共查询到16条相似文献，搜索用时 416 毫秒
1.
目的:为了研究血浆脂蛋白(α)[Lp(α)]水平与慢性肾功能衰竭(CRF)的关系,探讨Lp(α)在CRF(常)合并心脑血管疾病中的作用.方法:用酶联免疫吸附法测定了36例CRF与30名健康对照者的Lp(α)浓度,并同时测定了TG、TC、LDL-C和HDL-C的含量.结果:CRF患者Lp(α)、TC、LDL-C水平均明显高于正常对照组,而HDL-C显著低于对照组,血浆Lp(α)水平变化与LDL-C、HDL-C、TG、TC含量无明显相关性.结论:CRF患者体内存在着Lp(α)等脂代谢紊乱的情况,高血浆Lp(α)水平是CRF合并心脑血管疾病的独立危险因素之一. 相似文献
2.
目的:探讨心脑血管疾病患者脂蛋白(a)水平及其他脂类的关系,进一步阐明血浆高脂蛋白(a)水平为心脑血管疾病的独立危险因素,支持脂蛋白(a)的检测具有极为重要的意义.方法:采用ELISA法和酶法分别测定心肌梗塞、心绞痛、脑梗死等心脑血管疾病患者及健康对照者的Lp(a)、LDL-C、HDL-C、TG、TC含量.结果:心脑血管疾病患者血浆Lp(a)水平显著高于健康对照组(P＜0.01).血浆脂蛋白(a)水平变化与LDL-C、HDL-C、TG、TC含量无明显相关性.结论:Lp(a)是独立于其他血脂指标的心脑血管疾病的危险因子. 相似文献
3.
目的:探讨心脑血管疾病患者脂蛋白(a)水平及其他脂类的关系,进一步阐明血浆高脂蛋白(a)水平为心脑血管疾病的独立危险因素,支持脂蛋白(a)的检测具有极为重要的意义.方法:采用ELISA法和酶法分别测定心肌梗塞、心绞痛、脑梗死等心脑血管疾病患者及健康对照者的Lp(a)、LDL-C、HDL-C、TG、TC含量.结果:心脑血管疾病患者血浆Lp(a)水平显著高于健康对照组(P＜0.01).血浆脂蛋白(a)水平变化与LDL-C、HDL-C、TG、TC含量无明显相关性.结论:Lp(a)是独立于其他血脂指标的心脑血管疾病的危险因子. 相似文献
4.
观察山楂、杭菊花、决明子（SHJ）煎剂高、中、低剂量代茶灌胃对小鼠动脉硬化（AS）模型的保护作用.用甲基硫氧嘧啶和动物猪油造小鼠动脉硬化模型,采用血象法分析检测小鼠血清总胆固醇（TC）、血清甘油三脂（TG）、血清高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）的含量,观察小鼠主动脉弓血管的形态学变化.研究结果表明：与正常对照组比较,模型组小鼠血清HDL-C含量显著减少,TG、TC、LDL-C显著增加（p〈0.05）;与正常对照组比较,模型组血管壁增厚,脂肪堆积物增多.与模型组比较,山楂、杭菊花、决明子煎剂高、中剂量组小鼠血清HDL-C含量显著增加,TC、TG、LDL-C含量显著减少,对血管壁上脂肪的清除作用效果显著.结论：山楂、杭菊花、决明子煎剂代茶灌胃对小鼠高血脂模型具有保护作用,并能清除残留在血管壁上多余的脂肪堆积产物,加速脂肪物质代谢,预防动脉硬化的形成. 相似文献
5.
