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1.
重组人干扰素α-1b和利巴韦林治疗儿童手足口病疗效对比研究 总被引：1，自引：0，他引：1
目的：探讨重组人干扰素α-1b治疗儿童手足口病的疗效和安全性。方法：将388例手足口病患儿随机分为两组,两组患儿给予相同的对症和支持治疗。治疗组184例用重组人干扰素α-1b肌肉注射,〈1岁1 ug/（kg·d）,2-10岁10 ug/d,1次/d;对照组204例用利巴韦林〔10-15 mg/（kg·d）〕静脉滴注。结果：治疗组与对照组比较,在退热时间,手足皮疹及口腔溃疡愈合方面均优于对照组（P〈0.01）,除个别患儿有发热外,治疗组未发现明显副作用。结论：干扰素治疗儿童手足口病安全有效,值得临床推广使用。 相似文献
2.
目的:通过分析双眼阅读条件下弱视患者的弱视眼和非弱视眼与正常人主导眼和非主导眼的眼球运动特征,探究弱视患者与正常人阅读过程眼球运动的差异性,揭示弱视患者在正常阅读状态下两眼的影响作用。方法:选取成人单眼弱视16例及屈光矫正视力正常的被试32例,采用SMI公司生产的iView High-Speed1250眼动仪,记录被试在正常双眼汉语阅读状态下左右眼各自的眼球运动数据,并运用spss对实验所得的眼动数据进行统计分析。结果:双眼阅读条件下,正常人主导眼与非主导眼之间无论是阅读速度还是其他眼动指标均无显著性差异。重度弱视患者的弱视眼与非弱视眼在阅读速度、注视点次数及注视点持续时间上均存在显著性差异;中轻度弱视患者的弱视眼与非弱视眼之间的眼动指标基本类似。其中重度弱视患者的非弱视眼与正常人主导眼之间在阅读速度、注视次数及眼跳幅度上存在显著性差别;而中轻度弱视患者的非弱视眼与正常人主导眼的阅读速度、注视时间等比较均没有显著性差异。结论:在双眼汉语阅读条件下,弱视患者的弱视眼对非弱视眼的阅读速度及眼球运动产生影响,非弱视眼的阅读速度明显比正常人慢,且注视点持续时间长。其中重度弱视患者的非弱视眼对弱视眼的抑制作用更为明显。 相似文献
3.
清开灵对急性脑梗死患者血清中TNF-α和IL-6影响 总被引：1，自引：0，他引：1
目的:探讨清开灵对急性脑梗死患者血清中肿瘤坏死因子(TNF-α)和白介素-6(IL-6)的影响。方法:88例急性脑梗死患者随机分为对照组(常规治疗)和清开灵组(清开灵 常规治疗,生理盐水250 ml加入清开灵1200 mg,1次/d,连续14 d,静脉点滴),检测治疗前和治疗后患者血清中TNF-α和IL-6浓度的变化及两组的疗效。结果:治疗前清开灵组与对照组比较,血清中TNF-α和IL-6浓度差别无统计学意义(P>0.05)。治疗后清开灵组血清中TNF-α和IL-6浓度较对照组显著下降(P<0.01);清开灵组总有效率95.65%,对照组78.57%,两者差异有统计学意义(P<0.01)。结论:早期对急性脑梗死患者进行清开灵治疗可以减轻缺血脑细胞的损害、有利于病情的康复。其对脑缺血神经元的保护机制可能与抑制TNF-α和IL-6的产生、阻止白细胞向梗死区的浸润有关。 相似文献
4.
郭素梅 《河北北方学院学报(医学版)》1998,(2)
我科于1997年5月至10月间采用无环鸟苷治疗手足口病患儿20例,与采用病毒唑治疗的对照组30例比较,观察其疗效并报告如下。 1 资料与结果 1.1 一般资料 20例发病年龄最小6月,最大3岁。男12例,女8例。诊断标准:根据当地手足口病流行,临床表现以发热开始,体温37.8℃-40℃,多在38.5℃左右。继之或同时出现疱疹性口腔炎、手足及臀部斑丘疹或水疱。全部病例均无并发症。对照组30例,其 相似文献
5.
