共查询到20条相似文献，搜索用时 156 毫秒
1.
发现了具有逆光致变色性质的螺吡喃类化合物的结构特点,即在吲哚啉氮上连有极性基团,同时和吡喃环并连的芳环上具有强的吸电子基团.设计并合成了逆光致变色化合物1’-(2-羟乙基)-3’,3’-二甲基-6-硝基螺[吲哚啉-2,2’[2H-1]苯并吡喃].实验表明,用它配制成的逆光致变色油墨显示有很好的色度和耐疲劳度. 相似文献
2.
研究替米沙坦中间体2-正丙基-4-甲基-6-(1’-甲基苯并咪唑-2-基)苯并咪唑(1)的合成工艺，并进行了改进与优化。以丁亚氨酸乙酯盐酸盐（2）为起始原料，与4-氨基-3-甲基苯甲酸（3）反应生成4-丁眯基-3-甲基苯甲酸（4）,4经次氯酸钠溶液处理环合，生成2-正丙基-4-甲基-6-羧基苯并咪唑（5）,5与亚硫酰氯反应生成2-正丙基-4-甲基苯并咪唑-6-酰氯（6）,6与N-甲基邻苯二胺盐酸盐（7）发生亲核、环合反应最终得到替米沙坦关键中间体2-正丙基-4-甲基-6-(1’-甲基苯并咪唑-2-基)苯并咪唑(1)，目标产物1总收率72.14%，纯度99%。优化后工艺路线短，反应条件温和，适合工业化生产。 相似文献
3.
《赣南师范学院学报》2021,(6):43-48
以D-葡萄糖为起始原料,经4步反应,合成了2种氮杂环卡宾吡啶配位钯络合物[1-(2,3,4,6-四-O-乙酰基-β-D-吡喃葡萄糖基)-3-甲基-咪唑啉-2-亚基-溴化钯(II)-吡啶和1-(2,3,4,6-四-O-乙酰基-β-D-吡喃葡萄糖基)-3-正丁基-咪唑啉-2-亚基-溴化钯(II)-吡啶].这两种结构新颖的钯络合物,在水溶液中能够快速催化Suzuki偶联反应,仅使用0.05 mol%催化剂用量,就能取得优异的收率. 相似文献
4.
5.
本文合成了一个新的化合物C39H44N8O10:(NIT-1′-MeBzIm)2.(H3bta)(NIT-1′-MeBzIm=2-{2′-[(l′-甲基)苯并咪唑]}-4,4,5,5-四甲基咪唑啉-3-氧化-1-氧基自由基,H3bta=1,2,4-苯三酸),并测定了其晶体结构.该晶体属三斜晶系,P1空间群,晶胞参数:a=7.372(12),b=8.705(15),c=15.65(3),α=100.81(3)°,β=97.47(3)°,γ=101.55(2)°,V=952(3)3,Z=1,Dc=1.369 mg/m3,最终偏差因子R1=0.1047,WR2=0.2650(I>2σ(I)),F(000)=414.该化合物通过分子间氢键和π-π堆积作用形成二维网状结构. 相似文献
6.
采用H R-15型静态氧弹热量计测量了N,N'-双[(1-苯基-3-甲基-5-氧-4-吡唑啉基)-2-次乙基]-邻苯基二胺完全燃烧的恒容燃烧热,并根据热化学方程式和盖斯定律计算出其标准摩尔燃烧焓△cHmθ为-7 727.914 kJ/mol,标准摩尔生成焓△fHmθ为-8 061.916 kJ/mol,为进一步研究吡唑啉酮双席夫碱类化合物的生理、药理活性的作用机理提供了一些理论基础. 相似文献
7.
本文合成了一个新的配合物:[Mn(NIT-1'-MeBzIm)3](ClO4)2CH3CH2OH(NIT-1'-MeBzIm=2-{2'-[(l'-甲基)苯并咪唑]}-4,4,5,5-四甲基咪唑啉-3-氧化-1-氧基自由基),并测定了其晶体结构.该晶体属单斜晶系,P2(1)/c空间群,晶胞参数:a=18.349(5)A,b=21.761(6),c=14.721(4),α=90°,β=97.447(5)°,γ=90°,V=5828(3)A3,Z=4,Dc=1.324 g/cm3,最终偏差因子R1=0.1945,wR2=0.5138(I>2σ(I)),F(000)=2432.X衍射结构分析表明,中心金属Mn(II)离子与三个自由基螯合配位,形成六配位的畸变八面体构型. 相似文献
8.
