| 乳化剂对壳聚糖微球形成的影响 |
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| 引用本文： | 何强芳.乳化剂对壳聚糖微球形成的影响[J].广东教育学院学报,2005,25(3):67-70. |
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| 作者姓名： | 何强芳 |
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| 作者单位： | 广东教育学院化学系，广东广州510303 |
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| 摘 要： | 以壳聚糖溶液为分散相，戊二醛为交联剂，真空泵油和石蜡油相混合为连续相，通过油包水乳液分散-化学交联法制备医药载体壳聚糖微球．研究了乳化剂的种类和浓度对壳聚糖微球性状和形态的影响．实验结果表明，乳化剂的种类和浓度对微球的形成影响很大．在Span-80和硬脂酸镁以质量比3：1相复合为乳化剂及总乳化剂浓度在10～20g／L的条件下，所获得的微球球形规整，分散性好，粒径分布在1～5μm之间．
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| 关 键 词： | 壳聚糖 乳化剂 微球 |
| 文章编号： | 1007-8754(2005)03-0067-04 |
| 修稿时间： | 2005年3月9日 |
The Influence of Emulsifers on the Formation of Chitosan Microspheres |
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| HE Qiang-fang.The Influence of Emulsifers on the Formation of Chitosan Microspheres[J].Journal of Guangdong Education Institute,2005,25(3):67-70. |
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| Authors: | HE Qiang-fang |
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| Abstract: | Chitosan microspheres were prepared by emulsion-dispersed chemical-crosslinking method and by using glutaradelhye as crosslinking agent, vacuum-pump oil and paraffin oil mixture as oil phase. The influence of emulsifers on the formation of chitosan microspheres was investigated. The results show that kinds and concentration of emulsifers affect the formation of chitosan microspheres. Under conditions of span-80 and magnesium stearate mixture with mass ration 3:1 as emulsifier, and the total concentration of emulsifier ranged from 10 g/L to 20 g/L, chitosan microspheres are gained with good spherical shape and diameters ranged from 1 m to 5 m. |
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| Keywords: | chitosan emulsifers microspheres |
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