共查询到19条相似文献，搜索用时 203 毫秒
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小鼠灌服玫瑰红景天水煎剂10g/kg,有加强硫贲妥纳的催眠作用,拮抗咖啡因的惊厥作用,抗疲劳、耐缺氧、耐饥饿,耐寒作用.小鼠皮下注射玫瑰红景天水煎剂5.0g/kg,可明显抑制皮下注射肾上腺素1.0mg/kg 后1h 引起的血糖升高。此外,玫瑰红景天水煎剂可使离体蛙心收缩幅度增加,使离体肠管收缩运动变得有节律. 相似文献
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纯化伤寒杆菌HSP70,观察其对小鼠S180肿瘤细胞的抑制作用,对荷瘤小鼠连续皮下注射伤寒杆菌HSP70,每只小鼠每天注射100μ／mL,的伤寒杆菌HSP70．5mL,每天一次．9天后处死小鼠,剥离肿瘤,分别称量实验组与对照组小鼠肿瘤的重量．结果表明,伤寒杆菌HSP70能明显抑制小鼠S180肿瘤细胞在小鼠体内的生长． 相似文献
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1991年的诺贝尔物理学奖被法国物理学家皮埃尔吉尔·德热纳教授所获得,这是为了表彰他对自然物体中有序与无序现象的研究所作的贡献。他的这一理论为手表和袖珍计算器的液晶显示打下了基础。他在1974年写成的《液晶物理学》一书,被认为是该领域的权威著作。德热纳在巴黎对记者说:他为能够代表巴黎权威的物理化学学院获得此奖而感到高兴。他说:“我所有的研究哪怕是基础的,也都永远是有独创的。”他举出最近研究的“超级粘胶”为例,这种粘胶也许成 相似文献
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胎儿出生体重达到或超过4OOOg称为巨大胎）［,45O0g以上则称为特大胎）［或超巨大胎儿,属高危妊娠,对母儿预后影响很大现就IOO例特大胎儿分析报道如下．回临床资料1．1特大胎儿的分娩方式见表1由表1可见,阴道分娩34例,占34％,剖宫产分娩占66例,占66％,两者具有显著意义（P＜001）．1．2分娩方式与出生体重的关系见表2由表2可见,出生体重4扣O～46”吕共60例,自然分娩匕例,占25％;产钳分娩10例,占1667％;利宫产35例,占58．33％;出生体重470O～4899g共14例,自然分娩6例,占4285％;剖宫产8例,占力匕％;4900～5700g共26… 相似文献
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李亚琳 《渭南师范学院学报》2014,(11):32-35
建立液态甲醛诱导小鼠肝损伤及其纤维化模型,并初步观察小鼠肝组织的病变过程．将正常昆明小鼠随机分为实验组和对照组．实验组小鼠注射15％的甲醛溶液,注射量为1mL／kg,每周注射两次,并且每天用1％的甲醛溶液喂养．对照组小鼠以纯净水正常喂养,分别在实验开始后的第3、6、8周处死实验组小鼠各4只,肉眼及病理切片观察其肝脏形态的改变,发现小鼠的体重均呈增长趋势．与实验组小鼠比较,对照组小鼠体重增长显著（P〈0．05）．第8周小鼠肝脏出现明显的病变,表面粗糙,颜色暗黄,出现深色斑点．在石蜡切片中可观察到肝脏组织变得松散,窦周隙（Disse’s space）增大．肝星状细胞（hepatic stellate cell,HSC）较对照组明显增多．随着甲醛处理时间的延长,HSC不同程度地增多,肝损伤病变程度越来越严重． 相似文献
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研究不同浓度的气态甲醛吸入对小鼠肺组织的病理损伤作用.以昆明雄性小鼠为实验材料,40只小鼠随机分为4组,1组对照组,其他3组分别为25%、50%、75%的甲醛溶液试剂组（小鼠全天暴露在甲醛环境中）,自由饮食,每天称小鼠体重,观察其生理、形态、行为是否有异常.四周后将其全部颈椎脱臼处死,取肺组织经HE染色后在光镜下观察其损伤情况.对照组小鼠体重增长,肺组织结构清晰,有较少的纤维化现象,肺泡壁正常;实验组小鼠均出现不同程度的肺纤维化损伤、肺泡壁增厚、毛细血管破裂、肺泡腔内出现血细胞、小鼠体重不断下降等;随着甲醛浓度的增高,肺组织病变越严重,小鼠死亡率也相对越高.甲醛吸入会引起小鼠体重减轻和肺组织纤维化,且与甲醛浓度成正相关. 相似文献
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目的:研究牛奶和鸡蛋对运动能力的影响,探讨牛奶和鸡蛋对运动疲劳恢复影响的可能机制.方法:将普通成体雄性ICR小白鼠(18只)随机均分对照组(CG)、额外补充牛奶组(MG),额外补充鸡蛋组(EG);采用10d递增负荷的游泳运动方式使小白鼠力竭.分析牛奶与鸡蛋对小白鼠力竭运动后血糖、血红蛋白(Hb)、血肌酐(CRE)含量影响及体重变化,记录力竭时间、观察行为状态.结果:与实验前比较,各组小鼠实验后血糖、血红蛋白(Hb)浓度下降,血肌酐(CRE)浓度上升;两实验组小鼠体重增加均显著高于CG组;两实验组与CG相比,运动时间显著延长.结论:小鼠运动疲劳后,机体出现各种疲劳指标的变化,额外补充牛奶和鸡蛋可以减少这些疲劳指标的改变.可能是通过增加糖储备来提高运动能力,保证机体在长时间运动时的能量来源;减缓运动过程中对蛋白质的过度利用;增加体内磷酸肌酸的贮备,提高磷酸肌酸的代谢能力等方面缓解运动疲劳的,尚待进一步研究. 相似文献
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为了研究急性铅中毒对小鼠睾丸病理变化的影响,通过对小鼠饲喂含有醋酸铅的去离子水建立铅负荷小鼠模型.处理10 d后取材,分析体质量、睾丸指数和睾丸病理剖检变化.结果显示：与对照组相比,铅中毒组小鼠体质量无明显变化,睾丸指数降低,且差异显著（P＜0.05）;小鼠睾丸中支持细胞、生精细胞和间质细胞数量减少.铅对小鼠睾丸具有显著损害作用,从而影响小鼠的生殖健康. 相似文献
