| 卡铂壳聚糖/葡甘聚糖复合微球的制备及其性能测试 |
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| 引用本文： | 王碧,吴春燕,赵兵,崔秋兵.卡铂壳聚糖/葡甘聚糖复合微球的制备及其性能测试[J].内江师范学院学报,2007,22(4):57-60. |
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| 作者姓名： | 王碧 吴春燕 赵兵 崔秋兵 |
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| 作者单位： | 1. 内江师范学院,化学与生命科学系,内江,四川,641112
2. 四川大学华西医院骨科,四川,成都,610041 |
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| 基金项目： | 四川省科技厅应用基础项目.项目编号:04JY029-022 |
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| 摘 要： | 以液体石蜡作连续相,Span-80作乳化剂,以戊二醛为交联剂,在W/O型乳化体系中制备一种新型微球—卡铂壳聚糖/葡甘聚糖复合微球,探讨了制备工艺条件对微球形状性能的影响;通过显微镜观察,药物包裹率测定,药物释放量检测等分析了微球特性,评价了微球中卡铂的缓释性能.结果表明:制备的复合微球球形良好,球体表面光滑,微球中卡铂的包封率为39.13%,微球中的卡铂在生理盐水中具有一定缓释性能.
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| 关 键 词： | 卡铂 壳聚糖 葡甘聚糖 复合微球 制备工艺 缓释性能 |
| 文章编号： | 1671-1785（2007）04-0057-04 |
| 修稿时间： | 2007-02-27 |
Preparation and Property Characterization of Card Platinum-Chitosan-Konjac Glucomannan Composite Microspheres |
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| WANG Bi,WU Chun-yan,ZHAO Bing,CUI Qiu-bing.Preparation and Property Characterization of Card Platinum-Chitosan-Konjac Glucomannan Composite Microspheres[J].Journal of Neijiang Teachers College,2007,22(4):57-60. |
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| Authors: | WANG Bi WU Chun-yan ZHAO Bing CUI Qiu-bing |
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| Abstract: | Card platinum-chitosan-konjac glucomannan composite microspheres were prepared in a W/O system in which liquid proffin was used as a solvent,span-80 as an emulsifier and glutaradehyde as a crosslinking agent.The properties of the microspheres were also characterized by applying microscope and analyzing the embedding and release rates of a drug,In addition,the release of card platinum in the microspheres was determined.The microspheres showed good shape and smooth surface under microscope.The card platinum embedded rate was 39.13% in the microspheres.Card platinum in the microspheres demonstrated controlled release in normal saline. |
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| Keywords: | Card platinum chitosan konjac glucomannan composite microsphere preparative process slow-release Preparation |
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