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Infection with hepatitis C virus (HCV) affects approximately 170 million people worldwide. However, no vaccine or immunoglobulin
is currently available for the prevention of HCV infection. The standard of care (SOC) involving pegylated interferon-α (PEG-IFN
α) plus ribavirin (RBV) for 48 weeks results in a sustained virologic response in less than 50% of patients with chronic hepatitis
C genotype 1, the most prevalent type of HCV in North America and Europe. Recently, reliable in vitro culture systems have
been developed for accelerating antiviral therapy research, and many new specifically targeted antiviral therapies for hepatitis
C (STAT-C) and treatment strategies are being evaluated in clinical trials. These new antiviral agents are expected to improve
present treatment significantly and may potentially shorten treatment duration. The aim of this review is to summarize the
current developments in new anti-HCV drugs. 相似文献
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[目的/意义] 对科学研究成果与专利技术创新之间知识扩散和交叉融合发展态势的剖析，是学科领域布局、研发投入及科技资源配置等工作的重要决策依据。现有研究的测度指标未能详尽反映科技关联关系的特征及演变规律，通过设计新的指标，提出聚焦演变态势分析的领域科技关联关系测度指标及方法。[方法/过程] 通过对现有测度指标进行分析归纳，将单一的科学关联度和/或关联时滞指标扩展为紧密性、时效性、多样性三个方面分层次的测量指标，从而较全面地揭示和发现科技关联的程度及特征规律。[结果/结论] 利用本文构建的测度指标对HCV研究领域进行了计算和讨论，揭示出了该领域科技关联发展态势，并体现了新指标在测度维度系统性上的优势以及其结论对专利技术研发活动的参考价值。 相似文献
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2020年的诺贝尔生理学或医学奖授予了在发现丙肝病毒(HCV)方面作出突出贡献的哈维·阿尔特(Harvey J. Alter)、迈克尔·霍顿(Michael Houghton)和查尔斯·赖斯(Charles M. Rice)。然而,从1989年霍顿捕获HCV到1997年赖斯证明HCV能引发肝炎,间隔了8年时间。这看似一步之遥的距离何以耗时如此之久?文章通过回顾文献,对这一时期的研究脉络进行了梳理,明确了包括赖斯团队在内的不同研究者对于推进HCV相关认识所作的具体贡献。同时,针对研究过程中的两个关键节点——病毒RNA基因组3′末端的准确测序和感染性分子克隆的建立,文章从技术储备、路径依赖和目标定位的角度分析了赖斯团队为何能在科学研究竞争中拔得头筹。 相似文献
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目的:研究与丙型肝炎病毒(HCV)基因RNA序列同源的人染色体外环状DNA(eccDNA)序列.创新点:首次从HCV阴性者eccDNA中检测到HCV 5’-非编码区(5’-NCR)基因组RNA序列,验证了我们的假设: HCV同源DNA序列存在于人的外周血单核细胞的eccDNA组分中.方法:用分离的eccDNA进行HCV特异的聚合酶链反应(PCR),采用核苷酸序列同源性搜索分析软件(BLASTn)对测序结果进行比对分析,并检测其甲基化模式.结论:实验结果证实了我们的假设:即部分HCV 5’-NCR基因组RNA序列存在于外周血单核细胞的eccDNA组分.同时,甲基化分析结果显示了个体间的甲基化模式所代表的受遗传调控的表观遗传特征. 相似文献
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张年凤 《岳阳职业技术学院学报》2011,26(1):94-97
丙型病毒性肝炎由丙型肝炎病毒感染所致。HCV感染呈全球性分布,我国是高流行地区,其所具有较高的慢性化程度使之成为威胁人类健康的重要疾病。近年来,报道了很多丙型肝炎病毒的相关研究,本文主要讨论HCV包膜蛋白的结构、免疫状况及疫苗研究实验模型的相关研究。 相似文献
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Emad F. Eskander Ahmed A. Abd-Rabou Mervat S. Mohamed Shaymaa M. M. Yahya Olfat G. Shaker 《Indian journal of clinical biochemistry : IJCB》2012,27(4):344-350
The main objective of the current study is to examine the role of the statistical relation between BCL2 gene (Ala43Thr) single nucleotide polymorphism and growth hormone (GH1) levels in Egyptian HCV genotype-4 patients before and after treatment with pegylated interferon plus ribavirin. Eighty patients with HCV genotype-4 and 40 healthy volunteers as controls were enrolled in the prospective study. Gene polymorphism of BCL2 (Ala43Thr) using PCR-RFLP technique and GH1 concentrations using ELISA procedure were measured for all patients and controls. The present study resulted that Responder HCV genotype-4 Patients, with BCL2 43Ala genotype, have high significant increase in pre-treatment GH1 levels (>1 ng/ml); which represent normal levels, as compared to non-responders pre-treatment GH1 levels (<1 ng/ml); which represent low concentrations. We concluded that HCV genotype-4 patients who have normal GH1 concentrations and BCL-2 43Ala genotype can successfully achieve response to interferon based therapy. 相似文献
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