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Chronic morphine drinking establishes morphine tolerance, but not addiction in Wistar rats 总被引：1，自引：0，他引：1
Binsack R Zheng ML Zhang ZS Yang L Zhu YP 《Journal of Zhejiang University. Science. B》2006,7(11):892-898
Objective： Some animal models apply morphine in the drinking water to generate addiction, but related reports are not free of conflicting results. Accordingly, this study aimed to figure out if chronic consumption of morphine in the drinking water can induce morphine addiction in Wistar rats. Methods： For 3 weeks, the animals received a daily morphine dose of 35 mg/kg by offering a calculated volume of sugar water （5% sucrose） with morphine （0. l mg/ml） to each rat; animals receiving just sugar water served as controls. Immediately after the treatment phase, the tail immersion test was used to check for morphine tolerance, and all animals were then kept on tap water for one week （withdrawal phase）. Afterwards, all rats were allowed to choose their drinking source by offering two bottles, containing sugar water without and with morphine, simultaneously for two days （preference phase）. Results： While the chronic consumption of morphine led to a reduction in body weight and to morphine tolerance, the morphine-treated Wistar rats did not show any preference for the opiate-containing sugar water. Conclusion： Body weight loss and tolerance do not reveal a condition of drug craving, and current animal models should be re-evaluated regarding their potential to establish morphine addicted animals. 相似文献
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Effect of glycine site/NMDA receptor antagonist MRZ2/576 on the conditioned place preference and locomotor activity induced by morphine in mice 总被引：3，自引：0，他引：3
Objective： To study the effect of glycine site/NMDA （N-methyl-D-aspartate） receptor antagonist MRZ2/576 on the conditioned place preference （CPP） and locomotor activity induced by morphine in mice. Methods： Different doses （1.25, 2.5 and 5 mg/kg, i.p.） of MRZ2/576 were used to evaluate the effect of MRZ2/576 on the acquisition and expression of CPP induced by morphine （5 mg/kg） in mice. In addition, we examined the locomotor activity of mice in conditioning and testing phase of CPP paradigm. Results： MRZ2/576 alone could not establish place preference, but a 5 mg/kg dose of MRZ2/576 could block both acquisition and expression of morphine-induced CPP. In testing phase of CPP, there was no statistical difference for locomotor activity between the groups; injection of MRZ2/576 showed a dose-dependent decrease of locomotor activity on both control and morphine-treated mice, especially 5 mg/kg of MRZ2/576 significantly suppressed the locomotor activity of mice. Conclusion： Based on the present results, we assume that MRZ2/576 can antagonize the rewarding effect of morphine, suggesting that this glycine site/NMDA receptor antagonist could be used to treat addictions due to its light side effect profile. 相似文献