曾国平 《湖北第二师范学院学报》2008,25(8):29-31
首先利用二烯酮与甲胺溶液作用制得哌啶酮,然后利用Gewald反应使哌啶酮、氰乙酸乙酯与硫磺在吗啡啉催化下,合成2-氨基四氢吡啶并噻吩衍生物,最后再与三苯基膦、六氯乙烷在无水三乙胺存在下,合成2-膦亚胺基-6-甲基-3-乙氧羰基-5,7-二苯基-4,5,6,7-四氢吡啶并噻吩,产率80%。其结构由1H NMR,MS,元素分析所确证。 相似文献
9.
首先利用二烯酮与甲胺溶液作用制得哌啶酮,然后利用Gewald反应使哌啶酮、氰乙酸乙酯与硫磺在吗啡啉催化下,合成2-氨基四氢吡啶并噻吩衍生物,最后再与三苯基膦、六氯乙烷在无水三乙胺存在下,合成2-膦亚胺基-6-甲基-3-乙氧羰基-5,7-二苯基-4,5,6,7-四氢吡啶并噻吩,产率80%.其结构由1H NMR,MS,元素分析所确证. 相似文献
10.
首先利用二烯酮与甲胺溶液作用制得哌啶酮,然后利用Gewald反应使哌啶酮、氰乙酸乙酯与硫磺在吗啡啉催化下,合成2-氨基四氢吡啶并噻吩衍生物,最后再与三苯基膦、六氯乙烷在无水三乙胺存在下,合成2-膦亚胺基-6-甲基-3-乙氧羰基-5,7-二苯基-4,5,6,7-四氢吡啶并噻吩,产率80%。其结构由1H NMR,MS,元素分析所确证。 相似文献
11.
James P. McDaniel 《Quarterly Journal of Speech》2013,99(1):48-66
This essay attempts to counter the dreariness of postmodern critique and culture by locating the vital force of phantasy, rhetoric, argument, hope, and memory in contemporary public affairs. More particularly, it engages recent controversies about collective memory and the FDR memorial statue especially to generate a greater sensitivity to the fact that we are agents (and not just dupes) of history. The body, symbolic and material, is a core site for the history, theory, and practice of democracy, I argue, and is the hard kernel of collective identification and division. Methodologically, the essay fuses Aristotle and Lacan's ideas about phantasy as a perceptual device, which gages and creates public and personal desire, as an analytic frame for the study of public discourse. 相似文献
12.
Femke Bannink Koenraad Stroeken Richard Idro Geert van Hove 《International Journal of Disability, Development & Education》2015,62(2):182-201
This article describes the findings of a qualitative study on knowledge, beliefs, attitudes, and practices towards children with spina bifida and hydrocephalus in four regions of Uganda. Focus group discussions and semi-structured interviews were held with parents of children with spina bifida and hydrocephalus, policy-makers, and service providers. Our findings describe how negative knowledge, beliefs, attitudes, and practices create barriers to treatment and inclusion of children with spina bifida and hydrocephalus and their parents in Uganda. The findings show how knowledge, beliefs, attitudes, and practices evolve over time, are both similar and differ in the various regions, and become more conducive towards accessing treatment and achieving inclusion. Sensitisation and early intervention including parents and service providers in dissemination of knowledge, rehabilitative care to set the trend for positive change and support, as well as longitudinal studies of children with spina bifida and hydrocephalus and their parents are recommended. 相似文献
13.
《British Journal of Educational Studies》2001,49(2):213-238
Books reviewed:
Richard Edwards and Robin Usher, Globalisation and Pedagogy: Space, place and identity
Jackie Brine, Educating Women: Globalizing Inequality
David Carr, Professionalism and Ethics
Andrew Pollard and Ann Filer, The Social World of Pupil Career: Strategic Biographies through Primary School
Bernard Crick, Essays on Citizenship
Mike Bottery and Nigel Wright, Teachers and the State: Towards a Directed Profession
Stephen Heathorn, For Home, Country and Race: Constructing Gender, Class and Englishness in the Elementary School 1880-1914
Jane M. Page, Reframing the Early Childhood Curriculum: Educational Imperatives for the Future
Leslie P. Steffe and Patrick W. Thompson (eds), Radical Constructivism in Action
Patricia Broadfoot, Marilyn Osborne, Clare Planel and Keith Sharpe, Promoting Quality in Learning – Does England have the Answer?