缺血性脑血管病与血脂、脂蛋白水平相关性研究 总被引：1，自引：0，他引：1
目的：观察缺血性脑血管病（ICVD）患者血脂、脂蛋白的变化。方法：对113例缺血性脑血管病[包括脑梗塞（CI）急性期25例，恢复期30例，短暂性脑缺血发作（TIA）58例]和正常对照组77例进行血脂、脂蛋白测定。结果：脑梗塞组和TIA组甘油三酯（TG）、总胆固醇（TC）、载脂蛋白B100（ApoB100）、脂蛋白（a）（Lp（a））、氧化型低密度脂蛋白（OX—LDL）水平均显著高于对照组。结论：ICVD患者存在全面血脂、脂蛋白代谢紊乱。本结果对进一步了解ICVD的发病机理和治疗提供了依据，对于观察病情演变、判断预后均有重要意义。 相似文献
6.
本文以酶联免疫吸附法(ELISA)测定了54例不同类型及不同并发症的冠心病患者与30名健康人的血浆Lp(a)浓度。心肌梗塞组和心绞痛组的Lp(a)浓度均高于对照组,并发糖尿病组Lp(a)浓度显著高于其他各组,无并发症且年龄较轻者Lp(a)浓度显著高于年龄较高者。表明血浆高Lp(a)水平是冠心病的遗传危险因素,但其升高的程度不能反映冠心病的临床类型或严重程度;并发糖尿病是老年冠心病患者血浆Lp(a)浓度升高的原因之一。 相似文献
7.
本文以酶联免疫吸附法(ELISA)测定了54例不同类型及不同并发症的冠心病患者与30名健康人的血浆Lp(a)浓度 心肌梗塞组和心绞痛组的Lp(a)浓度均高于对照组,并发糖尿病组Lp(a)浓度显著高于其他各组,无并发症且年龄较轻者Lp(a)浓度显著高于年龄较高者,表明血浆高Lp(a)水平是冠心病的遗传危险因素,但其升高的程度不能反映冠心病的临床类型或严重程度;并发糖尿病是老年冠心病患者血浆Lp(a)浓度升高的原因之一。 相似文献
8.
目的:研究血清超敏C-反应蛋白(Hs-CRP)和血脂与糖尿病并发大血管病变的关系。方法:对健康对照组105例以及119例糖尿病患者(其中并发大血管病变者51例,无大血管病变68例)检测血清Hs-CRP、TC、TG、HDL-C和LDL-C。结果:Hs-CRP健康对照组为1.05±0.59,与糖尿病无论合并大血管病变与否均有显著性增高(P<0.01)。糖尿病合并大血管病变组TC、TG、LDL-C比健康对照组有显著性增高(P<0.01),而HDL-C三组之间无显著性差异。结论:Hs-CRP、TC、TG和LDL-C与糖尿病并发大血管病变有密切关系,而HDL-C与糖尿病并发大血管病变没有关联,因而血清超敏CRP与TC、TG及LDL-C联合检测对大血管并发症的检测、预防和治疗具有很好的价值。 相似文献
9.
目的 :为了研究动脉粥样硬化性心脑血管疾病患者血浆脂蛋白 (a)水平与纤溶活性的关系 ,探讨脂蛋白 (a)促血栓形成和致动脉粥样硬化的机理。方法 :分别测定 4 2例心肌梗塞患者、4 2例心绞痛患者、4 4例脑梗塞患者及 38名健康对照者的脂蛋白 (a)浓度、组织型纤溶酶原激活剂 (tPA[lj1])及其抑制物 (PAI)活性 ,并分析其相关性。结果 :各组动脉粥样硬化性心脑血管疾病患者血浆脂蛋白 (a)浓度和PAI活性明显升高 ,tPA活性明显降低 ;各组脂蛋白 (a)与PAI活性均呈显著正相关。结论 :血浆高脂蛋白 (a)浓度是动脉粥样硬化性心脑血管疾病的主要危险因素之一 ,脂蛋白 (a)水平的升高与纤溶活性低下有关 相似文献
10.