目的:观察马来酸桂哌齐特治疗脑出血临床疗效.方法:选择160例急性脑梗死患者随机分为治疗组和对照组各80例,对照组给予脑出血常规治疗,治疗组在发病第四天起在此基础上加用马来酸桂哌齐特注射液160mg加入0.9%氯化钠注射液250ml中,每天一次静脉滴注,连用14天.分别于入院时及治疗后7d、14d、21d行头颅CT检查,计算血肿和水肿体积;对两组患者于入院时、7d、14d、28d进行神经功能缺损评分,比较两组间是否存在差异.结果:两组血肿、水肿体积于治疗前差异无统计学意义(p>0.05),治疗后7d、14d、21d时差异有显著性(p﹤0.05),治疗组明显小于对照组;治疗前及治疗7d两组CSS评分比较差异无统计学意义(p>0.05);治疗14d、28d时差异有显著性(p﹤0.05),治疗组明显低于对照组.结论:马来酸桂哌齐特有利于脑出血患者血肿和水肿的吸收,降低神经功能缺损. 相似文献
6.
白内障术后反应性葡萄膜炎的治疗 总被引：1，自引：0，他引：1
[目的]探讨糖皮质激素滴眼液与糖皮质激素球结膜下注射对白内障术后反应性葡萄膜炎的治疗效果。[方法]对80例120只眼白内障术后继发葡萄膜炎患者,其中40例61只眼用糖皮质激素点眼液滴眼,根据炎症程度选择滴眼频率,每次1滴,40例59只眼用糖皮质激素球结膜下注射。根据炎症的程度每日一次或隔日一次注射,每组均用药至炎症消退,并同时使用非甾体类消炎滴眼液滴眼。[结果]糖皮质激素滴眼液组及球结膜下注射组治疗3周后炎症全部消退,没有显著差异(P>0.05),结膜下注射组有明显的球结膜充血,球结膜下出血、水肿、疼痛等副作用。[结论]糖皮质激素滴眼液局部滴眼能有效治疗白内障术后反应性葡萄膜炎。 相似文献
7.
郭文征 《河北北方学院学报(医学版)》2000,(3)
带状疱疹(下称本病)以往治疗多用聚肌胞,近年常用阿昔洛韦,但一些作者兼用其它药物治疗也取得满意效果。1 小剂量干扰素将36例本病患者分为治疗组和对照组。治疗组肌注干扰素4万u,每日2次,6d为一疗程。结果:停止出新疮疹、水疱干涸结痂,疼痛消失及治愈时间治疗组均优于对照组(P<0.05),且治疗组外周白细胞干扰素诱生能力比治疗前明显提高(P<0.01)。一组用本品10万u,每日1次肌注,同时在危疹皮损伤处外用本品1万u/ml,每日四次,疗程7d,也发现干扰素可以缩短病程,以止疱作用最明显。干扰素具有广谱抗病毒和免疫调节作用,安全性和耐受性好,可以推广使用。2 病霉唑病毒唑10-15mg/kg.d加入5％G.S500ml静滴,疗程5d。治疗本 相似文献
8.
1 病例介绍 病人男,9岁,因双眼球突出,视力下降,伴恶心、呕吐、嗜睡、烦躁15d,曾在北京某医院诊断为病毒性脑膜炎,给予无环鸟苷等药物治疗无效,于1998年5月3日收入我院。既往无外伤及慢性病史,近5～6年曾有恶心、呕吐,未系统诊治。入院查体:胸骨压痛明显,皮肤无出血点,肝右肋下2cm,脾、浅表淋巴结未及肿大,肱二、三头肌反射、膝反射弱,无病理反射。眼部检查:视力双眼无光感,双颞部可见隆起,双眼睑裂闭合不全约2mm,双眼球前突,右眼17mm,左眼18mm,眶距95mm。眼球固定,呈典型“青蛙”面容。 相似文献
9.