Claire Cameron, Peter Moss and Charlie Owen, Men in the Nursery: Gender and Caring Work
Mike Cole (ed), Education, Equality and Human Rights
R. Alexander, P. Broadfoot and D. Phillips, Learning from Comparing: New Directions in Comparative Educational Research , Volume 1 Contexts, Classrooms and Outcomes
OECD, Learning to Bridge the Digital Divide 相似文献
Richard Edwards and Robin Usher, Globalisation and Pedagogy: Space, place and identity
Jackie Brine, Educating Women: Globalizing Inequality
David Carr, Professionalism and Ethics
Andrew Pollard and Ann Filer, The Social World of Pupil Career: Strategic Biographies through Primary School
Bernard Crick, Essays on Citizenship
Mike Bottery and Nigel Wright, Teachers and the State: Towards a Directed Profession
Stephen Heathorn, For Home, Country and Race: Constructing Gender, Class and Englishness in the Elementary School 1880-1914
Jane M. Page, Reframing the Early Childhood Curriculum: Educational Imperatives for the Future
Leslie P. Steffe and Patrick W. Thompson (eds), Radical Constructivism in Action
Patricia Broadfoot, Marilyn Osborne, Clare Planel and Keith Sharpe, Promoting Quality in Learning – Does England have the Answer?
Claire Cameron, Peter Moss and Charlie Owen, Men in the Nursery: Gender and Caring Work
Mike Cole (ed), Education, Equality and Human Rights
R. Alexander, P. Broadfoot and D. Phillips, Learning from Comparing: New Directions in Comparative Educational Research , Volume 1 Contexts, Classrooms and Outcomes
OECD, Learning to Bridge the Digital Divide 相似文献
14.
《British Journal of Educational Studies》1997,45(1):83-116
Buckingham, David Moving Images: Understanding Children's Emotional Responses to Television
Aldrich, Richard (ed) In History and in Education: Essays presented to Peter Gordon
Kohli, Wendy (ed) Critical Conversations in Philosophy of Education
Griffiths, Morwenna Feminisms and the Self: the web of identity
Fryer, Marilyn Creative Teaching and Learning
Atkinson, Paul; Davies, Brian and Delamont, Sara (eds) Discourse and Reproduction: Essays in Honour of Basil Bernstein
Slee, Roger Changing Theories and Practices of Discipline
Woods, Peter and Jeffrey, Bob Teachable Moments: The Art of Teaching in Primary Schools
Best, Ron (ed) Education, Spirituality and the Whole Child
Bassey, Michael Creating Education Through Research
Higham, Jeremy; Sharp, Paul and Yeomans, David The Emerging 16–19 Curriculum: Policy and Provision
Bruner, Jerome The Culture of Education
Halsall, Rob and Cockett, Mike (eds) Education and Training: Chaos or Coherence
McBride, Rob (ed) Teacher Education Policy
Wideen, Marvin F. and Grimmett, Peter P. (eds) Changing Times in Teacher Education
Nixon, Jon; Martin, Jane; McKeown, Penny and Ranson, Stewart Encouraging Learning: towards a theory of the learning school
Gewirtz, Sharon; Ball, Stephen, J. and Bowe, Richard Markets, Choice and Equity in Education 相似文献
Aldrich, Richard (ed) In History and in Education: Essays presented to Peter Gordon
Kohli, Wendy (ed) Critical Conversations in Philosophy of Education
Griffiths, Morwenna Feminisms and the Self: the web of identity
Fryer, Marilyn Creative Teaching and Learning
Atkinson, Paul; Davies, Brian and Delamont, Sara (eds) Discourse and Reproduction: Essays in Honour of Basil Bernstein
Slee, Roger Changing Theories and Practices of Discipline
Woods, Peter and Jeffrey, Bob Teachable Moments: The Art of Teaching in Primary Schools
Best, Ron (ed) Education, Spirituality and the Whole Child
Bassey, Michael Creating Education Through Research
Higham, Jeremy; Sharp, Paul and Yeomans, David The Emerging 16–19 Curriculum: Policy and Provision
Bruner, Jerome The Culture of Education
Halsall, Rob and Cockett, Mike (eds) Education and Training: Chaos or Coherence
McBride, Rob (ed) Teacher Education Policy
Wideen, Marvin F. and Grimmett, Peter P. (eds) Changing Times in Teacher Education
Nixon, Jon; Martin, Jane; McKeown, Penny and Ranson, Stewart Encouraging Learning: towards a theory of the learning school
Gewirtz, Sharon; Ball, Stephen, J. and Bowe, Richard Markets, Choice and Equity in Education 相似文献
15.