Ⅱ型糖尿病血脂特点的观察 总被引：2，自引：0，他引：2
[目的]观察Ⅱ型糖尿病患者血清中总胆固醇(TC)、甘油三脂(TG)、高密度脂蛋白-胆固醇(HDL-C)、低密度脂蛋白-胆固醇(LDL-C)、载脂蛋白AI(apoAl)、载脂蛋白B(apoB)的浓度与正常人是否有差异,以了解Ⅱ型糖尿病病人的脂类代谢是否有变化以及变化趋势对Ⅱ型糖尿病患者并发症的影响。[方法]对50例临床已确诊的Ⅱ型糖尿病病人和10例健康人分别测定血清中的TC(CHOD-PAP)、TG(GPO-PAP)、HDL-C、LDL-C(直接法-液体双试剂)、apoAl、apoB(免疫比浊法).[结果]部分Ⅱ型糖尿病患者脂类代谢出现异常,其中TC、TG、LDL-C、apoB水平升高,而HDL-C、apoAl降低,这些患者从临床资料看,多数并发大血管病变(冠心病、脑血管病变、肢体的动脉硬化等);部分Ⅱ型糠尿病患者血脂与正常对照组无显著性差异,临床资料显示,这些患者仅为单纯血糖升高,没有并发症出现.[结论]Ⅱ型糖尿病患者的血脂代谢异常与并发症的关系密切. 相似文献
11.
Kimak E Hałabiś M Baranowicz-Gąszczyk I Solski J Książek A 《Journal of Zhejiang University. Science. B》2011,12(5):365-371
Disturbances in the metabolism of lipoprotein profiles and oxidative stress in hemodialyzed (HD) and post-renal transplant
(Tx) patients are proatherogenic, but elevated concentrations of plasma high-density lipoprotein (HDL) reduce the risk of
cardiovascular disease. We investigated the concentrations of lipid, lipoprotein, HDL particle, oxidized low-density lipoprotein
(ox-LDL) and anti-ox-LDL, and paraoxonase-1 (PON-1) activity in HD (n=33) and Tx (n=71) patients who were non-smokers without active inflammatory disease, liver disease, diabetes, or malignancy. HD patients
had moderate hypertriglyceridemia, normocholesterolemia, low HDL-C, apolipoprotein A-I (apoA-I) and HDL particle concentrations
as well as PON-1 activity, and increased ox-LDL and anti-ox-LDL levels. Tx patients had hypertriglyceridemia, hypercholesterolemia,
moderately decreased HDL-C and HDL particle concentrations and PON-1 activity, and moderately increased ox-LDL and anti-ox-LDL
levels as compared to the reference, but ox-LDL and anti-ox-LDL levels and PON-1 activity were more disturbed in HD patients.
However, in both patient groups, lipid and lipoprotein ratios (total cholesterol (TC)/HDL-C, LDL-C/HDL-C, triglyceride (TG)/HDL-C,
HDL-C/non-HDL-C, apoA-I/apoB, HDL-C/apoA-I, TG/HDL) were atherogenic. The Spearman’s rank coefficient test showed that the
concentration of ox-LDL correlated positively with HDL particle level (R=0.363, P=0.004), and negatively with TC (R=−0.306, P=0.012), LDL-C (R=−0.283, P=0.020), and non-HDL-C (R=−0.263, P=0.030) levels in Tx patients. Multiple stepwise forward regression analysis in Tx patients demonstrated that ox-LDL concentration,
as an independent variable, was associated significantly positively with HDL particle level. The results indicated that ox-LDL
and decreased PON-1 activity in Tx patients may give rise to more mildly-oxidized HDLs, which are less stable, easily undergo
metabolic remodeling, generate a greater number of smaller pre-β-HDL particles, and thus accelerate reverse cholesterol transport,
which may be beneficial for Tx patients. Further studies are necessary to confirm this. 相似文献
12.
