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R Abraham M Joseph John R Calton J Dhanoa 《Indian journal of clinical biochemistry : IJCB》2006,21(1):95-100
Homocysteine(Hcy) has been implicated as a novel risk factor of Coronary Artery Disease (CAD) among Asian Indians, but many
studies done in India failed to reveal any direct correlation. It has also been reported that Folic acid and Vitamin B12 levels
inversely affect serum levels of homocysteine. In this study, we looked at the levels of homocysteine among patients with
CAD. The effect of Vitamin B12, Folate and other risk factors on homocysteine levels were also evaluated. Mean homocysteine
levels in cases (22.81±13.9, n=70) were significantly higher (p=<0.001) than the controls (7.77±7.3, n=70). However no statistically
significant correlation could be deduced between homocysteine Vitamin B12, and Folate. Cumulative analysis have indicated
an increase in homocysteine levels among patients with CAD with every additional risk factor. 相似文献
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The level of serum cholesterol (Ch), serum-high density lipoprotein cholesterol (HDLc), serum-low density lipoprotein cholesterol
(LDLc), serum very low density lipoprotein cholesterol (VLDLc), Triglyceride (Tg), Apolipoprotein A-1, B and ratio of Apolipoprotein
A1/B were observed in 151 survivors of myocardial infarction in different age groups. A significant increase was found in
the level of triglyceride, LDLc, apolipoprotein-B and a significant decrease in apolipoprotein-A1 and the ratio of apolipoprotein
A1/B. No significant alteration was found in serum cholesterol, HDLc except in the age group of 31–40 years and 41–50 years
and VLDLc. Thus, serum Apo A-1 and Apo-B may be considerably better markers for coronary artery disease than traditional lipid
parameters. 相似文献
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Javad Mohiti Mostafa Behjati Mohammad H. Soltani Ali Babaei 《Indian journal of clinical biochemistry : IJCB》2004,19(1):113-117
Measurement of cardiac markers is an index of care standard in the assessment and diagnosis of cardiovascualr disease. Two
of the major cardiac markers are Creatine Kinase isoenzyme CK-MB and Troponin T, which are extensively used in the diagnosis
of heart disease. The release of Troponin T and creatine kinase isoenzyme (CK-MB) was investigated in 50 coronary artery bypass
surgery patients. Measurement of plasma samples was carried out at five different time points, namely before surgery, 1,6,12,24
hours after surgery. The results indicated that CK-MB level were increased by a factor more than four times compared with
the upper limit of baseline (befor surgery). Troponin T concentration showed more than six fold over the upper limit of baseline
(before surgert) at 1,6,12,24 hours after surgery. In order to assess the significance of the length of the surgical procedure
on the release of Troponin T and CK-MB, the surgery patient were divided into two groups according to the length of the surgical
procedure: group I was selected on the basis that the surgical procedure they underwent lasted above 90 minutes and group
II with a surgical procedure below 90 minutes. Both Troponin T and CK-MB showed a significant increase in-group I compared
to group II. To investigate the likelihood that this effect is party due to myocardial infarction during surgery, the patients
were divided into two groups: Group A with some sings of myocardial infarction on Q wave of ECG and group B without any change.
The results showed approximately a two-fold increase of these markers in-group A compared to group B. Since these markers
reach into blood following damage to myocardial their increase in patients with time course surgery of more than 90 minutes
and those with a probability of MI during operation, indicating that these patient fall into a high risk group of repeat (MI)
after surgery. 相似文献
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Harish Rao B V. Govindaraju C. N. Manjunath 《Indian journal of clinical biochemistry : IJCB》2007,22(1):18-21
Majority of patients who experience a Coronary Heart disease event have one or more of the conventional risk factors for atherosclerosis
and so do many people who have not yet experienced such an event. Thus predictive models based on conventional risk factors
have lower than the desired accuracy, providing a stimulus to search for new factors to predict accurately the risk of CHD.
In this regard newer risk factors like homocysteine, Lp(a), insulin resistances are the important ones and are called as ‘novel
risk factors’. The study was undertaken to find the prediction of CHD risk by homocysteine in comparison with other conventional
risk factors. The data obtained suggests a very high sensitivity, specificity and accuracy with above 90% positive prediction
value for homocysteine in CHD patients when compared to commonest conventional risk factors. 相似文献
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He H Huang JQ Ping FY Chen GF Zhang SZ 《Journal of Zhejiang University. Science. B》2007,8(10):704-708
Objective: Microcapsule chemoembolism is a promising treatment of tumors. We describe a deep lingual arterial embolization of tongue carcinoma with microcapsuled carboplatinum. Methods: Lingual artery cast specimens from cadavers were microscopically examined, and 78 patients with tongue cancer were recruited and treated with the deep lingual arterial embolization therapy. Results: Microcapsule embolism occurred approximately at the fifth or sixth level of the deep lingual artery branches. The five-year survival rate was 88.5% (69 out of 78), and the ten-year survival rate 52.6% (41 out of 78). Conclusion: The deep lingual arterial embolization of tongue carcinoma with microcapsuled carboplatinum is an effective therapy to treat carcinoma in mid-margin or mid-body of the tongue. 相似文献
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