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ＤＥＶＥＬＯＰＭＥＮＴＡＮＤＰＲＯＳＰＥＣＴＯＦＧＥＮＥＲＡＬＨＯＰＳＩＴＡＬＡＲＣＨＩＴＥＣＴＵＲＥＩＮＣＨＩＮＡＨｅＺｈｅｎｄｏｎｇ（贺镇东）（ＤｅｐａｒｔｍｅｎｔｏｆＡｒｃｈｉｔｅｃｔｕｒｅ）ＤＥＶＥＬＯＰＭＥＮＴＡＮＤＰＲＯＳＰＥＣＴＯＦＧＥ... 相似文献
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“ＳＰＥＣＩＦＩＣＡＴＩＯＮＰＬＵＳＴＲＡＮＳＦＯＲＭＡＴＩＯＮＴＯＰＲＯＧＲＡＭ”：ＡＮＥＷＭＯＤＥＬＯＦＳＯＦＴＷＡＲＥＤＥＶＥＬＯＰＭＥＮＴＳｈｅｎＪｕｎ（沈军）ＣｈｅｎｇＺｈｅｎｇｃｈａｏ（程正潮）（ＤｅｐａｒｔｍｅｎｔｏｆＣｏｍｐｕｔｅｒＳ... 相似文献
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一、中小学网络的配置目前中小学装备的微机网络大致有两种：１．ＮＯＶＥＬＬ３．１２＋ＰＷＩＮ３２：这种网络系统主要是装备微机较早的学校普遍采用的。一般装的是ＮＯＶＥＬＬ３．１２版（２５０用户）,硬件设备一般是４８６兼容机（少数学校是奔腾）,４Ｍ内存（少数学校是ＳＭ）,网络系统中装有常用的辅助教学软件,如ＷＴ、练习指法的ＣＡＩ、ＵＣＤＯＳ５．０或６．０网络版、中文ＷＩＮＤＯＷＳ３．２等。２．ＷＩＮＤＯＷＳＮＴ４．０＋文ＷＩＮＤＯＷＳ９５（ＤＯＳ）：这种网络系统主要是近期装备微机的学校采用的。一般安装… 相似文献
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ＬＯＣＡＬＩＮＦＬＵＥＮＣＥＡＮＡＬＹＳＩＳＢＡＳＥＤＯＮＴＨＥＫ－ＬＤＩＳＴＡＮＣＥＡＮＤＴＨＥＩＮＦＯＲＭＡＴＩＯＮＤＩＳＴＡＮＣＥＨｕＹｕｅｑｉｎｇ（胡跃清）（ＤｅｐａｒｔｍｅｎｔｏｆＭａｔｈｅｍａｔｉｃｓａｎｄｍｅｃｈａｎｉｃｓ）ＬＯＣＡＬＩ... 相似文献
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ＡＮＯＴＥＯＮＴＨＥＵＮＩＱＵＥＮＥＳＳＴＨＥＯＲＥＭＦＯＲＳＴＥＡＤＹ－ＳＴＡＴＥＳＥＭＩＣＯＮＤＵＣＴＯＲＥＱＵＡＴＩＯＮＳＧｕａｎＰｉｎｇ（管平）（ＤｅｐａｒｔｍｅｎｔｏｆＭａｔｈｅｍａｔｉｃｓａｎｄＭｅｃｈａｎｉｃｓ）ＡＮＯＴＥＯＮＴＨＥＵＮ... 相似文献
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ＩＮＦＬＵＥＮＣＥＭＥＡＳＵＲＥＯＦＰＥＲＴＵＲＢＡＴＩＯＮＡＮＤＶＡＲＩＡＢＬＥＳＩＮＲＥＧＲＥＳＳＩＯＮＭＯＤＥＬＳＨｕＹｕｅｑｉｒｉｇ（胡跃清）（ＤｅｐａｒｔｍｅｎｔｏｆＭａｔｈｅｍａｔｉｃｓａｎｄＭｅｃｈａｎｉｃｓ）ＩＮＦＬＵＥＮＣＥＭＥＡＳ... 相似文献
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于治国 《铜陵职业技术学院学报》2011,10(4):35-36
目的：探讨山茶花提取物（extractofCamelliajaponicaL．ECJ）预处理对小鼠脑缺血再灌注损伤的保护作用及其机制。方法：采用大脑中动脉线栓法制作小鼠大脑中动脉闭塞（MCAO）模型,观察ECJ预处理对小鼠大脑中动脉栓塞再灌注后脑梗死体积、血清小鼠神经特异性烯醇化酶（NSE）的活性及丙二醛（MDA）含量的变化。结果：与模型组对比,ECJ（15mgrkg^-1,30mg．kg^-1,60mg．kg-1）预处理明显减少脑梗塞体积,并可显著降低血清中NSE和MDA含量。结论：山茶花提取物预处理对小鼠脑缺血再灌注损伤具有明显的保护作用。 相似文献
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ＮＥＷＳＵＦＦＩＣＩＥＮＴＣＯＮＤＩＴＩＯＮＦＯＲＨＡＭＩＬＴＯＮＩＨＮＰＲＯＰＥＲＴＩＥＳＩＮＧＲＡＰＨＳＳｏｎｇＺｅｎｇｍｉｎ（宋增民）（ＤｅｐａｒｔｍｅｎｔｏｆＭａｔｈｅｍａｔｉｃｓａｎｄＭｅｃｈａｎｉｃｓ）ＮＥＷＳＵＦＦＩＣＩＥＮＴＣＯＮＤＩ... 相似文献
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目的：观察线栓法致大鼠局灶性脑缺血模型后,不同时相神经功能评分、脑梗死灶体积、血清神经元特异性烯醇化酶（neuron specific enolase,NSE）含量的变化.方法：大鼠随机分为脑缺血模型组和假手术组,每组大鼠又随机分为缺血1、6、12、24、72 h组与120 h组6个时相组.采用线栓法建立大鼠局灶性脑缺血模型,观察记录大鼠大脑中动脉栓塞（middle cerebral artery occlusion,MCAO）后不同时相神经功能评分、测定血清NSE含量的变化,TTC染色观察脑梗死灶体积.结果：假手术组神经功能评分均为0;模型组在缺血1h神经功能评分就明显升高,24 h达到最高,持续到120 h.假手术组脑梗死灶体积均为0;模型组在缺血6h脑梗死灶体积才明显升高,24 h达到最高,72 h明显下降,120 h再次升高.假手术组血清NSE含量在各个时相没有明显变化;模型组在缺血1h血清NSE含量就明显升高,12h达到最高,24 h明显下降,一直持续到120 h.结论：脑缺血后神经功能评分、脑梗死灶体积、血清中NSE含量都明显升高,但三者在不同时相的变化是不一致的. 相似文献