王妍 《泰州职业技术学院学报》2014,(1):73-74
目的：探讨全麻手术需特殊体位病人在应用医用水凝胶护眼贴后对预防眼睑水肿、结膜红肿等眼部并发症的效果。方法选择120例脊柱手术俯卧位全麻病人和食管癌手术侧卧位全麻病人,将其随机分为两组,各60例。试验组60例直接使用医用水凝胶护眼贴保护双眼,对照组60例采用金霉素眼膏结合3M 透明敷料贴保护双眼。观察术后24小时眼部并发症发生情况。结果术后24小时回访,试验组术后患者眼睑水肿2例、结膜红肿2例、视物模糊3例、畏光3例、黏滞感2例、异物感4例;对照组术后患者眼睑水肿9例、结膜红肿13例、视物模糊13例、畏光11例、黏滞感9例、异物感17例。两组间差异有统计学意义。结论特殊手术体位全麻病人术中使用护眼贴能更有效保护双眼,预防眼部并发症的发生。 相似文献
10.
目的:观察针灸推拿结合核心力量训练对腰肌劳损的疗效。方法:将60例腰肌劳损的患者随机分成对照组和治疗组,每组30例,对照组采用针灸、推拿治疗,治疗组在对照组的基础上结合核心力量训练,在治疗结束时和3月后随访。结果:两组在治疗结束时疗效无显著性差异,在3月随访时治疗组明显优于对照组。结论:核心力量训练对腰肌劳损的远期疗效和预防复发有较好效果。 相似文献
11.
Objective： To evaluate the effect of topical corticosteroid for treatment of moderate or severe dry eye. Methods： Sixty eyes of 30 patients with moderate or severe dry eye, who were not sensitive to artificial tears, were treated with 0.1% fluorometholone eye drops. Subjective symptom and objective tests were used to evaluate the efficacy of treatment before and after application of 0.1% fluorometholone eye drops for 1 week and 1 month. Side effects were also evaluated. Results： After 1 week of treatment, subjective symptoms were improved in all dry eye patients; objective tests were improved in all dry eye patients 1 month after treatment, and the difference was significant. Conclusion： Topical corticosteroid drops can rapidly and effectively relieve the symptoms and signs of moderate or severe dry eye. 相似文献
12.
Objective: To investigate the effects and complications of primary and secondary placements of motility coupling post (MCP) in the unwrapped porous polyethylene orbital implant (PPOI) following enucleation. Methods: We investigated 198 patients who received PPOI implantation following the standard enucleation procedure in the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China, from 2002 to 2004. These patients were subgrouped into PPOI-only patients (112 cases, received PPOI following enucleation), primary MCP patients (46 cases, received primary placement of MCP during PPOI operation), and secondary MCP patients (40 cases, received secondary placement of MCP 6 months after the initial surgery). Effects and complications among these three groups were compared. Results: The PPOI-only patients took shorter treatment course when compared with other two MCP groups (P<0.001), without significant difference noted between the two MCP groups. However, the two MCP groups had better prosthetic motility than PPOI-only group (P<0.001), without significant difference between the two MCP groups. In the early stage, 2 eyes in the PPOI-only group and 1 eye in the primary MCP group had PPOI infection. In PPOI-only group, 3 (2.68%) eyes had PPOI exposure, which occurred after fitting the prostheses; 4 eyes (8.70%) in primary MCP group and 1 eye (2.50%) in secondary MCP had PPOI exposure, which occurred before fitting the prostheses. After prosthesis was fit successfully, the excessive discharge and granuloma were 33.9% and 1.79% in PPOI group-only, 53.3% and 8.9% in primary MCP group, and 52.5% and 7.5% in secondary MCP group, respectively. Conclusion: Both primary and secondary placements of MCP into the PPOI following enucleation can help patients to obtain desirable prosthetic motility, but maybe associated with more complications. The primary placement of MCP with skilled operation in selected patients is more recommendable than secondary placement. 相似文献
13.
INTRODUCTION Cataract is frequently associated with vitreo-retinal pathology such as vitreous hemorrhage,retinal detachment,proliferative vitreoretinal disease,espe-cially in patients with diabetes mellitus,ocular trauma and elderly population(Vatavuk and Pentz,2004;Vatavuk et al.,2005).The cataract can be removed together with vitrectomy or later on in a separate surgical procedure(Tyagi et al.,1998;Lam et al.,1998).The primary indication for the primary re-moval of cataract and vitrect… 相似文献
14.
