluminum content, acid phosphatase acivity and aspartate aminotransferase activity. Though ethanol co-exposure significantly
influenced the aluminum load of brain, the interactions of these two neurotoxins were found to be significant only in case
of acid phosphatase activity of brain. Therefore, it can be suggested that general neurotoxicity produced by aluminum is not
modified by ethanol. However, the aluminum load caused by aluminum exposure, may be influenced by ethanol co-exposure. 相似文献
6.
Subir Kumar Das Hiran K. R. Sukhes Mukherjee D. M. Vasudevan 《Indian journal of clinical biochemistry : IJCB》2007,22(1):99-104
Damaging effects of reactive oxygen species on living systems are well documented. They include oxidative attack on vital
cell constituents. Chronic ethanol administration is able to induce an oxidative stress in the central nervous system. In
the present study, 16–18 week-old male albino rats of Wistar strain were exposed to different concentration of ethanol for
4 weeks. This exposure showed profound effect on body weight. Ascorbic acid level; and activities of alkaline phosphatase
and aspartate transaminase in the brain are dependent on the concentration of ethanol exposure. Chronic ethanol ingestion
elicits statistically significant increase in thiobarbituric acid reactive substances level and decrease in gluatathione level
in the brain. It reduces superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase activities in a
dose dependent manner. However, histological examination could not reveal any pathophysiological changes. Therefore, we conclude
that biochemical alterations and oxidative stress related parameters respond early in alcoholism than the histopathological
changes in brain. 相似文献
7.
Maneesh Mailankot H. Jayalekshmi Amit Chakrabarti D. M. Vasudevan 《Indian journal of clinical biochemistry : IJCB》2009,24(1):94-97
To investigate reversibility of ethanol induced testicular injuries on treatment with L-ornithine-L-aspartate, male Wistar
rats were treated with ethanol (1.6g/kg b.wt/day) and L-ornithine- L-aspartate (200mg/kg b.wt/ day) for 4 weeks. L-ornithine-L-aspartate
effectively prevented the ethanol induced body and testes weight reduction; changes in testicular weight well correlated with
body weight. Drug exhibited an ability to counteract ethanol induced oxidative challenge as it effectively reduced testicular
TBARS and increased tissue ascorbic acid, GSH and activities of superoxide dismutase, catalase, GSH-Red and Se-GSH-Px. However
the drug didn’t show promising effect on inhibitory effect of ethanol on testicular D5, 3-beta and 17-beta HSD (hydroxy steroid
dehydrogenase). 相似文献
8.
Subir Kumar Das Sowmya Varadhan L. Dhanya Sukhes Mukherjee D. M. Vasudevan 《Indian journal of clinical biochemistry : IJCB》2008,23(4):341-344
After administration, ethanol and its metabolites go through the kidneys and are excreted into urine. The kidney seems to
be the only vital organ generally spared in chronic alcoholics. Therefore, we investigated the multiple effects of chronic
ethanol exposure on renal function tests and on oxidative stress related parameters in the kidney. Chronic ethanol (1.6 g
ethanol/ kg body weight/ day) exposure did not show any significant change in relative weight (g/ 100g body weight) of kidneys,
serum calcium level or glutathione s-transferase activity. However, urea and creatinine concentration in serum, and TBARS
level in kidney elevated significantly, while reduced glutathione content and activities of glutathione peroxidase, glutathione
reductase and superoxide dismutase diminished significantly after 12 weeks of ethanol exposure. Catalase activity showed increased
activity after 4 weeks of ethanol exposure and decreased activity after 12 weeks of ethanol exposure. Genesis of renal ultrastructural
abnormalities after 12 weeks of ethanol exposure may be important for the development of functional disturbances. This study
revealed that chronic ethanol exposure for longer duration is associated with deleterious effects in the kidney. 相似文献
9.
MAIGA Abdoulaye Siddeye CHEN Guang-ming WANG Qin 《浙江大学学报(A卷英文版)》2007,8(2):216-220
INTRODUCTION In the past few decades, adsorption processes have been used exclusively for gas separation and purification purposes. It is only recently that this phenomenon has been exploited to produce cooling and heating. As regulations aiming at phasing out the CFCs are being implemented, thermally driven sorp-tion refrigeration machines are emerging as an at-tractive alternative to electrical vapor compression machines that produce no harmful effect on the en-vironment since their w… 相似文献
10.
Wei-xing Chen Chuan-qin Xu Shao-hua Chen Gen-yun Xu Huai-zhuang Ye 《Journal of Zhejiang University. Science. B》2012,13(5):395-401
Event-related potential (ERP) is a reliable neuroelectric measure of brain activity that helps to confirm the assessment of
mental status and cognitive impairment. Many studies have reported that alcoholics show a significantly lower ERP P300 amplitude
than the norm. In the present study, ERP P300 waves were measured to evaluate the effect of citric acid on cognitive function
during excessive alcohol consumption in healthy adults. Five volunteers were selected through clinical interview, physical
examination, and psychiatric assessment for participation in this study. In a double-blind placebo-controlled before-after
design, each subject was treated with 5 ml/kg body weight alcohol, 5 ml/kg body weight alcohol and 1 mg citric acid, or a
placebo on three separate occasions, one week apart. ERP P300, blood biochemical indicators, blood alcohol concentrations
(BACs) and acetaldehyde concentrations were assessed. Repeated measure analysis of variance (ANOVA) with a within-subjects
factor was used to evaluate differences in blood biochemical indicators, BACs, blood acetaldehyde concentrations, and ERP
P300 in the three sessions of assessments. Several blood biochemical indicators showed significant differences between treatments,
including the levels of cholinesterase (CHE), total bile acid (TBA), triglyceride (TG), total cholesterol (TC), high-density
lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), very low-density lipoprotein cholesterol (VLDL-C),
and glycylproline dipeptidyl aminopeptidase (GPDA). BACs after consumption of alcohol alone or citric acid with alcohol were
significantly higher compared to those after placebo treatment (P<0.05). There were no significant differences in blood acetaldehyde concentrations between the treatments. The P300 amplitudes
on the frontal (Fz), central (Cz), and parietal (Pz) regions of the scalp after consumption of alcohol were significantly
lower than those after consumption of the placebo or citric acid with alcohol (P<0.05), while there were no significant differences between the latter two treatments. The results of this study suggest that
citric acid could reduce the decline in ERP P300 amplitude and cognitive ability induced by acute alcohol consumption. It
may also affect some blood biochemical indicators, but the specific mechanisms need further research. 相似文献