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目的：通过康脑液干预观察其对脑缺血再灌注损伤大鼠血管内皮生长因子（vascular endothelial growth factor,VEGF）、脑源性神经生长因子（brain derived neurotrophic factor,BDNF）、基质金属蛋白酶（matrix metalloproteinase-9,MMP-9）表达的影响,探讨康脑液对脑缺血再灌注损伤的保护机制.方法：将雄性SD大鼠随机分为假手术组、脑缺血再灌注模型组及康脑液28.6、14.3、7.15 g·kg-1·d-1剂量组（灌胃给药7 d）,改进Longa等线栓法制备大鼠右侧大脑中动脉阻塞（middle cerebral artery occlusion,MCAO）再灌注模型.于缺血2h后再灌注（分别于再灌注后6h、12h、24 h、72 h、7d处死大鼠）;采用TTC染色法观察大鼠的脑梗死面积;免疫组织化学法观察大鼠脑组织VEGF、BDNF、MMP-9的表达.结果：比较各组缺血再灌注24 h大鼠脑梗死灶面积,发现28.6、14.3 g·kg--1·d-1剂量组较脑缺血再灌注模型组明显减小（P＜0.05）;与脑缺血再灌注模型组相比,28.6、14.3 g·kg--1·d-1剂量组各时间点的VEGF、BDNF表达量明显上调（P＜0.01）,MMP-9表达的阳性细胞明显减少（P＜0.01）,差异有统计学意义.结论：康脑液可促进大鼠局灶性脑缺血后脑组织中VEGF,BDNF的表达,同时抑制脑内MMP-9的表达,缩小脑梗死面积,发挥对神经血管单元（neurovascular unit,NVU）的保护作用,减轻脑缺血再灌注损伤. 相似文献
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GM1 stabilizes expression of NMDA receptor subunit 1 in the ischemic hemisphere of MCAo／reperfusion rat 总被引：3，自引：0，他引：3
Liu JR Ding MP Wei EQ Luo JH Song Y Huang JZ Ge QF Hu H Zhu LJ 《Journal of Zhejiang University. Science. B》2005,6(4):254-258
INTRODUCTION GM1 ganglioside (GM1) is the main kind ofgangliosides in mammalia, and most abundant inbrain tissue (Duchemin et al., 2002). It was reportedthat GM1 could protect cerebral ischemia in vivo andin vitro, one protective mechanism of which is thatGM1 could reduce neural injury induced by toxicityof excitatory amino acid via N-methyl-D-aspartate receptor (NMDAR) (Kharlamov et al., 1993; Simon et al., 1993; Garofalo and Cue… 相似文献
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目的:在康脑液方剂干预下观察皮质区内源性神经细胞干细胞因子(SCF)mRNA在大鼠脑缺血再灌注损伤后不同时间的表达情况。方法:成年SD大鼠,以线栓法建立大脑中动脉缺血再灌注模型,随机分为模型组、药物干预组和假手术组。原位杂交技术检测脑缺血1.5h再灌注1～14d后,脑皮质区SCFmRNA表达情况。结果:脑缺血再灌注后,药物干预组、模型组SCFmRNA的表达在皮质区均明显高于假手术组,于第7天达高峰,第14天下降。结论:药物干预后脑缺血再灌注脑皮质区SCFmRNA表达在不同时间点与模型组具备相同的表达规律,两组SCFmRNA的表达无显著性差异。 相似文献
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BACKGROUND: To determine whether CT-detected cerebral infarct in young children is associated more often with abuse or unintentional head injury. METHODS: Retrospective case-control study of injured children under age 6 who had abnormal initial head CT scans and who were admitted to the only Level I pediatric trauma center in Washington State for closed head injury (CHI) from January 1, 1992 to December 31, 1998. RESULTS: Fifteen children developed cerebral infarct after CHI during the 7 year period. These cases were compared to 53 controls (those who did not develop infarct). After adjusting for the presence of SDH and for severity of injury, patients with infarcts were six times more likely to have been abused than patients without infarcts (OR 6.1; 95% CI, 1.02-36.0). CONCLUSIONS: Cerebral infarct after CHI appears to result more frequently from abuse than unintentional injury in young children. 相似文献