目的 了解老年远视特点及误诊原因,探讨如何合理验配老年远视眼镜.方法 对年轻时视力≥31.0,而45岁以后视力下降,被诊断为眼科疾病,后经屈光检查矫正视力≥1.0者,诊断为老年远视的患者为调查对象.结果 28例56只眼裸眼视力分布在0.2～0.8,其中0.4～0.6占67.6％,远视屈光度＋0.50～＋1.75,其中＋0.75～＋1.25占78.5％,被诊断为眼病：白内障9例18眼,黄斑变性的8例16眼,玻璃体混浊的7例14眼.结论 屈光检查对老年人视力下降的诊断有重要作用,老年远视有其自身特点,应引起眼科医生的重视,更好的做好老年远视的诊断和验配工作. 相似文献
15.
[目的]探讨冷凝联合小梁切除术治疗新生血管性青光眼的疗效.[方法]A组12例14眼新生血管性青光眼,施行180°视网膜周边部巩膜外和睫状体冷凝;B组20例22眼,除上述冷凝外,又联合小梁切除术治疗.[结果]随访3～6个月,两组术后视力均无明显改善,A组平均眼压自57.48mmHg降至32mmHg,需要再做冷凝或手术减压;B组随访的15例(16眼)有14眼的眼压<21mmHg,2眼需加用0.1%噻吗心安滴眼治疗,两组术后短期内眼压控制有明显的差异(P<0.05).[结论]冷凝或联合小梁切除术对新生血管性青光眼治疗有较好的短期疗效. 相似文献
16.
探讨国产干涉条纹视力计对预测白内障术后视力的准确性及其影响因素。方法:收集105例(105眼)白内障患者,年龄为69.89±10.04岁(30~92岁),术前分别用德国Heine视网膜视力计和国产干涉条纹视力计检测患者的术后预测视力,与术后1月最佳矫正视力比较,进行统计学分析。国产干涉条纹视力计和德国Heine视网膜视力计测量的预测视力分别为0.13±0.04和0.17±0.11,术后1月的最佳矫正视力为0.07±0.03,三者之间两两比较,有显著性差异(P<0.05),国产干涉条纹视力计与术后最佳矫正视力之间的差异较小。国产干涉条纹视力计预测视力符合率为66.67%(两者之间相差≤2行)。晶状体重度混浊和合并眼部疾病如青光眼、黄斑前膜、糖尿病性眼底病变等是其影响因素。国产干涉条纹视力计能有效预测白内障术后视力,但在重度白内障和合并眼底其他疾病的患者应结合相关临床检查做综合性评估。 相似文献
17.
Objective: To evaluate the prevalence of primary iris and/or ciliary body cysts in eyes with shallow anterior chamber and their effect on the narrowing of the anterior chamber angle. Methods: Among the general physical check-up population, subjects with shallow anterior chambers, as judged by van Herick technique, were recruited for further investigation. Ultrasound biomicroscope (UBM) was used to detect and measure the cysts located in the iris and/or ciliary body, the anterior chamber depth (ACD), the angle opening distance at 500 μm (AOD500), and the trabecular-iris angle (TIA). A-scan ultrasonography was used to measure the ocular biometry, including lens thickness, axial length, lens/axial length factor (LAF), and relative lens position (RLP). The effect of the cyst on narrowing the corresponding anterior chamber angle and the entire angle was evaluated by the UBM images, ocular biometry, and gonioscopic grading. The eye with unilateral cyst was compared with the eye without the cyst for further analysis. Results: Among the 727 subjects with shallow anterior chamber, primary iris and ciliary body cysts were detected in 250 (34.4%) patients; among them 96 (38.4%) patients showed unilateral single cyst, 21 (8.4%) patients had unilateral double cysts, and 42 (16.8%) patients manifested unilateral multiple and multi-quadrants cysts. Plateau iris configuration was found in 140 of 361 (38.8%) eyes with cysts. The mean size of total cysts was (0.6547±0.2319) mm. In evaluation of the effect of the cyst size and location on narrowing the corresponding angle to their position, the proportion of the cysts causing corresponding angle narrowing or closure among the cysts larger than 0.8 mm (113/121, 93.4%) was found to be significantly higher than that of the cysts smaller than 0.8 mm (373/801, 46.6%), and a significant higher proportion was also found in the cysts located at iridociliary sulcus (354/437, 81.0%) than in that at the pars plicata (131/484, 27.1%). In evaluating the effect of the cyst on the entire anterior chamber angle, the eyes with multiple and multi-quadrants cysts manifested significant narrowing of the entire anterior chamber angle as compared with the eyes without cysts, based on the data analysis in comparison of TIA, AOD500, and gonioscopic grading evaluation. The unilateral single or double cysts in the eyes had no significant effect on narrowing of anterior chamber angle as compared with eyes without cysts. The iris and/or ciliary body cysts did not seem to affect the axial length, ACD, lens thickness, RLP, LAF. Conclusions: The prevalence of primary iris and ciliary body cyst was 34.4% in the subjects with shallow anterior chamber. The cysts larger than 0.8 mm, locating at iridociliary sulcus, or multiple and extensive cysts were inclined to cause the angle narrowing or closure. 相似文献
18.