创新源于实践 总被引：68，自引：66，他引：68
杨叔子 《实验室研究与探索》2004,23(7):1-3
从理性上分析了文化的知识、思维、方法和精神4个层面的内涵及其相互关系。并提出学习和知识，思考和思维，实践和方法三者的关系。其中学习、知识是基础，思考、思维是关键，实践、方法是根本。创新来源于实践，一切文化来源于实践。在素质教育中应处理好学习、思考和实践的关系。 相似文献
16.
作文教学的改革应该是一个系统的工程,它涉及了写作的思想与方法、过程与评价、反馈与矫正,还涉及了吸纳与输出、积累与整合、应用与拓展、发现与创新等方面的研究与改革。新课程理念下对作文的创新评价应从评价理念人本化、评价功能激励化、评价主体多元化、评价内容综合化、评价形式民主化、评价方法多样化等方面来进行,以激发学生自主写作、快乐写作的欲望,让学生在写作的实践过程中抒写自我的心灵感受,实现人格与能力的和谐发展。 相似文献
17.
Bronwyn Bevan 《Studies in Science Education》2017,53(1):75-103
Making is a rapidly emerging form of educational practice that involves the design, construction, testing, and revision of a wide variety of objects, using high and low technologies, and integrating a range of disciplines including art, science, engineering, and mathematics. It has garnered widespread interest and support in both policy and education circles because of the ways it has been shown to link science learning to creativity and investigation. Making has taken root in out-of-school settings, such as museums, science festivals, and afterschool and library programmes; and there is now growing interest from primary and secondary educators in how it might be incorporated into the classroom. Making expands on traditions associated with Technology Education and Design-Based Learning, but differs in ways that can potentially broaden participation in science and STEM learning to include learners from communities historically underrepresented in STEM fields. STEM-Rich Making is centrally organised around design and engineering practices, typically integrating digital tools and computational practices, and positions scientific and mathematical concepts and phenomena as the materials for design. This paper takes a critical view of the claims about Making as a productive form of science teaching and learning, and reviews the current research literature’s substantiation of the ways in which Making supports students’ agency, promotes active participation in science and engineering practices, and leverages learners’ cultural resources. 相似文献
18.
对西安市七区全民健身场所年龄分布、健身规律以及对健身功能的认知进行问卷调查，进行数理统计后，结合有关献进行分析。结果发现经济压力和生活压力，健身观念以及生活习惯，健身理论研究、健身运动的组织以及宣传等政府行为，工作性质以及工作时间等均对全民健身的开展有着不同程度的影响。建议政府、单位、社会结合，开发新运动项目、制定运动处方，并加大宣传力度，全面深入地开展群众性体育竞赛，促进全民健身从“我为”向“为我”转化，必能促进全民健身活动健康、有序地开展。 相似文献
19.
Adopting a person-centered approach, we profiled 5th and 6th grade children's (152 boys and 161 girls) school-related beliefs about perceived task difficulty and agency beliefs in ability and effort. Five clusters were compared across key learning-related dimensions encompassing underlying worldviews (means–ends beliefs, normative difficulty, nature of ability), motivation (intrinsic, identified, introjected, and extrinsic), and adjustment (achievement and well-being): Agentic (high ability, high effort, low difficulty), Strivers (above average ability, high effort, high difficulty), Normative (average ability, effort and difficulty), Disengaged (low ability, low effort, average difficulty) and Challenged (low ability, low effort, high difficulty). The findings suggest that difficulty, perceived either as challenge or obstacle, plays an important role for the belief profiles, and that relationships with worldviews and motivation are indicative of adaptation and maladaptation. 相似文献
20.
张之沧 《淮阴师范学院学报(哲学社会科学版)》2005,27(3):301-306,311,419
理查德·罗蒂立足后现代主义、解构主义、文化自由主义、相对主义和后哲学文化论,建立的协同性实用主义,批判分析哲学、现象学、传统的认识论、反映论、符合论和真理观,肯定解释学的功能与教化作用,否定客观性、绝对性、永恒性和不变性,反对理性主义、科学主义和实在论,主张解构形而上学,创立无冕哲学,提倡工具主义、约定主义、实用主义、多元主义,以及心灵与社会的协同性作用。 相似文献