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目的：研究肢体远隔缺血后适应（limbremoteisehemiepostconditioning,RIP）对脑缺血再灌注损伤的影响。方法：建造大脑中动脉闭塞模型,予以双下肢远隔缺血后适应,采用Bederson评分法对雄性SD大鼠脑缺血后12、24、72h进行评分,运用磁共振T2加权像（T2-WeightedImaging,T2WI）计算梗死体积。结果：RIP组大鼠24h后Bederson评分较再灌注模型组评分减少,差异有统计学意义（P〈0．05）,据T2WI算得RIP组脑梗死体积在12、24、72h均较再灌注模型组减少,差异有统计学意义（P〈0．05）。结论：RIP减少缺血后24h神经功能评分,减少梗死体积,具有减轻再灌注损伤作用。 相似文献
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目的：观察莫诺苷对局灶性脑缺血-再灌注大鼠细胞周期蛋白Cyclin D1及CDK6的影响。方法：用线栓法制备大鼠局灶性脑缺血-再灌注模型。将15只Sprague-Dawley（SD）大鼠随机分为假手术组,模型组,莫诺苷组（270、90、30 mg·kg-1）。利用免疫组化方法检测大鼠患侧海马Cyclin D1、CDK6表达。结果：与假手术组相比,模型组Cyclin D1及CDK6表达显著增加;给予莫诺苷治疗后,与模型组相比,莫诺苷（270、90 mg·kg-1）剂量组能显著降低大鼠Cyclin D1及CDK6的表达。结论：莫诺苷能通过降低脑缺血-再灌注后Cyclin D1及CDK6的表达而发挥神经保护作用。 相似文献
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Jie Cui Zhi Li Ling-bo Qian Qin Gao Jue Wang Meng Xue Xiao-e Lou Iain C. Bruce Qiang Xia Hui-ping Wang 《Journal of Zhejiang University. Science. B》2013,14(6):487-495
Objective
To investigate the beneficial effect of bicyclol on rat hearts subjected to ischemia-reperfusion (IR) injuries and its possible mechanism.Methods
Male Sprague-Dawley rats were intragastrically administered with bicyclol (25, 50 or 100 mg/(kg·d)) for 3 d. Myocardial IR was produced by occlusion of the coronary artery for 1 h and reperfusion for 3 h. Left ventricular hemodynamics was continuously monitored. At the end of reperfusion, myocardial infarct was measured by 2,3,5-triphenyltetrazolium chloride (TTC) staining, and serum lactate dehydrogenase (LDH) level and myocardial superoxide dismutase (SOD) activity were determined by spectrophotometry. Isolated ventricular myocytes from adult rats were exposed to 60 min anoxia and 30 min reoxygenation to simulate IR injuries. After reperfusion, cell viability was determined with trypan blue; reactive oxygen species (ROS) and mitochondrial membrane potential of the cardiomyocytes were measured with the fluorescent probe. The mitochondrial permeability transition pore (mPTP) opening induced by Ca2+ (200 μmol/L) was measured with the absorbance at 520 nm in the isolated myocardial mitochondria.Results
Low dose of bicyclol (25 mg/(kg·d)) had no significant improving effect on all cardiac parameters, whereas pretreatment with high bicyclol markedly reduced the myocardial infarct and improved the left ventricular contractility in the myocardium exposed to IR (P<0.05). Medium dose of bicyclol (50 mg/(kg·d)) markedly improved the myocardial contractility, left ventricular myocyte