目的:研究慢性肾功能衰竭患者血浆脂蛋白(a)与纤溶活性的关系.方法:应用酶联免疫吸附法分别测定58例慢性肾功能衰竭患者及51名健康对照者的血浆脂蛋白(a)浓度,并以底物显色法测定其组织型纤溶酶原激活剂(tPA)及其抑制物(PAI)活性.结果:慢性肾功能衰竭患者血浆脂蛋白(a)浓度和PAI活性明显升高,tPA活性明显降低;脂蛋白(a)浓度与血浆尿素氮水平、PAI活性均呈正相关;脂蛋白(a)浓度与tPA活性呈负相关.结论:肾功能对血浆脂蛋白(a)浓度起一定的调节作用,脂蛋白(a)水平的升高与纤溶活性低下有关. 相似文献
13.
Wei-xing Chen Chuan-qin Xu Shao-hua Chen Gen-yun Xu Huai-zhuang Ye 《Journal of Zhejiang University. Science. B》2012,13(5):395-401
Event-related potential (ERP) is a reliable neuroelectric measure of brain activity that helps to confirm the assessment of
mental status and cognitive impairment. Many studies have reported that alcoholics show a significantly lower ERP P300 amplitude
than the norm. In the present study, ERP P300 waves were measured to evaluate the effect of citric acid on cognitive function
during excessive alcohol consumption in healthy adults. Five volunteers were selected through clinical interview, physical
examination, and psychiatric assessment for participation in this study. In a double-blind placebo-controlled before-after
design, each subject was treated with 5 ml/kg body weight alcohol, 5 ml/kg body weight alcohol and 1 mg citric acid, or a
placebo on three separate occasions, one week apart. ERP P300, blood biochemical indicators, blood alcohol concentrations
(BACs) and acetaldehyde concentrations were assessed. Repeated measure analysis of variance (ANOVA) with a within-subjects
factor was used to evaluate differences in blood biochemical indicators, BACs, blood acetaldehyde concentrations, and ERP
P300 in the three sessions of assessments. Several blood biochemical indicators showed significant differences between treatments,
including the levels of cholinesterase (CHE), total bile acid (TBA), triglyceride (TG), total cholesterol (TC), high-density
lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), very low-density lipoprotein cholesterol (VLDL-C),
and glycylproline dipeptidyl aminopeptidase (GPDA). BACs after consumption of alcohol alone or citric acid with alcohol were
significantly higher compared to those after placebo treatment (P<0.05). There were no significant differences in blood acetaldehyde concentrations between the treatments. The P300 amplitudes
on the frontal (Fz), central (Cz), and parietal (Pz) regions of the scalp after consumption of alcohol were significantly
lower than those after consumption of the placebo or citric acid with alcohol (P<0.05), while there were no significant differences between the latter two treatments. The results of this study suggest that
citric acid could reduce the decline in ERP P300 amplitude and cognitive ability induced by acute alcohol consumption. It
may also affect some blood biochemical indicators, but the specific mechanisms need further research. 相似文献
14.
Xue-fen Yang Yue-qin Qiu Li Wang Kai-guo Gao Zong-yong Jiang 《Journal of Zhejiang University. Science. B》2018,19(11):884-894
Because of their physiological similarity to humans, pigs provide an excellent model for the study of obesity. This study evaluated diet-induced adiposity in genetically lean pigs and found that body weight and energy intake did not differ between controls and pigs fed the high-fat (HF) diet for three months. However, fat mass percentage, adipocyte size, concentrations of total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C), insulin, and leptin in plasma were significantly higher in HF pigs than in controls. The HF diet increased the expression in backfat tissue of genes responsible for cholesterol synthesis such as Insig-1 and Insig-2. Lipid metabolism-related genes including sterol regulatory element binding protein 1c (SREBP-1c), fatty acid synthase 1 (FASN1), diacylglycerol O-acyltransferase 2 (DGAT2), and fatty acid binding protein 4 (FABP4) were significantly up-regulated in backfat tissue, while the expression of proliferator-activated receptor-α (PPAR-α) and carnitine palmitoyl transferase 2 (CPT2), both involved in fatty acid oxidation, was reduced. In liver tissue, HF feeding significantly elevated the expression of SREBP-1c, FASN1, DGAT2, and hepatocyte nuclear factor-4α (HNF-4α) mRNAs. Microarray analysis further showed that the HF diet had a significant effect on the expression of 576 genes. Among these, 108 genes were related to 21 pathways, with 20 genes involved in adiposity deposition and 26 related to immune response. Our results suggest that an HF diet can induce genetically lean pigs into obesity with body fat mass expansion and adipose-related inflammation. 相似文献
15.