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目的:观察黄芩甙注射液对四氯化碳(CCl4)致急性肝损伤小鼠肝抗氧化功能的影响。方法:50只小鼠随机分为5组,每组10只,分别为对照组、模型组、黄芩甙注射液低、中、高(0.25 g/kg、0.50 g/kg、1.00g/kg)剂量组。用CCl4制备小鼠急性肝损伤模型,测定小鼠体重变化,肝指数,肝超氧化物歧化酶(SOD)及谷胱甘肽过氧化物酶(GSH-Px)活性,谷胱甘肽(GSH)及丙二醛(MDA)含量。结果:与对照组及模型组比较,黄芩甙各剂量组小鼠试验前后的体重及肝指数差异不显著(P>0.05)。与模型组比较,低剂量组小鼠肝SOD、GSH-Px活性及MDA含量差异不显著(P>0.05),而GSH含量显著升高(P<0.05);中、高剂量组SOD、GSH-Px活性极显著提高(P<0.01),GSH含量极显著升高(P<0.01),MDA含量极显著降低(P<0.01)。结论:黄芩甙能显著增强急性肝损伤小鼠肝SOD、GSH-Px活性,提高GSH含量,降低MDA含量,并表现正向的量效关系。 相似文献
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本文是对急性胰腺炎血浆内毒素含量测定的前瞻性研究,共观察患者24例,入院时病情按 Ranson 指标分为轻、重二组并随机分为常规治疗组与加用中药清下方的中西医结合治疗组。对各自血浆中的内毒素含量进行组间及治疗前后对比,并以50名正常人作为对照组。结果显示:急性胰腺炎病例血浆内毒素含量为:0.174±0.123Eu/mL;正常对照为:0.0785±0.027Eu/mL,二者差异显著(P<0.05)。按病情分型,轻型组内毒素含量为:0.160±0.099Eu/mL,而重型组则达:0.261±0.169Eu/mL,两组间也有显著差异(P<0.05)。经中西医结合治疗可使血浆内毒素含量明显减少(P<0.05).但常规治疗前后的差异不明显(P>0.05)。研究表明:急性胰腺炎时可使血浆内毒素水平明显升高,其含量与病情的轻重程度关系密切。在常规治疗中加用中药清下方则有使血浆内毒素水平降低的作用。 相似文献
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The attenuation of an LiCl-induced conditioned taste aversion (CTA) by LiCl preexposure is mediated primarily by associative blocking via injection-related cues. Given that preexposure to morphine attenuates morphine-induced CTAs, it was of interest to determine whether injection cues also mediate this effect. Certain morphine-induced behaviors such as analgesic tolerance are controlled associatively, via injection-related cues. Accordingly, animals in the present experiments were preexposed to morphine (or vehicle) every other day for five total exposures, followed by an extinction phase, in which the subjects were given saline injections (or no treatment) for 8 (Experiment 1) or 16 (Experiment 2) consecutive days. All of the animals then received five CTA trials with morphine (or vehicle). The morphine-preexposed animals in Experiment 1 displayed an attenuation of the morphine CTA that was unaffected by extinction saline injections, suggesting that blocking by injection cues during morphine preexposure does not mediate this effect. All of the morphine-preexposed subjects in Experiment 2 displayed a weakened preexposure effect, an effect inconsistent with a selective extinction of drug-associated stimuli. The attenuating effects of morphine preexposure in aversion learning are most likely controlled by nonassociative mechanisms, like drug tolerance. 相似文献