viability, and SOD activity, as well decreased infarct size, serum LDH level, ROS production, and mitochondrial membrane potential in rat myocardium exposed to IR. The reduction of ventricular myocyte viability in IR group was inhibited by pretreatment with 50 and 100 mg/(kg·d) bicyclol (P<0.05 vs. IR), but not by 25 mg/(kg·d) bicyclol. The opening of mPTP evoked by Ca2+ was significantly inhibited by medium bicyclol.Conclusions
Bicyclol exerts cardioprotection against IR injury, at least, via reducing oxidative stress and its subsequent mPTP opening. 相似文献19.
中药对脑缺血再灌注的保护作用已成为近年来的研究热点,该文按单味中药及其提取物、中药复方和中药注射液分类综述了不同类型的中药对脑缺血再灌注损伤的保护作用机制.中药在对脑缺血再灌注的干预方面具有多层次、多靶点、多环节的作用,分别从脑缺血再灌注后的能量代谢障碍、线粒体损伤、自由基损伤、兴奋性氨基酸的毒性作用、炎症损伤及血脑屏障破坏六个方面进行阐述,并对中药的发展进行展望. 相似文献
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冰片在中风及假手术大鼠体内的药代动力学研究(英文)简 总被引：1，自引：0，他引：1
Pan XU Ying LI Shou-ying DU Yang LU Jie BAI Qing-li GUO 《Journal of Zhejiang University. Science. B》2014,15(1):84-91
Objective： This study was designed to investigate the pharmacokinetics of borneol in the pathological conditions of stroke and evaluate the pharmacokinetic differences of borneol caused by stroke after oral administration of borneol and Xingnaojing （XNJ）. Methods： The rats were divided into two groups, ischemia-reperfusion （IR） and sham-operated （SO） rats. Each group contained two subgroups： pure borneol and XNJ subgroups. After administration with the same dosages of borneol 162.0 mg/kg, plasma samples were collected. The cerebral ischemia-reperfusion model was created by reversible middle cerebral artery occlusion （MCAO）. The blood samples were collected punc- tually after oral administration and a specific gas chromatographic system-flame ionization detector （GC-FID） method was developed and employed to determine the level of borneol in the plasma. The pharmacokinetic parameters were analyzed using non-compartmental methods with Kinetica. Results： After administration of borneol, the maximum plasma concentration （Cmax） and area under the curve （AUC） values in stroke rats significantly increased by 302% and 275%, respectively, compared with the SO rats, and the same phenomenon appeared after administration of XNJ. In the rats with the same physiological conditions, the Cmax and AUC had higher values in the borneol subgroup （P〈0.05）. Conclusions： These results suggest that the pathological damages of ischemia-reperfusion have a significant impact on the pharmacokinetic traits of borneol and that there are some components in XNJ inhibiting the absorption of borneol. 相似文献