Yan ZHANG Wenjia ZHANG Min XIA Zhujun XIE Fangmei AN Qiang ZHAN Wenying TIAN Tianyue ZHU 《Journal of Zhejiang University. Science. B》2021,22(2):136
Objective:To investigate the relationship between the fatty acid-binding protein 4(FABP4)and colorectal cancer(CRC).Methods:Using an enzyme-linked immunosorbent assay(ELISA),we measured the expression of FABP4 in plasma of50 patients who underwent surgery for CRC from October 2017 to May 2018 and 50 healthy controls.The content of the visceral fat area(VFA)as seen with abdominal computed tomography(CT)scanning was measured by ImageJ software.The expression levels of FABP4,E-cadherin,and Snail proteins in CRC and adjacent tissues were determined by immunohistochemistry.Results:The mean concentration of plasma FABP4 of CRC patients was higher than that of the control group(22.46 vs.9.82 ng/m L;P<0.05).The concentration of plasma FABP4 was related to the tumor,node,metastatis(TNM)stage and lymph node metastasis and was independent of age,body mass index(BMI),tumor size and location,and the degree of differentiation of CRC.The concentration of plasma FABP4 was positively correlated with high VFA and lipoprotein-a(LPA)(P<0.05);but it was not correlated with total cholesterol(TG),total triglyceride(TC),low-density lipoprotein(LDL),high-density lipoprotein(HDL),or apolipoprotein AI(Apo-AI).The expression of FABP4 protein in CRC tissues was positively correlated with the degree of CRC differentiation,tumor stage,and lymph node metastasis.The level of FABP4 protein was negatively correlated with E-cadherin protein(r=-0.3292,P=0.0196)and positively correlated with Snail protein(r=0.5856,P<0.0001).Conclusions:High LPA and VFA were risk factors for increased plasma FABP4 in CRC patients.FABP4 protein was highly expressed in CRC tissues and associated with TNM stage,differentiation,and lymph node metastasis of CRC.The level of FABP4 in CRC tissue was correlated with E-cadherin and Snail expression,suggesting that FABP4 may promote CRC progression related to epithelial-mesenchymal transition(EMT). 相似文献
16.
选择体重、产蛋率相近的430日龄健康罗曼褐蛋鸡48只,随机分为2组,每组4个重复,每个重复6只鸡,对照组饲喂基础日粮,试验组在基础日粮中添加1%决明子粉,预试期1周,试验期6周。研究决明子对罗曼褐蛋鸡生产性能、鸡蛋胆固醇含量及血清生化指标的影响。结果表明,日粮中添加1%决明子鸡蛋中的蛋白质、脂肪含量分别比对照组提高10.54%(P0.05)和9.86%(P0.05);每克蛋黄胆固醇含量比对照组降低27.00%(P0.01),每枚鸡蛋胆固醇含量比对照组降低32.85%(P0.01);添加决明子对蛋鸡的生产性能没有显著影响(P0.05),但降低了蛋鸡血清中低密度脂蛋白胆固醇(LDL-C)(P0.01)、总胆固醇(TC)(P0.01)和甘油三酯(TG)(P0.05)的含量,增加了血清高密度脂蛋白胆固醇(HDL-C)(P0.01)的浓度量。说明决明子具有显著降低鸡蛋胆固醇含量,改善鸡蛋品质的作用。 相似文献