Dan HUANG Wen-ya QIU Bei ZHANG Bing-hong WANG Yu-feng YAO 《Journal of Zhejiang University. Science. B》2014,15(12):1055-1063
研究目的：创新要点：研究方法：观察采用冰冻保存供体的周边深板层角膜移植治疗Terrien’s角膜变性（TMD）的临床疗效,探讨TMD的最佳手术治疗方式。供体角膜为冰冻保存,其中部分为中央角膜移植术后剩余的角巩膜环,并改进传统的手术方法。采用周边深板层角膜移植,既充分利用和节约供体,避免排斥反应,又简化了手术操作过程,有效地恢复了眼球完整性和提高术后视力。研究对象为1998年6月至2012年12月期间在浙江大学医学院附属邵逸夫医院眼科中心进行周边深板层角膜移植术的27例TMD病人的31只眼。根据病变范围和大小,分别进行环形深板层角膜移植和D形深板层角膜移植。所有植片均于-20℃冰冻保存,冰冻保存的角巩膜环植片用于环形深板层角膜移植,冰冻保存的整个眼球用于D形深板层角膜移植。对所有术眼的病例资料、视频及影像学检查进行回顾性分析,记录并总结患者的一般情况、术中表现、术后角膜结构的变化、屈光及视力的变化及术后并发症等。重要结论：采用冰冻保存供体的周边深板层角膜移植治疗TMD可以有效地恢复角膜结构的完整性且能长期维持（图3和4）。术后随访过程未发现免疫排斥反应,环形深板层角膜移植术后视力较前明显提高,而3例（100％）D形深板层角膜移植术后散光及视力均不提高（表1和2）。术前炎症及术中穿孔并不影响术后最终结果。 相似文献
19.
氟西汀抗脑卒中后抑郁的观察 总被引：1，自引：0，他引：1
目的:观察氟西汀抗脑卒中后抑郁对神经功能缺损的影响.方法:140例患者随机分为2组.治疗组80例,入院后即给予氟西汀0.4mg口服,晚1次,6～10周为1个疗程.对照组60例,入院后口服多虑平25mg,每日1次,其余治疗两组均按脑卒中常规处理.在治疗1周、2周、4周、6周后分别以HAMD量表及ESS量表评定治疗效果.结果:治疗组用药后1周即可显效,而对照组多在2周后显效.两组ESS评分均随HAMD评分下降而下降,两者呈正相关,而治疗组ESS评分较对照组下降明显,有显著性差异(P＜0.01).结论:氟西汀抗脑卒中后抑郁能够改善神经功能缺损症状及患者的预后. 相似文献
20.
目的 :观察奥美拉唑联合阿莫西林和呋喃唑酮治疗幽门螺杆菌感染的效果 .方法 :将2 4 0病例随机分为两组 .治疗组采用奥美拉唑联合阿莫西林和呋喃唑酮 (简称奥组 ) ,对照组采用果胶铋联合阿莫西林和甲硝唑 ,疗程两周 .结果 :治疗组和对照组HP根除率分别为96 7%和 6 8 3% ,溃疡及糜烂面愈合率分别为 90 0 %和 6 1 7% ,两组差异有显著性意义 (P <0 0 1) .结论 :奥美拉唑联合阿莫西林和呋喃唑酮是目前一种理想的根除HP治愈溃疡及糜烂面的方案 . 相似文献